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Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
Open accessAbstract
Cellular senescence is a tumor-suppressive mechanism that can paradoxically contribute to aging pathologies. Despite evidence of immune clearance in mouse models, it is not known how senescent cells (SnCs) persist and accumulate with age or in tumors in individuals. Here, we identify cooperative mechanisms that orchestrate the immunoevasion and persistence of normal and cancer human SnCs through extracellular targeting of natural killer receptor signaling. Damaged SnCs avoided immune recognition through MMP-dependent shedding of NKG2D ligands reinforced via paracrine suppression of NKG2D receptor–mediated immunosurveillance. These coordinated immunoediting processes were evident in residual, drug-resistant tumors from cohorts of more than 700 prostate and breast cancer patients treated with senescence-inducing genotoxic chemotherapies. Unlike in mice, these reversible senescence subversion mechanisms were independent of p53/p16 and exacerbated in oncogenic RAS-induced senescence. Critically, the p16 INK4A tumor suppressor could disengage the senescence growth arrest from the damage-associated immune senescence program, which was manifest in benign nevus lesions, where indolent SnCs accumulated over time and preserved a non-proinflammatory tissue microenvironment maintaining NKG2D-mediated immunosurveillance. Our study shows how subpopulations of SnCs elude immunosurveillance and reveals potential secretome-targeted therapeutic strategies to selectively eliminate — and restore the clearance of — the detrimental SnCs that actively persist after chemotherapy and accumulate at sites of aging pathologies.
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“At younger ages, senescent cells are cleared by the host immune system [63–66]”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [63]
Experimental — accuracy not yet measuredIn the citing paper
“Senescence is also an important mechanism of efficacy in the treatment of breast cancer with PARP inhibitors [59] and many typical chemotherapy agents used to treat breast cancer, such as epirubicin and cyclophosphamide [60].”
From Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies (2020) · cites this paper as [60]
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Cites
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Cancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 5×
“relevant in adult organisms, where retaining arrested yet functional cells may help maintain tissue homeostasis (1, 3, 63, 64).”
InfluentialSelf-citationNaturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Self-citationBRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160
The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
Self-citation
Research works printed but not linked: 1
- 10.1016/j.cell.2008.06.049 · DOI · Paper page
Cited by
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Exploiting senescence for the treatment of cancer
Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00450-9 · Cited by 867
Role of immune cells in the removal of deleterious senescent cells
Kale, A., Sharma, A., Stolzing, A., Desprez, P.-Y., & Campisi, J. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00187-9 · Cited by 351
Self-citationInterconnections between Inflammageing and Immunosenescence during Ageing
Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 323
Mechanisms driving the immunoregulatory function of cancer cells
van Weverwijk, A., & de Visser, K. E. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00544-4 · Cited by 288
Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies
Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., & Kirkland, J. L. (2020) · Cancers · doi:10.3390/cancers12082134 · Cited by 235
“Senescence is also an important mechanism of efficacy in the treatment of breast cancer with PARP inhibitors [59] and many typical chemotherapy agents used to treat breast cancer, such as epirubicin and cyclophosphamide [60].”
BackgroundAging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions
Brauning, A., Rae, M., Zhu, G., Fulton, E., Admasu, T. D., Stolzing, A., & Sharma, A. (2022) · Cells · doi:10.3390/cells11061017 · Cited by 215
Aging immunity may exacerbate COVID-19
Akbar, A. N., & Gilroy, D. W. (2020) · Science · doi:10.1126/science.abb0762 · Cited by 211
NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
Yang, D., Sun, B., Li, S., Wei, W., Liu, X., Cui, X., Zhang, X., Liu, N., Yan, L., Deng, Y., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1951 · Cited by 217
Bone Aging, Cellular Senescence, and Osteoporosis
Pignolo, R. J., Law, S. F., & Chandra, A. (2021) · JBMR Plus · doi:10.1002/jbm4.10488 · Cited by 217
Senescence in osteoarthritis: from mechanism to potential treatment
Liu, Y., Zhang, Z., Li, T., Xu, H., & Zhang, H. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02859-x · Cited by 210
Reducing Senescent Cell Burden in Aging and Disease
Pignolo, R. J., Passos, J. F., Khosla, S., Tchkonia, T., & Kirkland, J. L. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.03.005 · Cited by 177
The Skin Microbiome: Current Landscape and Future Opportunities
Smythe, P., & Wilkinson, H. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043950 · Cited by 218
Saleh, T., Carpenter, V. J., Tyutyunyk‐Massey, L., Murray, G., Leverson, J. D., Souers, A. J., Alotaibi, M. R., Faber, A. C., Reed, J., Harada, H., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12761 · Cited by 190
Senescence as a therapeutic target in cancer and age-related diseases
McHugh, D., Durán, I., & Gil, J. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01074-4 · Cited by 197
Discovering dominant tumor immune archetypes in a pan-cancer census
Combes, A. J., Samad, B., Tsui, J. L., Chew, N. W., Yan, P., Reeder, G. C., Kushnoor, D., Shen, A. S., Davidson, B. R., Barczak, A. J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.12.004 · Cited by 175
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Hu, L., Li, H., Zi, M., Li, W., Liu, J., Yang, Y., Zhou, D., Kong, Q., Zhang, Y., & He, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822816 · Cited by 174
Senescence and the tumor-immune landscape: Implications for cancer immunotherapy
Chibaya, L., Snyder, J. T., & Ruscetti, M. A. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.005 · Cited by 146
Upregulation of PD-L1 in Senescence and Aging
Onorati, A., Havas, A. P., Lin, B., Rajagopal, J., Sen, P., Adams, P. D., & Dou, Z. (2022) · Molecular and Cellular Biology · doi:10.1128/mcb.00171-22 · Cited by 131
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Song, S., Tchkonia, T., Jiang, J., Kirkland, J. L., & Sun, Y. (2020) · Advanced Science · doi:10.1002/advs.202002611 · Cited by 129
Self-citationSenolytics for Cancer Therapy: Is All that Glitters Really Gold?
Carpenter, V. J., Saleh, T., & Gewirtz, D. A. (2021) · Cancers · doi:10.3390/cancers13040723 · Cited by 124
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib, S., López-Domínguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marin, I., Boix, O., García-Garijo, A., Meyer, K., Muñoz, M. I., Aguilera, M., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00712-x · Cited by 114
Targeting senescence as an anticancer therapy
Bousset, L., & Gil, J. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13312 · Cited by 113
Biological functions of therapy-induced senescence in cancer
Fitsiou, E., Soto-Gamez, A., & Demaria, M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.021 · Cited by 105
Cellular senescence as a potential mediator of COVID‐19 severity in the elderly
Nehme, J., Borghesan, M., Mackedenski, S., Bird, T. G., & Demaria, M. (2020) · Aging Cell · doi:10.1111/acel.13237 · Cited by 94
Liu, H., Zhao, H., & Sun, Y. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.004 · Cited by 100
Self-citationBeyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
Triana-Martínez, F., Loza, M. I., & Domínguez, E. (2020) · Cells · doi:10.3390/cells9020346 · Cited by 102
The role of senescent T cells in immunopathology
Covre, L. P., De Maeyer, R. P. H., Gomes, D. C. O., & Akbar, A. N. (2020) · Aging Cell · doi:10.1111/acel.13272 · Cited by 93
Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms
Beck, J. A., Turnquist, C., Horikawa, I., & Harris, C. C. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa071 · Cited by 97
Dissecting primary and secondary senescence to enable new senotherapeutic strategies
Admasu, T. D., Rae, M. J., & Stolzing, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101412 · Cited by 98
Cellular senescence in cancer: clinical detection and prognostic implications
Domen, A., Deben, C., Verswyvel, J., Flieswasser, T., Prenen, H., Peeters, M., Lardon, F., & Wouters, A. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02555-3 · Cited by 94
Shahbandi, A., Chiu, F.-Y., Ungerleider, N., Kvadas, R. M., Mheidly, Z., Sun, M. J. S., Tian, D., Waizman, D. A., Anderson, A. Y., Machado, H. L., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00466-y · Cited by 88
Jia, Y., Han, L., Ramage, C. L., Wang, Z., Weng, C. C. Y., Yang, L., Colla, S., Ma, H., Zhang, W., Andreeff, M., et al. (2023) · Haematologica · doi:10.3324/haematol.2022.281915 · Cited by 80
Salminen, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101280 · Cited by 77
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Rossi, M., & Abdelmohsen, K. (2021) · Cells · doi:10.3390/cells10071740 · Cited by 71
Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis
Blander, H. D., Morel, A., Senaratne, A. P., Ouzounova, M., & Puisieux, A. (2021) · Cancers · doi:10.3390/cancers13184561 · Cited by 82
The senescence journey in cancer immunoediting
Zingoni, A., Antonangeli, F., Sozzani, S., Santoni, A., Cippitelli, M., & Soriani, A. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01973-5 · Cited by 77
Cellular Senescence: Mechanisms, Morphology, and Mouse Models
Beck, J. A., Horikawa, I., & Harris, C. C. (2020) · Veterinary Pathology · doi:10.1177/0300985820943841 · Cited by 80
Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
Dominic, A., Banerjee, P., Hamilton, D. J., Le, N., & Abe, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101614 · Cited by 72
Targeting tumor cell senescence and polyploidy as potential therapeutic strategies
Saleh, T., Carpenter, V. J., Bloukh, S., & Gewirtz, D. A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.010 · Cited by 70
Cellular senescence in lymphoid organs and immunosenescence
Budamagunta, V., Foster, T. C., & Zhou, D. (2021) · Aging · doi:10.18632/aging.203405 · Cited by 73
NKG2D Ligand Shedding in Response to Stress: Role of ADAM10
Zingoni, A., Vulpis, E., Loconte, L., & Santoni, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00447 · Cited by 59
Liu, Y., Lomeli, I., & Kron, S. J. (2024) · Cells · doi:10.3390/cells13151281 · Cited by 74
Exercise Counters the Age-Related Accumulation of Senescent Cells
Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000302 · Cited by 63
Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis
Walton, C. C., Begelman, D. V., Nguyen, W., & Andersen, J. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00129 · Cited by 62
Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
Battram, A. M., Bachiller, M., & Martín-Antonio, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124346 · Cited by 66
Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases
Han, T., Xu, Y., Sun, L., Hashimoto, M., & Wei, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385845 · Cited by 64
Aging and homeostasis of the hypodermis in the age-related deterioration of skin function
Liu, M., Lu, F., & Feng, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06818-z · Cited by 71
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
Banerjee, P., Kotla, S., Velatooru, L. R., Abe, R. J., Olmsted‐Davis, E. A., Cooke, J. P., Schadler, K., Deswal, A. M., Herrmann, J., Lin, S. H., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.763930 · Cited by 55
Senescence-associated hyper-activation to inflammatory stimuli in vitro
Budamagunta, V., Manohar‐Sindhu, S., Yang, Y., He, Y., Traktuev, D. O., Foster, T. C., & Zhou, D. (2021) · Aging · doi:10.18632/aging.203396 · Cited by 54
Luo, J., Sun, T., Liu, Z., Liu, Y., Liu, J., Wang, S., Shi, X., & Zhou, H. (2025) · International Journal of Oral Science · doi:10.1038/s41368-025-00380-w · Cited by 61
Senescent cells in cancer therapy: why and how to remove them
Zhang, J., Zhang, D., & Yu, B. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.07.002 · Cited by 52
The senescence-associated secretory phenotype: Fueling a wound that never heals
Pulido, T., Velarde, M. C., & Alimirah, F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111561 · Cited by 54
Senescence-induced immune remodeling facilitates metastatic adrenal cancer in a sex-dimorphic manner
Warde, K. M., Smith, L., Liu, L., Stubben, C., Lohman, B. K., Willett, P. W., Ammer, J. L., Castaneda-Hernandez, G., Imodoye, S. O., Zhang, C., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00420-2 · Cited by 52
Cell senescence in cardiometabolic diseases
Grootaert, M. O. J. (2024) · npj Aging · doi:10.1038/s41514-024-00170-4 · Cited by 56
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, J., Imanishi, M., Li, S., Zhang, A., Ko, K. A., Samanthapudi, V. S. K., Lee, L.-L., Paniagua-Bojorges, A., Gi, Y. J., Hobbs, B. P., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322017 · Cited by 46
Deconstructing tumor heterogeneity: the stromal perspective
Vickman, R. E., Faget, D. V., Beachy, P. A., Beebe, D. J., Bhowmick, N. A., Cukierman, E., Deng, W.-M., Granneman, J. G., Hildesheim, J., Kalluri, R., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27736 · Cited by 43
Self-citationSaleh, T., & Gewirtz, D. A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01787-6 · Cited by 42
Bai, Z., Yang, P., Yu, F., Li, Z., Yao, Z., Martinez, J., Li, M., & Xu, H. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04562-w · Cited by 43
“DDR is critical in inducing SNCs to up regulate NKG2D ligands, which enables NK cells to recognize and clear SNCs in a timely manner [37].”
BackgroundThe Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis
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A guide to senolytic intervention in neurodegenerative disease
Lee, S., Wang, E. Y., Steinberg, A. B., Walton, C. C., Chinta, S. J., & Andersen, J. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111585 · Cited by 43
Cellular senescence signaling in cancer: A novel therapeutic target to combat human malignancies
Fakhri, S., Moradi, S. Z., DeLiberto, L. K., & Bishayee, A. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114989 · Cited by 39
Harnessing Natural Killer Cells in Non-Small Cell Lung Cancer
Russell, É., Conroy, M. J., & Barr, M. P. (2022) · Cells · doi:10.3390/cells11040605 · Cited by 37
Insights into the role of senescence in tumor dormancy: mechanisms and applications
DeLuca, V. J., & Saleh, T. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10082-6 · Cited by 37
Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review
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Enhancing immunity during ageing by targeting interactions within the tissue environment
Bracken, O. V., Maeyer, R. P. H. D., & Akbar, A. N. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01126-9 · Cited by 43
Cellular senescence offers distinct immunological vulnerabilities in cancer
Zhou, L., Ma, B., & Ruscetti, M. A. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.010 · Cited by 40
Shachar, S. S., Deal, A. M., Reeder-Hayes, K. E., Nyrop, K. A., Mitin, N., Anders, C. K., Carey, L., Dees, E. C., Jolly, T. A., Kimmick, G. G., et al. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa082 · Cited by 33
Chaturvedi, P., George, V., Shrestha, N., Wang, M., Dee, M. J., Zhu, X., Liu, B., Egan, J. O., D’Eramo, F., Spanoudis, C. M., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.025 · Cited by 34
A nutrigeroscience approach: Dietary macronutrients and cellular senescence
Calubag, M. F., Robbins, P. D., & Lamming, D. W. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.07.025 · Cited by 33
Almasabi, S., Ahmed, A. U., Boyd, R. L., & Williams, B. R. G. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.638558 · Cited by 31
Cellular Senescence in Hepatocellular Carcinoma: The Passenger or the Driver?
Cai, X., Guillot, A., & Liu, H. (2022) · Cells · doi:10.3390/cells12010132 · Cited by 31
Reliable Hallmarks and Biomarkers of Senescent Lymphocytes
Сергеевна, М. Ю., Tereshchenko, V., Bogdanova, D. A., & Александрович, Р. С. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115653 · Cited by 28
Escriche‐Navarro, B., Garrido, E. M. N., Sancenón, F., García‐Fernández, A., & Martínez‐Máñez, R. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.002 · Cited by 29
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Saleh, T., Greenberg, E. F., Faber, A. C., Harada, H., & Gewirtz, D. A. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2219 · Cited by 28
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Qi, X., Li, J., & Cao, J. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.103365 · Cited by 25
Farhana, A., Alsrhani, A., Khan, Y. S., & Rasheed, Z. (2023) · Cancers · doi:10.3390/cancers15153836 · Cited by 25
Impact of senolytic treatment on immunity, aging, and disease
Lorenzo, E. C., Torrance, B. L., & Haynes, L. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1161799 · Cited by 28
Targeting immunosenescence for improved tumor immunotherapy
Liu, Z., Zuo, L., Zhou, Z., Liu, S., Ba, Y., Zuo, A., Ren, Y., Zhang, C., Chen, Y., Ma, H., et al. (2024) · MedComm · doi:10.1002/mco2.777 · Cited by 24
Role of low-dose radiation in senescence and aging: A beneficial perspective
Xu, J., Liu, D., Zhao, D., Jiang, X. M., Meng, X., Jiang, L., Meina, Y., Zhang, L., & Jiang, H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120644 · Cited by 30
Fabbri, F., Salvi, S., & Bravaccini, S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.015 · Cited by 27
Therapy-Induced Senescence: Novel Approaches for Markers Identification
Pacifico, F., Magni, F., Leonardi, A., & Crescenzi, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158448 · Cited by 25
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Self-citationAbu-Humaidan, A. H. A., Ismail, M. A., Ahmad, F. M., Shboul, S. A., Barham, R., Tadros, J. S., Alhesa, A., El‐Sadoni, M., Alotaibi, M. R., Ababneh, N. A., et al. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12727 · Cited by 13
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Nutritional Niches of Cancer Therapy-Induced Senescent Cells
Llop‐Hernández, À., Verdura, S., Cuyàs, E., & Menéndez, J. A. (2022) · Nutrients · doi:10.3390/nu14173636 · Cited by 13
Metadata
- Authors
- Muñoz, D. P., Yannone, S. M., Daemen, A., Sun, Y., Vakar-Lopez, F., Kawahara, M., Freund, A. M., Rodier, F., Wu, J. D., Desprez, P.-Y., Raulet, D. H., Nelson, P. S., van ’t Veer, L. J., Campisi, J., & Coppé, J.-P.
- Affiliations
- University of California, San Francisco (US)
- Lawrence Berkeley National Laboratory (US)
- Fred Hutch Cancer Center (US)
- Department of Pathology, University of Washington, Seattle, Washington, USA.
- Buck Institute for Research on Aging (US)
- Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, California, USA.
- University of Washington (US)
- University of California, Berkeley (US)
- Helen Diller Family Comprehensive Cancer Center, Department of Laboratory Medicine, UCSF, San Francisco, California, USA.
- Corresponding author
- Coppé, Jean-Philippe
- ORCID
- Venue
- JCI Insight
- Published
- 2019-07-25
- Volume
- 4
- Issue
- 14
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC6675550
- OpenAlex
- W2952749575
- Cited by
- 162
- References
- 92
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 25 · 2023: 21 · 2022: 30 · 2021: 26 · 2020: 23 · 2019: 1
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R56AG009909, R37AG009909, P01AG017242)
- National Cancer Institute (R01CA093678, R01CA204021, R01CA165573, P50CA097186)
- National Institute of Allergy and Infectious Diseases (R01AI113041)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, senescent cells, immune evasion, NKG2D, natural killer cells, matrix metalloproteinases, immune surveillance, immunoediting, chemoresistance, aging, prostate cancer, breast cancer, Ras-induced senescence, p16INK4a, benign nevi, tumor microenvironment
- MeSH terms
- Aging, Animals, Antineoplastic Agents, Biopsy, Breast, Breast Neoplasms, DNA Damage, Female, Humans, Immunologic Surveillance, Male, Metalloendopeptidases, Prostate, Prostatic Neoplasms, Gene Expression Regulation, Neoplastic, Cellular Senescence, Drug Resistance, Neoplasm, Tumor Escape, Cyclin-Dependent Kinase Inhibitor p16, Gene Expression Profiling, Cell Line, Tumor, Tissue Array Analysis, Mice, NK Cell Lectin-Like Receptor Subfamily K, Tumor Microenvironment, Datasets as Topic
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