Cited by 213Estrogen and related hormone effectsSteroid Chemistry and BiochemistryAdrenal Hormones and Disorders

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17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.

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Casey, M L, MacDonald, P C, Andersson, S·1994·Journal of Clinical Investigation

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Abstract

The cDNAs for two separate human 17 beta-hydroxysteroid dehydrogenases (17 beta-HSD) have been isolated and sequenced. The well-studied human placental cytosolic 17 beta-HSD (also referred to as estradiol dehydrogenase) preferentially catalyzes the reduction of estrone to estradiol-17 beta and the reduction of the C-20-ketone of progesterone to 20 alpha-dihydroprogesterone. This isoform of the enzyme has been referred to as 17 beta-HSD type 1 and localized to chromosome 17. A second 17 beta-HSD isoform (referred to as type 2) is localized in the endoplasmic reticulum of human trophoblast and is characterized by the preferential oxidation of the C-17 beta-hydroxyl group of C18- and C19-steroids and the C-20 alpha-hydroxyl group of 20 alpha-dihydroprogesterone. In this study, we determined the chromosomal localization of human 17 beta-HSD type 2, the expression of this gene in human endometrium, and the tissue distribution of the mRNA. We found that the human 17 beta-HSD type 2 gene is localized on chromosome 16, 16q24. 17 beta-HSD type 2 mRNA (approximately 1.5 kb) was identified in human endometrial tissues by Northern analysis of total RNA (10 micrograms). The highest levels of 17 beta-HSD type 2 mRNA were found in endometrial tissues obtained during the mid- to late secretory phase of the ovarian cycle (i.e., during the time of high plasma levels of progesterone). 17 beta-HSD type 2 mRNA levels were much greater in glandular epithelium than in the stromal cells isolated from secretory phase endometrium. The levels of 17 beta-HSD type 2 mRNA in secretory phase endometrium were approximately one-tenth that in villous trophoblast tissue from human placenta. We did not detect 17 beta-HSD type 1 mRNA in endometrial tissue by Northern analysis of total (10 micrograms) RNA. These findings are consistent with the view that the progestin-regulated 17 beta-HSD of the glandular epithelium of the human endometrium is primarily, if not exclusively, the product of the 17 beta-HSD type 2 gene. 17 beta-HSD type 2 mRNA was present in human placenta, liver, and small intestine; much smaller amounts, barely detectable by Northern analysis of poly(A)+ RNA, were present in prostate, kidney, pancreas, and colon, but not in heart, brain, skeletal muscle, spleen, thymus, ovary, or testis.

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Authors: Casey, M. L., MacDonald, P. C., & Andersson, S.
Affiliations: The University of Texas Southwestern Medical Center (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1994-11-01
Volume: 94
Issue: 5
Pages: 2135-2141
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117569
PMC: PMC294662
OpenAlex: W2053311013
Semantic Scholar: e0c45caf9b177e26120a97b0a2082feb33ac7b43
Cited by: 212
References: 46
Citations by year: 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 5.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hd011149-17)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (5-P50-HD-11149)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: chromosomal localization, endometrium, luteal phase, progesterone regulation, gene expression, trophoblast, endoplasmic reticulum, glandular epithelium, stromal cells
MeSH terms: Chromosome Mapping, Chromosomes, Human, Pair 16, Endometrium, Female, Gene Expression Regulation, Humans, Isoenzymes, Placenta, Progestins, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases

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17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.

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