The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
Open accessAbstract
Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) have been shown in mice to regulate metabolism via the central nervous system, but the specific neurons mediating these effects are unknown. Here, we have shown that proopiomelanocortin (POMC) neuron-specific deficiency in PTP1B or SHP2 in mice results in reciprocal effects on weight gain, adiposity, and energy balance induced by high-fat diet. Mice with POMC neuron-specific deletion of the gene encoding PTP1B (referred to herein as POMC-Ptp1b-/- mice) had reduced adiposity, improved leptin sensitivity, and increased energy expenditure compared with wild-type mice, whereas mice with POMC neuron-specific deletion of the gene encoding SHP2 (referred to herein as POMC-Shp2-/- mice) had elevated adiposity, decreased leptin sensitivity, and reduced energy expenditure. POMC-Ptp1b-/- mice showed substantially improved glucose homeostasis on a high-fat diet, and hyperinsulinemic-euglycemic clamp studies revealed that insulin sensitivity in these mice was improved on a standard chow diet in the absence of any weight difference. In contrast, POMC-Shp2-/- mice displayed impaired glucose tolerance only secondary to their increased weight gain. Interestingly, hypothalamic Pomc mRNA and alpha-melanocyte-stimulating hormone (alphaMSH) peptide levels were markedly reduced in POMC-Shp2-/- mice. These studies implicate PTP1B and SHP2 as important components of POMC neuron regulation of energy balance and point to what we believe to be a novel role for SHP2 in the normal function of the melanocortin system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“neuronal (17) or POMC-specific (7) PTP1B knockout mice are protected from DIO and exhibit increased leptin sensitivity.”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
Buettner, R., Schölmerich, J., & Bollheimer, L. C. (2007) · Obesity · doi:10.1038/oby.2007.608 · Cited by 1,284
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
Neel, B. G., Gu, H., & Pao, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00091-4 · Cited by 1,249
Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding
Bouret, S. G., Draper, S. J., & Simerly, R. B. (2004) · Science · doi:10.1126/science.1095004 · Cited by 1,247
Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Ntambi, J. M., Miyazaki, M., Stoehr, J. P., Hong, L., Kendziorski, C. M., Yandell, B. S., Song, Y., Cohen, P., Friedman, J. M., & Attie, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132384699 · Cited by 1,096
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074
Meier, U., & Gressner, A. M. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.032482 · Cited by 1,048
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss
Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., Sharma, R., Hudgins, L. C., Ntambi, J. M., & Friedman, J. M. (2002) · Science · doi:10.1126/science.1071527 · Cited by 826
PTP1B Regulates Leptin Signal Transduction In Vivo
Zabolotny, J. M., Bence, K. K., Stricker‐Krongrad, A., Haj, F. G., Wang, Y., Minokoshi, Y., Kim, Y., Elmquist, J. K., Tartaglia, L. A., Kahn, B. B., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00148-x · Cited by 818
Self-citationActivation of Downstream Signals by the Long Form of the Leptin Receptor
Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797
Protein tyrosine phosphatases in signal transduction
Neel, B. G., & Tonks, N. K. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80063-4 · Cited by 760
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700
Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production
Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.004 · Cited by 695
Neuronal PTP1B regulates body weight, adiposity and leptin action
Bence, K. K., Delibegovic, M., Xue, B., Gorgun, C. Z., Hotamisligil, G. S., Neel, B. G., & Kahn, B. B. (2006) · Nature Medicine · doi:10.1038/nm1435 · Cited by 633
Self-citationThe role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604
Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602
Self-citationBouret, S. G., Draper, S. J., & Simerly, R. B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-03.2004 · Cited by 584
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
Zhang, S., & Zhang, Z. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.03.011 · Cited by 566
Leptin Signaling in the Central Nervous System and the Periphery
Bjørbæk, C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.305 · Cited by 559
Molecular and anatomical determinants of central leptin resistance
Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550
Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B
Cheng, A., Uetani, N., Simoncic, P. D., Chaubey, V. P., Lee-Loy, A., McGlade, C. J., Kennedy, B. P., & Tremblay, M. L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00149-1 · Cited by 545
Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus
Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476
TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B
Myers, M. P., Andersen, J. N., Cheng, A., Tremblay, M. L., Horvath, C. M., Parisien, J.-P., Salmeen, A. E., Barford, D., & Tonks, N. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100583200 · Cited by 475
Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457
Central insulin action in energy and glucose homeostasis
Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29063 · Cited by 444
PI3K integrates the action of insulin and leptin on hypothalamic neurons
Xu, A. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524301 · Cited by 420
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Benoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09048.2002 · Cited by 417
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404
Baskin, D. G., Lattemann, D. F., Seeley, R. J., Woods, S. C., Porte, D., & Schwartz, M. W. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01974-5 · Cited by 401
A brain-liver circuit regulates glucose homeostasis
Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392
Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 379
Central melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G. B., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12954 · Cited by 370
Central melanocortin receptors regulate insulin action
Obici, S., Feng, Z., Tan, J., Liu, L., Karkanias, G., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112954 · Cited by 370
Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors
Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007439200 · Cited by 364
Westerbacka, J., Kolak, M., Kiviluoto, T. A., Arkkila, P. E. T., Sirén, J., Hamsten, A., Fisher, R. M., & Yki‐Järvinen, H. (2007) · Diabetes · doi:10.2337/db07-0156 · Cited by 363
Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
Buettner, C., Muse, E. D., Cheng, A. M., Chen, L., Scherer, T., Pocai, A., Su, K., Cheng, B., Li, X., Harvey-White, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1775 · Cited by 352
van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1132 · Cited by 338
Ahima, R. S., & Osei, S. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.014 · Cited by 332
Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27123 · Cited by 326
Enomoto, H., Crawford, P. A., Gorodinsky, A., Heuckeroth, R. O., Johnson, E. M., & Milbrandt, J. (2001) · Development · doi:10.1242/dev.128.20.3963 · Cited by 299
The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC
Myers, M. G., Münzberg, H., Leinninger, G. M., & Leshan, R. L. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.001 · Cited by 297
Morton, G. J., Gelling, R. W., Niswender, K. D., Morrison, C. D., Rhodes, C. J., & Schwartz, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.009 · Cited by 292
Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many
Feng, G.-S. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4668 · Cited by 285
Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity
Zhang, J., Fu, M., Cui, T., Chen, X., Xu, K., Zhong, W., Xiao, Y., Floyd, D., Liang, J., Li, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403652101 · Cited by 283
Central insulin action regulates peripheral glucose and fat metabolism in mice
Koch, L., Wunderlich, F. T., Seibler, J., Könner, A. C., Hampel, B., Irlenbusch, S., Brabant, G. E., Kahn, C. R., Schwenk, F., & Brüning, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci31073 · Cited by 278
Delibegović, M., Zimmer, D. J., Kauffman, C., Rak, K. J., Hong, E., Cho, Y.-R., Kim, J. K., Kahn, B. B., Neel, B. G., & Bence, K. K. (2008) · Diabetes · doi:10.2337/db08-0913 · Cited by 277
Self-citationSweeney, G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00006-2 · Cited by 271
The NPY/AgRP neuron and energy homeostasis
Morton, G., & Schwartz, M. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801915 · Cited by 270
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
Zhang, E. E., Chapeau, E. A., Hagihara, K., & Feng, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405041101 · Cited by 270
Besset, V., Scott, R. P., & Ibáñez, C. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006908200 · Cited by 256
Hypothalamic Neural Projections Are Permanently Disrupted in Diet-Induced Obese Rats
Bouret, S. G., Gorski, J. N., Patterson, C. M., Chen, S. H., Levin, B. E., & Simerly, R. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.001 · Cited by 252
Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 247
Adiponectin and its role in the obesity-induced insulin resistance and related complications.
Haluzı́k, M., Pařízková, J., & Haluzík, M. (2004) · Physiological Research · doi:10.33549/physiolres.930479 · Cited by 247
Cytoplasmic protein tyrosine phosphatases, regulation and function: the roles of PTP1B and TC-PTP
Bourdeau, A., Dubé, N., & Tremblay, M. L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.001 · Cited by 246
The role of insulin receptor substrate 2 in hypothalamic and β cell function
Choudhury, A. I., Heffron, H., Smith, M. A., Al‐Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., MacColl, G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24445 · Cited by 244
Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics
Coll, A. P., Farooqi, I. S., Challis, B., Yeo, G. S. H., & O’Rahilly, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0428 · Cited by 230
Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons
Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.-H., & Bjørbæk, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.003 · Cited by 226
Leptin Receptor Signaling and Action in the Central Nervous System
Leshan, R. L., Björnholm, M., Münzberg, H., & Myers, M. G. (2006) · Obesity · doi:10.1038/oby.2006.310 · Cited by 224
Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production
Fisher, S. J., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16426 · Cited by 211
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419511 · Cited by 210
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyń, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19511 · Cited by 209
Distributed Neural Control of Energy Balance: Contributions from Hindbrain and Hypothalamus
Grill, H. J. (2006) · Obesity · doi:10.1038/oby.2006.312 · Cited by 199
Neuro-hormonal control of food intake: basic mechanisms and clinical implications.
Konturek, P. C., Konturek, J. W., Cześnikiewicz‐Guzik, M., Brzozowski, T., Sito, E., & Konturek, S. J. (2005) · PubMed · Cited by 195
c-src gene product in developing rat brain is enriched in nerve growth cone membranes.
Maness, P. F., Aubry, M., Shores, C. G., Frame, L., & Pfenninger, K. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5001 · Cited by 191
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
Björnholm, M., Münzberg, H., Leshan, R. L., Villanueva, E. C., Bates, S. H., Louis, G. W., Jones, J. C., Ishida-Takahashi, R., Bjørbaek, C., & Myers, M. G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30688 · Cited by 183
Delibegović, M., Bence, K. K., Mody, N., Hong, E., Ko, H. J., Kim, J. K., Kahn, B. B., & Neel, B. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00959-07 · Cited by 173
Self-citationThe role of stearoyl-CoA desaturase in the control of metabolism
Dobrzyń, A., & Ntambi, J. M. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.011 · Cited by 169
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
Flowers, M. T., & Ntambi, J. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.12.011 · Cited by 165
Bronstein, D. M., Schäfer, M. K.-H., Watson, S. J., & Akil, H. (1992) · Brain Research · doi:10.1016/0006-8993(92)91007-2 · Cited by 154
White, C. L., Whittington, A., Barnes, M. J., Wang, Z., Bray, G. A., & Morrison, C. D. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90513.2008 · Cited by 150
Development of Leptin‐Sensitive Circuits
Bouret, S. G., & Simerly, R. B. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01563.x · Cited by 143
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G. B., et al. (2002) · Nature Medicine · doi:10.1038/nm798 · Cited by 138
Characterization of Leptin-Responsive Neurons in the Caudal Brainstem
Ellacott, K. L. J., Halatchev, I. G., & Cone, R. D. (2006) · Endocrinology · doi:10.1210/en.2005-0877 · Cited by 132
Myers, F. A., Evans, D. R., Clayton, A. L., Thorne, A. W., & Crane‐Robinson, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009472200 · Cited by 127
Leptin as a Therapeutic Agent--Trials and Tribulations
Mantzoros, C. S., & Flier, J. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.7062 · Cited by 117
Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus
Gamber, K. M., Macarthur, H., & Westfall, T. C. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.04.017 · Cited by 107
Tyrosine phosphorylation in early embryonic growth cones
Bixby, J. L., & Jhabvala, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03421.1993 · Cited by 104
From observation to experimentation: leptin action in the mediobasal hypothalamus
Williams, K. W., Scott, M. M., & Elmquist, J. K. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788d · Cited by 104
Distribution, function, and properties of leptin receptors in the brain
Funahashi, H., Yada, T., Suzuki, R., & Shioda, S. (2003) · International review of cytology · doi:10.1016/s0074-7696(05)24001-9 · Cited by 98
Minireview: The Brain as a Molecular Target for Diabetic Therapy
Prodi, E., & Obici, S. (2006) · Endocrinology · doi:10.1210/en.2006-0143 · Cited by 88
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
Shi, H., Strader, A. D., Sorrell, J. E., Chambers, J. B., Woods, S. C., & Seeley, R. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00704.2007 · Cited by 85
Mizuno, T. M., Kelley, K. A., Pasinetti, G. M., Roberts, J. L., & Mobbs, C. V. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2675 · Cited by 85
The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism
Walter, A. O., Peng, Z.-Y., & Cartwright, C. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202513 · Cited by 78
Distribution and possible origin of β-endorphin and ACTH in discrete brainstem nuclei of rats
Palkovits, M., & Eskay, R. L. (1987) · Neuropeptides · doi:10.1016/0143-4179(87)90051-5 · Cited by 77
Central Resistin Induces Hepatic Insulin Resistance via Neuropeptide Y
Singhal, N. S., Lazar, M. A., & Ahima, R. S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2443-07.2007 · Cited by 75
Developmental programming of the hypothalamus: a matter of fat
Horváth, T. L., & Brüning, J. C. (2006) · Nature Medicine · doi:10.1038/nm0106-52 · Cited by 73
Development of Diabesity in Mice with Neuronal Deletion of Shp2 Tyrosine Phosphatase
Krajewska, M., Banares, S., Zhang, E. E., Huang, X., Scadeng, M., Jhala, U. S., Feng, G.-S., & Krajewski, S. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070594 · Cited by 72
N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin
Guo, L., Münzberg, H., Stuart, R. C., Nillni, E. A., & Bjørbæk, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403165101 · Cited by 71
Elevated leptin: consequence or cause of obesity?
Philip, J. S. (2007) · Frontiers in bioscience · doi:10.2741/2332 · Cited by 67
Modulation of insulin signaling by protein tyrosine phosphatases
Elchebly, M., Cheng, A., & Tremblay, M. L. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000141 · Cited by 63
Janoschek, R., Plum, L., Koch, L., Münzberg, H., Diano, S., Shanabrough, M., Müller, W., Horváth, T. L., & Brüning, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600425103 · Cited by 59
Fornaro, M., Burch, P. M., Yang, W., Zhang, L., Hamilton, C., Kim, J. H., Neel, B. G., & Bennett, A. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602029 · Cited by 56
Self-citationp59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway
Wr, M., Whitesides, J. G., LaMantia, A., & Maness, P. F. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199807)36:1 · Cited by 54
Molecular Targets for Obesity Therapy in the Brain
Obici, S. (2009) · Endocrinology · doi:10.1210/en.2009-0409 · Cited by 45
SELECTION FOR GROWTH RATE, FEED EFFICIENCY AND BODY COMPOSITION IN MICE
Sutherland, T. M., Biondini, P. E., & Ward, G. M. (1974) · Genetics · doi:10.1093/genetics/78.1.525 · Cited by 40
Shp2 as a therapeutic target for leptin resistance and obesity
Feng, G. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.1.135 · Cited by 39
Insights from the Genetics of Severe Childhood Obesity
Farooqi, I. S. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110462 · Cited by 36
Chen, B., Hammonds-Odie, L. P., Perron, J. C., Masters, B. A., & Bixby, J. L. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0847 · Cited by 20
The Tyrosine Phosphatase Shp-2 Mediates Intracellular Signaling Initiated by Ret Mutants
D’Alessio, A. M., Califano, D., Incoronato, M., Santelli, G., Florio, T., Schettini, G., Carlomagno, M. S., Cerchia, L., & de Franciscis, V. (2003) · Endocrinology · doi:10.1210/en.2003-0620 · Cited by 17
Obesity Epidemic in Need of Answers
Ahima, R. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.061 · Cited by 16
Hypothalamic pathogenesis of type 2 diabetes
Koshiyama, H., Hamamoto, Y., Honjo, S., Wada, Y., & lkeda, H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.02.033 · Cited by 16
Plagemann, A., Davidowa, H., Harder, T., & Dudenhausen, J. W. (2006) · PubMed · Cited by 15
Elmquist (1998) · doi:10.1002/(sici)1096-9861(19980615)395:4
Flagged first, then by citations
Research works printed but not linked: 3
- Konturek, 2005, J Physiol Pharmacol., 56, 5
- 10.1210/jc.85.11.4000 · DOI
- Koch, 2008, J Clin Invest., 118, 2132
Cited by
Sorted by citations
Fuller, N. R., Colagiuri, S., SCHOFIELD, D. J., Olson, A. D., Shrestha, R. N., Holzapfel, C., Wolfenstetter, S. B., Holle, R., Ahern, A. L., Hauner, H., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.139 · Cited by 2,127
Obesity and leptin resistance: distinguishing cause from effect
Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.002 · Cited by 943
Biochemical and cellular properties of insulin receptor signalling
Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739
Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
Park, H. K., & Ahima, R. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.08.004 · Cited by 710
Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later
Izquierdo, A. G., Crujeiras, A. B., Casanueva, F. F., & Carreira, M. C. (2019) · Nutrients · doi:10.3390/nu11112704 · Cited by 525
Metadata
- Authors
- Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K.
- Affiliations
- University of Pennsylvania (US)
- Brown University (US)
- Corresponding author
- Bence, Kendra K.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-03-01
- Volume
- 120
- Issue
- 3
- Pages
- 720-734
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2827947
- OpenAlex
- W2118743996
- Cited by
- 214
- References
- 111
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 26 · 2013: 23 · 2012: 26
- FWCI
- 11.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01-CA-49152, R01CA049152)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082417, P30DK019525)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- PTP1B, SHP2, proopiomelanocortin neurons, energy balance, leptin sensitivity, energy expenditure, adiposity, high-fat diet, glucose homeostasis, insulin sensitivity, melanocortin system, alpha-melanocyte-stimulating hormone, hypothalamus, weight gain
- MeSH terms
- Animals, Energy Metabolism, Hypothalamus, Insulin, Neurons, Pro-Opiomelanocortin, RNA, Messenger, Weight Gain, Mice, Knockout, Adiposity, Mice, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 11
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review