Randomized trial of Internet-based relapse prevention for partially remitted depression: Preventing relapse in MDD via the Internet

Holländare, F.; Johnsson, S.; Randestad, M.; Tillfors, M.; Carlbring, P.; Andersson, G.; Engström, I.

doi:10.1111/j.1600-0447.2011.01698.x

Cited by 111Digital Mental Health InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Research Topics

Randomized trial of Internet-based relapse prevention for partially remitted depression: Preventing relapse in MDD via the Internet

Holländare, F., Johnsson, S., Randestad, M., Tillfors, M., Carlbring, P., Andersson, G., Engström, I.·2011·Acta Psychiatrica Scandinavica

DOI 10.1111/j.1600-0447.2011.01698.x

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Abstract

OBJECTIVE: To investigate whether Internet-based cognitive behaviour therapy (CBT) can prevent relapse in persons with partially remitted major depression after previous treatment. METHOD: Seventy-one women and 13 men (N = 84) with partially remitted major depression after treatment were randomly assigned to either 10 weeks of Internet-based CBT or to a control group. Self-help material was used in combination with e-mail contact with a personal therapist. Monthly self-ratings of depressive symptoms were made, and diagnostic interviews were conducted before and after the treatment period, as well as 6 months later. RESULTS: Significantly fewer participants in the CBT group experienced relapse (4/38 or 10.5%) compared with those in the control group (14/37 or 37.8%). The difference in relapse rates between groups occurred early in the study period and was still apparent after 6 months. A trend towards a larger reduction in depressive symptoms was observed at post-treatment in the participants who received CBT compared with controls. Reduction in depressive symptoms reduced the risk of relapse. A trend towards a higher remission rate was found in the CBT group at the 6 month follow-up. CONCLUSION: Internet-based CBT seems promising in preventing relapse in persons with partially remitted major depression after previous treatment.

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Several studies had multiple follow-up points, varying from 26 to 66 months.
“Several studies had multiple follow-up points, varying from 26 to 66 months [65–72].”
From Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as [67]
Previous studies have combined computerized manuals with face-to-face treatment, used technological adjuncts in therapy, or used the Internet after treatment completion to help prevent relapse.
“Previous studies have combined computerized manuals with face-to-face treatment [20,21], used technological adjuncts in therapy [22], or used the Internet after treatment completion to help prevent relapse [23,24].”
From Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study (2013) · cites this paper as [24]
In a trial of partially remitted depression, significantly fewer participants receiving ICBT experienced relapse compared with control (10.5% vs 37.8%).
“Significantly, fewer participants receiving ICBT experienced relapse compared with those in the control group (10.5 compared with 37.8%), which is in line with previous face-to-face studies [30].”
From Internet-based psychological treatments for depression (2012) · cites this paper as [29]

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Authors: Holländare, F., Johnsson, S., Randestad, M., Tillfors, M., Carlbring, P., Andersson, G., & Engström, I.
Affiliations: Örebro University (SE)
Umeå University (SE)
Linköping University (SE)
Corresponding author: Holländare, F.
ORCID: Holländare, F.
Tillfors, M.
Carlbring, P.
Andersson, G.
Engström, I.
Venue: Acta Psychiatrica Scandinavica
Publisher: Wiley
Published: 2011-03-14
Volume: 124
Issue: 4
Pages: 285-294
ISSN: 0001-690X (ISSN-L)
DOI: 10.1111/j.1600-0447.2011.01698.x
OpenAlex: W1561161729
Cited by: 111
References: 53
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 18 · 2016: 8 · 2015: 16 · 2014: 12 · 2013: 18 · 2012: 8
FWCI: 17.02
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1632 d)
Locations: Acta Psychiatrica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: relapse prevention, major depressive disorder, internet-based cognitive behavioral therapy, e-therapy, self-help, depressive symptoms, remission, women
MeSH terms: Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Patient Compliance, Psychiatric Status Rating Scales, Cognitive Behavioral Therapy, Treatment Outcome, Internet, Secondary Prevention

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Randomized trial of Internet-based relapse prevention for partially remitted depression: Preventing relapse in MDD via the Internet

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