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Cited by 331Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression

Liotti, Mario, Mayberg, Helen S., McGinnis, Scott, Brannan, Stephen L., Jerabek, Paul·2002·American Journal of Psychiatry
DOI 10.1176/appi.ajp.159.11.1830
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Abstract

OBJECTIVE: Remitted major depressive disorder is a vulnerable clinical state, suggesting persistence of an underlying disease diathesis between episodes. To investigate neural correlates of such risk and to identify potential depression trait markers, euthymic unipolar patients in remission, acutely depressed patients, and never-depressed volunteers were studied before and after transient sad mood challenge. METHOD: Common and differential changes in regional blood flow among the groups relative to the baseline state were examined with [(15)O]H(2)O positron emission tomography after provocation of sadness with autobiographical memory scripts. RESULTS: Mood provocation in both depressed groups resulted in regional cerebral blood flow (rCBF) decreases in medial orbitofrontal cortex Brodmann's area 10/11, which were absent in the healthy group. In the remitted group, mood provocation produced a unique rCBF decrease in pregenual anterior cingulate 24a. The main effects in healthy subjects, an rCBF increase in subgenual cingulate Brodmann's area 25 and a decrease in right prefrontal cortex Brodmann's area 9, were not present in the depressed groups. CONCLUSIONS: Mood challenge in unipolar euthymic patients in full remission unmasks an apparent depression trait marker. The pattern of acute CBF changes is distinct from that seen in euthymic healthy volunteers and mirrors the untreated depressed state seen during a major depressive episode and the pattern of change seen in depressed patients. These findings suggest that disease-specific modifications of pathways mediating transient mood changes are present in unipolar depression independent of clinical illness status. These findings have implications for understanding the vulnerability of remitted patients for illness relapse.

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Metadata

Authors
Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P.
Affiliations
University of Nottingham (GB)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2002-11-01
Volume
159
Issue
11
Pages
1830-1840
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.159.11.1830
OpenAlex
W2002611894
Cited by
331
References
56
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 17 · 2014: 17 · 2013: 13 · 2012: 24
FWCI
11.19
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, regional cerebral blood flow, medial orbitofrontal cortex, pregenual anterior cingulate cortex, subgenual anterior cingulate cortex, prefrontal cortex, relapse vulnerability, neural correlates of depression
MeSH terms
Adult, Affect, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Middle Aged, Neural Pathways, Oxygen Radioisotopes, Radionuclide Imaging, Recurrence, Reference Values, Regional Blood Flow, Risk

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