Cited by 331Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression

Liotti, Mario, Mayberg, Helen S., McGinnis, Scott, Brannan, Stephen L., Jerabek, Paul·2002·American Journal of Psychiatry

DOI 10.1176/appi.ajp.159.11.1830

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Abstract

OBJECTIVE: Remitted major depressive disorder is a vulnerable clinical state, suggesting persistence of an underlying disease diathesis between episodes. To investigate neural correlates of such risk and to identify potential depression trait markers, euthymic unipolar patients in remission, acutely depressed patients, and never-depressed volunteers were studied before and after transient sad mood challenge. METHOD: Common and differential changes in regional blood flow among the groups relative to the baseline state were examined with [(15)O]H(2)O positron emission tomography after provocation of sadness with autobiographical memory scripts. RESULTS: Mood provocation in both depressed groups resulted in regional cerebral blood flow (rCBF) decreases in medial orbitofrontal cortex Brodmann's area 10/11, which were absent in the healthy group. In the remitted group, mood provocation produced a unique rCBF decrease in pregenual anterior cingulate 24a. The main effects in healthy subjects, an rCBF increase in subgenual cingulate Brodmann's area 25 and a decrease in right prefrontal cortex Brodmann's area 9, were not present in the depressed groups. CONCLUSIONS: Mood challenge in unipolar euthymic patients in full remission unmasks an apparent depression trait marker. The pattern of acute CBF changes is distinct from that seen in euthymic healthy volunteers and mirrors the untreated depressed state seen during a major depressive episode and the pattern of change seen in depressed patients. These findings suggest that disease-specific modifications of pathways mediating transient mood changes are present in unipolar depression independent of clinical illness status. These findings have implications for understanding the vulnerability of remitted patients for illness relapse.

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Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy.
Teasdale, J. D., Segal, Z. V., Williams, J. M. G., Ridgeway, V. A., Soulsby, J. M., & Lau, M. A. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.4.615 · Cited by 3,236
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Self-citation
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036
Rapid Automated Algorithm for Aligning and Reslicing PET Images
Woods, R. P., Cherry, S. R., & Mazziotta, J. C. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199207000-00024 · Cited by 1,901
A Suggestion for Using Powerful and Informative Tests of Normality
D’Agostino, R. B., Belanger, A. J., & D’Agostino, R. B. (1990) · The American Statistician · doi:10.1080/00031305.1990.10475751 · Cited by 1,809
A Suggestion for Using Powerful and Informative Tests of Normality
D'agostino, R. B., Belanger, A., & D'agostino, R. B. (1990) · The American Statistician · doi:10.2307/2684359 · Cited by 1,809
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525

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Mauss, I. B., Bunge, S. A., & Gross, J. J. (2007) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2007.00005.x · Cited by 538
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Self-citation
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Authors: Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P.
Affiliations: University of Nottingham (GB)
ORCID: Mayberg, Helen S.
Brannan, Stephen L.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2002-11-01
Volume: 159
Issue: 11
Pages: 1830-1840
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.159.11.1830
OpenAlex: W2002611894
Cited by: 331
References: 56
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 6 · 2015: 17 · 2014: 17 · 2013: 13 · 2012: 24
FWCI: 11.19
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: major depressive disorder, regional cerebral blood flow, medial orbitofrontal cortex, pregenual anterior cingulate cortex, subgenual anterior cingulate cortex, prefrontal cortex, relapse vulnerability, neural correlates of depression
MeSH terms: Adult, Affect, Antidepressive Agents, Brain, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Middle Aged, Neural Pathways, Oxygen Radioisotopes, Radionuclide Imaging, Recurrence, Reference Values, Regional Blood Flow, Risk

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Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression

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