Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
Open accessAbstract
The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.
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Individuals with MCI and early AD have diminished regional brain uptake of 2-DG, as measured by FDG-PET, before MCI-AD conversion, brain atrophy, or neurodegenerative changes.
“Individuals with MCI and early AD have diminished regional brain uptake of 2-DG, as measured by FDG-PET, before MCI-AD conversion, brain atrophy, or neurodegenerative changes (268, 345, 424, 425, 517).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [345]
The Results (§3.2; page not provided) show lower regional FDG-PET metabolism in MCI and AD than in cognitively normal participants. The Introduction reports evidence that FDG-PET predicts conversion from MCI to AD, but neither it nor the Results establishes that reduced uptake precedes brain atrophy or other neurodegenerative changes. (LLM, conf=0.87)
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- Authors
- Landau, S. M., Harvey, D., Madison, C. M., Koeppe, R. A., Reiman, E. M., Foster, N. L., Weiner, M. W., & Jagust, W. J.
- Affiliations
- University of California, Berkeley (US)
- University of California, Davis (US)
- University of Michigan (US)
- Banner Alzheimer’s Institute (US)
- University of Utah (US)
- San Francisco VA Medical Center (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Landau, Susan M.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 32
- Issue
- 7
- Pages
- 1207-1218
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC2891865
- OpenAlex
- W2155277084
- Cited by
- 750
- References
- 35
- Citations by year
- 2026: 29 · 2025: 48 · 2024: 50 · 2023: 32 · 2022: 55 · 2021: 71 · 2020: 63 · 2019: 56 · 2018: 48 · 2017: 36 · 2016: 45 · 2015: 44 · 2014: 39 · 2013: 45 · 2012: 41
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (U01-AG-024904, P30AG010129, P30AG019610, U19AG010483)
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, mild cognitive impairment, cognitive decline, FDG-PET, glucose metabolism, Functional Activities Questionnaire, ADAS-Cog, functional decline, memory impairment, statistical power
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Blood Glucose, Disability Evaluation, Female, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Severity of Illness Index, Disease Progression, Fluorodeoxyglucose F18, Positron-Emission Tomography, Cognitive Dysfunction
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