Cited by 120Posttraumatic Stress Disorder ResearchPsychoanalysis and Psychopathology ResearchChild Abuse and Trauma

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Amygdala Volume in Adults with Posttraumatic Stress Disorder: A Meta-Analysis

Woon, Fu L., Hedges, Dawson W.·2009·The Journal of Neuropsychiatry and Clinical Neurosciences

DOI 10.1176/jnp.2009.21.1.5

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Abstract

Posttraumatic stress disorder (PTSD) may be associated with structural abnormalities in the amygdala. To better characterize amygdala volume in PTSD, the authors conducted a meta-analysis comparing amygdala volumes in PTSD patients and comparison subjects. Using electronic databases, the authors found nine studies comparing amygdala volumes in adult subjects with PTSD with amygdala volumes in comparison subjects (participants unexposed to trauma and participants exposed to trauma but without PTSD). Results showed no significant differences in amygdala volumes between the groups. Within each group, the right amygdala was significantly larger than the left, indicating an asymmetrically lateralized amygdala volume that is preserved in trauma exposure and in PTSD.

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Authors: Woon, F. L., & Hedges, D. W.
Affiliations: Brigham Young University (US)
Venue: The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher: American Psychiatric Association Publishing
Published: 2009-01
Volume: 21
Issue: 1
Pages: 5-12
ISSN: 0895-0172 (ISSN-L)
1545-7222
DOI: 10.1176/jnp.2009.21.1.5
OpenAlex: W2027015546
Cited by: 120
References: 51
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 13
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropsychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: post-traumatic stress disorder, amygdala volume, structural brain abnormalities, hemispheric lateralization, trauma exposure, neuroanatomy
MeSH terms: Adult, Amygdala, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Stress Disorders, Post-Traumatic, Stress, Psychological, Databases as Topic

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Amygdala Volume in Adults with Posttraumatic Stress Disorder: A Meta-Analysis

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