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Cited by 49Mindfulness and Compassion InterventionsPsychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

. An open trial of a new acceptance-based behavioral treatment for major depression with psychotic features.

Open access
Gaudiano, Brandon A., Nowlan, Kathryn, Brown, Lily A., Epstein-Lubow, Gary, Miller, Ivan W.·2013·Behavior Modification
DOI 10.1177/0145445512465173PMC PMC4049629
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Abstract

Research suggests that cognitive and behavioral therapies produce significant benefits over medications alone in the treatment of severe, nonpsychotic major depression or primary psychotic disorders such as schizophrenia. However, previous research has not demonstrated the efficacy of psychotherapy for major depression with psychotic features. In this initial treatment development study, we conducted an open trial of a new behavioral intervention that combines elements of behavioral activation and acceptance and commitment therapy for depression and psychosis. Fourteen patients with major depressive disorder with psychotic features were provided with up to 6 months of Acceptance-Based Depression and Psychosis Therapy (ADAPT) in combination with pharmacotherapy. Patients reported a high degree of treatment credibility and acceptability. Results showed that patients achieved clinically significant and sustained improvements through posttreatment follow-up in depressive and psychotic symptoms, as well as psychosocial functioning. In addition, the processes targeted by the intervention (e.g., acceptance, mindfulness, values) improved significantly over the course of treatment, and changes in processes were correlated with changes in symptoms. Results suggest that ADAPT combined with pharmacotherapy is a promising treatment approach for psychotic depression that should be tested in a future randomized trial.

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Crossref · 10.1177/0145445512465173

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89 of 89 references verified0 citation errors · 0 not checkable

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  • Experiential avoidance is positively associated with delusional experiences such as paranoia.

    “Recent work has also shown that experiential avoidance is positively associated with delusional experiences such as paranoia,29,30 and that it may contribute to cognitive impairments in schizophrenia.31”

    From Acceptance-based Behavior Therapy for Depression With Psychosis (2015) · cites this paper as [30]

    The Introduction section “Experiential Avoidance in Depression and Psychosis” says avoidance-based coping has been implicated in psychosis, and the References list a study of experiential avoidance and paranoia. Our copy does not report a positive association specifically with paranoia or other delusional experiences; its Results report changes in delusion proneness and psychological inflexibility, not their correlation. No page numbers are available in our copy. (LLM, conf=0.80)

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  • Similar effects have been observed following brief ACT interventions for repetitive negative thinking and psychotic depression.

    “Similar effects have been observed following brief ACT interventions for other presented concerns, including repetitive negative thinking and psychotic depression [48,49].”

    From Brief and Telehealth Acceptance and Commitment Therapy (ACT) Interventions for Stress in Inflammatory Bowel Disease (IBD): A Series of Single Case Experimental Design (SCED) Studies (2022) · cites this paper as [49]

    The Results report large improvements in depressive and psychotic symptoms among patients receiving an acceptance-based treatment for psychotic depression. But the Treatment Received section reports an average of 21 sessions, so describing this intervention as brief is not supported. The paper also says the treatment combined ACT with behavioral activation and pharmacotherapy; this citation does not establish effects for repetitive negative thinking. (LLM, conf=0.88)

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Research works printed but not linked: 5

  1. Bach P Gaudiano BA Hayes SC Herbert JD Acceptance and Commitment Therapy for psychosis: Intent to treat hospitalization outcome and mediation by believability Psychosis in press
  2. Epping-Jordan J Bedirhan Ustun T The WHODAS II: Leveling the playing field for all disorders WHO Bulletin of Mental Health 2001 6 5
  3. First M Spitzer R Gibbon M Williams J Structured Clinical Interview for DSM-IV Personality Disorders, SCID-II 1997 Washington, D.C. American Psychiatric Press
  4. First M Spitzer R M G Williams J Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. SCID-I/P 2002 New York Biometrics Research, New York State Psychiatric Institute
  5. Gaudiano BA Steel C Brief acceptance and commitment therapy for the acute treatment of hospitalized patients with psychosis Cognitive behaviour therapy for schizophrenia: Evidence based interventions and future directions Hoboken, NJ Wiley & Sons in press

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Authors
Gaudiano, B. A., Nowlan, K., Brown, L. A., Epstein-Lubow, G., & Miller, I. W.
Affiliations
  • Brown University (US)
  • University of California, Los Angeles (US)
ORCID
Venue
Behavior Modification
Publisher
SAGE Publications
Published
2012-12-06
Volume
37
Issue
3
Pages
324-355
ISSN
  • 0145-4455 (ISSN-L)
  • 1552-4167
DOI
10.1177/0145445512465173
PMC
PMC4049629
OpenAlex
W2125322753
Cited by
49
References
89
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 2
FWCI
2.91
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Behavior Modification (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (K23MH076937)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
psychotic depression, major depressive disorder with psychotic features, acceptance and commitment therapy, behavioral activation, treatment acceptability, mindfulness, values, treatment credibility, psychosocial functioning
MeSH terms
Adult, Affective Disorders, Psychotic, Aged, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Psychotropic Drugs, Patient Satisfaction, Acceptance and Commitment Therapy

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