Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor
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The neuropeptides oxytocin (OT) and vasopressin (AVP) are recognized for their modulation of social processes in humans when delivered peripherally. However, there is surprisingly little evidence for acute social effects of peripherally administered OT or AVP in animal models. On the other hand, the party drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') has powerful prosocial effects in rats that appear to occur through stimulation of central OT release. Here, we directly compared the social effects of peripherally administered OT and AVP with those of MDMA, and examined a possible role for the vasopressin 1A receptor (V1AR) in the observed prosocial effects. Adult male Long-Evans rats were tested in a social interaction paradigm after OT (0.1, 0.25, 0.5, and 1 mg/kg, intraperitoneal (IP)), AVP (0.001, 0.0025, 0.005, 0.01, and 0.1 mg/kg, IP), and MDMA (2.5, 5 mg/kg, IP), or combined low doses of OT and MDMA, or AVP and MDMA. The effects of pretreatment with the non-peptide OT receptor antagonist compound 25 (C25; 5 mg/kg, IP) and the V1AR antagonist SR49059 (1 mg/kg, IP) were also examined. OT (0.5 mg/kg), AVP (0.01 mg/kg), and MDMA (5 mg/kg) potently increased 'adjacent lying', where rats meeting for the first time lie passively next to each other. C25 did not inhibit adjacent lying induced by OT, whereas SR49059 inhibited adjacent lying induced by MDMA (5 mg/kg), OT (0.5 mg/kg), and AVP (0.01 mg/kg). Interestingly, when ineffective doses of OT and MDMA, or AVP and MDMA, were combined, a robust increase in adjacent lying was observed. These results show for the first time acute prosocial effects of peripherally injected OT and AVP in laboratory rats, and suggest a commonality of action of OT, AVP, and MDMA in stimulating social behavior that involves V1ARs.
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A selective V1aR antagonist, but not an OTR antagonist, inhibits adjacent lying following peripheral administration of OT or AVP.
“A selective V1aR, but not an OTR antagonist, inhibits adjacent lying following peripheral administration of OT or AVP.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [44]
Both OT and AVP administered peripherally increase a form of social interaction in male rats called 'adjacent lying'.
“Both OT and AVP administered peripherally increase a form of social interaction in male rats referred to as “adjacent lying” in which rats maintain passive side-by-side contact during their first interaction [44].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [44]
Cites
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1× · see citing works
“Intracranial administration of AVP facilitates social memory and recognition in rats (Le Moal et al, 1987), and it helps form partner preference as well as mediates selective aggression in prairie voles (Winslow, 1993).”
BackgroundFile, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 820 · see citing works
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T., Jerome, L., & Doblin, R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110378371 · Cited by 674 · see citing works
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics
Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works
Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403 · see citing works
Sala, M., Braida, D., Lentini, D., Busnelli, M., Bulgheroni, E., Capurro, V., Finardi, A., Donzelli, A., Pattini, L., Rubino, T., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.022 · Cited by 375 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Guastella, A. J., Howard, A. L., Dadds, M. R., Mitchell, P., & Carson, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.005 · Cited by 366 · see citing works
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Sex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
MANNING, M., STOEV, S., CHINI, B., DURROUX, T., MOUILLAC, B., & GUILLON, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00437-8 · Cited by 296 · see citing works
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Septal vasopressin modulates social memory in male rats
Dantzer, R., Koob, G. F., Bluthe´, R.-M., & Le Moal, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90066-2 · Cited by 262 · see citing works
Enhanced social interactions in rats following chronic, centrally infused oxytocin
Witt, D. M., Winslow, J. T., & Insel, T. R. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90418-f · Cited by 244 · see citing works
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works
Dumont, G. J. H., Sweep, F. C. G. J., van der Steen, R., Hermsen, R., Donders, A. R. T., Touw, D. J., van Gerven, J. M. A., Buitelaar, J. K., & Verkes, R. J. (2009) · Social Neuroscience · doi:10.1080/17470910802649470 · Cited by 238 · see citing works
Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.032 · Cited by 237 · see citing works
Self-citationEngelmann, M., & Landgraf, R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90022-1 · Cited by 225 · see citing works
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., et al. (2010) · Nature · doi:10.1038/nature08826 · Cited by 213 · see citing works
Play as a reinforcer for maze-learning in juvenile rats
Humphreys, A. P., & Einon, D. F. (1981) · Animal Behaviour · doi:10.1016/s0003-3472(81)80173-x · Cited by 199 · see citing works
Chronic icv oxytocin attenuates the pathological high anxiety state of selectively bred Wistar rats
Slattery, D. A., & Neumann, I. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.038 · Cited by 195 · see citing works
Egashira, N., Tanoue, A., Matsuda, T., Koushi, E., Harada, S., Takano, Y., Tsujimoto, G., 三島, 健., Iwasaki, K., & Fujiwara, M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.12.009 · Cited by 193 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
Central administration of oxytocin modulates the infant rats response to social isolation
Insel, T. R., & Winslow, J. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90806-2 · Cited by 185 · see citing works
The effects of vasopressin on human facial responses related to social communication
Thompson, R. R., Gupta, S., Miller, K., Mills, S. D., & Orr, S. P. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00133-6 · Cited by 184 · see citing works
Serotonin Receptors Involved in Vasopressin and Oxytocin Secretion
Jørgensen, H., Riis, M., Knigge, U., Kjær, A., & Warberg, J. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00978.x · Cited by 182 · see citing works
Low-dose MDMA (“ecstasy”) induces vasopressin secretion
Henry, J. A., Fallon, J. K., Kicman, A. T., Hutt, A. J., Cowan, D., & Forsling, M. L. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78744-4 · Cited by 171 · see citing works
Oxytocin, Vasopressin, and the Neuroendocrine Basis of Pair Bond Formation
Insel, T. R., Winslow, J. T., Wang, Z., & Young, L. J. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_28 · Cited by 170 · see citing works
Dluzen, D. E., Muraoka, S., Engelmann, M., & Landgraf, R. (1998) · Peptides · doi:10.1016/s0196-9781(98)00047-3 · Cited by 169 · see citing works
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., Oishi, M., Kimura, T., Onaka, T., Ozono, K., et al. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0048 · Cited by 151 · see citing works
A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers
Dumont, G. J. H., & Verkes, R. J. (2006) · Journal of Psychopharmacology · doi:10.1177/0269881106063271 · Cited by 149 · see citing works
Ettenberg, A., VANDERKOOY, D., Moal, M. L., Koob, G. F., & Bloom, F. E. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90024-4 · Cited by 147 · see citing works
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143 · see citing works
Self-citationLukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 136 · see citing works
Effects of vasopressin on active and passive avoidance behavior
Bohus, B. (1972) · Hormones and Behavior · doi:10.1016/0018-506x(72)90031-1 · Cited by 136 · see citing works
Pietrowsky, R., Strüben, C., Mölle, M., Fehm, H. L., & Jan Born, A. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00180-8 · Cited by 133 · see citing works
Centrally injected arginine vasopressin (AVP) facilitates social memory in rats
Moal, M. L., Dantzer, R., Michaud, B., & Koob, G. F. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90527-1 · Cited by 131 · see citing works
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.002 · Cited by 129 · see citing works
Strain differences in fear-motivated behavior of rats
Rex, A., Sondern, U., Voigt, J., Franck, S., & Fink, H. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02128-0 · Cited by 125 · see citing works
McGregor, I. S., Clemens, K. J., Plasse, G., Li, K. M., Hunt, G. E., Chen, F., & Lawrence, A. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300185 · Cited by 122 · see citing works
Self-citationOxytocin modulates psychotomimetic-induced deficits in sensorimotor gating
Feifel, D., & Reza, T. L. (1999) · Psychopharmacology · doi:10.1007/s002130050811 · Cited by 121 · see citing works
Adjunctive intranasal oxytocin improves verbal memory in people with schizophrenia
Feifel, D., MacDonald, K. S., Cobb, P., & Minassian, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.018 · Cited by 117 · see citing works
Kelly, A. M., Kingsbury, M. A., Hoffbuhr, K., Schrock, S. E., Waxman, B., Kabelik, D., Thompson, R. R., & Goodson, J. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.012 · Cited by 106 · see citing works
Koob, G. F., Moal, M. L., Gaffori, O., Manning, M., Sawyer, W. H., Rivier, J., & Bloom, F. E. (1981) · Regulatory Peptides · doi:10.1016/0167-0115(81)90009-4 · Cited by 103 · see citing works
Maggi, M., Malozowski, S., Kassis, S., Guardabasso, V., & Rodbard, D. (1987) · Endocrinology · doi:10.1210/endo-120-3-986 · Cited by 100 · see citing works
Vasopressin administration modulates anxiety-related behavior in rats
Appenrodt, E., Schnabel, R., & Schwarzberg, H. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00119-x · Cited by 91 · see citing works
Dębiec, J. (2005) · BioEssays · doi:10.1002/bies.20301 · Cited by 90 · see citing works
Sex Differences in the Effects of MDMA (Ecstasy) on Plasma Copeptin in Healthy Subjects
Simmler, L. D., Hysek, C. M., & Liechti, M. E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1143 · Cited by 89 · see citing works
Engelmann, M., Ludwig, M., & Landgraf, R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00598.x · Cited by 76 · see citing works
Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C. W., Kassiou, M., Hunt, G. E., & McGregor, I. S. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02311.x · Cited by 73 · see citing works
Self-citationBrown, A. D., Brown, T. B., Calabrese, A. A., Ellis, D. J., Puhalo, N., Ralph, M. J., & Watson, L. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.11.097 · Cited by 73 · see citing works
Dimethyl sulfoxide (DMSO) toxicology, pharmacology, and clinical experience
Jacob, S. W., & Wood, D. C. (1967) · The American Journal of Surgery · doi:10.1016/0002-9610(67)90166-3 · Cited by 71 · see citing works
Tribollet, E., Raufaste, D., Maffrand, J., & Gal, C. S. (1999) · Neuroendocrinology · doi:10.1159/000054409 · Cited by 66 · see citing works
Social interactions among rats housed in grouped and enriched conditions
Renner, M., & Rosenzweig, M. R. (1986) · Developmental Psychobiology · doi:10.1002/dev.420190403 · Cited by 61 · see citing works
Social deprivation, housing density, and gregariousness in rats.
Latané, B., Cappell, H., & Joy, V. (1970) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028742 · Cited by 60 · see citing works
Action of MDMA (Ecstasy) and Its Metabolites on Arginine Vasopressin Release
Fallon, J. K., Shah, D., Kicman, A. T., Hutt, A. J., Henry, J. A., Cowan, D., & Forsling, M. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04181.x · Cited by 52 · see citing works
Hunt, G. E., McGregor, I. S., Cornish, J. L., & Callaghan, P. D. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.011 · Cited by 51 · see citing works
Self-citationMDMA (‘ecstasy’) exhibits an anxiogenic-like activity in social encounters between male mice
Maldonado, E., & Navarro, J. F. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0824 · Cited by 50 · see citing works
Neural correlates of MDMA (“Ecstasy”)-induced social interaction in rats
Thompson, M. R., Hunt, G. E., & McGregor, I. S. (2008) · Social Neuroscience · doi:10.1080/17470910802045042 · Cited by 48 · see citing works
Self-citationAndó, R. D., Benkő, A., Ferrington, L., Kirilly, E., Kelly, P. A. T., & Bagdy, G. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.010 · Cited by 46 · see citing works
Broadbear, J. H., Tunstall, B. J., & Beringer, K. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00267.x · Cited by 38 · see citing works
Social interaction between drugged and undrugged rats
File, S. E., & Pope, J. H. (1974) · Animal Learning & Behavior · doi:10.3758/bf03199167 · Cited by 30 · see citing works
The effects of vasopressin on positively rewarded responding and on locomotor activity in rats
Andrews, J. S., Newton, B. A., & Sahgal, A. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90004-5 · Cited by 26 · see citing works
Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats
Thompson, M. R., Callaghan, P. D., Hunt, G. E., & McGregor, I. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.014 · Cited by 25 · see citing works
Self-citationLoyens, E., Vermoesen, K., Schallier, A., Michotte, Y., & Smolders, I. (2012) · Brain Research · doi:10.1016/j.brainres.2011.11.059 · Cited by 25 · see citing works
Verbal memory after three months of intranasal vasopressin in healthy old humans
Perras, B., Droste, C., Jan Born, A., Fehm, H. L., & Pietrowsky, R. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00047-4 · Cited by 21 · see citing works
Capurro, A., Reyes-Parada, M. I., Olazábal, D. E., Perrone, R., Silveira, R., & Macadar, O. (1997) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/s0300-9629(97)00132-1 · Cited by 17 · see citing works
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Schmid, Y., Enzler, F., Gasser, P., Grouzmann, E., Preller, K. H., Vollenweider, F. X., Brenneisen, R., Müller, F., Borgwardt, S., & Liechti, M. E. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.015 · Cited by 409 · see citing works
Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects
Holze, F., Vizeli, P., Müller, F., Ley, L., Duerig, R., Varghese, N., Eckert, A., Borgwardt, S., & Liechti, M. E. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0569-3 · Cited by 247 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Liechti, M. E. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14043 · Cited by 201 · see citing works
Kamilar-Britt, P., & Bedi, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.016 · Cited by 163 · see citing works
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 162 · see citing works
Roles of Oxytocin in Stress Responses, Allostasis and Resilience
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Differential effects of MDMA and methylphenidate on social cognition
Schmid, Y., Hysek, C. M., Simmler, L. D., Crockett, M. J., Quednow, B. B., & Liechti, M. E. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114542454 · Cited by 155 · see citing works
Effects of MDMA and intranasal oxytocin on social and emotional processing
Kirkpatrick, M. G., Lee, R., Wardle, M. C., Jacob, S., & de Wit, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.12 · Cited by 143 · see citing works
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.006 · Cited by 106 · see citing works
Sabihi, S., Durosko, N. E., Dong, S. M., & Leuner, B. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.009 · Cited by 106 · see citing works
The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants
Bershad, A. K., Miller, M. A., Baggott, M. J., & de Wit, H. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116663120 · Cited by 106 · see citing works
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Calcagnoli, F., Kreutzmann, J. C., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.019 · Cited by 92 · see citing works
Kuypers, K. P. C., de la Torre, R., Farre, M., Yubero-Lahoz, S., Dziobek, I., Van den Bos, W., & Ramaekers, J. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100719 · Cited by 88 · see citing works
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Bedi, G., Cecchi, G., Slezak, D. F., Carrillo, F., Sigman, M., & de Wit, H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.80 · Cited by 88 · see citing works
He, Z., Young, L., Ma, X.-M., Guo, Q., Wang, L., Yang, Y., Luo, L., Yuan, W., Li, L., Zhang, J., et al. (2019) · eLife · doi:10.7554/elife.44026 · Cited by 81 · see citing works
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Bowen, M. T., & Neumann, I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.003 · Cited by 83 · see citing works
Sabihi, S., Dong, S. M., Maurer, S., Goodpaster, C. M., & Leuner, B. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.024 · Cited by 84 · see citing works
Hicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76 · see citing works
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Mitre, M., Minder, J. L., Morina, E., Chao, M. V., & Froemke, R. C. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_7 · Cited by 76 · see citing works
Bowen, M. T., Peters, S. T., Absalom, N. L., Chebib, M., Neumann, I. D., & McGregor, I. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416900112 · Cited by 72 · see citing works
Self-citationDumais, K. M., Alonso, A. G., Immormino, M. A., Bredewold, R., & Veenema, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.007 · Cited by 72 · see citing works
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 63 · see citing works
Lukas, M., & Wöhr, M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.03.005 · Cited by 65 · see citing works
Oxytocin and vasopressin modulate the social response to threat: a preclinical study
Bowen, M. T., & McGregor, I. S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000388 · Cited by 63 · see citing works
Self-citationFerris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60 · see citing works
Kohli, S., King, M. V., Williams, S. A., Edwards, A., Ballard, T. M., Steward, L. J., Alberati, D., & Fone, K. C. F. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0171-0 · Cited by 60 · see citing works
Strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin
Finkenwirth, C., van Schaik, C., Ziegler, T. E., & Burkart, J. M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.034 · Cited by 59 · see citing works
Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice
Tan, O., Musullulu, H., Raymond, J. S., Wilson, B. B., Langguth, M., & Bowen, M. T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.016 · Cited by 56 · see citing works
Sex Differences in the Embryonic Development of the Central Oxytocin System in Mice
Tamborski, S., Mintz, E. M., & Caldwell, H. K. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12364 · Cited by 55 · see citing works
Li, L., Yuan, W., He, Z., Wang, L., Jing, X.-Y., Zhang, J., Yang, Y., Guo, Q., Zhang, X., Cai, W., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.238 · Cited by 55 · see citing works
Duque‐Wilckens, N., Steinman, M. Q., Laredo, S. A., Hao, R., Perkeybile, A. M., Bales, K. L., & Trainor, B. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.018 · Cited by 52 · see citing works
Wardle, M. C., Kirkpatrick, M. G., & de Wit, H. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu035 · Cited by 52 · see citing works
Everett, N. A., Turner, A. J., Costa, P. A., Baracz, S. J., & Cornish, J. L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0719-7 · Cited by 52 · see citing works
Dolder, P. C., Holze, F., Liakoni, E., Harder, S., Schmid, Y., & Liechti, M. E. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4431-6 · Cited by 52 · see citing works
Baracz, S. J., Everett, N. A., & Cornish, J. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.014 · Cited by 52 · see citing works
Lysergic acid diethylamide: a drug of ‘use’?
Das, S., Barnwal, P., Ramasamy, A., Sen, S., & Mondal, S. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316640440 · Cited by 50 · see citing works
Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs
MacLean, E. L., Gesquiere, L. R., Gruen, M. E., Sherman, B. L., Martin, W. L., & Carter, C. S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01613 · Cited by 49 · see citing works
Song, Z., Larkin, T. E., Malley, M. O., & Albers, H. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.02.004 · Cited by 47 · see citing works
Muroy, S. E., Long, K. L. P., Kaufer, D., & Kirby, E. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.16 · Cited by 47 · see citing works
Everett, N. A., Baracz, S. J., & Cornish, J. L. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0566-6 · Cited by 48 · see citing works
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Baracz, S. J., & Cornish, J. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.08.001 · Cited by 46 · see citing works
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Kirkpatrick, M. G., & de Wit, H. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3752-6 · Cited by 42 · see citing works
Everett, N. A., McGregor, I. S., Baracz, S. J., & Cornish, J. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.036 · Cited by 43 · see citing works
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Pitts, E. G., Curry, D. W., Hampshire, K. N., Young, M. B., & Howell, L. L. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4812-5 · Cited by 40 · see citing works
Li, L., Yuan, W., He, Z., Ma, H., Xun, Y., Meng, L.-R., Zhu, S.-J., Wang, L., Zhang, J., Cai, W., et al. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz060 · Cited by 41 · see citing works
Dumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 40 · see citing works
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Ramos, L., Hicks, C., Caminer, A., Goodwin, J., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3899-9 · Cited by 40 · see citing works
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Rice, L. J., & Einfeld, S. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000135 · Cited by 38 · see citing works
Baracz, S. J., Everett, N. A., & Cornish, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136132 · Cited by 37 · see citing works
Suraev, A. S., Bowen, M. T., Ali, S. O., Hicks, C., Ramos, L., & McGregor, I. S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.002 · Cited by 35 · see citing works
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Blanco-Gandía, M. C., Mateos-García, A., García-Pardo, M. P., Montagud‐Romero, S., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000162 · Cited by 35 · see citing works
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Lee, S. Y., Lee, A. R., Hwangbo, R., Han, J., Hong, M., & Bahn, G. H. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.312 · Cited by 32 · see citing works
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Hou, D., & Jin, F. (2016) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.1000211 · Cited by 32 · see citing works
Kevin, R. C., Wood, K., Stuart, J. M., Mitchell, A. J., Moir, M., Banister, S. D., Kassiou, M., & McGregor, I. S. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116684336 · Cited by 30 · see citing works
Self-citationLan, A., Stein, D., Portillo, M., Toiber, D., & Kofman, O. (2019) · Behavioral and Brain Functions · doi:10.1186/s12993-019-0153-3 · Cited by 30 · see citing works
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Lukas, M., & A, T. R. D. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_428 · Cited by 29 · see citing works
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Holley, A., Bellevue, S., Vosberg, D., Wenzel, K., Roorda, S., & Pfaus, J. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.039 · Cited by 28 · see citing works
Hodges, T. E., Eltahir, A. M., Patel, S. D., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104579 · Cited by 26 · see citing works
Moy, S. S., Teng, B. L., Nikolova, V. D., Riddick, N. V., Simpson, C. D., Deusen, A. L. V., Janzen, W. P., Sassano, M. F., Pedersen, C. A., & Jarstfer, M. B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.036 · Cited by 26 · see citing works
Ramos, L., Hicks, C., Caminer, A., Couto, K., Narlawar, R., Kassiou, M., & McGregor, I. S. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.10.002 · Cited by 25 · see citing works
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Varı̀, M. R., Pichini, S., Giorgetti, R., & Busardò, F. P. (2018) · Wiley Interdisciplinary Reviews Forensic Science · doi:10.1002/wfs2.1197 · Cited by 25 · see citing works
Amoroso, T. (2015) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2015.1094156 · Cited by 25 · see citing works
Duarte‐Guterman, P., Lieblich, S. E., Qiu, W., Splinter, J. E. J., Go, K. A., Casanueva-Reimon, L., & Galea, L. A. M. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104734 · Cited by 23 · see citing works
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Lawson, S. K., Gray, A. C., & Woehrle, N. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.027 · Cited by 25 · see citing works
Hicks, C., Ramos, L., Reekie, T. A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3902-5 · Cited by 23 · see citing works
Hicks, C., Ramos, L., Dampney, B., Baracz, S. J., McGregor, I. S., & Hunt, G. E. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.005 · Cited by 22 · see citing works
Self-citationTan, O., Martin, L. J., & Bowen, M. T. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120913150 · Cited by 20 · see citing works
Inhaled vasopressin increases sociability and reduces body temperature and heart rate in rats
Ramos, L., Hicks, C., Caminer, A., & McGregor, I. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.013 · Cited by 21 · see citing works
Self-citationSchatz, K. C., Kyne, R. F., Parmeter, S. L., & Paul, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.08.015 · Cited by 21 · see citing works
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Burkhart, J. C., Gupta, S., Borrego, N., Heilbronner, S. R., & Packer, C. (2021) · iScience · doi:10.1016/j.isci.2022.104049 · Cited by 19 · see citing works
Huang, B., Sun, B., Yang, R., Liang, S., Li, X., Guo, Y., Meng, Q., Fu, Y., Li, W., Zhao, P., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109164 · Cited by 20 · see citing works
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Gzieło, K., Piotrowska, D., Litwa, E., Popik, P., & Nikiforuk, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-28919-z · Cited by 22 · see citing works
Kent, P., Awadia, A., Zhao, L. L., Ensan, D., Silva, D., Cayer, C., James, J. S., Anisman, H., & Merali, Z. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.019 · Cited by 20 · see citing works
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Price, D., Burris, D., Cloutier, A., Thompson, C. B., Rilling, J. K., & Thompson, R. R. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00220 · Cited by 18 · see citing works
Madrid, J. E., Oztan, O., Sclafani, V., Rosso, L. A. D., Calonder, L. A., Chun, K., Capitanio, J. P., Garner, J. P., & Parker, K. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13109-5 · Cited by 17 · see citing works
Conditioned mate-guarding behavior in the female rat
Holley, A., Shalev, S., Bellevue, S., & Pfaus, J. G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.034 · Cited by 17 · see citing works
Empathic accuracy and oxytocin after tryptophan depletion in adults at risk for depression
Hogenelst, K., Schoevers, R. A., Kema, I. P., Sweep, F. C. G. J., & Rot, M. A. H. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4093-9 · Cited by 17 · see citing works
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Smith, D. H., & Wang, L. (2016) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-137-26317-9_29 · Cited by 16 · see citing works
Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications
Godino, A., & Renard, G. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12611 · Cited by 17 · see citing works
Childhood stress impairs social function through AVP-dependent mechanisms
Brydges, N. M., Hall, J., Best, C., Rule, L., Watkin, H., Drake, A. J., Lewis, C., Thomas, K. L., & Hall, J. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0678-0 · Cited by 17 · see citing works
Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice
Kuteykin‐Teplyakov, K. B., & Maldonado, R. J. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.007 · Cited by 16 · see citing works
Simmons, T. C., Balland, J. F., Dhauna, J., Yang, S. Y., Traina, J. L., Vazquez, J., & Bales, K. L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00145 · Cited by 16 · see citing works
Wronikowska‐Denysiuk, O., Mrozek, W., & Budzyńska, B. (2023) · Biomolecules · doi:10.3390/biom13030405 · Cited by 13 · see citing works
Physiological Correlates of Volunteering
Bekkers, R., Konrath, S., & Smith, D. (2016) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-137-26317-9_26 · Cited by 4 · see citing works
Social rank-dependent effects of testosterone on huddling strategies in mice
Zhao, Y., Yin, X., Yu, Y., Huang, S., Feng, H., Wang, S., Cai, Y., Zhao, R., Gao, S., Liu, Y., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106516 · Cited by 12 · see citing works
Sharp, J. L., & Smith, M. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.805139 · Cited by 10 · see citing works
Dayı, A., Kıray, M., Şişman, A. R., Özbal, S., Baykara, B., Aksu, İ., & Uysal, N. (2019) · Biotechnic & Histochemistry · doi:10.1080/10520295.2018.1528384 · Cited by 9 · see citing works
Wronikowska‐Denysiuk, O., Zykubek, M., Kurach, Ł., Michalak, A., Boguszewska‐Czubara, A., & Budzyńska, B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05910-y · Cited by 9 · see citing works
Higuchi, Y., & Arakawa, H. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105128 · Cited by 9 · see citing works
Ponzoni, L., Braida, D., Bondiolotti, G., & Sala, M. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00146 · Cited by 9 · see citing works
Schatz, K. C., Brown, L. M., Barrett, A., Roth, L. C., Grinevich, V., & Paul, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-44776-1 · Cited by 9 · see citing works
Observational learning in rats: Interplay between demonstrator and observer behavior
Troha, R., Gowda, M., Lee, S. L. T., & Markus, E. J. (2023) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2023.109807 · Cited by 8 · see citing works
Smith, M. A., Schmidt, K. T., Sharp, J. L., Pearson, T., Davis, A. L., Gibson, A. N., & Potter, K. M. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174646 · Cited by 8 · see citing works
A Systematic Review of the MDMA Model to Address Social Impairment in Autism
Chaliha, D. R., Mamo, J. C. L., Albrecht, M. A., Lam, V., Takechi, R., & Vaccarezza, M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210101130258 · Cited by 7 · see citing works
Naloxone increases conditioned fear responses during social buffering in male rats
Yamasaki, T., Kiyokawa, Y., Munetomo, A., & Takeuchi, Y. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16343 · Cited by 7 · see citing works
Biosca-Brull, J., Oña, G., Alarcon-Franco, L., & Colomina, M. T. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02773-7 · Cited by 6 · see citing works
Mukai, S., Nakada, S., Kamada, H., Yaguchi, R., Deyama, S., & Kaneda, K. (2020) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12124 · Cited by 6 · see citing works
Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day
Rehn, S., Raymond, J. S., Boakes, R. A., & Bowen, M. T. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06014-3 · Cited by 6 · see citing works
- Authors
- Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., & McGregor, I. S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- McGregor, Iain S
- Venue
- Neuropsychopharmacology
- Published
- 2013-05-16
- Volume
- 38
- Issue
- 11
- Pages
- 2249-2259
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3773675
- OpenAlex
- W2033282483
- Cited by
- 128
- References
- 76
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 9 · 2017: 14 · 2016: 17 · 2015: 19 · 2014: 17
- FWCI
- 26.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council (1011518, 1033444)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, vasopressin, MDMA, ecstasy, prosocial behavior, vasopressin V1a receptor, social interaction, neuropeptides, drug combination effects
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Drug Synergism, Hallucinogens, Hormone Antagonists, Indoles, Male, Oxytocin, Pyrrolidines, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, N-Methyl-3,4-methylenedioxyamphetamine, Rats, Antidiuretic Hormone Receptor Antagonists
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