A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder
Abstract
Although cognitive-behavioral therapy (CBT) is an effective treatment for posttraumatic stress disorder (PTSD), many patients fail to attain remission with CBT. The authors propose augmentation of CBT with oxytocin in the treatment of PTSD. Oxytocin has a combination of pharmacologic effects that result in a “sense of safety” for the patient, which is a prerequisite to successful treatment of PTSD. We suggest a dual explanatory mechanism as to why oxytocin may be effective: through a reduction of fear response (decreasing amygdala activation, inhibiting fear response, and enhancing extinction learning) and through an increase of social interaction (activating social reward-related brain regions increasing engagement in the therapeutic alliance). Given that PTSD is marked by deficits in anxiety/stress regulation and in social functioning, and that oxytocin is implicated in both of these areas, oxytocin seems a likely candidate for treatment of patients with PTSD. Further clinical studies of the therapeutic value of oxytocin are indicated.
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Oxytocin may enhance retention in PE by reducing excessive distress and facilitating therapeutic alliance.
“oxytocin may enhance retention by reducing excessive distress and facilitating therapeutic alliance.”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Olff et al., 2010
These findings suggest that oxytocin has potential as an adjunctive therapy for extinction-based PTSD treatments such as PE.
“These findings suggest that oxytocin has potential as an adjunctive therapy for extinction-based PTSD treatments such as PE (Koch et al., 2014; Olff et al., 2010).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Olff et al., 2010
Oxytocin has been suggested as a promising pharmacological agent to enhance treatment response in PTSD.
“OT has been suggested as a promising pharmacological agent to enhance treatment response in PTSD (Koch et al, 2014;Olff et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Olff et al, 2010
OT could potentially enhance motivation for treatment, as well as the therapeutic alliance.
“This way, OT could potentially enhance motivation for treatment, as well as the therapeutic alliance (Olff et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Olff et al, 2010
Oxytocin has been proposed as an effective novel drug treatment for PTSD.
“oxytocin has been repeatedly proposed as an effective novel drug treatment for PTSD [3, 58]”
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- Authors
- Olff, M., Langeland, W., Witteveen, A., & Denys, D.
- Affiliations
- University of Amsterdam (NL)
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-08
- Volume
- 15
- Issue
- 8
- Pages
- 522-530
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W2282777834
- Semantic Scholar
- 136c9af6051eaa1126d3fb325d994310119c6bee
- Cited by
- 135
- References
- 143
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 9 · 2016: 10 · 2015: 13 · 2014: 7 · 2013: 14 · 2012: 9
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- oxytocin, post-traumatic stress disorder, fear extinction, amygdala activation, social reward, therapeutic relationship, anxiety regulation, social functioning, sense of security
- MeSH terms
- Anxiety Disorders, Brain, Humans, Oxytocin, Stress Disorders, Post-Traumatic, Cognitive Behavioral Therapy
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