Effects of acute tyrosine depletion on subjective craving and selective processing of smoking-related cues in abstinent cigarette smokers
Abstract
We investigated the impact of the administration of a tyrosine-depleting amino acid mixture compared to a balanced mixture on measures of mood, craving and selective processing of smoking-related cues in healthy cigarette smokers instructed to abstain from smoking for 12 h prior to, and during, the experiment. A modified stroop task was used to index selective processing of smoking-related cues. We observed evidence for an increase in subjective craving among males, and an attenuation of the selective processing of smoking-related cues compared to control cues among females, in the tyrosine-depleting condition compared to the balanced condition. No effects of mixture were observed on measures of subjective mood. These results tentatively support for the role of dopaminergic neurotransmission in mediating the response of cigarette smokers to smoking-related cues. In addition, these results also provide further evidence for sex differences in the factors that maintain cigarette smoking, in particular with respect to conditioned reinforcement of smoking behaviour, and suggest that the relationship between subjective craving and selective processing of smoking-related cues may differ in males and females.
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Rats given nine daily injections of amphetamine or nicotine acquired cocaine self-administration much quicker than control animals.
“A study by Horger et al. found that rats given nine daily injections of amphetamine or nicotine, acquired cocaine self-administration much quicker than control animals (Casey, Benkelfat, Young, & Leyton, 2006; Horger et al., 1992; Munafò, Mannie, Cowen, Harmer, & McTavish, 2007)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Munafò, Mannie, Cowen, Harmer, & McTavish, 2007
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- Authors
- Munafó, M. R., Mannie, Z. N., Cowen, P. J., Harmer, C. J., & McTavish, S. B.
- Affiliations
- Department of Experimental Psychology, University of Bristol, Bristol, UK,
- University of Oxford (GB)
- Department of Psychiatry, University of Oxford, Oxford, UK
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2007-11
- Volume
- 21
- Issue
- 8
- Pages
- 805-814
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W1971149187
- Cited by
- 25
- References
- 49
- Citations by year
- 2019: 1 · 2018: 1 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 2
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- cigarette craving, smoking-related cues, cigarette smokers, smoking abstinence, dopamine signaling, sex differences, conditioned reinforcement, mood, amino acid mixtures
- MeSH terms
- Adult, Cues, Dopamine, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Sex Characteristics, Smoking, Tyrosine, Smoking Cessation
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