Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers

Casey, Kevin F.; Benkelfat, Chawki; Young, Simon N.; Leyton, Marco

doi:10.1016/j.euroneuro.2006.02.002

Cited by 54Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers

Casey, Kevin F., Benkelfat, Chawki, Young, Simon N., Leyton, Marco·2006·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2006.02.002

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Abstract

Rationale Nicotine increases dopamine (DA) release but its role in nicotine dependence remains unclear.Objective To assess the role of DA in nicotine craving and self-administration using acute phenylalanine/tyrosine depletion (APTD).Methods Fifteen nicotine-dependent men ingested, a minimum of 3days apart, a nutritionally balanced amino acid (AA) mixture (BAL), a mixture deficient in the catecholamine precursors, phenylalanine and tyrosine, and APTD followed by the immediate DA precursor, L-DOPA. Beginning 3h after ingestion of the AA mixture, subjects smoked 4 cigarettes. Craving, mood, and other aspects of subjective state were assessed with self-report scales. Smoking puff topography was measured with a computerized flowmeter.Results APTD did not change smoking puff topography, cigarette craving, or subjective effects of smoking.Conclusions The findings suggest that in nicotine-dependent smokers craving for cigarettes, subjective effects of nicotine, and the self-administration of freely available cigarettes are largely unrelated to acute changes in DA neurotransmission.

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Rats given nine daily injections of amphetamine or nicotine acquired cocaine self-administration much quicker than control animals.
“A study by Horger et al. found that rats given nine daily injections of amphetamine or nicotine, acquired cocaine self-administration much quicker than control animals (Casey, Benkelfat, Young, & Leyton, 2006; Horger et al., 1992; Munafò, Mannie, Cowen, Harmer, & McTavish, 2007)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Casey, Benkelfat, Young, & Leyton, 2006

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Ongoing and Future Research Directions
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Impaired Physicians
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Index
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Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction
Venugopalan, V. V., Casey, K. F., O'Hara, C., O'Loughlin, J., Benkelfat, C., Fellows, L. K., & Leyton, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.135 · Cited by 70 · see citing works
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Cocaine craving, euphoria, and self-administration: A preliminary study of the effect of catecholamine precursor depletion.
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Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers
Hitsman, B. L., MacKillop, J. M., Lingford-Hughes, A. R., Williams, T. A., Ahmad, F., Adams, S. H., Nutt, D., & Munafo, M. R. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0995-5 · Cited by 61 · see citing works
New Developments in Drug Dependence Studies. Recent advances in research on nicotine dependence and reward mechanism.
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Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study
Takahashi, H., Fujimura, Y., Hayashi, M., Takano, H., Kato, M., Okubo, Y., Kanno, I., Ito, H., & Suhara, T. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008103 · Cited by 71 · see citing works

Authors: Casey, K. F., Benkelfat, C., Young, S. N., & Leyton, M.
Affiliations: McGill University (CA)
Corresponding author: Leyton, Marco
ORCID: Young, Simon N.
Leyton, Marco
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2006-10
Volume: 16
Issue: 7
Pages: 512-520
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2006.02.002
OpenAlex: W2037230797
Cited by: 54
References: 79
Citations by year: 2020: 43 · 2018: 2 · 2016: 1 · 2015: 1 · 2012: 1
FWCI: 1.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nicotine dependence, dopamine, nicotine craving, L-DOPA, dopamine precursor, nicotine self-administration, mood
MeSH terms: Adult, Dopamine, Humans, Levodopa, Male, Pain Measurement, Phenylalanine, Surveys and Questionnaires, Self Administration, Time Factors, Tobacco Use Disorder, Tyrosine, Dopamine Agents, Diet, Protein-Restricted

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Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers

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