Cited by 113Effects and risks of endocrine disrupting chemicalsAutism Spectrum Disorder ResearchSexual Differentiation and Disorders

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis

Kardas, Fatih, Bayram, Ayse Kacar, Demirci, Esra, Akin, Leyla, Ozmen, Sevgi, Kendirci, Mustafa, Canpolat, Mehmet, Oztop, Didem Behice +4 more·2016·Journal of Child Neurology

Abstract

The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively ( P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.

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Crossref · 10.1177/0883073815609150

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  • The published literature on bisphenol A and autism is conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits.

    “Concerning bisphenol A, the published literature, mostly characterized by smaller case–control studies is also conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits [203–206].”

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Authors
Kardas, F., Bayram, A. K., Demirci, E., Akin, L., Ozmen, S., Kendirci, M., Canpolat, M., Oztop, D. B., Narin, F., Gumus, H., Kumandas, S., & Per, H.
Affiliations
  • Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey
  • Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey
  • Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey
  • Department of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey
  • Erciyes University (TR)
Venue
Journal of Child Neurology
Published
2015-10-08
Volume
31
Issue
5
Pages
629-635
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
OpenAlex
W1929491033
Cited by
107
References
40
Citations by year
2026: 9 · 2025: 4 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 16 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 1
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
autism spectrum disorder, phthalates, mono(2-ethylhexyl) phthalate, DEHP, bisphenol A, endocrine disruptors, serum biomarkers, children, autism pathogenesis, environmental exposure
MeSH terms
Autism Spectrum Disorder, Bisphenol A Compounds, Benzhydryl Compounds, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diethylhexyl Phthalate, Female, Humans, Male, Phenols

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