Cited by 133Sleep and Work-Related FatigueSleep and Wakefulness ResearchCircadian rhythm and melatonin

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Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

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Ruiz, Francieli S, Andersen, Monica L, Martins, Raquel CS, Zager, Adriano, Lopes, José D, Tufik, Sergio·2012·Innate Immunity

DOI 10.1177/1753425910385962

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Abstract

We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T- (CD4/CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4 + T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1β, IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4 + T-cells and IgA levels were not re-established after sleep recovery.

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Authors: Ruiz, F. S., Andersen, M. L., Martins, R. C., Zager, A., Lopes, J. D., & Tufik, S.
Affiliations: Universidade Federal de São Paulo (BR)
Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
ORCID: Ruiz, Francieli S
Martins, Raquel CS
Zager, Adriano
Lopes, José D
Venue: Innate Immunity
Publisher: SAGE Publications
Published: 2010-11-18
Volume: 18
Issue: 1
Pages: 44-54
ISSN: 1753-4259 (ISSN-L)
1753-4267
DOI: 10.1177/1753425910385962
OpenAlex: W1973416971
Cited by: 132
References: 59
Citations by year: 2026: 2 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 9 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 7
FWCI: 9.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Innate Immunity (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Associação Fundo de Incentivo à Pesquisa
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep deprivation, REM sleep deprivation, total sleep deprivation, sleep recovery, immune function, CD4+ T cells, IgA, immunoglobulins, complement system, cytokines, white blood cell count, neutrophils, healthy men
MeSH terms: Adult, B-Lymphocytes, Cell Count, Complement System Proteins, Homeostasis, Humans, Immunoglobulin A, Male, Neutrophils, Sleep Deprivation, Sleep, REM, CD4-Positive T-Lymphocytes, Cytokines, Polysomnography, CD8-Positive T-Lymphocytes, Young Adult

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Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

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