The dual effect of paradoxical sleep deprivation on murine immune functions
Abstract
We aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with thioglycollate and exposed to paradoxical sleep deprivation. Sleep-deprived animals presented decreased cell migration compared to controls. Nitric oxide production was reduced in macrophages from sleep-deprived mice compared to controls. Cell surface analysis showed that sleep deprivation reduced F4/80(+)/CD80(low) peritoneal cell population induced by thioglycollate injection. Sleep-deprived mice were not more susceptible to infection than control mice. Our findings challenge the general perception that sleep loss always increases infection susceptibility.
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In addition to infectious and chronic inflammatory conditions that involve a clear immunopathology, numerous other diseases have mild systemic elevations of inflammatory markers, including cardiovascular and metabolic diseases, certain forms of chronic pain, certain cancers, and neurodegenerative diseases.
“In addition to infectious and chronic inflammatory conditions that involve a clear immunopathology (e.g., HIV, RA), numerous other diseases emerged in the last decades for which mild systemic elevations of inflammatory markers are characteristic, including cardiovascular (481) and metabolic diseases (153), certain forms of chronic pain (23), certain cancers (165), and neurodegenerative diseases (9”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [481]
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- Authors
- Sá-Nunes, A., Bizzarro, B., Egydio, F., Barros, M. S., Sesti-Costa, R., Soares, E. M., Pina, A., Russo, M., Faccioli, L. H., Tufik, S., & Andersen, M. L.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 290
- Pages
- 9-14
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2179524123
- Cited by
- 11
- References
- 47
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Associação Fundo de Incentivo à Pesquisa
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/21501-5)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (305509/2012-8, 305177/2013-3)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- REM sleep deprivation, sleep deprivation, immune function, peritoneal macrophages, macrophage phenotype, nitric oxide, cell migration, infection susceptibility, A/J mice, F4/80, CD80
- MeSH terms
- Animals, Cell Movement, Corticosterone, Male, Sleep Deprivation, Macrophages, Peritoneal, Mice
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