The role of limbic vasopressin and oxytocin in social recognition
Abstract
Young male rats were exposed two times for 5 min, to older male rats with an interval of 30 min in the anti-vasopressin serum experiments and with an interval of 120 min in the anti-oxytocin serum experiments. The time spent by the older rats with social investigation of the younger animal was scored during the two encounters. In placebo-treated animals the time spent on social investigation of the younger animal during the second encounter at 30 min is significantly shorter than during the first one (social recognition). However, intracerebroventricular or local application of anti-vasopressin serum in the dorsal or ventral hippocampus or in the dorsal septal area, but not in the n. olfactorius, results in similar periods of time spent for social investigation during the two encounters. Thus, endogenous vasopressin in the dorsal and ventral hippocampus and in the dorsal septal region plays a physiological role in social recognition/memory. In placebo-treated rats the time spent on social investigation of the younger animal during the second encounter at 120 min is similar to that during the first encounter. However, local administration of anti-oxytocin serum in the ventral hippocampus, but not in the dorsal hippocampus, nor in the n. olfactorius or the septal area, results in shorter investigation times during the second encounter. Thus, taken together the presence or local release of vasopressin and oxytocin in the ventral hippocampus and that of vasopressin (but not oxytocin) in the dorsal hippocampus and dorsal septal area are of physiological importance for social recognition.
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Peripheral and central release are dissociated under certain circumstances.
“This separation of projection targets is supported by microdialysis studies showing that peripheral and central release are dissociated under certain circumstances [128-130].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [129]
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- Authors
- van Wimersma Greidanus, T. B., & Maigret, C.
- Affiliations
- Utrecht University (NL)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 713
- Issue
- 1-2
- Pages
- 153-159
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2079654047
- Cited by
- 117
- References
- 6
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin, oxytocin, social recognition, social memory, hippocampus, dorsal hippocampus, ventral hippocampus, olfactory bulb, social investigation, rats
- MeSH terms
- Animals, Behavior, Animal, Hippocampus, Immune Sera, Male, Oxytocin, Social Identification, Vasopressins, Rats, Wistar, Rats
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