The Immunomodulatory Effects of Statins on Macrophages

Exploring the full spectrum of macrophage activation

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NF-κB signaling in inflammation

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Macrophage activation and polarization: nomenclature and experimental guidelines

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Macrophage plasticity, polarization, and function in health and disease

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Macrophages in Tissue Repair, Regeneration, and Fibrosis

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Toll-like receptor control of the adaptive immune responses

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Interferon-γ: an overview of signals, mechanisms and functions

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Toll-like receptors in innate immunity

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Toll-Like Receptor Signaling Pathways

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

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Macrophages in atherosclerosis: a dynamic balance

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Small GTP-Binding Proteins

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LPS induction of gene expression in human monocytes.

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Signaling to NF-κB by Toll-like receptors

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Rho GTPases and signaling networksPreprint

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Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis

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C-Reactive Protein Levels and Outcomes after Statin Therapy

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Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B

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The metabolic signature of macrophage responses

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C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men

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Interpretation of the evidence for the efficacy and safety of statin therapy

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

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Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease and stroke: systematic review and meta-analysis

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Effect of Statin Therapy on C-Reactive Protein Levels

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Understanding the mechanism of IL-1β secretion

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Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis

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Statins as a newly recognized type of immunomodulator.

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Novel Risk Factors for Systemic Atherosclerosis

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

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Pleiotropic Effects of Statins on the Cardiovascular System

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Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

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Immunity, atherosclerosis and cardiovascular disease

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Effect of Two Intensive Statin Regimens on Progression of Coronary Disease

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Global epidemiology of dyslipidaemias

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Decline in Cardiovascular Mortality

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Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly: Results From the Cardiovascular Health Study and the Rural Health Promotion Project

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Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

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Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

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Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages

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Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease

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Macrophages in Atherosclerosis Regression

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Distribution of macrophage polarization markers in human atherosclerosis

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An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.

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Pleiotropic Effects of Statins - Basic Research and Clinical Perspectives -

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Relationship Between Coronary Artery Remodeling and Plaque Vulnerability

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Modulation of atherosclerosis in mice by Toll-like receptor 2

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Endogenous toll‐like receptor ligands and their biological significance

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Abandoning M1/M2 for a Network Model of Macrophage Function

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HMG-CoA Reductase Inhibitors Reduce MMP-9 Secretion by Macrophages

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Macrophages and the maintenance of homeostasis

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Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

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Targeting Macrophages in Cancer: From Bench to Bedside

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Regulation of MHC class II gene expression by the class II transactivator

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Statins Enhance Formation of Phagocyte Extracellular Traps

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Statins: a repurposed drug to fight cancer

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Withdrawal of Cerivastatin from the World Market

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The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

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Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

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Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

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The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review

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C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men

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Simvastatin Lowers C-Reactive Protein Within 14 Days

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Vastatins Inhibit Tissue Factor in Cultured Human Macrophages

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Statins Inhibit Secretion of Metalloproteinases-1, -2, -3, and -9 From Vascular Smooth Muscle Cells and Macrophages

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Convenience versus Biological Significance: Are PMA-Differentiated THP-1 Cells a Reliable Substitute for Blood-Derived Macrophages When Studying in Vitro Polarization?

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Blood Pressure, C-Reactive Protein, and Risk of Future Cardiovascular Events

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GENETICS OF ATHEROSCLEROSIS

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Trends in the epidemiology of cardiovascular disease in the UK

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Interferon gamma: a master regulator of atherosclerosis.

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Hydrophilic or Lipophilic Statins?

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Isoprenoids: Remarkable diversity of form and function

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Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

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Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

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Reversal of Hyperlipidemia With a Genetic Switch Favorably Affects the Content and Inflammatory State of Macrophages in Atherosclerotic Plaques

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Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages

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The interferon in TLR signaling: more than just antiviral

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THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

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SOD1 suppresses pro-inflammatory immune responses by protecting against oxidative stress in colitis

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Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?

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Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages

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Role of Nuclear Factor-κB Activation in Metalloproteinase-1, -3, and -9 Secretion by Human Macrophages In Vitro and Rabbit Foam Cells Produced In Vivo

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The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL

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NF-κB and AP-1 Activation by Nitric Oxide Attenuated Apoptotic Cell Death in RAW 264.7 Macrophages

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CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

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Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages

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Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

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Toll‐like receptor 4 in atherosclerosis

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Small GTPase and Regulation of Inflammation Response in Atherogenesis

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Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs

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Anti-Inflammatory Effects of Lipid-Lowering Drugs and Supplements—A Narrative Review

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Matrix Metalloproteinase-9 (MMP-9) as a Therapeutic Target: Insights into Molecular Pathways and Clinical Applications

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Exploring the polarization of M1 and M2 macrophages in the context of skin diseases

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Regulatory impact of statins on macrophage polarization: mechanistic and therapeutic implications

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Advancing Head and Neck Cancer Therapies: From Conventional Treatments to Emerging Strategies

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Use of Statins in Heart Failure with Preserved Ejection Fraction: Current Evidence and Perspectives

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Omega-3 (n-3) Fatty Acid–Statin Interaction: Evidence for a Novel Therapeutic Strategy for Atherosclerotic Cardiovascular Disease

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Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

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Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

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Targeting innate immune memory: a new paradigm for gout treatment

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A Dual Pharmacological Strategy against COVID-19: The Therapeutic Potential of Metformin and Atorvastatin

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Host-Directed Therapy with Inhalable Lovastatin Microspheres for Matrix Metalloproteinase Inhibition in Tuberculosis

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Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

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Cardioprotection During Myocardial Infarction in Diabetic Cardiomyopathy

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Host-directed therapy for tuberculosis: Repurposed drugs toward global tuberculosis elimination

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Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies

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Sensor Array-Enabled Identification of Drugs for Repolarization of Macrophages to Anti-Inflammatory Phenotypes

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Modulation of Staphylococcus aureus Biofilm Formation through Subinhibitory Concentrations of Biogenic Silver Nanoparticles and Simvastatin

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Acute Kidney Injury in the Context of COVID-19: An Analysis in Hospitalized Mexican Patients

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The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats

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Molecular Docking and Functional Analyses Reveal the Chondroprotective and Anti‐Inflammatory Potential of Statins in Osteoarthritis

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Statin-Mediated Modulation of Nrf2 Signaling: Mechanisms and Therapeutic Implications in Atherosclerosis

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Innovative simvastatin-loaded emulgel effectively treats vulvovaginal candidiasis: in vivo efficacy and in vitro biopharmaceutical analysis

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Distinct Effects of Selective Serotonin Reuptake Inhibitors and Serotonin-Norepinephrine Reuptake Inhibitors on Soluble Biomarkers in Blood and Cerebrospinal Fluid of People With HIV

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Rosuvastatin Intervention in Patients with Chronic Hepatitis B (CHB) Expands CD14+ CD16− Classical Monocytes via Aryl Hydrocarbon Receptor (AHR)

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Natural products as HMG-CoA reductase inhibitors (statins) for the management of non-communicable diseases

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Mitochondrial Quality Control in Macrophages During Cardiovascular Disease

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Statins for women with polycystic ovary syndrome not actively trying to conceive

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Prospective evaluation of lipid management following acute coronary syndrome in Saudi Arabia

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Pre-Injury Statin Exposure is Associated With Improved Outcomes in Injured Patients That Receive Whole Blood

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Immunometabolic alterations induced by GBD surgery and adjunct pharmacotherapy with metformin, orlistat, statins, and ACE inhibitors

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Differential TET1/2/3 Protein Expression in Circulating Leukocytes of Statin-Treated Patients with HFrEF

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Short-Term Atorvastatin Therapy in Healthy Individuals Results in Unaltered Plasma MMP Levels and Disrupted MMP-7 Correlation with Blood Lipids and Blood Count-Derived Inflammatory Markers

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The Probable Role of Chlamydia pneumoniae Infection in Acute Stroke

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Protective Effect of Statin Therapy in Ankylosing Spondylitis

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Atorvastatin Attenuated the Inflammatory Outcomes of COVID-19: A Double-Blind, Randomized Controlled Trial

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Statins in Orthodontics: Pharmacological Modulation of Relapse and Tooth Movement

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Association Between Genetic Variants and Circulating Biomarkers of Extracellular Matrix Remodelling in Indian Patients With Acute and Recurrent Myocardial Infarction

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Immunomodulatory Effects of Ticagrelor in Myocardial Infarction: Shifting the Cytokine Balance Toward an Anti-Inflammatory Profile

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How macrophage phenotypes affect atherosclerotic plaque

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Cellular lipids: fundamental host factors for monkeypox virus replication and pathogenesis

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Severity Matters: Injury Severity May Limit the Protective Association of Pre-injury Statin Therapy After Traumatic Brain Injury

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Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank

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Atherosclerotic Cell Fates: A Single-Cell View of ER Stress

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Regulatory impact of statins on macrophage polarization: mechanistic and therapeutic implications

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Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation

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Antiinflammatory and Immunomodulatory Properties of Statins

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Immunotropic Effects and Proposed Mechanism of Action for 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors (Statins)

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