Paradoxical sleep deprivation impairs mouse survival after infection with malaria parasites
Open accessAbstract
BACKGROUND: Parasitic diseases like malaria are a major public health problem in many countries and disrupted sleep patterns are an increasingly common part of modern life. The aim of this study was to assess the effects of paradoxical sleep deprivation (PSD) and sleep rebound (RB) on malarial parasite infection in mice. METHODS: After PSD, one group was immediately infected with parasites (PSD). The two other PSD rebound groups were allowed to sleep normally for either 24 h (24 h RB) or 48 h (48 h RB). After the recovery periods, mice were inoculated with parasites. RESULTS: The PSD group was the most affected by parasites presenting the higher death rate (0.02), higher number of infected cells (p < 0.01), and decrease in body weight (p < 0.04) compared to control and 48 h RB groups. The 24 h RB group was also different from control group in survival (p < 0.03), number of infected cells (p < 0.05) and body weight (p < 0.04). After 48 hours of sleep rebound animals were allowed to restore their response to parasitic infection similar to normal sleep animals. CONCLUSIONS: These results suggest that PSD is damaging to the immune system and leads to an increased infection severity of malaria parasites; only 48 hours of recovery sleep was sufficient to return the mice infection response to baseline values.
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Sleep deprivation before malaria infection increased the death rate and number of infected cells in mice, an effect that was reversed after animals had experienced rebound sleep.
“However, sleep deprivation before malaria infection increased the death rate and number of infected cells in mice, an effect that was reversed after animals had experienced rebound sleep (345).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [345]
In mice, 48 h of recovery sleep reversed the reduction in survival of a malaria infection induced by prolonged REM sleep deprivation, whereas 24 h of recovery sleep were not enough.
“A recovery sleep period of 48 h reversed the reduction in survival of a malaria infection, induced by prolonged REM sleep deprivation in mice; in contrast, 24 h of recovery sleep were not enough to reverse the sleep-deprivation-induced effects (345).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [345]
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- Authors
- Lungato, L., Gazarini, M. L., Paredes-Gamero, E. J., Tufik, S., & D’Almeida, V.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- D’Almeida, Vânia
- Venue
- Malaria Journal
- Published
- 2015-04-28
- Volume
- 14
- Issue
- 1
- Pages
- 183-183
- ISSN
- 1475-2875 (ISSN-L)
- PMC
- PMC4416287
- OpenAlex
- W2128047701
- Cited by
- 21
- References
- 39
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 3
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Malaria Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Associação Fundo de Incentivo à Pesquisa
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- REM sleep deprivation, sleep rebound, malaria, survival, immune response, weight loss, mice
- MeSH terms
- Animals, Immunity, Innate, Longevity, Malaria, Male, Sleep Deprivation, Sleep, REM, Plasmodium chabaudi, Mice
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