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Cited by 181Seaweed-derived Bioactive CompoundsNatural Products and Biological ResearchAlgal biology and biofuel production

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of mexican population: a preliminary report

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Torres-Duran, Patricia V., Ferreira-Hermosillo, Aldo, Juarez-Oropeza, Marco A.·2007·Lipids in Health and Disease
DOI 10.1186/1476-511x-6-33PMC PMC2211748
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Abstract

Background: Spirulina maxima is a filamentous cyanobacterium used as food supplement because of its high nutrient contents. It has been experimentally proven, in vivo and in vitro that posses several pharmacological properties. The purpose of this study was to evaluate the effects of Spirulina maxima orally supplied (4.5 g/day, for 6 weeks) to a sample of 36 subjects (16 men and 20 women, with ages between 18–65 years) on serum lipids, glucose, aminotransferases and on blood pressure. The volunteers did not modify their dietary habits or lifestyle during the whole experimental period. From each subject, a sample of blood was drawn in fasting state of 12 hours to determi the plasma concentrations of glucose, triacylglycerols (TAG), total cholesterol (TC), cholesterol associated to high density lipoprotein (HDL-C) and aspartate aminotransferase (AST). Anthropometric measurements including systolic (SYST-P) and diastolic (DIAST-P) blood pressure, height, weight and Body Mass Index (BMI) were also recorded. Results: Comparing initial and final data, the results showed that there were no significant changes in the values of glucose and AST, but significant differences in TAG, TC, and HDL-C, were observed: TAG 233.7 ± 177.8 vs. 167.7 ± 100.7 mg/dL (p < 0.001), TC 181.7 ± 37.5 vs. 163.5 ± 34.4 mg/dL (p < 0.001), C-HDL 43.5 ± 14.4 vs. 50 ± 18.8 mg/dL (p < 0.01). The univariated analysis showed that the changes in the HDL-C and TC concentrations were dependent on TAG concentration (p = 0.247 and p = 0.108, respectively); nevertheless the calculated values for cholesterol associated to low density lipoprotein (LDL-C) were significantly reduced by the Spirulina maxima treatment but independently of the TAG changes. In addition, significant differences were found comparing initial and final SYST-P and DIAST-P blood pressure in both male and female: SYST-P male 121 ± 9 vs. 111 ± 8 mm Hg (p < 0.01), DIAST-P male 85 ± 6.5 vs. 77 ± 9 mm Hg (p < 0.01); SYST-P female 120 ± 9.5 vs. 109 ± 11 mm Hg (p < 0.002), DIAST-P female 85 ± 11 vs. 79 ± 7.5 mm Hg (p < 0.03). Conclusion: The Spirulina maxima showed a hypolipemic effect, especially on the TAG and the LDL-C concentrations but indirectly on TC and HDL-C values. It also reduces systolic and diastolic blood pressure.

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Research works printed but not linked: 3

  1. Kato T, Takemoto K: Effects of Spirulina on hypercholesterolemia and fatty liver in rats. Japan Nutr Foods Assoc J. 1984, 37: 321-
  2. Olaiz-Fernandez G, Rivera-Dommarco J, Shamah-Levy T, Rojas R, Villalpando-Hernandez S, Hernandez-Avila M, Sepulveda-Amor J, : Mexican National Health and Nutrition Survey 2006. 2006, Cuernavaca, Mexico: National Public Health Institute.
  3. Chamorro G, Salazar M, Salazar S: Estudio teratogenico de Spirulina en rata. Arch Latinoam Nutr. 1989, 29: 641-649.

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Metadata

Authors
Torres-Duran, P. V., Ferreira-Hermosillo, A., & Juarez-Oropeza, M. A.
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2007-11-26
Volume
6
Issue
1
Pages
33-33
ISSN
1476-511X (ISSN-L)
DOI
10.1186/1476-511x-6-33
PMC
PMC2211748
OpenAlex
W2019647669
Cited by
181
References
57
Citations by year
2026: 8 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 23 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 7 · 2013: 10 · 2012: 2
FWCI
7.82
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Greater South Information System
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords
Spirulina maxima, cyanobacteria, dietary supplementation, hyperlipidemia, hypertension, serum lipids, HDL cholesterol, LDL cholesterol, triglycerides, blood pressure, aspartate aminotransferase, glucose, body mass index, Mexican population, hypolipidemic effect, antihypertensive effect, sex differences, body composition, anthropometry
MeSH terms
Adolescent, Adult, Aged, Antihypertensive Agents, Hypolipidemic Agents, Blood Pressure, Female, Humans, Hypertension, Cholesterol, HDL, Cholesterol, LDL, Male, Mexico, Middle Aged, Triglycerides, Prevalence, Dietary Supplements, Dyslipidemias, Spirulina

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