Drug response-related DNA methylation changes in schizophrenia, bipolar disorder, and major depressive disorder
Open accessAbstract
Pharmacotherapy is the most common treatment for schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Pharmacogenetic studies have achieved results with limited clinical utility. DNA methylation (DNAm), an epigenetic modification, has been proposed to be involved in both the pathology and drug treatment of these disorders. Emerging data indicates that DNAm could be used as a predictor of drug response for psychiatric disorders. In this study, we performed a systematic review to evaluate the reproducibility of published changes of drug response-related DNAm in SCZ, BD and MDD. A total of 37 publications were included. Since the studies involved patients of different treatment stages, we partitioned them into three groups based on their primary focuses: (1) medication-induced DNAm changes (n = 8); (2) the relationship between DNAm and clinical improvement (n = 24); and (3) comparison of DNAm status across different medications (n = 14). We found that only BDNF was consistent with the DNAm changes detected in four independent studies for MDD. It was positively correlated with clinical improvement in MDD. To develop better predictive DNAm factors for drug response, we also discussed future research strategies, including experimental, analytical procedures and statistical criteria. Our review shows promising possibilities for using BDNF DNAm as a predictor of antidepressant treatment response for MDD, while more pharmacoepigenetic studies are needed for treatments of various diseases. Future research should take advantage of a system-wide analysis with a strict and standard analytical procedure.
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Review: Promises and challenges in pharmacoepigenetics — R1/PR7
(2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr7
Recommendation: Promises and challenges in pharmacoepigenetics — R1/PR8
(2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr8
Decision: Promises and challenges in pharmacoepigenetics — R1/PR9
(2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr9
Author comment: Promises and challenges in pharmacoepigenetics — R1/PR6
Altman, R. B. (2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr6
Decision: Promises and challenges in pharmacoepigenetics — R0/PR5
(2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr5
Recommendation: Promises and challenges in pharmacoepigenetics — R0/PR4
(2022) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr4
Review: Promises and challenges in pharmacoepigenetics — R0/PR3
(2022) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr3
Review: Promises and challenges in pharmacoepigenetics — R0/PR2
(2022) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr2
Author comment: Promises and challenges in pharmacoepigenetics — R0/PR1
Altman, R. B. (2022) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.6.pr1
Pharmacoepigenetics of memantine in dementia and related considerations in SARS-CoV-2 virulence
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Epigenetic modifications in schizophrenia: diagnostic and therapeutic implications
Monteiro, V. A. P., & Cabeda, J. M. (2026) · Athena health & research journal. · doi:10.62741/ahrj.v3i1.121
- Authors
- Zhou, J., Li, M., Wang, X., He, Y., Xia, Y., Sweeney, J. A., Kopp, R. F., Liu, C., & Chen, C.
- Affiliations
- Central South University (CN)
- University of Cincinnati (US)
- SUNY Upstate Medical University (US)
- Corresponding author
- Liu, Chunyu
- Chen, Chao
- ORCID
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2021-05-13
- Volume
- 15
- Pages
- 674273-674273
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC8155631
- OpenAlex
- W3160157557
- Cited by
- 56
- References
- 127
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 10 · 2022: 16 · 2021: 7
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China-Guangdong Joint Fund (Grants Nos. 82022024, Grants Nos. 31970572, Grants Nos. 31871276)
- NIH Clinical Center (U01 MH122591, 1U01MH116489, 1R01MH110920)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- DNA methylation, epigenetics, pharmacogenomics, drug response prediction, schizophrenia, bipolar disorder, major depressive disorder, antidepressant response, brain-derived neurotrophic factor, pharmacoepigenetics, clinical improvement
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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