Differential effects of coconut versus soy oil on gut microbiota composition and predicted metabolic function in adult mice
Open accessAbstract
BACKGROUND: Animal studies show that high fat (HF) diet-induced gut microbiota contributes to the development of obesity. Oil composition of high-fat diet affects metabolic inflammation differently with deleterious effects by saturated fat. The aim of the present study was to examine the diversity and metabolic capacity of the cecal bacterial community in C57BL/6 N mice administered two different diets, enriched respectively with coconut oil (HFC, high in saturated fat) or soy oil (HFS, high in polyunsaturated fat). The relative impact of each hypercaloric diet was evaluated after 2 and 8 weeks of feeding, and compared with that of a low-fat, control diet (LF). RESULTS: The HFC diet induced the same body weight gain and fat storage as the HFS diet, but produced higher plasma cholesterol levels after 8 weeks of treatment. At the same time point, the cecal microbiota of HFC diet-fed mice was characterized by an increased relative abundance of Allobaculum, Anaerofustis, F16, Lactobacillus reuteri and Deltaproteobacteria, and a decreased relative abundance of Akkermansia muciniphila compared to HFS mice. Comparison of cecal microbiota of high-fat fed mice versus control mice indicated major changes that were shared between the HFC and the HFS diet, including the increase in Lactobacillus plantarum, Lutispora, and Syntrophomonas, while some other shifts were specifically associated to either coconut or soy oil. Prediction of bacterial gene functions showed that the cecal microbiota of HFC mice was depleted of pathways involved in fatty acid metabolism, amino acid metabolism, xenobiotic degradation and metabolism of terpenoids and polyketides compared to mice on HFS diet. Correlation analysis revealed remarkable relationships between compositional changes in the cecal microbiota and alterations in the metabolic and transcriptomic phenotypes of high-fat fed mice. CONCLUSIONS: The study highlights significant differences in cecal microbiota composition and predictive functions of mice consuming a diet enriched in coconut vs soy oil. The correlations established between specific bacterial taxa and various traits linked to host lipid metabolism and energy storage give insights into the role and functioning of the gut microbiota that may contribute to diet-induced metabolic disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Medium-chain fatty acids increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter in animal studies.
“Results from animal studies show that medium-chain fatty acids (7-12 carbons) increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter (119, 124-126).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [126]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
UCHIME improves sensitivity and speed of chimera detection
Edgar, R. C., Haas, B. J., Clemente, J. C., Quince, C., & Knight, R. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr381 · Cited by 15,114 · see citing works
VSEARCH: a versatile open source tool for metagenomics
(2016) · doi:10.7717/peerj.2584 · Cited by 10,773 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
STAMP: statistical analysis of taxonomic and functional profiles
Parks, D. H., Tyson, G. W., Hugenholtz, P., & Beiko, R. G. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu494 · Cited by 4,200 · see citing works
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works
High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · see citing works
Complete genome sequence of <i>Lactobacillus plantarum</i> WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472 · see citing works
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works
Kim, K., Gu, W., Lee, I., Joh, E., & Kim, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047713 · Cited by 1,184 · see citing works
Early differences in fecal microbiota composition in children may predict overweight
Kalliomäki, M. A., Collado, M. C., Salminen, S., & Isolauri, E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,056 · see citing works
Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960 · see citing works
Murphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 942 · see citing works
Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women
Collado, M. C., Isolauri, E., Laitinen, K., & Salminen, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.894 · Cited by 863 · see citing works
The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility
Özdal, T., Sela, D. A., Xiao, J., Boyacıoğlu, D., Chen, F., & Çapanoğlu, E. (2016) · Nutrients · doi:10.3390/nu8020078 · Cited by 812 · see citing works
PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update
Wang, X., Spandidos, A., Wang, H., & Seed, B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1013 · Cited by 720 · see citing works
Collado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706 · see citing works
High-fat diet alters gut microbiota physiology in mice
Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 680 · see citing works
Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
Everard, A., Lazarevic, V., Gaïa, N., Johansson, M., Ståhlman, M., Backhed, F., Delzenne, N. M., Schrenzel, J., François, P., & Cani, P. D. (2014) · The ISME Journal · doi:10.1038/ismej.2014.45 · Cited by 598 · see citing works
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
Schwarzer, M., Makki, K., Storelli, G., Machuca‐Gayet, I., Šrůtková, D., Hermanová, P. P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., et al. (2016) · Science · doi:10.1126/science.aad8588 · Cited by 590 · see citing works
Increased obese mRNA expression in omental fat cells from massively obese humans
Hamilton, B. S., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995) · Nature Medicine · doi:10.1038/nm0995-953 · Cited by 526 · see citing works
Structural modulation of gut microbiota in life-long calorie-restricted mice
Zhang, C., Li, S., Yang, L., Huang, P., Li, W., Wang, S., Zhao, G., Zhang, M. H., Pang, X., Yan, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3163 · Cited by 496 · see citing works
Marten, B., Pfeuffer, M., & Schrezenmeir, J. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.06.015 · Cited by 456 · see citing works
de Wit, N., Derrien, M., Bosch-Vermeulen, H., Oosterink, E., Keshtkar, S., Duval, C., de Vogel-van den Bosch, J., Kleerebezem, M., Müller, M., & van der Meer, R. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2011 · Cited by 428 · see citing works
Lecomte, V., Kaakoush, N. O., Maloney, C., Raipuria, M., Huinao, K. D., Mitchell, H. M., & Morris, M. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126931 · Cited by 418 · see citing works
Rienzi, S. C. D., Sharon, I., Wrighton, K. C., Koren, O., Hug, L. A., Thomas, B. C., Goodrich, J. K., Bell, J. T., Spector, T. D., Banfield, J. F., et al. (2013) · eLife · doi:10.7554/elife.01102 · Cited by 404 · see citing works
Wang, X., Ouyang, Y., Liu, J., & Zhao, G. (2013) · British Journal Of Nutrition · doi:10.1017/s000711451300278x · Cited by 384 · see citing works
Kaliannan, K., Wang, B., Li, X., Kim, K., & Kang, J. X. (2015) · Scientific Reports · doi:10.1038/srep11276 · Cited by 362 · see citing works
Martínez, I., Wallace, G., Zhang, C., Legge, R. M., Benson, A. K., Carr, T. P., Moriyama, E. N., & Walter, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-09 · Cited by 355 · see citing works
Hamilton, M. K., Boudry, G., Lemay, D. G., & Raybould, H. E. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00029.2015 · Cited by 324 · see citing works
Clostridium ramosum Promotes High-Fat Diet-Induced Obesity in Gnotobiotic Mouse Models
Woting, A., Pfeiffer, N., Loh, G., Klaus, S., & Blaut, M. (2014) · mBio · doi:10.1128/mbio.01530-14 · Cited by 224 · see citing works
Lam, Y. Y., Ha, C. W. Y., Hoffmann, J. M. A., Oscarsson, J., Dinudom, A., Mather, T. J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., et al. (2015) · Obesity · doi:10.1002/oby.21122 · Cited by 223 · see citing works
Brinig, M. M., Lepp, P. W., Ouverney, C., Armitage, G. C., & Relman, D. A. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.3.1687-1694.2003 · Cited by 221 · see citing works
Ghosh, S., DeCoffe, D., Brown, K., Rajendiran, E., Estaki, M., Dai, C., Yip, A., & Gibson, D. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055468 · Cited by 214 · see citing works
Patterson, E., O' Doherty, R. M., Murphy, E. F., Wall, R., O' Sullivan, O., Nilaweera, K., Fitzgerald, G. F., Cotter, P. D., Ross, R. P., & Stanton, C. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514000117 · Cited by 211 · see citing works
Sousa, D. Z., Smidt, H., Alves, M. M., & Stams, A. J. M. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00680.x · Cited by 209 · see citing works
Alterations of the gut microbiota in high-fat diet mice is strongly linked to oxidative stress
Qiao, Y., Sun, J., Ding, Y., Le, G., & Shi, Y. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4323-6 · Cited by 206 · see citing works
Lahti, L., Salonen, A., Kekkonen, R. A., Salojärvi, J., Jalanka, J., Palva, A., Orešič, M., & de Vos, W. M. (2013) · PeerJ · doi:10.7717/peerj.32 · Cited by 196 · see citing works
Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease
Kuehbacher, T., Rehman, A., Lepage, P., Hellmig, S., Fölsch, U. R., Schreiber, S., & Ott, S. J. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47719-0 · Cited by 190 · see citing works
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Flynn, C. R., Albaugh, V. L., Cai, S. B., Cheung‐Flynn, J., Williams, P. E., Brucker, R. M., Bordenstein, S. R., Guo, Y. P., Wasserman, D. H., & Abumrad, N. N. (2015) · Nature Communications · doi:10.1038/ncomms8715 · Cited by 176 · see citing works
Lin, H., An, Y., Hao, F., Wang, Y., & Tang, H. (2016) · Scientific Reports · doi:10.1038/srep21618 · Cited by 169 · see citing works
Shen, W., Gaskins, H. R., & McIntosh, M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.009 · Cited by 161 · see citing works
Clavel, T., Lippman, R., Gavini, F., Dore, J. M., & Blaut, M. (2006) · Systematic and Applied Microbiology · doi:10.1016/j.syapm.2006.02.003 · Cited by 145 · see citing works
The bacterial communities associated with fecal types and body weight of rex rabbits
Zeng, B., Han, S., Wang, P., Wen, B., Jian, W., Guo, W., Yu, Z., Du, D., Fu, X., Kong, F., et al. (2015) · Scientific Reports · doi:10.1038/srep09342 · Cited by 143 · see citing works
Huang, E. Y., Leone, V. A., Devkota, S., Wang, Y., Brady, M. J., & Chang, E. B. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113486931 · Cited by 133 · see citing works
Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats
Cha, M. C., & Jones, P. J. H. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32195-7 · Cited by 111 · see citing works
Lifestyle of Lactobacillus plantarum in the mouse caecum
Marco, M. L., Peters, T. H. F., Bongers, R. S., Douwe Molenaar, B., van Hemert, S., Sonnenburg, J. L., Gordon, J. I., & Kleerebezem, M. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02001.x · Cited by 109 · see citing works
Nishina, P. M., Lowe, S., Verstuyft, J. G., Naggert, J. Κ., Kuypers, F. A., & Paigen, B. J. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36970-4 · Cited by 100 · see citing works
Deol, P., Evans, J. R., Dhahbi, J. M., Chellappa, K., Han, D. S. C., Spindler, S. R., & Sladek, F. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132672 · Cited by 98 · see citing works
Calamari, L., Ferrari, A., Minuti, A., et al. (2016) · BMC Veterinary Research · doi:10.1186/s12917-015-0621-4 · Cited by 90 · see citing works
Self-citationBueno, A. A., Oyama, L. M., de Oliveira, C., Pisani, L. P., Ribeiro, E. B., Silveira, V. L. F., & do Nascimento, C. M. O. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0330-3 · Cited by 89 · see citing works
Torriani, S., Clementi, F., Vancanneyt, M., Hoste, B., Dellaglio, F., & Kersters, K. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00071 · Cited by 84 · see citing works
Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice
Deol, P., Fahrmann, J. F., Yang, J., Evans, J. R., Rizo, A., Grapov, D., Salemi, M., Wanichthanarak, K., Fiehn, O., Phinney, B. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12624-9 · Cited by 74 · see citing works
Shiratori, H., Ohiwa, H., Ikeno, H., et al. (2008) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.65490-0 · Cited by 70 · see citing works
Kratz, M., von Eckardstein, A., Fobker, M., Buyken, A. E., Posny, N., Schulte, H., Assmann, G., & Wahrburg, U. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020496 · Cited by 63 · see citing works
Localization, Identification, and Excision of Murine Adipose Depots
Mann, A., Thompson, A., Robbins, N., et al. (2014) · Journal of Visualized Experiments · doi:10.3791/52174 · Cited by 53 · see citing works
Xiao, Y., Cui, J., Shi, Y., et al. (2010) · Nutrition · doi:10.1016/j.nut.2009.11.021 · Cited by 52 · see citing works
Fish Oil Promotes Macrophage Reverse Cholesterol Transport in Mice
Nishimoto, T., Pellizzon, M., Aihara, M., Stylianou, I. M., Billheimer, J. T., Rothblat, G. H., & Rader, D. J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.187252 · Cited by 51 · see citing works
Energy intake and adiponectin gene expression
Qiao, L., Lee, B., Kinney, B., Yoo, H. S., & Shao, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00004.2011 · Cited by 49 · see citing works
Castro-Mejía, J. L., Jakesevic, M., Krych, Ł., Nielsen, D. S., Hansen, L. H., Sondergaard, B. C., Kvist, P. H., Hansen, A. K., & Holm, T. L. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/4953120 · Cited by 41 · see citing works
Duivenvoorde, L. P. M., van Schothorst, E. M., Swarts, H. J. M., Kuda, O., Steenbergh, E., Termeulen, S., Kopecký, J., & Keijer, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128515 · Cited by 36 · see citing works
Short-term modifications in the distal gut microbiota of weaning mice induced by a high-fat diet
Patrone, V., Ferrari, S., Lizier, M., Lucchini, F., Minuti, A., Tondelli, B., Trevisi, E., Rossi, F., & Callegari, M. L. (2012) · Microbiology · doi:10.1099/mic.0.054247-0 · Cited by 28 · see citing works
Self-citationDietary fat‐induced taurocholic acid production promotes pathobiont and colitis in IL‐10−/− mice
Devkota, S., Wang, Y., Leone, V., Musch, M. W., Nadimpalli, A., Antonopoulos, D., Jabrì, B., & Chang, E. B. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1155.2 · Cited by 25 · see citing works
A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid
Weirdt, R. D., Coenen, E., Vlaeminck, B., Fievez, V., den Abbeele, P. V., & de Wiele, T. V. (2013) · Beneficial Microbes · doi:10.3920/bm2013.0017 · Cited by 23 · see citing works
Tovar, A. R., Díaz‐Villaseñor, A., Cruz-Salazar, N., Ordáz, G., Granados, O., Palacios‐González, B., Tovar‐Palacio, C., López, P. V., & Torres, N. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.10.004 · Cited by 23 · see citing works
Lizier, M., Bomba, L., Minuti, A., Chegdani, F., Capraro, J., Tondelli, B., Mazza, R., Callegari, M. L., Trevisi, E., Rossi, F., et al. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0344-8 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243 · see citing works
<p>Spotlight on Icosapent Ethyl for Cardiovascular Risk Reduction: Evidence to Date</p>
Jia, X., Koh, S., Al Rifai, M., Blumenthal, R. S., & Virani, S. S. (2020) · Vascular Health and Risk Management · doi:10.2147/vhrm.s210149 · Cited by 14 · see citing works
- Authors
- Patrone, V., Minuti, A., Lizier, M., Miragoli, F., Lucchini, F., Trevisi, E., Rossi, F., & Callegari, M. L.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Institute of Genetic and Biomedical Research (IT)
- Corresponding author
- Patrone, Vania
- ORCID
- Venue
- BMC Genomics
- Published
- 2018-11-07
- Volume
- 19
- Issue
- 1
- Pages
- 808-808
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC6223047
- OpenAlex
- W2900428732
- Cited by
- 47
- References
- 75
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 11 · 2020: 11 · 2019: 4
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Genomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- Funders
- Fondazione Romeo ed Enrica Invernizzi
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- coconut oil, soybean oil, gut microbiota, high-fat diet, saturated fat, polyunsaturated fat, cecal microbiota, Akkermansia muciniphila, Lactobacillus reuteri, Lactobacillus plantarum, serum cholesterol, obesity, lipid metabolism, energy storage, metabolic inflammation, Deltaproteobacteria
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cecum, Cocos, Female, Inflammation, Mice, Inbred C57BL, Soybean Oil, Lipid Metabolism, Mice, Diet, High-Fat, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
