A complex systems approach to the study of change in psychotherapy
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BACKGROUND: A growing body of research highlights the limitations of traditional methods for studying the process of change in psychotherapy. The science of complex systems offers a useful paradigm for studying patterns of psychopathology and the development of more functional patterns in psychotherapy. Some basic principles of change are presented from subdisciplines of complexity science that are particularly relevant to psychotherapy: dynamical systems theory, synergetics, and network theory. Two early warning signs of system transition that have been identified across sciences (critical fluctuations and critical slowing) are also described. The network destabilization and transition (NDT) model of therapeutic change is presented as a conceptual framework to import these principles to psychotherapy research and to suggest future research directions. DISCUSSION: A complex systems approach has a number of implications for psychotherapy research. We describe important design considerations, targets for research, and analytic tools that can be used to conduct this type of research. CONCLUSIONS: A complex systems approach to psychotherapy research is both viable and necessary to more fully capture the dynamics of human change processes. Research to date suggests that the process of change in psychotherapy can be nonlinear and that periods of increased variability and critical slowing might be early warning signals of transition in psychotherapy, as they are in other systems in nature. Psychotherapy research has been limited by small samples and infrequent assessment, but ambulatory and electronic methods now allow researchers to more fully realize the potential of concepts and methods from complexity science.
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Modeling downstream mechanisms will likely require complex approaches such as network analytic frameworks.
“Modeling downstream mechanisms will likely require complex approaches such as network analytic frameworks”
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Hitchcock, C., Gormley, S., Rees, C., Rodrigues, E., Gillard, J., Panesar, I., Wright, I. M., Hammond, E. R., Watson, P., Werner‐Seidler, A., et al. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.08.008 · Cited by 38 · see citing works
Hosseinichimeh, N., Wittenborn, A. K., Rick, J., Jalali, M. S., & Rahmandad, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204389 · Cited by 38 · see citing works
A Comparison of Methods for Estimating Change in Drinking following Alcohol Treatment
Witkiewitz, K. A., Maisto, S. A., & Donovan, D. M. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01308.x · Cited by 36 · see citing works
Cabrieto, J., Adolf, J. K., Tuerlinckx, F., Kuppens, P., & Ceulemans, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-33819-8 · Cited by 34 · see citing works
Hoffart, A., & Johnson, S. U. (2020) · Clinical Psychological Science · doi:10.1177/2167702620901744 · Cited by 30 · see citing works
Ellison, W. D., Levy, K. N., Newman, M. G., Pincus, A. L., Wilson, S. J., & Molenaar, P. C. M. (2019) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000363 · Cited by 29 · see citing works
Tschacher, W., & Haken, H. (2019) · Psychotherapy Research · doi:10.1080/10503307.2019.1685139 · Cited by 26 · see citing works
Vittengl, J. R., Clark, L. A., Thase, M. E., & Jarrett, R. B. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.08.008 · Cited by 25 · see citing works
Helmich, M. A., Snippe, E., Kunkels, Y. K., Riese, H., Smit, A. C., & Wichers, M. (2021) · doi:10.31234/osf.io/fertq · Cited by 24 · see citing works
Coherence, Complexity, and Information Flow: Self-Organizing Processes in Psychotherapy
Pincus, D. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9781139058544.012 · Cited by 23 · see citing works
Mining concepts of health responsibility using text mining and exploratory graph analysis
Kjellström, S., & Golino, H. F. (2018) · Scandinavian Journal of Occupational Therapy · doi:10.1080/11038128.2018.1455896 · Cited by 20 · see citing works
Pascual‐Leone, A., Yeryomenko, N., Sawashima, T., & Warwar, S. H. (2017) · Psychotherapy Research · doi:10.1080/10503307.2017.1315779 · Cited by 18 · see citing works
The Role of Self-Injury in Behavioral Flexibility and Resilience
Pincus, D., Eberle, K., Walder, C. S., Kemp, A. S., Sandman, C. A., & Lenjavi, M. (2013) · PsycEXTRA Dataset · doi:10.1037/e634192013-034 · Cited by 16 · see citing works
Self-Organization in Psychotherapy
Goudsmit, A. L. (1989) · Recent research in psychology · doi:10.1007/978-3-642-48704-0 · Cited by 16 · see citing works
A Fast-Slow Dynamical System Model of Addiction: Predicting Relapse Frequency
Duncan, J. P., Aubele-Futch, T., & McGrath, M. (2019) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/18m121410x · Cited by 16 · see citing works
Andrews, L. A., Hayes, A. M., Abel, A., & Kuyken, W. (2020) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000467 · Cited by 16 · see citing works
Self-citationAltman, A. D., Shapiro, L. A. S., & Fisher, A. J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00782 · Cited by 16 · see citing works
How to modify psychopathological states? Hypotheses based on complex systems theory
Haken, H., & Tschacher, W. (n.d.) · PubMed · doi:10.7892/boris.108121 · Cited by 15 · see citing works
Strunk, G., & Lichtwarck‐Aschoff, A. (2019) · Journal for Person-Oriented Research · doi:10.17505/jpor.2019.08 · Cited by 14 · see citing works
Lichtwarck‐Aschoff, A., & van Rooij, M. M. J. W. (2019) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2383 · Cited by 10 · see citing works
Schöller, H. J., Viol, K., Goditsch, H., Aichhorn, W., Hütt, M. ‐., & Schiepek, G. K. (2019) · PubMed · Cited by 10 · see citing works
Self-Organization in Social Groups
Tschacher, W., Brunner, E. J., & Schiepek, G. K. (1992) · Springer series in synergetics · doi:10.1007/978-3-642-77534-5_19 · Cited by 9 · see citing works
Pincus, D. (2019) · PubMed · Cited by 4 · see citing works
Causation and Chance: Integrating the Dynamical Systems Approach with Statistical Thinking
Tschacher, W., & Haken, H. (2019) · Springer eBooks · doi:10.1007/978-3-030-12748-0_1 · Cited by 2 · see citing works
Interventions in Psychotherapy
Tschacher, W., & Haken, H. (2019) · Springer eBooks · doi:10.1007/978-3-030-12748-0_3 · Cited by 1 · see citing works
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Research works printed but not linked: 2
- [8]Tschacher W, Schiepek G, Brunner EJ, editors. Self-organization and clinical psychology. 1st ed. Berlin, Heidelberg: Springer Berlin Heidelberg; 1992. 366 p. (Springer Series in Synergetics).
- [90]Hayes AM, Andrews LA. Early warning signs and the study of transitions in psychotherapy. In: Viol K, Schöller H, editors. Self-organization: a paradigm for the human sciences? New York: Springer Publishing Company. in press.
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Sorted by citations
Modeling psychopathology: From data models to formal theories.
Haslbeck, J. M. B., Ryan, O., Robinaugh, D. J., Waldorp, L., & Borsboom, D. (2021) · Psychological Methods · doi:10.1037/met0000303 · Cited by 222 · see citing works
Roefs, A., Fried, E. I., Kindt, M., Martijn, C., Elzinga, B., Evers, A. W. M., Wiers, R. W., Borsboom, D., & Jansen, A. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104096 · Cited by 185 · see citing works
“It is embedded in a wider framework of systems science and network science (e.g., Hayes, 2020; Robinaugh, Hoekstra, Toner, & Borsboom, 2020; Schiepek, 2009, 2020).”
BackgroundSystems all the way down: embracing complexity in mental health research
Fried, E. I., & Robinaugh, D. J. (2020) · BMC Medicine · doi:10.1186/s12916-020-01668-w · Cited by 167 · see citing works
Complexity theory of psychopathology.
Olthof, M., Hasselman, F., Oude Maatman, F., Bosman, A. M. T., & Lichtwarck-Aschoff, A. (2023) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000740 · Cited by 131 · see citing works
van der Velden, A. M., Scholl, J., Elmholdt, E.-M., Fjorback, L. O., Harmer, C. J., Lazar, S. W., O’Toole, M. S., Smallwood, J., Roepstorff, A., & Kuyken, W. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.038 · Cited by 83 · see citing works
Early warning signals and critical transitions in psychopathology: challenges and recommendations
Helmich, M. A., Olthof, M., Oldehinkel, A. J., Wichers, M., Bringmann, L. F., & Smit, A. C. (2021) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2021.02.008 · Cited by 80 · see citing works
A cultural-ecosocial systems view for psychiatry
Gómez-Carrillo, A., & Kirmayer, L. J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1031390 · Cited by 80 · see citing works
“In clinical settings, nonlinear dynamics are commonly observed and putative explanations in terms of loops could be tested by interventions that target specific parameters (188, 189).”
BackgroundBos, F. M., Schreuder, M. J., George, S. V., Doornbos, B., Bruggeman, R., van der Krieke, L., Haarman, B. C. M., Wichers, M., & Snippe, E. (2022) · International Journal of Bipolar Disorders · doi:10.1186/s40345-022-00258-4 · Cited by 64 · see citing works
“2016; Hayes and Andrews 2020).”
Measuring the active elements of cognitive-behavioral therapies
Cohen, Z. D., Barnes-Horowitz, N. M., Forbes, C. N., & Craske, M. G. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104364 · Cited by 58 · see citing works
Pattern breaking: a complex systems approach to psychedelic medicine
Hipólito, I., Mago, J., Rosas, F. E., & Carhart-Harris, R. L. (2023) · Neuroscience of Consciousness · doi:10.1093/nc/niad017 · Cited by 66 · see citing works
“…described ‘thin-skinned’ or ‘open-hearted’ quality of individuals in the aftermath of a psychedelic experience, where interpersonal support and a grounded psychosocial matrix (Eisner 1997) may be vital for a positive therapeutic trajectory [see Hayes and Andrews (2020) for relevant material].”
Complexity in psychological self-ratings: implications for research and practice
Olthof, M., Hasselman, F., & Lichtwarck‐Aschoff, A. (2020) · BMC Medicine · doi:10.1186/s12916-020-01727-2 · Cited by 56 · see citing works
“Our primary aim is to illustrate how the clinical implications of a complex systems approach, as we and others have proposed elsewhere [1, 2, 90, 91], relate to the three characteristics that we examined.”
BackgroundNetworks of Adversity in Childhood and Adolescence and Their Relationship to Adult Mental Health
Pollmann, A., Fritz, J., Barker, E. D., & Fuhrmann, D. (2022) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-022-00976-4 · Cited by 47 · see citing works
“Using this approach in psychopathology, instead of analysing individual parts of a mental health disorder (e.g., a specific symptom), we can look at different aspects of a disorder interacting and changing over time (Hayes & Andrews, 2020).”
MethodFried, E. I., Rieble, C., & Rieble, C. (2023) · Clinical Psychology in Europe · doi:10.32872/cpe.10075 · Cited by 52 · see citing works
“In clinical psychology and psychiatry, recent studies have demonstrated the potential utility of a systems approach for understanding mental health problems like depression (Hayes & Andrews, 2020; Lutz et al., 2018; Olthof et al., 2023; Robinaugh et al., 2020; Wichers, 2014).”
BackgroundImplications of the Network Theory for the Treatment of Mental Disorders
Schumacher, L., Klein, J. P., Elsaeßer, M., Härter, M. C., Hautzinger, M., Schramm, E., & Kriston, L. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.2823 · Cited by 41 · see citing works
Slow down and be critical before using early warning signals in psychopathology
Helmich, M. A., Schreuder, M. J., Bringmann, L. F., Riese, H., Snippe, E., & Smit, A. C. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00369-y · Cited by 39 · see citing works
“Clinically, a method such as EWS (which promises to facilitate personalized early detection of destabilization) could be extremely valuable for timely intervention in relapse prevention, or for reinforcement when the patient is most receptive in the context of therapy 10,36–40 .”
Helmich, M. A., Smit, A. C., Bringmann, L. F., Schreuder, M. J., Oldehinkel, A. J., Wichers, M., & Snippe, E. (2022) · Clinical Psychological Science · doi:10.1177/21677026221137006 · Cited by 41 · see citing works
“…for those individuals, the process of depressive remission showed the nonlinearity one would expect from a dynamic system, particularly in the context of therapy (Hayes & Andrews, 2020; Hayes & Strauss, 1998; Heinzel et al., 2014; Schiepek, 2009; Shapiro, 2015; Strunk & Lichtwarck-Aschoff, 2019).”
BackgroundLazarus, G., & Rafaeli, E. (2023) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000699 · Cited by 27 · see citing works
The best of both worlds? General principles of psychopathology in personalized assessment.
Olthof, M., Hasselman, F., Aas, B., Lamoth, D., Scholz, S., Daniels-Wredenhagen, N., Goldbeck, F., Weinans, E., Strunk, G., Schiepek, G. K., et al. (2023) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000858 · Cited by 27 · see citing works
Burger, S. R., Hardy, A., van der Linden, T., van Zelst, C., de Bont, P. A. J. M., van der Vleugel, B. M., Staring, A. B. P., de Roos, C., de Jongh, A., Marcelis, M. C., et al. (2023) · Journal of Traumatic Stress · doi:10.1002/jts.22907 · Cited by 27 · see citing works
Therapeutic Potential of Embodied Cognition for Clinical Psychotherapies: From Theory to Practice
Fugate, J. M. B., Macrine, S. L., & Hernandez-Cuevas, E. M. (2024) · Cognitive Therapy and Research · doi:10.1007/s10608-024-10468-y · Cited by 24 · see citing works
“Recognizing the intertwined nature of body, mind, and social environment enhances the effectiveness of therapeutic interventions, allowing for a deeper understanding of human change processes (Hayes & Andrews, 2020).”
Transdiagnostic symptom dynamics during psychotherapy
O'Driscoll, C., Epskamp, S., Fried, E. I., Saunders, R., Cardoso, A., Stott, J., Wheatley, J., Cirkovic, M., Naqvi, S. A., Buckman, J., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-14901-8 · Cited by 22 · see citing works
Examining emotional processing theory and predictors of outcome in prolonged exposure for PTSD
Alpert, E., Hayes, A. M., & Foa, E. B. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104341 · Cited by 21 · see citing works
Self-citationWesthoff, M., Berg, M., Reif, A., Rief, W., & Hofmann, S. G. (2024) · Cognitive Therapy and Research · doi:10.1007/s10608-024-10487-9 · Cited by 26 · see citing works
“Both assumptions are violated in psychological testing (Gomes et al., 2019) and in treatment research most of the time (Hayes et al., 2020).”
InfluentialThe Kere of Madagascar: a qualitative exploration of community experiences and perspectives
Ralaingita, M. I., Ennis, G., Russell‐Smith, J., Sangha, K. K., & Razanakoto, T. (2022) · Ecology and Society · doi:10.5751/es-12975-270142 · Cited by 18 · see citing works
Preventive mental health care: A complex systems framework for ambient smart environments
White, B. P., & Hipólito, I. (2023) · Cognitive Systems Research · doi:10.1016/j.cogsys.2023.101199 · Cited by 17 · see citing works
Individual-Specific Animated Profiles of Mental Health
Zilcha‐Mano, S. (2024) · Perspectives on Psychological Science · doi:10.1177/17456916231226308 · Cited by 18 · see citing works
“…whereas changes in the dynamic patterns can be understood as destabilizing the pathological attractor and developing new, more healthy patterns of functioning, switching from a pathological to a healthier attractor, or making minor adjustments to maladaptive patterns (Hayes & Andrews, 2020).”
InfluentialOn the transience or stability of subthreshold psychopathology
Schreuder, M. J., Wigman, J. T. W., Groen, R. N., Wichers, M., & Hartman, C. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-02711-3 · Cited by 16 · see citing works
Gauld, C., & Depannemaecker, D. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1099257 · Cited by 15 · see citing works
“The warning signals leading to this attracting state can thus be detected upstream (Hayes and Andrews, 2020).”
BackgroundThe need for systems thinking to advance Alzheimer's disease research
Uleman, J. F., Quax, R., Melis, R. J. F., Hoekstra, A. G., & Rikkert, M. G. M. O. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115741 · Cited by 15 · see citing works
“Consequently, an increasing number of researchers recommend conceptualizing such disorders (Cramer et al., 2016; Hayes and Andrews, 2020; Kenzie et al., 2017; van der Wal et al., 2021), including LOAD (Cohen et al., 2022; Pomorska and Ockene, 2017; Rollo et al., 2016; Tang et al., 2019) as emergent…”
BackgroundHoffart, A., Bauer, D. J., Johnson, S. U., & Ebrahimi, O. V. (2022) · Scientific Reports · doi:10.1038/s41598-022-22686-z · Cited by 14 · see citing works
Understanding the Risk of Sexual Reoffending in Adult Men: A Network-Based Model
van den Berg, J. W., van Beek, D. J., Bouman, Y. H. A., Janssen, E., Smid, W., & Gijs, L. A. C. L. (2023) · Sexual Abuse · doi:10.1177/10790632231153633 · Cited by 14 · see citing works
“From the NBM-RSR, both the relative stability of and changes in risk of sexual reoffending can be understood from self-sustaining networks of dynamic risk factors and their critical transitions (Hayes & Andrews, 2020; Kossakowski, 2020).”
BackgroundAn Introduction to Change in Psychotherapy: Moderators, Course of Change, and Change Mechanisms
Antichi, L., & Giannini, M. (2023) · Journal of Contemporary Psychotherapy · doi:10.1007/s10879-023-09590-x · Cited by 14 · see citing works
Helmich, M. A., Smit, A. C., Bringmann, L. F., Schreuder, M. J., Oldehinkel, A. J., Wichers, M., & Snippe, E. (2021) · doi:10.31234/osf.io/vf86s · Cited by 13 · see citing works
Pattern Breaking: A Complex Systems Approach to Psychedelic MedicinePreprint
Hipólito, I., Mago, J., Rosas, F. E., & Carhart-Harris, R. L. (2022) · doi:10.31234/osf.io/ydu3h · Cited by 13 · see citing works
A complex systems view on physical activity with actionable insights for behaviour change
Schüler, J., Heino, M. T. J., Balagué, N., Chater, A., Grüber, M., Kanning, M. K., Keim, D. A., Mier, D. U., Moreno‐Villanueva, M., Nußbeck, F. W., et al. (2025) · Nature Human Behaviour · doi:10.1038/s41562-025-02279-2 · Cited by 13 · see citing works
“The illustration is reminiscent of similar representations of attractor landscapes 48 , such as those used in psychotherapy research 30 . d , In all panels, the progression from left to right represents the second layer of complexity: the temporal dynamics inherent in the interactions between…”
Problem-sustaining patterns: redesigning the concept of mental disorder
Voerman, S. A., Strijbos, D., Staring, A. B. P., de Boer, F. E., van Dijk, M. B., Driessen, J., Glas, G. G., Goekoop, R., Mulder, A., Tromp, N., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1382915 · Cited by 12 · see citing works
“Mental healthcare may thus be viewed as a form of assisted equilibrium-shifting or phase transition (40, 68), where the goal is often not merely to disrupt the problem-sustaining equilibrium, but also to establish and strengthen a new equilibrium that facilitates the client ’ s values and plans.”
Alpert, E., Hayes, A. M., Barnes, J. B., & Sloan, D. M. (2022) · Behavior Therapy · doi:10.1016/j.beth.2022.09.002 · Cited by 12 · see citing works
Self-citationFried, E. I., Rieble, C., & Proppert, R. K. K. (2022) · doi:10.31234/osf.io/9qcvs · Cited by 12 · see citing works
Freichel, R., Veer, I. M., Wiers, R. W. H. J., McNally, R. J., & Epskamp, S. (2023) · doi:10.31234/osf.io/b94qt · Cited by 15 · see citing works
Quantifying the stability landscapes of psychological networks
Cui, J., Lunansky, G., Lichtwarck‐Aschoff, A., Mendoza, N. B., & Hasselman, F. (2026) · Behavior Research Methods · doi:10.3758/s13428-025-02917-7 · Cited by 11 · see citing works
“…stability landscape metaphor has been frequently used in the literature of psychopathology, especially from the complex systems approach (Scheffer et al., 2018; van Bork et al., 2024; Hayes & Andrews, 2020; Olthof et al., 2023b), it has not been fully computed from estimated psychological networks.”
The inner workings of anger: A network analysis of anger and emotion regulation
Larsson, J., Bjureberg, J., Zhao, X., & Hesser, H. (2023) · Journal of Clinical Psychology · doi:10.1002/jclp.23622 · Cited by 17 · see citing works
“In each cluster, every anger node reinforces the other nodes within that cluster, a phenomenon akin to “ pathological attractor states ” as outlined by Hayes and Andrews (2020).”
Sarasso, P., Tschacher, W., Schoeller, F., Francesetti, G., Roubal, J., Gecele, M., Sacco, K., & Ronga, I. (2024) · Physics of Life Reviews · doi:10.1016/j.plrev.2024.09.005 · Cited by 12 · see citing works
“The therapeutic dyad or group self-organizes and reorganizes into more and less stable relational patterns [6 – 14] and destabilizes and transits into novel patterns [15].”
Elkarif, T., Orkibi, H., & Keisari, S. (2024) · The Journal of Positive Psychology · doi:10.1080/17439760.2024.2427581 · Cited by 11 · see citing works
“Change process research examines how or why psychotherapy leads to change (Hayes & Andrews, 2020).”
Hoffart, A., Skjerdingstad, N., Freichel, R., Mansueto, A. C., Johnson, S. U., Epskamp, S., & Ebrahimi, O. V. (2023) · Clinical Psychological Science · doi:10.1177/21677026231208172 · Cited by 11 · see citing works
Helmich, M. A., Wichers, M., Peeters, F. P. M. L., & Snippe, E. (2022) · Cognition & Emotion · doi:10.1080/02699931.2022.2129593 · Cited by 10 · see citing works
Ambient smart environments: affordances, allostasis, and wellbeing
White, B., & Miller, M. (2024) · Synthese · doi:10.1007/s11229-024-04679-9 · Cited by 9 · see citing works
“…relating it to work in psychiatry and complex systems theory that casts the primary role of therapeutic intervention as disrupting so-called ‘stuck states’, wherein a cognitive system becomes rigidly trapped within a particular attractor state (Hayes & Andrews, 2020 ; Olthof et al., 2020).”
Modeling the onset of a depressive episode: A self-regulation perspective
Strauman, T. J. (2021) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2021.04.003 · Cited by 10 · see citing works
Dynamic Associations Among Sleep, Emotion Dysregulation, and Desire to Live in a Perinatal Sample
Kaliush, P. R., Butner, J., Williams, P., Conradt, E. D., & Crowell, S. E. (2024) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001297 · Cited by 9 · see citing works
“Predictors of change are meaningfully distinct from variables that correlate with or simply predict each other because they help to illuminate temporal patterns and potentially more impactful treatment targets (10,64,65).”
BackgroundImproving treatments for mental disorders using computational models
Ryan, O., Haslbeck, J. M. B., & Robinaugh, D. J. (2025) · Behaviour Research and Therapy · doi:10.1016/j.brat.2025.104706 · Cited by 8 · see citing works
Brazeau, B. W., Cunningham, J. A., & Hodgins, D. C. (2024) · Internet Interventions · doi:10.1016/j.invent.2023.100707 · Cited by 7 · see citing works
“Complexity science can inform the field in terms of more sophisticated theories and analytic methods to discover how people change and how that can be facilitated (Hayes and Andrews, 2020; Hayes et al., 2022; Heino et al., 2022; Hofmann et al., 2020; Olthof et al., 2020).”
BackgroundCoyne, A. E., Mattson, E. K., Bagley, J. M., Klein, A. B., Shekhtman, K., Payat, S., Levine, D. S., Feeny, N. C., & Zoellner, L. A. (2023) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000837 · Cited by 7 · see citing works
Resurrecting Gaia: harnessing the Free Energy Principle to preserve life as we know it
Montgomery, C., & Hipólito, I. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1206963 · Cited by 6 · see citing works
“thinking, so that the Earth and its inhabitants can be encountered as the highly complex adaptive systems they are (Varela et al., 1991; Margulis and Sagan, 1995; Capra, 1997; Duncan, 2018; Fried and Robinaugh, 2020; Hayes and Andrews, 2020).”
BackgroundA Dynamic Autocatalytic Network Model of Therapeutic Change
Ganesh, K., & Gabora, L. M. (2022) · Entropy · doi:10.3390/e24040547 · Cited by 7 · see citing works
“Traditional methods for studying psychotherapeutic change have limitations [54] that the complex systems approach is well positioned to overcome [85–88], by enabling psychotherapy to be modeled and understood more precisely, using tools that embed it in a larger framework that includes other systems and disciplines.”
BackgroundTransitions and resilience in ecological momentary assessment: A multiple single-case study
Olthof, M., Bunge, A., Maciejewski, D. F., Hasselman, F., & Lichtwarck‐Aschoff, A. (2024) · Journal for Person-Oriented Research · doi:10.17505/jpor.2024.27102 · Cited by 6 · see citing works
“Such pattern transitions have been extensively studied with EMA in psychotherapy and psychopathology research (Hayes & Andrews, 2020).”
Shifting boundaries, extended minds: ambient technology and extended allostatic control
White, B. P., Clark, A., GUÉNIN--CARLUT, A., Constant, A., & Paolo, L. D. D. (2025) · Synthese · doi:10.1007/s11229-025-04924-9 · Cited by 6 · see citing works
Methodological challenges and opportunities when studying the course of autism
Bal, V. H., Szatmári, P., Georgiades, S., Gentles, S. J., Girault, J. B., Howlin, P., Lai, M., Leno, V. C., Lord, C., Madgett, K., et al. (2025) · Autism · doi:10.1177/13623613251341012 · Cited by 6 · see citing works
“…data analysis allow for sophisticated approaches to estimating change over time (e.g. Mund & Nestler, 2019), encompassing multiple outcome domains (e.g. Hayes & Andrews, 2020) and assessing the impact of many prognostic variables simultaneously via formalized theories (Haslbeck et al., 2022).”
Dynamic changes in network structure of depressive symptoms: a two-year naturalistic follow-up study
Shen, G., Yang, X., Zou, Y., Zheng, Y., Fang, J., Huang, J., Tang, J., Wu, S., & Chen, L. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07124-4 · Cited by 7 · see citing works
A Network Analysis of Fear-Avoidance Beliefs, Mood, and Disability in Chronic Pain
van der Wijk, G., Huygelier, H., Haslbeck, J. M. B., Evers, A. W. M., Peters, M. L., Teppers, M., & Vlaeyen, J. W. S. (2025) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001322 · Cited by 7 · see citing works
Mirzaie, K., Burns-Gebhart, A., Meyerheim, M., Sander, A., & Graf, N. M. (2022) · Cancers · doi:10.3390/cancers14163874 · Cited by 7 · see citing works
The network dynamics of self‐compassion components and psychological symptoms during an intervention
Huang, J., Chen, S., Yang, W., & Wang, Y. (2023) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.12488 · Cited by 11 · see citing works
Myers, C. E., Dave, C. V., Chesin, M. S., Marx, B. P., Hill, L. M. S., Reddy, V., Miller, R. B., King, A. R., & Interian, A. (2024) · Behaviour Research and Therapy · doi:10.1016/j.brat.2024.104637 · Cited by 6 · see citing works
MT Evaluation in the Context of Language Complexity
Munková, D., Munk, M., Benko, Ľ., & Stastny, J. (2021) · Complexity · doi:10.1155/2021/2806108 · Cited by 6 · see citing works
“Complex systems have shifted from reductionist analyses of component parts (agents) and simple linear change to the study of interconnected elements ([24], p.”
BackgroundZhang, W., Zhang, K., Yang, M.-B., & Si, S. (2024) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2971 · Cited by 6 · see citing works
Cao, J., Pai, Y. S., Li, C., Hoermann, S., & Billinghurst, M. (2025) · CHI Conference Extended Abstracts on Human Factors in Computing Systems (CHI EA) · doi:10.1145/3706599.3720086 · Cited by 5 · see citing works
“Giventhe dynamic nature of psychological therapy[11], co-design sessions with therapists during the development phase are important for implementing effective programmatic controls in virtual supporters.”
Eckes, T., & Nestler, S. (2023) · Clinical Psychological Science · doi:10.1177/21677026231165677 · Cited by 5 · see citing works
“Dynamic systems emerge when elements that behave in a self-organizing and nonlinear fashion interact in a way that creates system-specific patterns (DeRuiter et al., 2017; Gelo & Salvatore, 2016; Hayes & Andrews, 2020).”
BackgroundHulsmans, D. H. G., Otten, R., Poelen, E. A. P., van Vonderen, A., Daalmans, S., Hasselman, F., Olthof, M., & Lichtwarck‐Aschoff, A. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05836-7 · Cited by 5 · see citing works
“Figure 1A shows instability-induced change, in which an existing attractor destabilizes to the extent that there is no valley left to contain the ball, making the ball roll towards a new valley [11, 12, 32].”
BackgroundTrajectories of parent criticism across treatment for youth self‐harm
Aitken, M., Perquier, F., Park, B., Carvalho, D., Wright-Hughes, A. M., Cottrell, D. J., & Szatmári, P. (2025) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.14144 · Cited by 7 · see citing works
“Participating in therapy may change established parent – youth interaction patterns, creating opportunities for therapy effects (Hayes & Andrews, 2020).”
Bouwman, V., Mobach, L., Teachman, B. A., & Salemink, E. (2025) · Behaviour Research and Therapy · doi:10.1016/j.brat.2025.104685 · Cited by 4 · see citing works
A Narrative Identity Perspective on Mechanisms of Change in Imagery Rescripting
Çili, S., & Stopa, L. L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.636071 · Cited by 5 · see citing works
Cane, T. P. C., Newton, P. D., & Foster, J. (2022) · Advances in Dual Diagnosis · doi:10.1108/add-12-2021-0019 · Cited by 4 · see citing works
Prediction of depression onset and development based on network analysis
Weixia, Z., Min, X., Tiantian, Y., Cheng, W., & Shubin, S. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.02129 · Cited by 4 · see citing works
Cui, J., Olthof, M., Hasselman, F., & Lichtwarck‐Aschoff, A. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06688-5 · Cited by 4 · see citing works
“The destabilization of the unhealthy phase, which corresponds to the loosening of undesirable cognitive, affective, or behavioral patterns [12], then functions as a mechanism for the sudden gain toward a healthier phase.”
InfluentialFeyaerts, J., Brar, P. S., Sass, L. A., & Nelson, B. (2025) · The Lancet Psychiatry · doi:10.1016/s2215-0366(25)00244-5 · Cited by 3 · see citing works
Seizer, L., Kratzer, L., Löchner, J., Schöller, H. J., Aichhorn, W., & Schiepek, G. K. (2026) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.70222 · Cited by 3 · see citing works
“This pattern resonates with dynamic systems perspectives that conceptualize improvement as the emergence of new attractor states after periods of instability (Hayes and Andrews 2020; G. Schiepek et al. 2020).”
Driessen, J., Goekoop, R., Voerman, S. A., Mulder, A., Verhaar, M., Bos, J. H., Glas, G. G., & van den Berg, D. P. G. (2026) · Clinical Psychological Science · doi:10.1177/21677026251414040 · Cited by 3 · see citing works
Bernardi, R., & Eidlin, M. (2025) · The Psychoanalytic Quarterly · doi:10.1080/00332828.2025.2518927 · Cited by 3 · see citing works
Echterhoff, J., Kriston, L., Klein, J. P., Härter, M. C., Schramm, E., & Schumacher, L. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2320349 · Cited by 3 · see citing works
“A first step in understanding potential mechanisms of change is to investigate whether the treatment had effects on the postulated mediators of a treatment and whether these postulated mediators impacted, in turn, relevant symptoms (Hayes & Andrews, 2020).”
Bos, F. M., Schreuder, M. J., George, S. V., Doornbos, B., Bruggeman, R., van der Krieke, L., Haarman, B. C. M., Wichers, M., & Snippe, E. (2021) · doi:10.31234/osf.io/v5b7t · Cited by 3 · see citing works
A unified pathogenic hypothesis for mental disorders based on schismogenesis
Garcı́a-Toro, M., & Gómez-Juanes, R. (2025) · Biosystems · doi:10.1016/j.biosystems.2025.105431 · Cited by 3 · see citing works
Darnell, B. C., Benfer, N., & Litz, B. (2025) · Clinical Psychology Review · doi:10.1016/j.cpr.2025.102671 · Cited by 2 · see citing works
Ngabo-Woods, H., Dunai, L., & Verdú, I. S. (2025) · Applied Sciences · doi:10.3390/app152312524 · Cited by 2 · see citing works
The Future of the Biopsychosocial Model: Toward a Transdisciplinary Systems Science of Mental Health
Robinaugh, D. J., Blanken, T. F., Bridger, E. K., Casamento‐Moran, A., de Ron, J., Henry, T. R., Hoekstra, R. H. A., Stratis, G., van de Leemput, I. A., van Nes, E. H., et al. (2026) · Clinical Psychological Science · doi:10.1177/21677026261435464 · Cited by 4 · see citing works
“…the notion that mental disorders emerge from complex systems of interacting components has seen a resurgence of interest (e.g., Borsboom, 2017; Hayes & Andrews, 2020; Nelson et al., 2017; Olthof et al., 2023; Schiepek & Pincus, 2023), and researchers collaborating across ecology, psychiatry,…”
A Multimodal Framework for Prognostic Modelling of Mental Health Treatment and Recovery Trajectories
Ngabo-Woods, H., Dunai, L., Verdú, I. S., & Sui, L. (2026) · Applied Sciences · doi:10.3390/app16020763 · Cited by 2 · see citing works
Mikkonen, K., Lintula, S. J., Rosenström, T. H., Lahti, J. M. T., Helminen, E.-E., Saarni, S. I., & Saarni, S. E. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121225 · Cited by 2 · see citing works
A topological data analysis method for revealing dynamic changes in psychotherapy microprocesses
Luo, X., & Zhang, M. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1711782 · Cited by 2 · see citing works
“Such saddle-driven dynamics are rarely examined in psychotherapy literature [see recent reviews by Hayes and Andrews (2020), and Klocek et al. (2024)], while continue to gain attention in other domains such as neuroscience (Kelso, 2012; Tognoli and Kelso, 2014; Hancock et al., 2025).”
Pham, T. D. (2021) · International Conference on Electrical, Computer and Energy Technologies (ICECET) · doi:10.1109/icecet52533.2021.9698467 · Cited by 2 · see citing works
“Based on this hypothesis, the theory of chaos and methods for nonlinear data analysis of complex systems have been applied for studying mood disorders and psychotherapy [5], [6].”
BackgroundThe subject-environment interplay between runners from different Brazilian macro-regions
Thuany, M., Bandeira, P. F. R., Vieira, D. A., Weiss, K., Knechtle, B., & Gomes, T. N. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1134797 · Cited by 3 · see citing works
“, 2022), psychology (Medin, 2017; Hayes and Andrews, 2020), and sports science”
BackgroundBooth, N., McConnell, T., Tully, M. A., Hamill, R., & Best, P. (2024) · Mental Health and Digital Technologies · doi:10.1108/mhdt-11-2023-0002 · Cited by 2 · see citing works
Kroemeke, A., Dudek, J. E., Kijowska, M., Owen, R., & Sobczyk‐Kruszelnicka, M. (2024) · Trials · doi:10.1186/s13063-024-08235-1 · Cited by 2 · see citing works
“The latter assumes that an intervention transforms the connectivity of the networks of intervention goals, the outcome of the intervention, and the connections between the two networks [35, 36].”
BackgroundComparing two major approaches to unifying psychology: Different goals, different outcomes
Young, G. C. (2024) · Current Psychology · doi:10.1007/s12144-024-06838-0 · Cited by 2 · see citing works
“In terms of the research program required to test the cur - rent model, the article gives one example related to sys - tems theory, following Gelo and Salvatore ( 2016), Hayes and Andrews ( 2020), Hofmann et al. (2020 ), and Schiepek and Pincus (2023 ).”
The Evolution of Parenting: Styles or Principles?
Friggieri, J., & Ellul, D. B. (2025) · Education and human development · doi:10.5772/intechopen.1008384 · Cited by 2 · see citing works
Systemische (Psychotherapie-)Forschung
Ochs, M. (2024) · Springer eBooks · doi:10.1007/978-3-662-64728-8_7 · Cited by 2 · see citing works
Preventive Mental Health Care: A Complex Systems Framework for Ambient Smart EnvironmentsPreprint
White, B. P., & Hipólito, I. (2023) · doi:10.31234/osf.io/etsu4 · Cited by 3 · see citing works
Mind as “E”nteraction: Towards the Complexity HypothesisPreprint
Hipólito, I., van Geert, P. L. C., & Pessoa, L. (2023) · doi:10.31234/osf.io/2dtp6 · Cited by 2 · see citing works
Cui, J., Hasselman, F., Olthof, M., & Lichtwarck‐Aschoff, A. (2024) · doi:10.31234/osf.io/b68wh · Cited by 2 · see citing works
Farahani, H., Blagojević, M., Azadfallah, P., Watson, P., Esrafilian, F., & Saljoughi, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-31172-7_4 · Cited by 1 · see citing works
Otaif, F. A., & Asiri, A. (2025) · Multimodal Communication · doi:10.1515/mc-2024-0080 · Cited by 1 · see citing works
Psychodynamic psychotherapists’ perceptions of change: A phenomenological analysis
Antichi, L., Biondi, B., Giannini, M., & Grotto, R. L. (2025) · Psychotherapy Research · doi:10.1080/10503307.2025.2535564 · Cited by 1 · see citing works
“Research suggests that change often happens nonli-nearly, through sudden shifts or early rapid gains (Hayes et al., 2005; Hayes & Andrews, 2020; Tang & DeRubeis, 1999), which challenges models that assume steady progression.”
Pacing in New York City Marathon: a tracking approach
Thuany, M., Weiss, K., Villiger, E., Scheer, V., Gomes, T. N., Čuk, I., Andrade, M. S., Nikolaidis, P. Τ., Rosemann, T. J., & Knechtle, B. (2025) · Sport Sciences for Health · doi:10.1007/s11332-025-01549-w · Cited by 1 · see citing works
“Stability, change, and predictability are important facets of tracking, having been primordially studied in the context of motor behavior [20] and physical activity [19, 21].”
Cheng, F., Ma, Z., & Zeng, C. (2025) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2025.131170 · Cited by 1 · see citing works
- Authors
- Hayes, A. M., & Andrews, L. A.
- Affiliations
- University of Delaware (US)
- Corresponding author
- Hayes, Adele M.
- Venue
- BMC Medicine
- Published
- 2020-07-14
- Volume
- 18
- Issue
- 1
- Pages
- 197-197
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC7359463
- OpenAlex
- W3042416448
- Cited by
- 149
- References
- 128
- Citations by year
- 2026: 25 · 2025: 31 · 2024: 25 · 2023: 33 · 2022: 22 · 2021: 11 · 2020: 2
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Foundation for the National Institutes of Health (R21-MH062662, R01-MH086558)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Chaos, Complexity, and Education
- Keywords
- psychotherapeutic change, complex systems, dynamical systems theory, synergetics, network theory, critical slowing down, critical fluctuations, early warning indicators, system transition, nonlinear dynamics, psychopathology, ambulatory assessment, digital assessment
- MeSH terms
- Delivery of Health Care, Feedback, Humans, Psychotherapy
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