The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease
Open accessAbstract
Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Excessive uremic toxins are produced as a result of gut microbiota alteration, including indoxyl sulphate, p-cresyl sulphate, and trimethylamine-N-oxide, all implicated in the variant processes of kidney diseases development. This review focuses on the pathogenic association between gut microbiota and kidney diseases (the gut-kidney axis), covering CKD, IgA nephropathy, nephrolithiasis, hypertension, acute kidney injury, hemodialysis and peritoneal dialysis in clinic. Targeted interventions including probiotic, prebiotic and symbiotic measures are discussed for their potential of re-establishing symbiosis, and more effective strategies for the treatment of kidney diseases patients are suggested. The novel insights into the dysbiosis of the gut microbiota in kidney diseases are helpful to develop novel therapeutic strategies for preventing or attenuating kidney diseases and complications.
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Citations
Cites
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Gut Dysbiosis Is Linked to Hypertension
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Cited by
Singh, V., Lee, G., Son, H., Koh, H., Kim, E. S., Unno, T., & Shin, J.-H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1103836 · Cited by 705
Creatinine: from physiology to clinical application
Kashani, K., Rosner, M. H., & Ostermann, M. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2019.10.025 · Cited by 474
Metabolomic analysis in inflammatory bowel disease: A systematic review
Gallagher, K., Catesson, A., Griffin, J. L., Holmes, E., & Williams, H. R. T. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjaa227 · Cited by 133
Lagoumintzis, G., & Patrinos, G. P. (2023) · Human Genomics · doi:10.1186/s40246-023-00561-w · Cited by 132
Socioeconomic position links circulatory microbiota differences with biological age
Craven, H., McGuinness, D., Buchanan, S., Galbraith, N., McGuinness, D. H., Jones, B., Combet, E., Mafra, D., Bergman, P., Ellaway, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92042-0 · Cited by 21
Metadata
- Authors
- Chen, Y.-Y., Chen, D.-Q., Chen, L., Liu, J.-R., Vaziri, N. D., Guo, Y., & Zhao, Y.-Y.
- Venue
- Journal of Translational Medicine
- Published
- 2019-01-03
- Volume
- 17
- Issue
- 1
- Pages
- 5-5
- ISSN
- 1479-5876 (ISSN-L)
- OpenAlex
- W2923723307
- Cited by
- 431
- References
- 104
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, Y.-Y., Chen, D.-Q., Chen, L., Liu, J.-R., Vaziri, N. D., Guo, Y., & Zhao, Y.-Y. (2019). Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease. Journal of Translational Medicine. https://doi.org/10.1186/s12967-018-1756-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
