Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
Open accessAbstract
Alzheimer’s disease is a complex neurodegenerative disorder leading to a decline in cognitive function and mental health. Recent research has positioned the gut microbiota as an important susceptibility factor in Alzheimer’s disease by showing specific alterations in the gut microbiome composition of Alzheimer’s patients and in rodent models. However, it is unknown whether gut microbiota alterations are causal in the manifestation of Alzheimer’s symptoms. To understand the involvement of Alzheimer’s patient gut microbiota in host physiology and behaviour, we transplanted faecal microbiota from Alzheimer’s patients and age-matched healthy controls into microbiota-depleted young adult rats. We found impairments in behaviours reliant on adult hippocampal neurogenesis, an essential process for certain memory functions and mood, resulting from Alzheimer’s patient transplants. Notably, the severity of impairments correlated with clinical cognitive scores in donor patients. Discrete changes in the rat caecal and hippocampal metabolome were also evident. As hippocampal neurogenesis cannot be measured in living humans but is modulated by the circulatory systemic environment, we assessed the impact of the Alzheimer’s systemic environment on proxy neurogenesis readouts. Serum from Alzheimer’s patients decreased neurogenesis in human cells in vitro and were associated with cognitive scores and key microbial genera. Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, confirming a causal role of gut microbiota in Alzheimer’s disease, and highlight hippocampal neurogenesis as a converging central cellular process regulating systemic circulatory and gut-mediated factors in Alzheimer’s.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fecal microbiota transplantation studies demonstrate that AD pathological features can be largely transferred to a healthy host via the gut microbiota, indicating a possible causal role of commensal microbes in AD.
“Fecal microbiota transplantation studies demonstrate that AD pathological features can be largely transferred to a healthy host via the gut microbiota, indicating a possible causal role of commensal microbes in AD.”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [98]
The Discussion reports that microbiota from Alzheimer’s patients transferred cognitive and neurogenic alterations to healthy young rats and describes this as evidence for a causal role of gut microbiota. But the Results report no amyloid plaque deposition in the recipient rats, so the broader assertion that AD pathological features were largely transferred overstates what the study showed. Page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredReduced SCFA-producing species and SCFA levels are reported in individuals with mild cognitive impairment and AD patients.
“Several studies have reported reduced SCFAs-producing species and SCFA levels in individuals with mild cognitive impairment (MCI) and AD patients.292–295”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [294]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · cited 1× · see citing works
“27,28 29-36 Recently, a significant genetic overlap and correlation between Alzheimer’s disease and gastrointestinal tract disorders has been suggested.”
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01024-z · Cited by 2,498 · see citing works
Gut microbiome alterations in Alzheimer’s disease
Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137 · see citing works
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120 · see citing works
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Self-citationThe gut microbiome in neurological disorders
Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336 · see citing works
Self-citationLifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173 · see citing works
Neuropsychiatric symptoms in Alzheimer's disease
Lyketsos, C. G., Carrillo, M. C., Ryan, J. M., Khachaturian, A. S., Trzepacz, P., Amatniek, J., Cedarbaum, J., Brashear, R., & Miller, D. S. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.05.2410 · Cited by 1,139 · see citing works
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072 · see citing works
Tau pathology in Alzheimer disease and other tauopathies
Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works
Regional variation limits applications of healthy gut microbiome reference ranges and disease models
He, Y., Wu, W., Zheng, H.-M., Li, P., McDonald, D., Sheng, H.-F., Chen, M.-X., Chen, Z.-H., Ji, G.-Y., Zheng, Z.-D.-X., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0164-x · Cited by 894 · see citing works
Gut Microbiota is Altered in Patients with Alzheimer’s Disease
Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works
Staging of Alzheimer-Related Cortical Destruction
Braak, H., Braak, E., & Bohl, J. (2008) · European Neurology · doi:10.1159/000116984 · Cited by 836 · cited 1× · see citing works
“8 The hippocampus is also host to a population of neural stem cells, which generate new neurons throughout the lifespan in a process called adult hippocampal neurogenesis (AHN).”
The gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817 · see citing works
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Karran, E., & De Strooper, B. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00391-w · Cited by 742 · see citing works
Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works
Drapeau, E., Mayo, W., Aurousseau, C., Moal, M. L., Piazza, P., & Abrous, D. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334169100 · Cited by 657 · see citing works
Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654 · see citing works
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works
Gut microbiota and dysbiosis in Alzheimer's disease: Implications for pathogenesis and treatment
Liu, S., Gao, J., Zhu, M., Liu, K., & Zhang, H.-L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02073-3 · Cited by 516 · see citing works
Sample storage conditions significantly influence faecal microbiome profiles
Choo, J. M., Leong, L. E. X., & Rogers, G. B. (2015) · Scientific Reports · doi:10.1038/srep16350 · Cited by 506 · see citing works
Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works
Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus
Bettcher, B. M., Tansey, M. G., Dorothée, G., & Heneka, M. T. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00549-x · Cited by 427 · see citing works
Haran, J. P., Bhattarai, S. K., Foley, S. E., Dutta, P., Ward, D. V., Bucci, V., & McCormick, B. A. (2019) · mBio · doi:10.1128/mbio.00632-19 · Cited by 412 · see citing works
Plümpe, T., Ehninger, D., Steiner, B., Klempin, F., Jessberger, S., Brandt, M., Römer, B., Rodriguez, G. R., Kronenberg, G., & Kempermann, G. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-77 · Cited by 388 · see citing works
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works
Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., Flynn, I., Khochanskiy, D., Moya-Pérez, A., Peterson, V., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.020 · Cited by 364 · see citing works
Self-citationMarizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200306 · Cited by 340 · see citing works
Self-citationMolecular landscapes of human hippocampal immature neurons across lifespan
Zhou, Y. F., Su, Y., Li, S., Kennedy, B. C., Zhang, D. Y., Bond, A. M., Sun, Y. Y., Jacob, F., Lu, L., Hu, P., et al. (2022) · Nature · doi:10.1038/s41586-022-04912-w · Cited by 309 · see citing works
Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease
Ling, Z., Zhu, M., Yan, X., Cheng, Y., Shao, L., Liu, X., Jiang, R., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634069 · Cited by 245 · see citing works
Gut Microbiota Composition Is Related to AD Pathology
Verhaar, B. J. H., Hendriksen, H. M. A., de Leeuw, F. A., Doorduijn, A. S., van Leeuwenstijn, M. S. S. A., Teunissen, C. E., Barkhof, F., Scheltens, P., Kraaij, R., van Duijn, C. M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.794519 · Cited by 237 · see citing works
Staley, C. M., Kaiser, T., Beura, L. K., Hamilton, M. J., Weingarden, A. R., Bobr, A., Kang, J., Masopust, D., Sadowsky, M. J., & Khoruts, A. (2017) · Microbiome · doi:10.1186/s40168-017-0306-2 · Cited by 236 · see citing works
Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus
Li, B., Yamamori, H., Tatebayashi, Y., Shafit-Zagardo, B., Tanimukai, H., Chen, S., Iqbal, K., & Grundke-Iqbal, I. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318160c5db · Cited by 234 · see citing works
Kim, N., Jeon, S. H., Ju, I. G., Gee, M. S., Do, J., Oh, M. S., & Lee, J. K. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.09.002 · Cited by 231 · see citing works
Jang, L.-G., Choi, G., Kim, S.-W., Kim, B.-Y., Lee, S., & Park, H. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0290-y · Cited by 224 · see citing works
Garthe, A., & Kempermann, G. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00063 · Cited by 222 · see citing works
Role of adult hippocampal neurogenesis in stress resilience
Levone, B. R., Cryan, J. F., & O'Leary, O. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.11.003 · Cited by 218 · see citing works
Self-citationMicrobial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
Walgrave, H., Balusu, S., Snoeck, S., Eynden, E. V., Craessaerts, K., Thrupp, N., Wolfs, L., Horré, K., Fourne, Y., Ronisz, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.05.001 · Cited by 193 · see citing works
Self-citationSawin, E. A., Wolfe, T. J. D., Aktaş, B., Stroup, B. M., Murali, S. G., Steele, J. L., & Ney, D. M. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00211.2015 · Cited by 190 · see citing works
An online atlas of human plasma metabolite signatures of gut microbiome composition
Dekkers, K. F., Sayols-Baixeras, S., Baldanzi, G., Nowak, C., Hammar, U., Nguyen, D. T., Varotsis, G., Brunkwall, L., Nielsen, N., Eklund, A. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33050-0 · Cited by 186 · see citing works
Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study
Stadlbauer, V., Engertsberger, L., Komarova, I., Feldbacher, N., Leber, B., Pichler, G., Fink, N., Scarpatetti, M., Schippinger, W., Schmidt, R., et al. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01644-2 · Cited by 182 · see citing works
Guo, M., Peng, J., Huang, X., Xiao, L., Huang, F., & Zuo, Z. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201040 · Cited by 179 · see citing works
Ren, T., Gao, Y., Qiu, Y., Jiang, S., Zhang, Q., Zhang, J., Wang, L., Zhang, Y., Wang, L., & Nie, K. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00137 · Cited by 173 · see citing works
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance
Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R. E., Lucassen, P. J., & Choi, S. H. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.01.002 · Cited by 165 · see citing works
Plasma Metabolite Profiles of Alzheimer’s Disease and Mild Cognitive Impairment
Wang, G., Zhou, Y., Huang, F., Tang, H., Xu, X., Liu, J., Wang, Y., Deng, Y., Ren, R., Xu, W. L., et al. (2014) · Journal of Proteome Research · doi:10.1021/pr5000895 · Cited by 159 · see citing works
Ally, B. A., Hussey, E. P., Ko, P. C., & Molitor, R. J. (2013) · Hippocampus · doi:10.1002/hipo.22162 · Cited by 155 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Chen, Y., Fang, L., Chen, S., Zhou, H., Fan, Y., Li, L., Li, J., Xu, J., Chen, Y., Ma, Y., et al. (2020) · BioMed Research International · doi:10.1155/2020/8456596 · Cited by 150 · see citing works
Bacteroidetes Species Are Correlated with Disease Activity in Ulcerative Colitis
Nomura, K., Ishikawa, D., Okahara, K., Ito, S., Haga, K., Takahashi, M., Arakawa, A., Shibuya, T., Osada, T., Kuwahara-Arai, K., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081749 · Cited by 150 · see citing works
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 149 · see citing works
Self-citationDonoso, F., Cryan, J. F., Olavarría‐Ramírez, L., Nolan, Y. M., & Clarke, G. A. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2581 · Cited by 147 · see citing works
Self-citationBorn this way: Hippocampal neurogenesis across the lifespan
Kozareva, D. A., Cryan, J. F., & Nolan, Y. M. (2019) · Aging Cell · doi:10.1111/acel.13007 · Cited by 146 · see citing works
Self-citationA ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome
Benjamin, J. S., Pilarowski, G. O. W., Carosso, G. A., Zhang, L., Huso, D. L., Goff, L. A., Vernon, H. J., Hansen, K. D., & Bjornsson, H. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611431114 · Cited by 138 · see citing works
Young hippocampal neurons are critical for recent and remote spatial memory in adult mice
Goodman, T. H., Trouche, S. G., Massou, I., Verret, L., Zerwas, M., Roullet, P., & Rampon, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.047 · Cited by 136 · see citing works
Fujii, Y., Nguyen, T. T. T., Fujimura, Y., Kameya, N., Nakamura, S., Arakawa, K., & Morita, H. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1644149 · Cited by 133 · see citing works
The Use of Fecal Calprotectin in Inflammatory Bowel Disease.
Bjarnason, I. (2017) · PubMed · Cited by 130 · see citing works
BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.
Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.09.027 · Cited by 124 · see citing works
Whiley, L., Chappell, K. E., D’Hondt, E., Lewis, M. R., Jiménez, B., Snowden, S. G., Soininen, H. S., Kłoszewska, I., Mecocci, P., Tsolaki, M., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00741-z · Cited by 123 · see citing works
A peripheral signature of Alzheimer’s disease featuring microbiota-gut-brain axis markers
Marizzoni, M., Mirabelli, P., Mombelli, E., Coppola, L., Festari, C., Lopizzo, N., Luongo, D., Mazzelli, M., Naviglio, D., Blouin, J.-L., et al. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01218-5 · Cited by 121 · see citing works
Self-citationElevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut
Leblhuber, F., Geisler, S., Steiner, K., Fuchs, D., & Schütz, B. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1381-9 · Cited by 113 · see citing works
The vascular niche in adult neurogenesis
Licht, T., & Keshet, E. (2015) · Mechanisms of Development · doi:10.1016/j.mod.2015.06.001 · Cited by 107 · see citing works
Shobeiri, P., Kalantari, A., Teixeira, A. L., & Rezaei, N. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00422-6 · Cited by 105 · see citing works
Xi, J., Ding, D., Zhu, H., Wang, R., Su, F., Wu, W., Xiao, Z., Liang, X., Zhao, Q., Hong, Z., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02286-z · Cited by 103 · see citing works
Murray, E. R., Kemp, M., & Nguyen, T. T. (2022) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acac008 · Cited by 98 · see citing works
Berron, D., Cárdenas‐Blanco, A., Bittner, D., Metzger, C. D., Spottke, A. E., Heneka, M. T., Fließbach, K., Schneider, A., Teipel, S. J., Wagner, M., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1279-19.2019 · Cited by 95 · see citing works
Mazurkiewicz-Kwilecki, I. M., & Nsonwah, S. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-013 · Cited by 94 · see citing works
Tachikawa, M., & Hosoya, K. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-13 · Cited by 94 · see citing works
Adewuyi, E. O., O’Brien, E. K., Nyholt, D. R., Porter, T., & Laws, S. M. (2022) · Communications Biology · doi:10.1038/s42003-022-03607-2 · Cited by 83 · see citing works
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 82 · see citing works
Hernández‐Benítez, R., Ramos‐Mandujano, G., & Pasantes‐Morales, H. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.02.004 · Cited by 80 · see citing works
Marizzoni, M., Gurry, T., Provasi, S., Greub, G., Lopizzo, N., Ribaldi, F., Festari, C., Mazzelli, M., Mombelli, E., Salvatore, M., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01262 · Cited by 80 · see citing works
Self-citationSerum Amino Acid Profiles in Normal Subjects and in Patients with or at Risk of Alzheimer Dementia
Corso, G., Cristofano, A., Sapere, N., la Marca, G., Angiolillo, A., Vitale, M., Fratangelo, R., Lombardi, T., Porcile, C., Intrieri, M., et al. (2017) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000466688 · Cited by 79 · see citing works
Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome
Liu, G., Yu, Q., Tan, B., Ke, X., Zhang, C., Li, H., Zhang, T.-M., & Lu, Y.-M. (2022) · Gut microbes · doi:10.1080/19490976.2022.2104089 · Cited by 79 · see citing works
Taurine increases hippocampal neurogenesis in aging mice
Gebara, E., Udry, F., Sultan, S., & Toni, N. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.04.001 · Cited by 77 · see citing works
Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia
Rodríguez-Iglesias, N., Sierra, A., & Valero, J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00024 · Cited by 74 · see citing works
Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis
Guzzetta, K. E., Cryan, J. F., & O’Leary, O. F. (2022) · Brain Plasticity · doi:10.3233/bpl-220141 · Cited by 74 · see citing works
Self-citationThe systemic environment: at the interface of aging and adult neurogenesis
Smith, L. K., White, C., & Villeda, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2715-8 · Cited by 68 · see citing works
Mishra, R., Phan, T., Kumar, P., Morrissey, Z. D., Gupta, M., Hollands, C., Shetti, A., Lopez, K. L., Maienschein‐Cline, M., Suh, H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220391 · Cited by 68 · see citing works
Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, P., Loviselli, A., Velluzzi, F., & Manzin, A. (2022) · Nutrients · doi:10.3390/nu14122436 · Cited by 67 · see citing works
The role of histidines in amyloid β fibril assembly
Brännström, K., Islam, T., Sandblad, L., & Olofsson, A. (2017) · FEBS Letters · doi:10.1002/1873-3468.12616 · Cited by 46 · see citing works
Huang, W.-C., Tung, C., Yang, Y. S. H., Lin, I., Ng, X. E., & Tung, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-07317-x · Cited by 46 · see citing works
Gallart‐Palau, X., Serra, A., Lee, B. S. T., Guo, X., & Sze, S. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0946-y · Cited by 45 · see citing works
Spatial Pattern Separation in Early Alzheimer’s Disease
Pařízková, M., Lerch, O., Andel, R., Kalinová, J., Marková, H., Vyhnálek, M., Hort, J., & Laczó, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200093 · Cited by 44 · see citing works
Sinha, N., Berg, C. N., Tustison, N. J., Shaw, A., Hill, D., Yassa, M. A., & Gluck, M. A. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.023 · Cited by 43 · see citing works
Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
Nielsen, J. E., Maltesen, R. G., Havelund, J. F., Færgeman, N. J., Gotfredsen, C. H., Vestergård, K., Kristensen, S. R., & Pedersen, S. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100125 · Cited by 43 · see citing works
de Lucia, C., Murphy, T., Steves, C. J., Dobson, R., Proitsi, P., & Thuret, S. (2020) · Communications Biology · doi:10.1038/s42003-020-0844-1 · Cited by 41 · see citing works
Self-citationXie, K., Qin, Q., Long, Z., Yang, Y., Peng, C., Xi, C., Li, L., Wu, Z., Daria, V., Zhao, Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.602887 · Cited by 40 · see citing works
Wang, F., Gu, Y., Xu, C., Du, K., Zhao, C., Zhao, Y., & Liu, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.858130 · Cited by 39 · see citing works
When the infectious environment meets the AD brain
Ganz, T., Fainstein, N., & Ben-Hur, T. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00559-3 · Cited by 39 · see citing works
Pessoa, J., Belew, G. D., Barroso, C., Egas, C., & Jones, J. G. (2023) · Nutrients · doi:10.3390/nu15092097 · Cited by 39 · see citing works
Divergence in the metabolome between natural aging and Alzheimer’s disease
Hunsberger, H. C., Greenwood, B. P., Tolstikov, V., Narain, N. R., Kiebish, M. A., & Denny, C. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68739-z · Cited by 36 · see citing works
Smith, D. G., Ciccotosto, G. D., Tew, D. J., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1334 · Cited by 34 · see citing works
High throughput multiorgan metabolomics in the APP/PS1 mouse model of Alzheimer's disease
González‐Domínguez, R., García‐Barrera, T., Vitórica, J., & Gómez‐Ariza, J. L. (2015) · Electrophoresis · doi:10.1002/elps.201400544 · Cited by 34 · see citing works
Leal, S. L., Ferguson, L. A., Harrison, T. M., & Jagust, W. J. (2019) · Learning & Memory · doi:10.1101/lm.048967.118 · Cited by 32 · see citing works
Ferreiro, E. B., Lanzillo, M., Canhoto, D. M. M., Silva, A. C., Mota, S. I., Dias, I. S., Ferreira, I. L., Fontes, A. R., Mastrella, G., Pinheiro, P. S., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.003 · Cited by 32 · see citing works
Zhao, Y., Chen, H., Iqbal, J., Liu, X., Zhang, H., Xiao, S., Jin, N., Yao, F., & Shen, L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24750 · Cited by 32 · see citing works
Histidine Alleviates Impairments Induced by Chronic Cerebral Hypoperfusion in Mice
Song, J., Yang, L., Nan, D., He, Q., Wan, Y., & Guo, H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00662 · Cited by 30 · see citing works
Beta-amyloid burden predicts poorer mnemonic discrimination in cognitively normal older adults
Webb, C. E., Foster, C. M., Horn, M. M., Kennedy, K. M., & Rodrigue, K. M. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117199 · Cited by 28 · see citing works
Predicting progression to Alzheimer’s disease with human hippocampal progenitors exposed to serum
Maruszak, A., Silajdžić, E., Lee, H.-A., Murphy, T., Liu, B., Shi, L., de Lucia, C., Douiri, A., Salta, E., Nevado‐Holgado, A. J., et al. (2022) · Brain · doi:10.1093/brain/awac472 · Cited by 27 · see citing works
Self-citationHan, Y., Quan, X., Chuang, Y. C., Liang, Q., Li, Y., Yuan, Z., Bian, Y., Wei, L., Wang, J., & Zhao, Y. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.909 · Cited by 25 · see citing works
Rosenzweig, S. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00034 · Cited by 22 · see citing works
Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus
Kozareva, D. A., Hueston, C. M., Ó’Léime, C. S., Crotty, S., Dockery, P., Cryan, J. F., & Nolan, Y. M. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.08.008 · Cited by 22 · see citing works
Self-citationPreez, A. D., Lefèvre‐Arbogast, S., Houghton, V., de Lucia, C., Low, D. Y., Helmer, C., Féart, C., Delcourt, C., Proust‐Lima, C., Pallàs, M., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12428 · Cited by 22 · see citing works
Self-citationDiet Is a Stronger Covariate than Exercise in Determining Gut Microbial Richness and Diversity
Yun, E.-J., Imdad, S., Jang, J.-H., Park, J.-H., So, B., Kim, J., & Kang, C. (2022) · Nutrients · doi:10.3390/nu14122507 · Cited by 22 · see citing works
Gao, J., Zhou, N., Wu, Y., Lu, M., Wang, Q., Xia, C., Zhou, M., & Xu, Y. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03032-9 · Cited by 21 · see citing works
Nicolas, S., McGovern, A. J., Hueston, C. M., O’Mahony, S. M., Cryan, J. F., O’Leary, O. F., & Nolan, Y. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.016 · Cited by 21 · see citing works
Self-citationThe gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?
Dohm-Hansen, S., Donoso, F., Lucassen, P. J., Clarke, G. A., & Nolan, Y. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105746 · Cited by 20 · see citing works
Self-citationWang, X., Eguchi, A., Fujita, Y., Wan, X., Chang, L., Yang, Y. H., Shan, J., Qu, Y., Ma, L., Shirayama, Y., et al. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.073 · Cited by 18 · see citing works
García‐Corzo, L., Calatayud-Baselga, I., Casares-Crespo, L., Mora‐Martínez, C., Escribano-Saiz, J. J., Hortigüela, R., Asenjo-Martínez, A., Jordán‐Pla, A., Ercoli, S., Flames, N., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.912319 · Cited by 17 · see citing works
de Lucia, C., Murphy, T., Maruszak, A., Wright, P., Powell, T. R., Hartopp, N., de Jong, S., O'Sullivan, M. J., Breen, G. D., Price, J., et al. (2021) · Aging and Disease · doi:10.14336/ad.2021.0409 · Cited by 16 · see citing works
Self-citationAlzheimer’s Disease Is a Multi-Organ Disorder: It May Already Be Preventable
Eiser, A. R., & Fülöp, T. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221078 · Cited by 14 · see citing works
Saad, Y., Segal, D., & Ayali, A. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140009 · Cited by 12 · see citing works
The Microbiome-Gut-Brain Axis in Neurocognitive Development and Decline
Cowan, C. S. M., & Cryan, J. F. (2021) · Modern trends in psychiatry · doi:10.1159/000510414 · Cited by 12 · see citing works
Self-citationAuthor Correction: Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
Pluvinage, J. V., & Wyss‐Coray, T. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0293-3 · Cited by 11 · see citing works
Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's Disease by Restoring the EngramPreprint
Mishra, R., Phan, T., Kumar, P., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3844716 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Xu, K., Huang, Q., Lyu, Y., Wang, S., Lu, Y., & Qian, G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117200 · Cited by 11 · see citing works
What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease?
Brutkiewicz, R. R., Cao, W., Morgan, D., Reis, R. S. D., Suryadevara, V., Willette, A. A., Willette, S. A., Wyatt-Johnson, S. K., & Duggan, M. R. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.05.009 · Cited by 3 · see citing works
- Authors
- Grabrucker, S., Marizzoni, M., Silajdžić, E., Lopizzo, N., Mombelli, E., Nicolas, S., Dohm-Hansen, S., Scassellati, C., Moretti, D. V., Rosa, M., Hoffmann, K., Cryan, J. F., O’Leary, O. F., English, J. A., Lavelle, A., O’Neill, C., Thuret, S., Cattaneo, A., & Nolan, Y. M.
- Affiliations
- University College Cork (IE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- King's College London (GB)
- University of Milan (IT)
- Corresponding author
- Nolan, Yvonne M
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-10-18
- Volume
- 146
- Issue
- 12
- Pages
- 4916-4934
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC10689930
- OpenAlex
- W4387729030
- Cited by
- 236
- References
- 127
- Citations by year
- 2026: 55 · 2025: 103 · 2024: 71 · 2023: 7
- FWCI
- 21.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc)
- Funders
- Network of Centres of Excellence in Neurodegeneration (SFI 17/COEN/3475, SFI 19/FFP/6820)
- Italian Ministry of Health
- Medical Research Council (MR/S00484X/1)
- APC Microbiome Ireland
- SFI
- Irish Government’s National Development Plan (12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Alzheimer's disease, gut microbiota, fecal microbiota transplantation, hippocampal neurogenesis, cognitive impairment, microbial genera, gut-brain axis, neurodegeneration
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Animals, Cognition, Hippocampus, Humans, Rats, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
