Cited by 2,119Extracellular vesicles in diseaseCellular transport and secretionNanoparticle-Based Drug Delivery

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Exosomes: biogenesis, biologic function and clinical potential

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Zhang, Yuan, Liu, Yunfeng, Liu, Haiying, Tang, Wai Ho·2019·Cell & Bioscience

DOI 10.1186/s13578-019-0282-2PMC PMC6377728

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Abstract

Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of multivesicular bodies and the plasma membrane. They were shown to carry cell-specific cargos of proteins, lipids, and genetic materials, and can be selectively taken up by neighboring or distant cells far from their release, reprogramming the recipient cells upon their bioactive compounds. Therefore, the regulated formation of exosomes, specific makeup of their cargo, cell-targeting specificity are of immense biological interest considering extremely high potential of exosomes as non-invasive diagnostic biomarkers, as well as therapeutic nanocarriers. In present review, we outline and discuss recent progress in the elucidation of the regulatory mechanisms of exosome biogenesis, the molecular composition of exosomes, and technologies used in exosome research. Furthermore, we focus on the potential use of exosomes as valuable diagnostic and prognostic biomarkers for their cell-lineage and state-specific contents, and possibilities as therapeutic vehicles for drug and gene delivery. Exosome research is now in its infancy, in-depth understanding of subcellular components and mechanisms involved in exosome formation and specific cell-targeting will bring light on their physiological activities.

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Fig. 1 The schematic diagram of pathways involved in exosome mediated cell-to-cell communication. (1) Exosomes signal recipient cells via direct surface-bound ligands. (2) Exosomes transfer activated receptors to recipient cells. (3) Exosomes may epigenetically reprogram recipient cells via delivery of functional proteins, lipids, and RNAsCC BY · PubMed Central

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Authors: Zhang, Y., Liu, Y., Liu, H., & Tang, W. H.
Affiliations: Guangzhou Women and Children Medical Center (CN)
Corresponding author: Liu, Haiying
Tang, Wai Ho
ORCID: Zhang, Yuan
Liu, Yunfeng
Liu, Haiying
Tang, Wai Ho
Venue: Cell & Bioscience
Publisher: Springer Science and Business Media LLC
Published: 2019-02-15
Volume: 9
Issue: 1
Pages: 19-19
ISSN: 2045-3701 (ISSN-L)
DOI: 10.1186/s13578-019-0282-2
PMC: PMC6377728
OpenAlex: W2931418311
Cited by: 2,119
References: 156
Citations by year: 2026: 203 · 2025: 327 · 2024: 386 · 2023: 361 · 2022: 334 · 2021: 297 · 2020: 184 · 2019: 24
FWCI: 18.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: Cell & Bioscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: exosomes, exosome biogenesis, multivesicular bodies, exosome cargo, exosome uptake, cell targeting, diagnostic biomarkers, prognostic factors, drug delivery, gene delivery, extracellular vesicles

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Exosomes: biogenesis, biologic function and clinical potential

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