Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 1× · see citing works

The Physiology of Glucagon-like Peptide 1

Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · cited 1× · see citing works

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

Astrocyte scar formation aids central nervous system axon regeneration

Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851 · see citing works

A review on Alzheimer's disease pathophysiology and its management: an update

Kumar, A., Singh, A., & Ekavali (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.09.004 · Cited by 1,578 · see citing works

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

Ittner, L. M., & Götz, J. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2967 · Cited by 1,357 · see citing works

Astrocyte barriers to neurotoxic inflammation

Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202 · see citing works

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works

Disease-associated astrocytes in Alzheimer’s disease and aging

Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009 · see citing works

Inflammation in CNS neurodegenerative diseases

Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966 · see citing works

Microglia in Alzheimer's disease

Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90606 · Cited by 911 · see citing works

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808 · see citing works

P1‐146: Chlamydia Pneumoniae‐Infected Astrocytes Alter Their Expression of Adam10, Bace1, and Presenilin‐1 Proteases

Al-Atrache, Z., Cader, A., & Appelt, D. M. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.894 · Cited by 765 · see citing works

Alzheimer's disease drug development pipeline: 2018

Cummings, J., Lee, G., Ritter, A., & Zhong, K. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.03.009 · Cited by 697 · see citing works

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Booth, H. D. E., Hirst, W. D., & Wade-Martins, R. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.001 · Cited by 633 · see citing works

The stress of dieting

Hutchinson, E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2985 · Cited by 534 · see citing works

Update on Alzheimer’s Disease Therapy and Prevention Strategies

Graham, W. V., Bonito-Oliva, A., & Sakmar, T. P. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-042915-103753 · Cited by 506 · see citing works

Discovery, characterization, and clinical development of the glucagon-like peptides

Drucker, D. J., Habener, J. F., & Holst, J. J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci97233 · Cited by 418 · see citing works

Microglia and astrocyte dysfunction in parkinson's disease

Kam, T., Hinkle, J. T., Dawson, T. M., & Dawson, V. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105028 · Cited by 399 · see citing works

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

McClean, P. L., & Hölscher, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.005 · Cited by 359 · see citing works

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

Hölscher, C. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0221 · Cited by 294 · see citing works

Early Oligodendrocyte/Myelin Pathology in Alzheimer's Disease Mice Constitutes a Novel Therapeutic Target

Desai, M. K., Mastrangelo, M. A., Ryan, D. A., Sudol, K. L., Narrow, W. C., & Bowers, W. J. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100087 · Cited by 232 · see citing works

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

Andrabi, S. A., Kang, H. C., Haince, J.-F., Lee, Y.-I., Zhang, J., Chi, Z., West, A. B., Koehler, R. C., Poirier, G. G., Dawson, T. M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2387 · Cited by 216 · see citing works

Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

Muscogiuri, G., DeFronzo, R. A., Gastaldelli, A., & Holst, J. J. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.10.001 · Cited by 171 · see citing works

Astrocytes, Microglia, and Parkinson’s Disease

Joe, E.-H., Choi, D., An, J., Eun, J.-H., Jou, I., & Park, S.-M. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.2.77 · Cited by 142 · see citing works

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

McClean, P. L., Jalewa, J., & Hölscher, C. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.024 · Cited by 125 · see citing works

Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease

Cai, H.-Y., Yang, J.-T., Wang, Z.-J., Zhang, J., Yang, W., Wu, M.-N., & Qi, J.-S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.114 · Cited by 108 · see citing works

A new method to isolate microglia from adult mice and culture them for an extended period of time

Moussaud, S., & Draheim, H. J. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.01.017 · Cited by 104 · see citing works

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

Xu, J.-C., Fan, J., Wang, X., Eacker, S. M., Kam, T., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0623 · Cited by 93 · see citing works

Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals

Bomba, M., Ciavardelli, D., Silvestri, E., Canzoniero, L. M. T., Lattanzio, R., Chiappini, P. B. O., Piantelli, M., Ilio, C. D., Consoli, A., & Sensi, S. L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.139 · Cited by 84 · see citing works

GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling

Wang, Y., Chen, S., Zheng, X., Chen, S., Yao, W., & Gao, X. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.048 · Cited by 67 · see citing works

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

Hansen, H. H., Fabricius, K., Barkholt, P., Wismann, P., Schlumberger, C., Jelsing, J., Terwel, D., Termont, A., Pyke, C., Knudsen, L. B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158205 · Cited by 63 · see citing works

FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

Kam, T., Park, H., Gwon, Y., Song, S., Kim, S.-H., Moon, S. W., Jo, D., & Jung, Y. (2016) · eLife · doi:10.7554/elife.18691 · Cited by 47 · see citing works

Modern approaches to investigating non‐neuronal aspects of Alzheimer's disease

Liddelow, S. A. (2019) · The FASEB Journal · doi:10.1096/fj.201802592 · Cited by 24 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease

Singh, D. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02565-0 · Cited by 569 · see citing works

Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment

Kopp, K. O., Glotfelty, E. J., Li, Y., & Greig, N. H. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106550 · Cited by 298 · see citing works

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248 · see citing works

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer’s disease

Cummings, J. L., Atri, A., Feldman, H. H., Hansson, O., Sano, M., Knop, F. K., Johannsen, P., León, T., & Scheltens, P. (2025) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01666-7 · Cited by 168 · see citing works

Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Diz-Chaves, Y., Mastoor, Z., Spuch, C., González-Matías, L. C., & Mallo, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179583 · Cited by 148 · see citing works

The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer’s disease

Du, H., Meng, X., Yao, Y., & Xu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1033479 · Cited by 125 · see citing works

The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease

Ren, Y. L., Savadlou, A., Park, S., Siska, P., Epp, J. R., & Sargin, D. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101061 · Cited by 130 · see citing works

Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway

Nakano-Kobayashi, A., Canela, A., Yoshihara, T., & Hagiwara, M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303809120 · Cited by 121 · see citing works

Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS

Toader, C., Tătaru, C. P., Munteanu, O., Șerban, M., Covache-Busuioc, R.-A., Ciurea, A. V., & Enyedi, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312613 · Cited by 106 · see citing works

Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials

Cummings, J. L., Atri, A., Sano, M., Zetterberg, H., Scheltens, P., Knop, F. K., Johannsen, P., Wichmann, C. A., Abschneider, R. M., Leon, T., et al. (2026) · The Lancet · doi:10.1016/s0140-6736(26)00459-9 · Cited by 110 · see citing works

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

Barmaki, H., Nourazarian, A., & Khaki‐Khatibi, F. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1281338 · Cited by 89 · see citing works

Role of glucagon-like peptide-1 receptor agonists in Alzheimer’s disease and Parkinson’s disease

Hong, C.-T., Chen, J.-H., & Hu, C.-J. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01090-x · Cited by 78 · see citing works

Immune Activation in Alzheimer Disease

Mary, A., Mancuso, R., & Heneka, M. T. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035222 · Cited by 79 · see citing works

Natural product-derived compounds in clinical trials and drug approvals

Butler, M. S., Capon, R. J., Blaskovich, M. A. T., & Henderson, I. R. (2025) · Natural Product Reports · doi:10.1039/d5np00031a · Cited by 77 · see citing works

Glucagon-like peptide 1 receptor agonist use is associated with reduced risk for glaucoma

Sterling, J., Hua, P., Dunaief, J. L., Cui, Q. N., & VanderBeek, B. L. (2023) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2021-319232 · Cited by 75 · see citing works

Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts

Cullinane, P. W., Pablo‐Fernández, E. D., König, A., Outeiro, T. F., Jaunmuktane, Z., & Warner, T. T. (2022) · Movement Disorders · doi:10.1002/mds.29298 · Cited by 73 · see citing works

The Role of Microglia in the Development of Neurodegenerative Diseases

Lee, J., Chun, W., Lee, H. J., Kim, S., Min, J., Kim, D.-Y., Kim, M.-O., Ryu, H. W., & Lee, S. U. (2021) · Biomedicines · doi:10.3390/biomedicines9101449 · Cited by 63 · see citing works

Ultrastructural Remodeling of the Blood–Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation

Erickson, M. A., Shulyatnikova, T. V., Banks, W. A., & Hayden, M. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021640 · Cited by 64 · see citing works

Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis

Xie, L., Wu, Q., Li, K., Khan, M. A. S., Zhang, A., Sinha, B., Li, S., Chang, S. L., Brody, D. L., Grinstaff, M. W., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0134 · Cited by 63 · see citing works

The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells

Cai, W., Wu, T., & Chen, N. (2023) · Biomolecules · doi:10.3390/biom13020313 · Cited by 65 · see citing works

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Chandra, S., Di Meco, A., Dodiya, H. B., Popovic, J., Cuddy, L. K., Weigle, I. Q., Zhang, X., Sadleir, K., Sisodia, S. S., & Vassar, R. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00635-2 · Cited by 58 · see citing works

An emerging role of astrocytes in aging/neuroinflammation and gut-brain axis with consequences on sleep and sleep disorders

Gudkov, S. V., Burmistrov, D. E., Kondakova, E. V., Sarimov, R. M., Yarkov, R. S., Franceschi, C., & Vedunova, M. V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101775 · Cited by 56 · see citing works

A Therapeutic Nanovaccine that Generates Anti‐Amyloid Antibodies and Amyloid‐specific Regulatory T Cells for Alzheimer's Disease

Jung, M., Lee, S., Park, S., Hong, J., Kim, C., Cho, I., Sohn, H. S., Kim, K. H., Park, I. W., Yoon, S., et al. (2022) · Advanced Materials · doi:10.1002/adma.202207719 · Cited by 56 · see citing works

LPS-Induced Systemic Inflammation Affects the Dynamic Interactions of Astrocytes and Microglia with the Vasculature of the Mouse Brain Cortex

Xingi, E., Koutsoudaki, P. N., Thanou, I., Phan, M.-S., Margariti, M., Scheller, A., Tinévez, J.-Y., Kirchhoff, F., & Thomaidou, D. (2023) · Cells · doi:10.3390/cells12101418 · Cited by 53 · see citing works

The role of glial autophagy in Alzheimer’s disease

Litwiniuk, A., Juszczak, G. R., Stankiewicz, A. M., & Urbańska, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02242-5 · Cited by 54 · see citing works

The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice

Forny Germano, L., Koehler, J. A., Baggio, L. L., Cui, F., Wong, C. K., Rittig, N., Cao, X., Matthews, D., & Drucker, D. J. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102019 · Cited by 50 · see citing works

Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases

Ullah, R., & Lee, E. J. (2023) · Experimental Neurobiology · doi:10.5607/en23014 · Cited by 49 · see citing works

Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer’s Disease

Huang, W., Xia, Q., Zheng, F., Zhao, X. L., Ge, F., Xiao, J., Liu, Z., Shen, Y., Ye, K., Wang, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221064 · Cited by 46 · see citing works

Potential Role of Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Cognitive Decline and Dementia in Diabetes Mellitus

Pelle, M. C., Zaffina, I., Giofrè, F., Pujia, R., & Arturi, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411301 · Cited by 49 · see citing works

Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis

Gharagozloo, M., Smith, M. D., Sotirchos, E. S., Jin, J., Meyers, K. R., Taylor, M., Garton, T. P., Bannon, R. N., Lord, H., Dawson, T. M., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01088-5 · Cited by 44 · see citing works

Astrocyte and oligodendrocyte pathology in Alzheimer's disease

Ziar, R., Tesar, P. J., & Clayton, B. L. L. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00540 · Cited by 47 · see citing works

The gut microbiota‐astrocyte axis: Implications for type 2 diabetic cognitive dysfunction

Li, Z.-H., Jiang, Y., Long, C., Peng, Q., & Yue, R. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14077 · Cited by 41 · see citing works

The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective

Bouvier, D. S., Fixemer, S., Heurtaux, T., Jeannelle, F., Frauenknecht, K. B. M., & Mittelbronn, M. G. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.814889 · Cited by 41 · see citing works

Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma

Lawrence, E. C. N., Guo, M., Schwartz, T. D., Wu, J. J., Lu, J., Nikonov, S. S., Sterling, J. K., & Cui, Q. N. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1156829 · Cited by 43 · see citing works

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes

Santiago-Balmaseda, A., Aguirre-Orozco, A., Valenzuela-Arzeta, I. E., Villegas-Rojas, M. M., Pérez‐Segura, I., Jiménez-Barrios, N., Hurtado-Robles, E., Rodríguez-Hernández, L. D., Rivera-German, E. R., Guerra‐Crespo, M., et al. (2024) · Cells · doi:10.3390/cells13110921 · Cited by 43 · see citing works

From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics

Roy, A., Dawson, V. L., & Dawson, T. M. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00712 · Cited by 41 · see citing works

Antidiabetic GLP-1 Receptor Agonists Have Neuroprotective Properties in Experimental Animal Models of Alzheimer’s Disease

Urkon, M., Ferencz, E., Szász, J. A., Szabó, M. I. M., Orbán-Kis, K., Szatmári, S., & Nagy, E. E. (2025) · Pharmaceuticals · doi:10.3390/ph18050614 · Cited by 40 · see citing works

Astrocytic Neuroimmunological Roles Interacting with Microglial Cells in Neurodegenerative Diseases

Gotoh, M., Miyamoto, Y., & Ikeshima‐Kataoka, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021599 · Cited by 39 · see citing works

Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection

Pitha, I., Kambhampati, S. P., Sharma, A., Sharma, R. B., McCrea, L. T., Mozzer, A., & Kannan, R. M. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.2c01381 · Cited by 38 · see citing works

(Re)building the nervous system: A review of neuron–glia interactions from development to disease

Demmings, M. D., Chagas, L. D. S., Traetta, M. E., Rodrigues, R. S., Acutain, M. F., Barykin, E. P., Datusalia, A. K., German‐Castelan, L., Mattera, V. S., Mazengenya, P., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16258 · Cited by 36 · see citing works

Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice

Yang, S., Zhao, X., Zhang, Y., Tang, Q., Li, Y., Du, Y., & yu, P. (2024) · Peptides · doi:10.1016/j.peptides.2024.171271 · Cited by 37 · see citing works

The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer’s disease

Ma, C., Wu, Y., Song, L., Yin, L., Yin, J.-J., Wang, Q., Yu, J., & Xiao, B. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355747 · Cited by 37 · see citing works

Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain

Diz-Chaves, Y., Mastoor, Z., Spuch, C., Lamas, J. A., González-Matías, L. C., & Mallo, F. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389626 · Cited by 39 · see citing works

Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives

Mohamed, W. M. Y., Kumar, J., Alghamdi, B. S. A., Wadan, A.-H. S., & Yamashita, T. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.003 · Cited by 38 · see citing works

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Zhang, W.-B., Huang, Y. M., Guo, X., Zhang, M.-Q., Yuan, X.-S., & Zu, H. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01593-y · Cited by 34 · see citing works

Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline

Jadiya, P., Cohen, H. M., Kolmetzky, D. W., Kadam, A. A., Tomar, D., & Elrod, J. W. (2023) · iScience · doi:10.1016/j.isci.2023.106296 · Cited by 34 · see citing works

Comparative outcomes of systemic diseases in people with type 2 diabetes, or obesity alone treated with and without GLP-1 receptor agonists: a retrospective cohort study from the Global Collaborative Network

Nassar, M., Nassar, O., Abosheaishaa, H. M., & Misra, A. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02466-4 · Cited by 34 · see citing works

Semaglutide Ameliorates Diabetic Neuropathic Pain by Inhibiting Neuroinflammation in the Spinal Cord

Lee, S.-O., Kuthati, Y., Huang, W.-H., & Wong, C. (2024) · Cells · doi:10.3390/cells13221857 · Cited by 39 · see citing works

Region-Specific Characteristics of Astrocytes and Microglia: A Possible Involvement in Aging and Diseases

Lee, J., Kim, S. W., & Kim, K. (2022) · Cells · doi:10.3390/cells11121902 · Cited by 34 · see citing works

Inflammatory proteins associated with Alzheimer’s disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial

Koychev, I. G., Reid, G., Nguyen, M., Mentz, R. J., Joyce, D. W., Shah, S. H., & Holman, R. R. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01573-x · Cited by 35 · see citing works

Viral mediated knockdown of GATA6 in SMA iPSC ‐derived astrocytes prevents motor neuron loss and microglial activation

Allison, R. L., Welby, E., Khayrullina, G., Burnett, B. G., & Ebert, A. D. (2022) · Glia · doi:10.1002/glia.24153 · Cited by 29 · see citing works

Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?

Que, M., Li, Y., Wang, X., Zhan, G., Luo, X., & Zhou, Z. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1188306 · Cited by 33 · see citing works

Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities

Liu, Y., Wu, L., Peng, W., & Mao, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102638 · Cited by 31 · see citing works

Hydrolyzed Chicken Meat Extract Attenuates Neuroinflammation and Cognitive Impairment in Middle-Aged Mouse by Regulating M1/M2 Microglial Polarization

Ni, L., Zhuge, F., Yang, S., Ma, L., Zheng, A., Zhao, Y., Hu, L., Fu, Z., & Ni, Y. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03541 · Cited by 30 · see citing works

GLP-1 Analogs, SGLT-2, and DPP-4 Inhibitors: A Triad of Hope for Alzheimer’s Disease Therapy

Złotek, M., Kurowska, A., Herbet, M., & Piątkowska‐Chmiel, I. (2023) · Biomedicines · doi:10.3390/biomedicines11113035 · Cited by 30 · see citing works

Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions

Zhang, A. Y., Elias, E., & Manners, M. T. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106610 · Cited by 29 · see citing works

Current understandings and perspectives of petroleum hydrocarbons in Alzheimer’s disease and Parkinson’s disease: a global concern

Rajendran, R., Raghavan, R. P., Al-Sehemi, A. G., Uddin, M. S., Aleya, L., & Mathew, B. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-17931-3 · Cited by 29 · see citing works

Microglia-derived exosomes selective sorted by YB-1 alleviate nerve damage and cognitive outcome in Alzheimer’s disease

Wei, H., Zhu, Z., Xu, Y., Li, L., Chen, Q., Liu, Y., Li, Y., & Zhu, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05256-x · Cited by 28 · see citing works

Unlocking the Potential: Semaglutide’s Impact on Alzheimer’s and Parkinson’s Disease in Animal Models

Meca, A.-D., Boboc, I. K. Ş., Mititelu-Tarțău, L., & Bogdán, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46060354 · Cited by 28 · see citing works

Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice

Lin, C., Hérisson, F., Le, H., Jaafar, N., Chetal, K., Oram, M. K., Flynn, K. L., Gavrilles, E. P., Sadreyev, R. I., Schiffino, F. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113141 · Cited by 29 · see citing works

The promise of GLP-1 receptor agonists for neurodegenerative diseases

Athauda, D. S., Greig, N. H., Meissner, W. G., Foltynie, T., & Gandhi, S. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194745 · Cited by 30 · see citing works

Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer’s Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway

He, Y., Wang, Y., Li, X., Qi, Y., Qu, Z., & Hu, Y. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08784-3 · Cited by 26 · see citing works

Alzheimer’s-Like Pathology at the Crossroads of HIV-Associated Neurological Disorders

Chemparthy, D. T., Kannan, M., Gordon, L., Buch, S. J., & Sil, S. (2021) · Vaccines · doi:10.3390/vaccines9080930 · Cited by 26 · see citing works

The immunomodulatory effects of GLP-1 receptor agonists in neurogenerative diseases and ischemic stroke treatment

Sun, H., Hao, Y., Liu, H., & Gao, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1525623 · Cited by 25 · see citing works

The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics

VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 26 · see citing works

Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease

Phillips, J., Winfree, R. L., Seto, M., Schneider, J. A., Bennett, D. A., Dumitrescu, L. C., & Hohman, T. J. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02828-5 · Cited by 23 · see citing works

Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence

Teixeira, L. C. R., Luizon, M. R., & Gomes, K. B. (2025) · Receptors · doi:10.3390/receptors4010002 · Cited by 24 · see citing works

Myeloid cells in retinal and brain degeneration

Guo, M., Schwartz, T. D., Dunaief, J. L., & Cui, Q. N. (2021) · FEBS Journal · doi:10.1111/febs.16177 · Cited by 24 · see citing works

The rise of astrocytes: are they guardians or troublemakers of the brain disorder?

Kim, H. Y., Kim, S., Akaydin, A. N., Kim, S. S., Hyeon, S. J., Lee, J.-H., & Ryu, H. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01627-6 · Cited by 28 · see citing works

Recent advances in preventing neurodegenerative diseases

Chou, S.-C., Aggarwal, A., Dawson, V. L., Dawson, T. M., & Kam, T. (2021) · Faculty Reviews · doi:10.12703/r/10-81 · Cited by 24 · see citing works

Why to Study Peptides from Venomous and Poisonous Animals?

de Oliveira, A. L. N., Soares, A. M., & Silva, S. L. D. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10543-0 · Cited by 22 · see citing works

Kai-Xin-San ameliorates Alzheimer's disease-related neuropathology and cognitive impairment in APP/PS1 mice via the mitochondrial autophagy-NLRP3 inflammasome pathway

Shan, X., Tao, W., Li, J., Tao, W., Li, D., Zhou, L., Yang, X., Dong, C., Huang, S., Chu, X., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118145 · Cited by 22 · see citing works

Dual-Targeted Magnetic Mesoporous Silica Nanoparticles Reduce Brain Amyloid-β Burden via Depolymerization and Intestinal Metabolism

Liu, N., Liang, X., Yang, C., Hu, S., Luo, Q., & Luo, H. (2022) · Theranostics · doi:10.7150/thno.76574 · Cited by 21 · see citing works

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives

Gharagozloo, M., Galleguillos, D., Jank, L., Sotirchos, E. S., Smith, M. D., Garton, T., Kumar, S., Hussein, O., Potluri, S., Taylor, M., et al. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01390-4 · Cited by 23 · see citing works

Effects of antidiabetic medications on the relationship between type 2 diabetes mellitus and cognitive impairment

Cozza, A., Chinigò, C., Filicetti, E., Greco, G. I., Lappano, R., Marinaro, C., Muglia, L., Soraci, L., Corsonello, A., Lattanzio, F., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102834 · Cited by 20 · see citing works

The Role of Astrocytes and Blood–Brain Barrier Disruption in Alzheimer’s Disease

Cruz, J. V. R., Batista, C., Diniz, L., & Mendes, F. (2023) · Neuroglia · doi:10.3390/neuroglia4030015 · Cited by 15 · see citing works

Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats

Huf, F., Gutierres, J. M., da Silva, G. N., Zago, A. M., Koenig, L. F. C., & Fernandes, M. D. C. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04872-3 · Cited by 19 · see citing works

GLP-1/Sigma/RAGE receptors: An evolving picture of Alzheimer's disease pathology and treatment

Neha, N., Wali, Z., Pinky, P., Hattiwale, S. H., Jamal, A., & Parvez, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102134 · Cited by 19 · see citing works

The Role of Astrocytes and Alpha-Synuclein in Parkinson’s Disease: A Review

Brash-Arias, D., García, L. I., Pérez-Estudillo, C. A., Rojas-Durán, F., Aranda-Abreu, G. E., Herrera‐Covarrubias, D., & Chi-Castañeda, D. (2024) · NeuroSci · doi:10.3390/neurosci5010005 · Cited by 18 · see citing works

Epidermal Growth Factor Receptor Kinase Inhibitor Ameliorates β-Amyloid Oligomer-Induced Alzheimer Disease in Swiss Albino Mice

Dhamodharan, J., Sekhar, G., & Muthuraman, A. (2022) · Molecules · doi:10.3390/molecules27165182 · Cited by 18 · see citing works

The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strain

Tian, S. L., Ye, T., & Cheng, X. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114505 · Cited by 19 · see citing works

Molecular mechanisms implicated in protein changes in the Alzheimer’s disease human hippocampus

Nguyen, H. D., Kim, W.-K., & Vu, G. H. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111930 · Cited by 17 · see citing works

Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer’s disease

Yang, X., Wang, Y., Qiao, Y., Lin, J., Lau, J. K. Y., Fu, W., Fu, A. K. Y., & Ip, N. Y. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420324122 · Cited by 17 · see citing works

Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET

Deden, L. N., Booij, J., Grandjean, J., Homberg, J. R., Hazebroek, E. J., Gotthardt, M., & Boss, M. (2021) · Brain Sciences · doi:10.3390/brainsci11121647 · Cited by 17 · see citing works

Histone deacetylase inhibition mitigates cognitive deficits and astrocyte dysfunction induced by amyloid‐β (Aβ) oligomers

Morgado, J., Diniz, L. P., Araújo, A. P. B., Antônio, L. M. D. S., Mota-Araujo, H. P., Pinheiro, P. D. S. M., Sagrillo, F. S., Vargas, G., Ferreira, S. T., Figueiredo, C. P., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16439 · Cited by 17 · see citing works

Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer’s Disease

Satarker, S., Gurram, P. C., Nassar, A., Manandhar, S., Vibhavari, R. J. A., Yarlagadda, D. L., Mudgal, J., Lewis, S. A., Arora, D. S., & Nampoothiri, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03844-4 · Cited by 16 · see citing works

Prospects of antidiabetic drugs in the treatment of neurodegenerative disease

Hu, L., Wang, W., Chen, X., Bai, G., Ma, L., Yang, X., Shu, Q., & Li, X. (2024) · Brain‐X · doi:10.1002/brx2.52 · Cited by 16 · see citing works

Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease

Badina, A. M., Ceyzériat, K., Amossé, Q., Tresh, A., Abjean, L., Guénat, L., Vauthey, E., Tsartsalis, S., Millet, P., & Tournier, B. B. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106950 · Cited by 17 · see citing works

Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?

Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17 · see citing works

The Influence of the Gut Microbiota on Alzheimer's Disease: A Narrative Review

Yin, J.-T., Xu, X., Jin, C.-Y., Yuan, X., & Wang, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2202038 · Cited by 15 · see citing works

Oxiracetam alleviates anti-inflammatory activity and ameliorates cognitive impairment in the early phase of traumatic brain injury

Youn, D. H., Han, S. W., Kim, J.-T., Choi, H., Lee, A., Kim, N., Jung, H., Hong, E. P., Park, C. H., Lee, Y., et al. (2023) · Acta Neurochirurgica · doi:10.1007/s00701-023-05674-8 · Cited by 15 · see citing works

Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease

Leitao, A. D. G., Ahammad, R. U., Spencer, B. J., Wu, C., Masliah, E., & Rissman, R. A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106285 · Cited by 15 · see citing works

Glial cell crosstalk in Parkinson's disease: Mechanisms, implications, and therapeutic strategies

Wang, N., Xiao, X., Chen, Z., Xu, K., Cao, X., Kou, D., & Zeng, J. (2025) · Fundamental Research · doi:10.1016/j.fmre.2024.12.023 · Cited by 17 · see citing works

Refining the interactions between microglia and astrocytes in Alzheimer’s disease pathology

Chen, J., Xu, S., Wang, L., Liu, X., Liu, G., Tan, Q., Li, W., Zhang, S., & Du, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.033 · Cited by 16 · see citing works

An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury

Liao, S., Luo, Y., Chunchai, T., Singhanat, K., Arunsak, B., Benjanuwattra, J., Apaijai, N., Chattipakorn, N., & Chattipakorn, S. C. (2022) · Inflammation Research · doi:10.1007/s00011-022-01590-2 · Cited by 14 · see citing works

Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders

Sabbagh, M. N., Cummings, J. L., Ballard, C. G., van der Flier, W. M., Heneka, M. T., Holst, J. J., Knudsen, L. B., Salloway, S., Tansey, M. G., & Drucker, D. J. (2025) · Nature Aging · doi:10.1038/s43587-025-01029-3 · Cited by 14 · see citing works

Altered circadian behavior and light sensing in mouse models of Alzheimer’s disease

Weigel, T. K., Guo, C. L., Güler, A. D., & Ferris, H. A. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1218193 · Cited by 14 · see citing works

A genetic tool for the longitudinal study of a subset of post-inflammatory reactive astrocytes

Agnew‐Svoboda, W., Ubina, T., Figueroa, Z. A., Wong, Y.-C. E., Vizcarra, E. A., Roebini, B., Wilson, E. H., Fiacco, T. A., & Riccomagno, M. M. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100276 · Cited by 14 · see citing works

Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies

Corraliza-Gómez, M., Vargas-Soria, M., & Garcı́a-Alloza, M. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00894-1 · Cited by 13 · see citing works

Regulation of neuroinflammation with GLP-1 receptor targeting nanostructures to alleviate Alzheimer’s symptoms in the disease models

Zhao, Y., Tian, S., Zhang, J., Cheng, X., Huang, W., Cao, G., Chang, Y., Wang, H., Nie, G., & Qiu, W. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101457 · Cited by 23 · see citing works

Additional file 1 of Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Park, J.-S., Kam, T.-I., Lee, S., Park, H., Oh, Y., Kwon, S.-H., Song, J.-J., Kim, D., Kim, H., Jhaldiyal, A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14489894

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

Hinkle, J. T., Dawson, V. L., & Dawson, T. M. (2019) · Movement Disorders · doi:10.1002/mds.27718 · Cited by 98 · see citing works

Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes

Zhang, M., Wu, Y., Gao, R., Chen, X., Chen, R., & Zhou, C. Y. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111529 · Cited by 60 · see citing works

Manipulation of microglial activity as a therapy for Alzheimer s disease

Ling, E. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s342 · Cited by 15 · see citing works