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Human apolipoprotein C-I expression in mice impairs learning and memory functions

Abildayeva, Karlygash, Berbée, Jimmy F.P., Blokland, Arjan, Jansen, Paula J., Hoek, Frans J., Meijer, Onno, Lütjohann, Dieter, Gautier, Thomas, Pillot, Thierry, De Vente, Jan, Havekes, Louis M., Ramaekers, Frans C.S., Kuipers, Folkert, Rensen, Patrick C.N., Mulder, Monique·2008·Journal of Lipid Research
DOI 10.1194/jlr.m700518-jlr200
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  • A transgenic mouse study revealed that overexpression of human APOC1 protein impaired learning and memory, regardless of APOE expression, indicating a modulatory role for APOC1 in AD development.

    “Additionally, a transgenic mouse study revealed that overexpression of human APOC1 protein impaired learning and memory, regardless of APOE expression, indicating a modulatory role for APOC1 in AD development [94].”

    From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [94]

  • APOC1 has been shown to exacerbate soluble Aβ oligomer-induced neuronal cell death in vitro, which may help explain the pronounced hippocampal and cortical atrophy observed in cognitively impaired patients.

    “Additionally, APOC1 has been shown to exacerbate soluble Aβ oligomer-induced neuronal cell death in vitro [94], which may help explain the pronounced hippocampal and cortical atrophy observed in cognitively impaired patients.”

    From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [94]

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Research works printed but not linked: 76

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Metadata

Authors
Abildayeva, K., Berbée, J. F. P., Blokland, A., Jansen, P. J., Hoek, F. J., Meijer, O., Lütjohann, D., Gautier, T., Pillot, T., De Vente, J., Havekes, L. M., Ramaekers, F. C. S., Kuipers, F., Rensen, P. C. N., & Mulder, M.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2008-04
Volume
49
Issue
4
Pages
856-869
ISSN
0022-2275
DOI
10.1194/jlr.m700518-jlr200
Cited by
39
References
4
Language
en
Licence

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