Intestinal transport and metabolism of bile acids

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904

The interaction between bacteria and bile

Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689

Bile Acid Metabolism and Signaling

Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662

Gut microbiota and healthy longevity

Luo, J., Liang, S., & Jin, F. (2024) · Science China Life Sciences · doi:10.1007/s11427-023-2595-5 · Cited by 37

Spaceflight alters host-gut microbiota interactions

González, E., Lee, M., Tierney, B. T., Lytell, N., Flores, P., Mishra, M., Beckett, L., Finkelstein, A., Mo, A., Walton, P., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00545-1 · Cited by 41

Microbiota-derived bile acid metabolic enzymes and their impacts on host health

Ma, H., Wang, K., & Jiang, C. (2025) · Cell Insight · doi:10.1016/j.cellin.2025.100265 · Cited by 37

Habitual animal fat consumption in shaping gut microbiota and microbial metabolites

Wan, Y., Tong, W., Zhou, R., Li, J., Yuan, J., Wang, F., & Li, D. (2019) · Food & Function · doi:10.1039/c9fo01490j · Cited by 37

Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers

Chen, X., Qiu, W., Ma, X., Ren, L., Feng, M., Hu, S., Xue, C., & Chen, R. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2905182 · Cited by 36

Bile salt hydrolase and lipase inhibitory activity in reconstituted skim milk fermented with lactic acid bacteria

Gil-Rodríguez, A. M., & Beresford, T. P. J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104342 · Cited by 36

Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

Fu, Z., Dean, J. W., Xiong, L., Dougherty, M. W., Oliff, K. N., Chen, Z. E., Jobin, C., Garrett, T. J., & Zhou, L. (2021) · Nature Communications · doi:10.1038/s41467-021-24755-9 · Cited by 36

Bile Formation and the Enterohepatic Circulation

Dawson, P. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00041-4 · Cited by 36

A commercial grain-free diet does not decrease plasma amino acids and taurine status but increases bile acid excretion when fed to Labrador Retrievers

Donadelli, R. A., Pezzali, J. G., Oba, P. M., Swanson, K. S., Coon, C. N., Varney, J. L., Pendlebury, C., & Shoveller, A. K. K. (2020) · Translational Animal Science · doi:10.1093/tas/txaa141 · Cited by 36

A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters

Ge, M., Niu, W., Ren, J., Cai, S., Yu, D., Liu, H., Zhang, N., Zhang, Y., Wang, Y., Shao, R., et al. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0195-3 · Cited by 35

Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptome

McMillan, A. S., Foley, M. H., Perkins, C. E., & Theriot, C. M. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03576-23 · Cited by 34

Game of microbes: the battle within – gut microbiota and multiple sclerosis

Turner, T.-A. J., Lehman, P., Ghimire, S., Shahi, S. K., & Mangalam, A. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2387794 · Cited by 33

Is bariatric surgery resolving NAFLD via microbiota-mediated bile acid ratio reversal? A comprehensive review

Talavera-Urquijo, E., Beisani, M., Balibrea, J. M., & Alverdy, J. C. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.03.013 · Cited by 34

A critical review of bile acids and their receptors in hepatic encephalopathy

Williams, E., Chu, C. S., & DeMorrow, S. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114436 · Cited by 34

Species Differences of Bile Acid Redox Metabolism: Tertiary Oxidation of Deoxycholate is Conserved in Preclinical Animals

Lin, Q.-H., Tan, X., Wang, W., Zeng, W., Gui, L., Su, M., Liu, C., Jia, W. P., Xu, L., & Lan, K. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.090464 · Cited by 34

Bile acids as global regulators of hepatic nutrient metabolism

Hylemon, P. B., Takabe, K., Dozmorov, M. G., Nagahashi, M., & Zhou, H. (2017) · Liver Research · doi:10.1016/j.livres.2017.03.002 · Cited by 33

Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism

Lefort, C., Roumain, M., Hul, M. V., Rastelli, M., Manco, R., Leclercq, I. A., Delzenne, N. M., Marzo, V. D., Flamand, N., Luquet, S. H., et al. (2020) · Cells · doi:10.3390/cells9051247 · Cited by 33

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

Chen, X., Liu, M., Tang, J., Wang, N., Feng, Y., & Ma, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911710 · Cited by 33

Advances in primary sclerosing cholangitis

Horsley‐Silva, J. L., Carey, E. J., & Lindor, K. D. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30010-3 · Cited by 33

Bile acids, bioactive signalling molecules in interoceptive gut‐to‐brain communication

Joyce, S. A., & O'Malley, D. (2022) · The Journal of Physiology · doi:10.1113/jp281727 · Cited by 32

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants

Lee, J. M., Ong, J. R., Vergnes, L., Vallim, T. Q. D. A., Nolan, J., Cantor, R. M., Walters, J. F., & Reue, K. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m078279 · Cited by 32

Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy

Panzitt, K., Fickert, P., & Wagner, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166017 · Cited by 32

Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo

Miyauchi, S., Kim, S., Lee, W., & Sugiyama, Y. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107938 · Cited by 32

Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host

Wexler, A. G., Guiberson, E. R., Beavers, W. N., Shupe, J. A., Washington, M. K., Lacy, D. B., Caprioli, R. M., Spraggins, J. M., & Skaar, E. P. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109683 · Cited by 32

An extract from the Atlantic brown algae Saccorhiza polyschides counteracts diet-induced obesity in mice via a gut related multi-factorial mechanisms

Huebbe, P., Nikolai, S., Schloesser, A., Herebıan, D., Campbell, G. M., Glüer, C., Zeyner, A., Demetrowitsch, T. J., Schwarz, K., Metges, C. C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18113 · Cited by 32

Bile acids and their receptors in hepatic immunity

Fiorucci, S., Marchianò, S., Distrutti, E., & Biagioli, M. (2025) · Liver Research · doi:10.1016/j.livres.2025.01.005 · Cited by 31

Microbial metabolites and their influence on the tumor microenvironment

Duan, H., Xu, B., Luo, P., Chen, T., & Zou, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1675677 · Cited by 31

Roles of the inflammasome in the gut‑liver axis (Review)

Wang, J., Dong, R., & Zheng, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9679 · Cited by 31

Pleiotropic roles of FXR in liver and colorectal cancers

Huang, X., Fan, M., & Huang, W. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111543 · Cited by 32

Bile acid signaling in MASLD: From pathogenesis to therapeutic applications

Simbrunner, B., Paternostro, R., Reiberger, T., & Trauner, M. (2025) · Hepatology · doi:10.1097/hep.0000000000001539 · Cited by 30

BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination

Jung, H.-K., Chen, J., Hu, X., Sun, H., Wu, S.-Y., Chiang, C., KEMPER, B. W., Chen, L., & Kemper, J. K. (2020) · JCI Insight · doi:10.1172/jci.insight.141640 · Cited by 30

Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury

Truong, J. K., Bennett, A. L., Klindt, C., Donepudi, A. C., Malla, S. R., Pachura, K. J., Zaufel, A., Moustafa, T., Dawson, P. A., & Karpen, S. J. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100261 · Cited by 30

Metabolic Effects of Cholecystectomy: Gallbladder Ablation Increases Basal Metabolic Rate through G-Protein Coupled Bile Acid Receptor Gpbar1-Dependent Mechanisms in Mice

Cortés, V., Amigo, L., Zanlungo, S., Galgani, J. E., Robledo, F., Arrese, M. A., Bozinovic, F., & Nervi, F. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118478 · Cited by 30

n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD

Vauzour, D., Rodríguez‐Ramiro, I., Rushbrook, S., Ipharraguerre, I. R., Bevan, D., Davies, S. E., Tejera, N., Mena, P. R., de Pascual‐Teresa, S., Rio, D. D., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.10.002 · Cited by 30

Interaction of a bile salt (sodium taurocholate) with cationic (ε-polylysine) and anionic (pectin) biopolymers under simulated gastrointestinal conditions

Lopez-Pena, C. L., Arroyo-Maya, I. J., & McClements, D. J. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.08.029 · Cited by 30

Running Head: Heat Affects Cholesterol and Bile Acid Alterations in Cholesterol and Bile Acids Metabolism in Large White Pigs during Short-Term Heat Exposure

Fang, W., Wen, X., Meng, Q., Liu, L., Xie, J., Zhang, H., & Everaert, N. (2020) · Animals · doi:10.3390/ani10020359 · Cited by 29

Hepatoprotective impact of the bile acid receptor TGR5

Merlen, G., Bidault, V., Kahale, N., Glénisson, M., Bedoya, J. U., Doignon, I., Garcin, I., Humbert, L., Rainteau, D. P., & Tordjmann, T. (2020) · Liver International · doi:10.1111/liv.14427 · Cited by 29

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Gillard, J., & Leclercq, I. A. (2023) · Clinical Science · doi:10.1042/cs20220697 · Cited by 29

Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species

Zhang, J., Gao, L.-Z., Chen, Y.-J., Zhu, P.-P., Yin, S.-S., Su, M., Ni, Y., Miao, J., Wu, W.-L., Chen, H., et al. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.118.085670 · Cited by 29

Lactobacillus plantarum 06CC2 reduces hepatic cholesterol levels and modulates bile acid deconjugation in Balb/c mice fed a high‐cholesterol diet

Yamasaki, M., Minesaki, M., Iwakiri, A., Miyamoto, Y., Ogawa, K., Nishiyama, K., Tsend‐Ayush, C., Oyunsuren, T., Li, Y., Nakano, T., et al. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1909 · Cited by 28

Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non‐alcoholic fatty liver disease

Zhang, M., Xiao, B., Chen, X., Ou, B., & Wang, S. (2023) · Acta Physiologica · doi:10.1111/apha.14065 · Cited by 28

Benefits and challenges to therapeutic targeting of bile acid circulation in cholestatic liver disease

Trauner, M., Karpen, S. J., & Dawson, P. A. (2025) · Hepatology · doi:10.1097/hep.0000000000001438 · Cited by 27

Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer

Yin, Y., Wang, M., Gu, W., & Chen, L. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114430 · Cited by 27

Use of bile acids as potential markers of liver dysfunction in humans

Azer, S. A., & Hasanato, R. M. W. (2021) · Medicine · doi:10.1097/md.0000000000027464 · Cited by 27

Chronic Heat Stress Affects Bile Acid Profile and Gut Microbiota in Broilers

Zhang, Y., Chen, H., Cong, W., Zhang, K., Jia, Y., & Wu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210238 · Cited by 27

The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism

Sun, Y., Zhang, L., & Jiang, Z. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13971 · Cited by 27

Alteration in bile acids profile in large white pigs during chronic heat exposure

Fang, W., Wen, X., Meng, Q., Wu, W., Everaert, N., Xie, J., & Zhang, H. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.07.027 · Cited by 26

Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis

Gallucci, G. M., Trottier, J., Hemme, C., Assis, D. N., Boyer, J. L., Barbier, O., & Ghonem, N. S. (2021) · Hepatology Communications · doi:10.1002/hep4.1787 · Cited by 26

Immunologic Responses and the Pathophysiology of Primary Biliary Cholangitis

Chen, R., Tang, R., Ma, X., & Gershwin, M. E. (2022) · Clinics in Liver Disease · doi:10.1016/j.cld.2022.06.003 · Cited by 26

Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism

Rowe, J. C., & Winston, J. A. (2024) · Veterinary Sciences · doi:10.3390/vetsci11020094 · Cited by 26

Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives

Cătoi, A. F., Vodnar, D. C., Corina, A., Nikolić, D., Citarrella, R., Pérez‐Martínez, P., & Rizzo, M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190708190437 · Cited by 26

Pediatric Cholestasis: Epidemiology, Genetics, Diagnosis, and Current Management

Karpen, S. J. (2020) · Clinical Liver Disease · doi:10.1002/cld.895 · Cited by 26

Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation

Schadt, H. S., Wolf, A., Mahl, J. A., Wuersch, K., Couttet, P., Schwald, M., Fischer, A., Lienard, M., Emotte, C., Teng, C.-H., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy031 · Cited by 26

Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs

Call, L., Molina, T. L., Stoll, B., Guthrie, G. J., Chacko, S. K., Plat, J., Robinson, J. L., Lin, S., Vonderohe, C. E., Mohammad, M. A., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000652 · Cited by 25

Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative–lipid complex

Jha, S. K., Han, H.-S., Subedi, L., Pangeni, R., Chung, J. Y., Kweon, S., Choi, J. U., Byun, Y., Kim, Y., & Park, J. W. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1837293 · Cited by 25

Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat

Zembroski, A. S., D’Aquila, T., & Buhman, K. K. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00084.2021 · Cited by 25

Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids

Dhonnabháín, R. N., Xiao, Q., & O’Malley, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745190 · Cited by 25

Environmental Enteric Dysfunction Is Associated With Altered Bile Acid Metabolism

Semba, R. D., González‐Freire, M., Moaddel, R., Trehan, I., Maleta, K. M., Khadeer, M., Ordiz, M. I., Ferrucci, L., & MANARY, M. J. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001313 · Cited by 25

Serum bile acids in cystic fibrosis patients – glycodeoxycholic acid as a potential marker of liver disease

Drzymała-Czyż, S., Dziedzic, K., Szwengiel, A., Krzyżanowska-Jankowska, P., Nowak, J. K., Nowicka, A., Aringazina, R. A., Drzymała, S., Kashirskaya, N. Y., & Walkowiak, J. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.06.034 · Cited by 24

Protective mechanism of homologous lactic acid bacteria against cholestatic liver injury in snakehead fish

Kong, Y., Li, M., Wu, X., Xia, C., Liu, X., & Wang, G. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737845 · Cited by 24

Targeted metabolomics analysis of bile acids and cell biology studies reveal the critical role of glycodeoxycholic acid in buffalo follicular atresia

Wei, Y., Cheng, J., Luo, M., Yang, S., Xing, Q., Cheng, J., Lv, J., Yu, C., Sun, L., Shi, D., et al. (2022) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2022.106115 · Cited by 24

Intestinal Barrier Dysfunction in Fatty Liver Disease: Roles of Microbiota, Mucosal Immune System, and Bile Acids

Gupta, B., Rai, R. P., Oertel, M., & Raeman, R. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1748037 · Cited by 24

Microbiome-liver crosstalk: A multihit therapeutic target for liver disease

Kirundi, J., Moghadamrad, S., & Urbaniak, C. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i11.1651 · Cited by 24

Gut microbiota and bile acids: Metabolic interactions and impacts on diabetic kidney disease

Liu, P., Jin, M., Hu, P., Sun, W., Tang, Y., Wu, J., Zhang, D., Yang, L., He, H., & Xu, X. (2024) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2024.100315 · Cited by 23

Serum bile acid level and fatty acid composition in Chinese children with non‐alcoholic fatty liver disease

Lu, L. P., Wan, Y. P., Xun, P., Zhou, K., Chen, C., Cheng, S., Zhang, M. Z., Wu, C., Lin, W. W., Jiang, Y., et al. (2017) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12494 · Cited by 24

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

Ahmad, T. R., Higuchi, S., Bertaggia, E., Hung, A., Shanmugarajah, N., Guilz, N. C., Gamarra, J. R., & Haeusler, R. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012792 · Cited by 24

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders

Darmanto, A. G., Yen, T., Jan, J., Linh, T. T. D., Taliyan, R., Yang, C. H., & Sheu, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107564 · Cited by 23

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

Zhao, L., Wang, S., Zhang, N., Zhou, J., Mehmood, A., Raka, R. N., Zhou, F. L., & Zhao, L. (2022) · Antioxidants · doi:10.3390/antiox11061211 · Cited by 23

Antibiotic-induced alterations in taurocholic acid levels promote gastrointestinal colonization of Candida albicans

Guinan, J., & Thangamani, S. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny196 · Cited by 23

Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes

Meiring, S., Meessen, E. C. E., van Baar, A. C. G., Holleman, F., Nieuwdorp, M., Damink, S. W. M. O., Schaap, F. G., Vaz, F. M., Groen, A. K., Soeters, M. R., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00337.2021 · Cited by 23

The bile acid profile

Liu, Z., & You, C. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120004 · Cited by 22

Enteronephrohepatic circulation of bile acids and therapeutic potential of systemic bile acid transporter inhibitors

Ghallab, A., Mandorfer, M., Stirnimann, G., Geyer, J., Lindström, E., Luedde, T., der Merwe, V., Rashidi‐Alavijeh, J., Schmidt, H., Karpen, S. J., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.05.009 · Cited by 22

Effect of a Flaxseed Lignan Intervention on Circulating Bile Acids in a Placebo-Controlled Randomized, Crossover Trial

Navarro, S. L., Levy, L., Curtis, K. R., Elkon, I., Kahsai, O. J., Ammar, H., Randolph, T. W., Hong, N. N., Neto, F. C., Raftery, D., et al. (2020) · Nutrients · doi:10.3390/nu12061837 · Cited by 22

Plasma Levels of Bile Acids Are Related to Cardiometabolic Risk Factors in Young Adults

Osuna‐Prieto, F. J., Rubio‐López, J., Di, X., Yang, W., Köhler, I., Rensen, P. C. N., Ruiz, J. R., & Martínez‐Téllez, B. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab773 · Cited by 22

Polygonum multiflorum Thunb. Induces hepatotoxicity in SD rats and hepatocyte spheroids by Disrupting the metabolism of bilirubin and bile acid

Wang, Q., Wen, H., Ma, S., & Zhang, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115461 · Cited by 22

Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats

Sun, H., Su, X., Liu, Y., Li, G., & Du, Q. (2023) · iScience · doi:10.1016/j.isci.2023.108392 · Cited by 22

Biomechanics of the Small Intestinal Contractions

Avvari, R. K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86539 · Cited by 22

Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative

Pangeni, R., Jha, S. K., Maharjan, R., Choi, J. U., Chang, K.-Y., Choi, Y. K., Byun, Y., & Park, J. W. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s209722 · Cited by 22

Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of Oral Metronomic Dosing on Colorectal Cancer

Pangeni, R., Subedi, L., Jha, S. K., Kweon, S., Kang, S.-H., Chang, K.-Y., Choi, J. U., Byun, Y., & Park, J. W. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s267424 · Cited by 22

Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes

Lamazière, A., Rainteau, D. P., Pukar, K. C., Humbert, L., Gauliard, E., Ichou, F., Ponnaiah, M., Bouby, N., Salem, J., Mallet, J., et al. (2020) · Nutrients · doi:10.3390/nu12113545 · Cited by 22

Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders

Wankhede, N. L., Kale, M. B., Kyada, A., Rekha, M. M., Chaudhary, K., Naidu, K. S., Rahangdale, S. R., Shende, P. V., Taksande, B. G., Khalid, M., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.070 · Cited by 21

Adaptive and metabolic convergence in rhizosphere and gut microbiomes

Ilyaskina, D., Altveş, S., Dong, L., Bouwmeester, H. J., & Aidy, S. E. (2025) · Microbiome · doi:10.1186/s40168-025-02179-7 · Cited by 21

Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives

Li, Y., Wang, K., Ding, J., Sun, S., Ni, Z., & Yu, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.954684 · Cited by 21

Bile Acids: Physiological Activity and Perspectives of Using in Clinical and Laboratory Diagnostics

Shansky, Y. D., & Bespyatykh, J. (2022) · Molecules · doi:10.3390/molecules27227830 · Cited by 21

Bile salts: unlocking the potential as bio-surfactant for enhanced drug absorption

Chakravarthy, P. S. A., Popli, P., Challa, R. R., Vallamkonda, B., Singh, I., & Swami, R. (2024) · Journal of Nanoparticle Research · doi:10.1007/s11051-024-05985-6 · Cited by 21

Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea

Peiper, A. M., Aparicio, J. M., Hu, Z., Phophi, L., Helm, E. W., Rubinstein, R., Phillips, M. B., Williams, C. G., Subramanian, S., Cross, M., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.08.003 · Cited by 21

Bile acid profiles within the enterohepatic circulation in a diabetic rat model after bariatric surgeries

Wei, M., Shao, Y., Liu, Q.-R., Wu, Q., Zhang, X., Zhong, M., Liu, S.-Z., Zhang, G., & Hu, S. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00311.2017 · Cited by 21

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity

Chen, Y., Zhang, J., Zhu, P.-P., Xian-wen, T., Lin, Q.-H., Wang, W., Yin, S.-S., Gao, L.-Z., Su, M., Liu, C., et al. (2019) · Drug Metabolism and Disposition · doi:10.1124/dmd.119.086637 · Cited by 21

Biodegradable, bile salt microparticles for localized fat dissolution

Safari, H., Kaczorowski, N., Felder, M. L., Brannon, E. R., Varghese, M., Singer, K., & Eniola‐Adefeso, O. (2020) · Science Advances · doi:10.1126/sciadv.abd8019 · Cited by 21

LC-MS/MS Analysis of Bile Acids

Krautbauer, S., & Liebisch, G. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7592-1_8 · Cited by 21

Microbial bile acid modifications: current understandings, key problems, and future perspectives

Zhang, H., Wen, J., Liu, X., Feng, Y., Liu, X., & Ning, K. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3019-2 · Cited by 20

Impact of Primary and Secondary Bile Acids on Clostridioides difficile Infection

Łukawska, A., & Mulak, A. (2022) · Polish Journal of Microbiology · doi:10.33073/pjm-2022-007 · Cited by 20

Detection of Bile Acids in Complex Matrices Using a Transcription Factor-Based Biosensor

Beabout, K., Breedon, A. M. E., Blum, S. M., Miklos, A. E., Lux, M. W., Chávez, J. L., & Goodson, M. S. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01006 · Cited by 19

Swainsonine Induces Liver Inflammation in Mice via Disturbance of Gut Microbiota and Bile Acid Metabolism

Fu, K., Chen, X., Shou, N., Wang, Z., Yuan, X., Wu, D., Wang, Q., Cheng, Y., Ling, N., & Shi, Z. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08519 · Cited by 19

Gut microbiome and metabolic-associated fatty liver disease: Current status and potential applications

Guo, G.-J., Yao, F., Lu, W.-P., & Xu, H. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i7.867 · Cited by 19

The Pathophysiology of Portal Hypertension

Ramkissoon, R. A., Cao, S., & Shah, V. H. (2024) · Clinics in Liver Disease · doi:10.1016/j.cld.2024.03.001 · Cited by 19

Chicken bile powder protects against α-naphthylisothiocyanate-induced cholestatic liver injury in mice

Li, Y., Wu, J., Dai, Y., Dai, Y., Zheng, M., Zeng, J., Wang, G.-F., Wang, T., Li, W.-K., Zhang, X.-Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21385 · Cited by 19

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

Staats, S., Rimbach, G. H., Künstner, A., Graspeuntner, S., Rupp, J., Busch, H. S., Sina, C., Ipharraguerre, I. R., & Wagner, A. E. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800424 · Cited by 19

Mass Spectrometry-Based Metabolomic and Lipidomic Analysis of the Effect of High Fat/High Sugar Diet and GreenshellTM Mussel Feeding on Plasma of Ovariectomized Rats

Abshirini, M., Cabrera, D. L., Fraser, K., Siriarchavatana, P., Wolber, F. M., Miller, M. R., Tian, H. S., & Kruger, M. C. (2021) · Metabolites · doi:10.3390/metabo11110754 · Cited by 19

Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity

Lamichhane, S., Dickens, A. M., Buchacher, T., Lou, T., Charron‐Lamoureux, V., Kattelus, R., Karmacharya, P., da Silva, L. P., Kråkström, M., Rasool, O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66619-6 · Cited by 18

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Ferrebee, C. B., & Dawson, P. A. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.001 · Cited by 131

Advances in research on the effects of bile acids and their receptors on intestinal function

Cheng, Y., Zhang, L., Zhang, M., & Yu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1821418 · Cited by 6

Meetings and Courses

Lei, S.-Y. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60407-6

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L., & Patterson, A. D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108238 · Cited by 529

A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling

Shulpekova, Y. O., Shirokova, E. N., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., et al. (2022) · Molecules · doi:10.3390/molecules27061983 · Cited by 77