The DOI matches its Crossref record; 245 of the 249 references it cites were found in a registry or an index.
Intestinal transport and metabolism of bile acids
Open accessAbstract
In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling.
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“These primary bile acids, cholic acid and chenodeoxycholic acid (CDCA), are transported into the gut through the enterohepatic circulation system and are further metabolized by gut microbiota by dehydroxylation, dehydrogenation, and epimerization to generate secondary bile acids reviewed previously.102”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [102]
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Metadata
- Authors
- Dawson, P. A., & Karpen, S. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Dawson, Paul A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 56
- Issue
- 6
- Pages
- 1085-1099
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC4442867
- OpenAlex
- W2316224242
- Cited by
- 598
- References
- 249
- Citations by year
- 2026: 59 · 2025: 80 · 2024: 72 · 2023: 51 · 2022: 65 · 2021: 64 · 2020: 59 · 2019: 43 · 2018: 43 · 2017: 31 · 2016: 20 · 2015: 10
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056239, R29DK047987, DK056239, DK-047987, R01DK047987)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, bile acid metabolism, enterohepatic circulation, gut microbiota, bile acid signaling, nuclear receptors, G protein-coupled receptors, intestinal homeostasis, host-microbe interactions
- MeSH terms
- Animals, Bile Acids and Salts, Enterohepatic Circulation, Homeostasis, Intestinal Mucosa, Signal Transduction, Hepatocytes, Receptors, G-Protein-Coupled, Lipid Metabolism, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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