The DOI matches its Crossref record; 245 of the 249 references it cites were found in a registry or an index.
Intestinal transport and metabolism of bile acids
Open accessAbstract
In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling.
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“These primary bile acids, cholic acid and chenodeoxycholic acid (CDCA), are transported into the gut through the enterohepatic circulation system and are further metabolized by gut microbiota by dehydroxylation, dehydrogenation, and epimerization to generate secondary bile acids reviewed previously.102”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [102]
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Metadata
- Authors
- Dawson, P. A., & Karpen, S. J.
- Affiliations
- Emory University (US)
- Corresponding author
- Dawson, Paul A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 56
- Issue
- 6
- Pages
- 1085-1099
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC4442867
- OpenAlex
- W2316224242
- Cited by
- 598
- References
- 249
- Citations by year
- 2026: 59 · 2025: 80 · 2024: 72 · 2023: 51 · 2022: 65 · 2021: 64 · 2020: 59 · 2019: 43 · 2018: 43 · 2017: 31 · 2016: 20 · 2015: 10
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056239, R29DK047987, DK056239, DK-047987, R01DK047987)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, bile acid metabolism, enterohepatic circulation, gut microbiota, bile acid signaling, nuclear receptors, G protein-coupled receptors, intestinal homeostasis, host-microbe interactions
- MeSH terms
- Animals, Bile Acids and Salts, Enterohepatic Circulation, Homeostasis, Intestinal Mucosa, Signal Transduction, Hepatocytes, Receptors, G-Protein-Coupled, Lipid Metabolism, Microbiota
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