Intestinal transport and metabolism of bile acids

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904

The interaction between bacteria and bile

Begley, M., Gahan, C. G. M., & Hill, C. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.09.003 · Cited by 1,776

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689

Bile Acid Metabolism and Signaling

Chiang, J. Y. L. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120023 · Cited by 1,662

Ex vivo permeability study of poorly soluble drugs across gastrointestinal membranes: acceptor compartment media composition

Šitovs, A., & Mohylyuk, V. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104214 · Cited by 18

Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice

Jones, R., Lopez, A. M., Tong, E. Y., Posey, K. S., Chuang, J.-C., Repa, J. J., & Turley, S. D. (2014) · Steroids · doi:10.1016/j.steroids.2014.11.002 · Cited by 18

On the Evolution of Bile Salts and the Farnesoid X Receptor in Vertebrates

Frisch, K., & Alstrup, A. K. O. (2017) · Physiological and Biochemical Zoology · doi:10.1086/695810 · Cited by 18

Dietary raffinose ameliorates hepatic lipid accumulation induced by cholic acid via modulation of enterohepatic bile acid circulation in rats

Maegawa, K., Koyama, H., Fukiya, S., Yokota, A., Ueda, K., & Ishizuka, S. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521002610 · Cited by 18

Intermittent Fasting Alleviates Non‐Alcoholic Steatohepatitis by Regulating Bile Acid Metabolism and Promoting Fecal Bile Acid Excretion in High‐Fat and High‐Cholesterol Diet Fed Mice

Lin, X., Zhu, X., Xin, Y., Zhang, P., Xiao, Y., He, T., & Guo, H. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200595 · Cited by 18

Deletion of Intestinal SHP Impairs Short-term Response to Cholic Acid Challenge in Male Mice

Nguyen, J. T., Riessen, R., Zhang, T., Kieffer, C., & Anakk, S. (2021) · Endocrinology · doi:10.1210/endocr/bqab063 · Cited by 18

Diet-Induced Non-alcoholic Fatty Liver Disease and Associated Gut Dysbiosis Are Exacerbated by Oral Infection

Simas, A. M., Kramer, C. D., & Genco, C. A. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2021.784448 · Cited by 17

Transcriptome analysis to assess the cholestatic hepatotoxicity induced by Polygoni Multiflori Radix: Up-regulation of key enzymes of cholesterol and bile acid biosynthesis

Jiang, L.-L., Zhao, D., Fan, Y.-X., Yu, Q., Lai, Y., Li, P., & Li, H. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.02.014 · Cited by 17

Dietary Glycaemic Index and Type 2 Diabetes Mellitus: Potential Modulation of Gut Microbiota

Durganaudu, H., Kunasegaran, T., & Ramadas, A. (2020) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000082 · Cited by 17

Drug-Induced Dynamics of Bile Colloids

Hanio, S., Schlauersbach, J., Lenz, B., Spiegel, F., Böckmann, R. A., Schweins, R., Nischang, I., Schubert, U. S., Endres, S., Pöppler, A., et al. (2021) · Langmuir · doi:10.1021/acs.langmuir.0c02282 · Cited by 17

Epiberberine ameliorates ulcerative colitis by regulating bile acids hepatoenteral circulation through intestinal FXR

Chen, M., Wang, Y., Chen, L., Chen, M., Li, X., & Wang, G. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156831 · Cited by 16

Bile acid modulation of host immunity

Anh, N. B., Yang, X., & Hang, H. C. (2025) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70014 · Cited by 16

The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism

Wang, X., Li, A., Jing, H., Zhang, X., Dong, X., Song, Z., Wu, N., & Zheng, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653472 · Cited by 16

Effect of lactic acid fermented foods on glycemic control in diabetic adults: a systemic review and meta-analysis of randomized controlled trials

Teo, W. Z., See, J. Y., Ramazanu, S., Chan, J. C. Y., & Wu, X. V. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2128032 · Cited by 16

Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid Homeostasis

Burchat, N., Vidola, J., Pfreundschuh, S., Sharma, P., Rizzolo, D., Guo, G. L., & Sampath, H. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101403 · Cited by 16

Gut-Microbiota-Driven Lipid Metabolism: Mechanisms and Applications in Swine Production

Xiong, S. (2025) · Metabolites · doi:10.3390/metabo15040248 · Cited by 16

Bile Acids as a New Type of Steroid Hormones Regulating Nonspecific Energy Expenditure of the Body (Review)

Загоскин, П. П., & Erlykina, E. I. (2020) · Современные технологии в медицине · doi:10.17691/stm2020.12.5.13 · Cited by 16

Mediators of Host–Microbe Circadian Rhythms in Immunity and Metabolism

Frazier, K., Frith, M., Harris, D., & Leone, V. (2020) · Biology · doi:10.3390/biology9120417 · Cited by 16

Blunted serum 25(OH)D response to vitamin D3supplementation in children with autism

Kerley, C. P., Elnazir, B., Greally, P., & Coghlan, D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1529342 · Cited by 16

Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake

Chaves, L. D., Abyad, S., Honan, A. M., Bryniarski, M. A., McSkimming, D. I., Stahura, C. M., Wells, S. C., Ruszaj, D. M., Morris, M. E., Quigg, R. J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.144410 · Cited by 16

An Updated Perspective on the Dual-Track Model of Enterocyte Fat Metabolism

Cook, J. R., Kohan, A. B., & Haeusler, R. A. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100278 · Cited by 15

Lactiplantibacillus plantarum LPJZ-658 Improves Non-Alcoholic Steatohepatitis by Modulating Bile Acid Metabolism and Gut Microbiota in Mice

Liu, L., Deng, L., Wei, W., Li, C., Lu, Y., Bai, J., Li, L., Zhang, H., Jin, N., Li, C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813997 · Cited by 15

Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite

Huang, W., Xu, R., Kimball, A. K., Witola, W. H., Baldridge, M. T., Feng, Y., Xiao, L., & Sibley, L. D. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.07.024 · Cited by 15

Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells

Wang, J., Bakker, W., Zheng, W., de Haan, L., Rietjens, I. M. C. M., & Bouwmeester, H. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03256-8 · Cited by 15

Serum Bile Acid Profiling and Mixed Model Analysis Reveal Biomarkers Associated with Pruritus Reduction in Maralixibat-Treated Patients with BSEP Deficiency

Zhao, X., Zhang, W., Vig, P., Kostrub, C., & Setchell, K. D. R. (2022) · Metabolites · doi:10.3390/metabo12100952 · Cited by 15

Peroxisome Proliferator-Activated Receptor- γ Prevents Cholesterol Gallstone Formation in C57bl Mice by Regulating Bile Acid Synthesis and Enterohepatic Circulation

Wang, G., Han, T., Wang, S., Chen, M., Sun, Y., & Fu, Z. (2018) · BioMed Research International · doi:10.1155/2018/7475626 · Cited by 15

Drug-gut microbiota metabolic interactions: the case of UniPR1331, selective antagonist of the Eph-ephrin system, in mice

Ferlenghi, F., Castelli, R., Scalvini, L., Giorgio, C., Corrado, M., Tognolini, M., Mor, M., Lodola, A., & Vacondio, F. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.113067 · Cited by 15

Bile acid profiles and classification model accuracy for inflammatory bowel disease diagnosis

Xu, R., Shen, J.-N., Jing-bo, L., Liu, Y., Song, Y., Cao, Y., Wang, Z.-H., & Zhang, J. (2024) · Medicine · doi:10.1097/md.0000000000038457 · Cited by 14

Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora

Li, M., Wang, Q., Zhang, X., Li, K., Niu, M., & Zhao, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138754 · Cited by 14

FXR inhibition functions as a checkpoint blockade of the pathogenic Tfh cell response in lupus

Wang, X., Ye, L., Liu, S., Zheng, Y., Zhu, L., Huang, W., Song, J., Shao, J., Wu, F., Zhang, C., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01309-3 · Cited by 14

Intestinal Transporter-Associated Drug Absorption and Toxicity

Xue, Y., Ma, C., Hanna, I. H., & Pan, G. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7647-4_8 · Cited by 14

Pharmacokinetics of CamSA, a potential prophylactic compound against Clostridioides difficile infections

Yip, C., Okada, N. C., Howerton, A., Amei, A., & Abel‐Santos, E. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114314 · Cited by 14

Gut microbiome and metabolic response in non-alcoholic fatty liver disease

Abuwani, A. M., Dash, S. P., Ganesan, R., Renu, K., Vellingiri, B., Kandasamy, S., Sundara Rajan, C. R., & Gopalakrishnan, A. V. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.10.014 · Cited by 14

Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota

Hu, Y., Chen, S., Yan, W., Ji, L., Shao, M., Sun, Z., He, D., Zhang, L., Xia, Z., Li, X., et al. (2023) · eFood · doi:10.1002/efd2.101 · Cited by 14

Multiplexed Quantitative Assessment of the Fate of Taurine and Sulfoquinovose in the Intestinal Microbiome

Haange, S., Groeger, N., Froment, J., Rausch, T., Burkhardt, W., Gonnermann, S., Braune, A., Blaut, M., von Bergen�, M., & Rolle-Kampczyk, U. E. (2020) · Metabolites · doi:10.3390/metabo10110430 · Cited by 14

Comprehensive Characterization of Bile Acids in Human Biological Samples and Effect of 4-Week Strawberry Intake on Bile Acid Composition in Human Plasma

Zhao, A., Zhang, L., Zhang, X., Edirisinghe, I., Burton‐Freeman, B. M., & Sandhu, A. K. (2021) · Metabolites · doi:10.3390/metabo11020099 · Cited by 14

Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers

Li, X., Thelingwani, R. S., Bertilsson, L., Diczfalusy, U., Andersson, T. B., & Masimirembwa, C. M. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060457 · Cited by 13

Dysbiosis of gut microbiota, a potential mediator of bile acid compositions, and prevalence of hand synovitis: a community-based study

Jiang, T., Yang, Z., Zhang, Y., Zhang, W., Doherty, M., Li, H., Yang, T., Yang, Y., Li, J., Wang, Y., et al. (2023) · Rheumatology · doi:10.1093/rheumatology/kead042 · Cited by 13

Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis

Liu, X., Wang, J., Li, M., Qiu, J., Li, X., Qi, L., Liu, J., Liu, P., Xie, G., & Wang, X. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16279 · Cited by 13

Altered bile acids profile is a risk factor for hyperandrogenism in lean women with PCOS: a case control study

Zhu, Y., Lin, S., Zhang, Y., Yu, J., Fu, J., Li, Y., Shan, C., Cai, J., Liu, W. X., & Tao, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-77645-7 · Cited by 13

Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice

Ren, C., Shuang, Z., Ma, J., Huang, J., Huang, P., Qu, M., Zhao, H., Zhou, Z., & Gong, A. (2024) · Biology · doi:10.3390/biology13121028 · Cited by 13

Bile acids as germinants for Clostridioides difficile spores, evidence of adaptation to the gut?

Vinay, G., Seppen, J., Setlow, P., & Brul, S. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf005 · Cited by 13

Novel Insights into the Human Gut Microbially Conjugated Bile Acids: The New Diversity of the Amino Acid-Conjugated Derivatives

García, C. J., Garcı́a-Villalba, R., Frutos-Lisón, M. D., Beltrán, D., Martínez‐Sánchez, M. A., Núñez‐Sánchez, M. Á., Ramos‐Molina, B., & Tomás-Barberán, F. A. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c03548 · Cited by 13

Hypocholesterolemic Effects of Capsaicinoids and Lactobacillus plantarum Swun5815 Combined by Inhibiting Cholesterol Synthesis and Increasing Bile Acid and Sterols Excretion on Ovariectomized Rats

Ren, T., You, Y., Luo, Y., Wang, Y., & Liu, X. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14285 · Cited by 13

Secondary bile acids and the biliary epithelia: The good and the bad

Lenci, I., Milana, M., Signorello, A., Grassi, G. B., & Baiocchi, L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i2.357 · Cited by 13

Altered bile acid metabolism in skin tissues in response to ionizing radiation: deoxycholic acid (DCA) as a novel treatment for radiogenic skin injury

Zhang, Y., Yan, T., Mo, W., Song, B., Zhang, Y., Geng, F., Hu, Z., Yu, D., & Zhang, S. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2245461 · Cited by 13

Bile Acid Metabolism

Dawson, P. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-63438-2.00012-2 · Cited by 13

Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites

Dopico, A. M., & Bukiya, A. N. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2017.07.001 · Cited by 13

ASBT inhibitors in cholangiopathies – Good for mice, good for men?

Poupon, R. Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.12.007 · Cited by 13

Improvement of obesity-induced fatty liver disease by intermittent hypoxia exposure in a murine model

Chen, L., Wang, Y., Zheng, W., Zhang, H., Sun, Y., Chen, Y., & Liu, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1097641 · Cited by 12

Determination of Bile Acids in Canine Biological Samples: Diagnostic Significance

Németh, K., Sterczer, Á., Kiss, D. S., Lányi, R. K., Hemző, V., Vámos, K., Bartha, T., Buzás, A., & Lányi, K. (2024) · Metabolites · doi:10.3390/metabo14040178 · Cited by 12

The role of the gut microbial metabolism of sterols and bile acids in human health

Tang, J., Xu, W., Yu, Y., Yin, S., Ye, B.-C., & Zhou, Y. (2024) · Biochimie · doi:10.1016/j.biochi.2024.11.003 · Cited by 12

Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

Rodrigues, D., Gibson, C. R., & Isoherranen, N. (2025) · Clinical and Translational Science · doi:10.1111/cts.70299 · Cited by 12

Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters

Leuenberger, M., Häusler, S., Höhn, V., Euler, A., Stieger, B., & Lochner, M. (2021) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000449 · Cited by 12

Moxibustion improves experimental colitis in rats with Crohn’s disease by regulating bile acid enterohepatic circulation and intestinal farnesoid X receptor

Shen, J., Qi, Q., Han, D. K., Lü, Y., Huang, R., Zhu, Y., Zhang, L., Qin, X.-D., Zhang, F., Wu, H., et al. (2023) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2023.01.001 · Cited by 12

Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues

Overbey, E. G., Ng, T. T., Catini, P., Griggs, L., Stewart, P., Tkalčić, S., Hawkins, R. D., & Drechsler, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.664424 · Cited by 12

Ex vivo metabolism kinetics of primary to secondary bile acids via a physiologically relevant human faecal microbiota model

Ng, D. Z. W., Low, A., Tan, A. J. H., Ong, J. H., Kwa, W. T., Lee, J. W. J., & Chan, E. C. Y. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111140 · Cited by 11

Propagating and banking genetically diverse human sapovirus strains using a human duodenal cell line: investigating antigenic differences between strains

Oka, T., Li, T., Yonemitsu, K., Ami, Y., Suzaki, Y., Kataoka, M., Doan, Y. H., Okemoto‐Nakamura, Y., Kobayashi, T., Saito, H., et al. (2024) · Journal of Virology · doi:10.1128/jvi.00639-24 · Cited by 11

Gut microbiota in the development and progression of chronic liver diseases: Gut microbiota-liver axis

Yakut, A. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i3.104167 · Cited by 11

Targeting the gut microbiota-bile acid axis: Therapeutic strategies for cholestatic liver disease and metabolic dysfunction-associated steatotic liver disease

Zhao, X., Li, R., Sun, R., Pan, Q., Lu, H., & Chai, J. (2025) · EngMedicine · doi:10.1016/j.engmed.2025.100088 · Cited by 11

Bile acid binding capacity, dietary fibre and phenolic contents of modern and old bread wheat varieties and landraces: a comparison over the course of around one century

Çetiner, B., Tömösközi, S., Schall, E., Salantur, A., & Köksel, H. (2021) · European Food Research and Technology · doi:10.1007/s00217-021-03906-8 · Cited by 11

Bile Acids and Short-Chain Fatty Acids Are Modulated after Onion and Apple Consumption in Obese Zucker Rats

Balderas, C., de Ancos, B., & Sánchez‐Moreno, C. (2023) · Nutrients · doi:10.3390/nu15133035 · Cited by 11

Effects of dietary supplementation with bile acids on growth performance, antioxidant capacity, lipid metabolism, and cecal microbiota of Danzhou chickens

Yu, X., Cao, T., Ipemba, E., Bakala, G. B., Leveut, L. G. D., Peng, W., Ji, F., Li, H., Xu, L., & Wu, H. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105276 · Cited by 11

Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia

Laue, T., & Baumann, U. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2151890 · Cited by 11

Preservation of conjugated primary bile acids by oxygenation of the small intestinal microbiota in vitro

Firrman, J., Friedman, E. S., Hecht, A. L., Strange, W. C., Narrowe, A. B., Mahalak, K. K., Wu, G. D., & Liu, L. (2024) · mBio · doi:10.1128/mbio.00943-24 · Cited by 10

Glycodeoxycholic Acid Inhibits Primary Bile Acid Synthesis With Minor Effects on Glucose and Lipid Homeostasis in Humans

Meessen, E. C. E., Majait, S., Ay, Ü., Damink, S. W. M. O., Romijn, J. A., Holst, J. J., Hartmann, B., Kuipers, F., Nieuwdorp, M., Schaap, F. G., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae399 · Cited by 10

Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis

Chen, J., Zhang, L., Chen, Y., Yan, Y., & Lu, C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157108 · Cited by 10

A Narrative Review on the Functional Applications, Safety, and Probiotic Characteristics of Pichia

Samiksha, F., Valentin, E. M. D. S., Li, G., Blazer, M., McCormick, T. S., & Ghannoum, M. A. (2025) · Nutrients · doi:10.3390/nu17223594 · Cited by 10

Interactions of bile acids and gut microbiota modulate neurological health: a comprehensive review on mechanisms and therapeutic potential of dietary phytochemicals

Wang, J., Zhang, Y., Wu, Q., Zhong, Y., Xu, Z., & Yang, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1757551 · Cited by 10

Developmental Expression of Drug Transporters and Conjugating Enzymes Involved in Enterohepatic Recycling: Implication for Pediatric Drug Dosing

Thakur, A., Subash, S., Ahire, D. S., & Prasad, B. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3409 · Cited by 10

Molecular Cloning and Characterization of a Fasciola gigantica Nuclear Receptor Subfamily 1 (FgNR1)

Martviset, P., Chantree, P., Chaimon, S., Torungkitmangmi, N., Prathaphan, P., Ruangtong, J., Sornchuer, P., Thongsepee, N., Sangpairoj, K., & Adisakwattana, P. (2022) · Pathogens · doi:10.3390/pathogens11121458 · Cited by 10

Diagnostic approaches for infants with cholestatic liver diseases: Position paper and perspectives of the Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition

Chen, H., Taylor, S. A., Lee, W. S., Ciocca, M. E., El‐Guindi, M. A., Yachha, S. K., Fawaz, R. L., Botero, V., Treepongkaruna, S., Gonzales, E. M., et al. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70207 · Cited by 9

The role of the gut-liver axis in modulating non-alcoholic fatty liver disease through dietary patterns and microecological agents

Fang, Y., Fang, Z., Li, Z., Yu, R., Zhang, H., Wang, Q., Cheng, X., Le, G., & Wu, G. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103335 · Cited by 9

Bile Acid Alterations Characterize the Early Onset and Progression of Nonalcoholic Fatty Liver Disease in Young Mice Fed with High Fat and Fructose Diet

Xiang, W., Liu, A., Xu, C., Zhang, D., Li, W., & Ni, Y. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200636 · Cited by 9

Bile Acid Metabolism During Development

Karpen, H. E., & Karpen, S. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00095-0 · Cited by 9

An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut

Spiga, L., Fansler, R. T., Wu, Y., Grote, A., Langford-Butler, M., Miller, A. K., Neal, M. J., Hale, O. F., Singla, D., Calcutt, M. W., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.012 · Cited by 8

The microbiota-gut-brain axis in Huntington’s disease: Evidence, mechanisms and therapeutic opportunities

Gu, Y., Wang, M., & Mao, Y. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101247 · Cited by 9

Gut microbiota-liver-kidney axis in diabetic kidney disease: mechanistic insights into amino acid metabolism and nutritional intervention strategies targeting natural bioactive compounds

Sun, L.-Y., Sun, G.-Y., Nan, Y., Wang, H., Sun, Y., Shi, Y., Yang, Y., & Wang, Q.-F. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778473 · Cited by 8

Lipids

Jones, P. J. H., & Lichtenstein, A. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-66162-1.00004-4 · Cited by 8

Associations between Ileal Juice Bile Acids and Colorectal Advanced Adenoma

Luu, H. N., Tran, C., Wang, R., Nguyen, M. V., Tran, M. T., Tuong, T. T., Tran, Q., Le, L. C., Pham, H., Vu, H. T., et al. (2023) · Nutrients · doi:10.3390/nu15132930 · Cited by 8

Chronic small intestinal helminth infection perturbs bile acid homeostasis and disrupts bile acid signaling in the murine small intestine

Lane, J. M., Brosschot, T. P., Gatti, D. M., Gauthier, C. M., Lawrence, K. M., Pluzhnikova, V., & Reynolds, L. A. (2023) · Frontiers in Parasitology · doi:10.3389/fpara.2023.1214136 · Cited by 8

An Innovative Enzymatic Surface Plasmon Resonance-Based Biosensor Designed for Precise Detection of Glycine Amino Acid

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Metabolismo en rumiantes y su asociación con analitos bioquímicos sanguíneos

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Pregnane X receptor as a therapeutic target for cholestatic liver injury

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Synthesis of 12β-Methyl-18-nor-bile Acids

Luxenburger, A., Harris, L. D., Ure, E. M., Aponte, R. A. L., Woolhouse, A. D., Cameron, S. A., Ling, C. D., Piltz, R. O., Lewis, A. R., Gainsford, G. J., et al. (2021) · ACS Omega · doi:10.1021/acsomega.1c04199 · Cited by 8

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

Zhang, M., Zhong, J., Shen, Y., & Song, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1533141 · Cited by 7

Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization

Li, T., & Jing, W. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1565778 · Cited by 7

The Collaborative Collapse: Bile Acid Dysmetabolism as a Central Pathogenic Driver in Canine and Feline Multi-Systemic Disorders—From Mechanisms to Precision Therapeutics

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The gut microbiome–bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases

Shou, J., & Fu, T. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2665890 · Cited by 7

Fat Malabsorption and Ursodeoxycholic Acid Treatment in Children With Reduced Organic Solute Transporter‐α ( SLC51A ) Expression

Tronstad, R. R., Berland, S., Tjora, E., Jellas, K. E., Aukrust, I., Kristensen, K., Tveitnes, D., Molven, A., Marschall, H., Rao, A., et al. (2022) · JPGN Reports · doi:10.1097/pg9.0000000000000229 · Cited by 7

Postoperative diarrhea in Crohn’s disease: Pathogenesis, diagnosis, and therapy

Wu, E.-H., Guo, Z., & Zhu, W. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i1.7 · Cited by 7

Adaptations in Gastrointestinal Nutrient Absorption and its Determinants During Pregnancy in Monogastric Mammals: A Scoping Review

Overduin, T. S., Page, A. J., Young, R. L., & Gatford, K. L. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae064 · Cited by 7

Gut Microbiota and Its Metabolite Taurine-β-Muricholic Acid Contribute to Antimony- and/or Copper-Induced Liver Inflammation

Wu, D., Lin, Q., Hou, S., Cui, X., Shou, N., Yuan, X., Xu, W., Fu, K., Wang, Q., & Shi, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073332 · Cited by 7

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Felton, J. M., Cheng, K., Said, A. H., Shang, A. C., Xu, S., Vivian, D., Metry, M., Polli, J. E., & Raufman, J. (2016) · Journal of Visualized Experiments · doi:10.3791/54597 · Cited by 7

Correlation analysis between jejunum metabolites and immune function in Saba and Landrace piglets

He, Y., Li, Y., Pan, Y., Li, A., Huang, Y., Mi, Q., Zhao, S., Zhang, C., Ran, J., Hu, H., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1069809 · Cited by 7

Featuring molecular regulation of bile acid homeostasis in pediatric short bowel syndrome

Mutanen, A., & Pakarinen, M. P. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102220 · Cited by 7

Application of bacteria and bacteriophage cocktails for biological control of houseflies

Zhang, K., Wang, S., Li, Y., Yin, Y., Zhang, X., Zhang, Q., Kong, X., Liu, W., Yao, D., Zhang, R., et al. (2024) · Parasites & Vectors · doi:10.1186/s13071-023-06082-8 · Cited by 7

Regionalization of intestinal microbiota and metabolites in the small intestine of the Bactrian camel

Cheng, Y., Ren, Y. X., Zhang, W., Lu, J., Xie, F., Fang, Y.-D., Fan, X., He, W., & Wang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1464664 · Cited by 7

N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: Radiosynthesis and proof-of-concept studies in rats

Frisch, K., Stimson, D. H. R., Venkatachalam, T. K., Pierens, G. K., Keiding, S., Reutens, D. C., & Bhalla, R. (2018) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2018.04.004 · Cited by 7

In vitro models to measure effects on intestinal deconjugation and transport of mixtures of bile acids

Zhang, N., Zheng, W., Bakker, W., van Ravenzwaay, B., & Rietjens, I. M. C. M. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110445 · Cited by 7

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Ferrebee, C. B., & Dawson, P. A. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.001 · Cited by 131

Advances in research on the effects of bile acids and their receptors on intestinal function

Cheng, Y., Zhang, L., Zhang, M., & Yu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1821418 · Cited by 6

Meetings and Courses

Lei, S.-Y. (2015) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(15)60407-6

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Cai, J., Rimal, B., Jiang, C., Chiang, J. Y. L., & Patterson, A. D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108238 · Cited by 529

A Recent Ten-Year Perspective: Bile Acid Metabolism and Signaling

Shulpekova, Y. O., Shirokova, E. N., Жаркова, М. С., Tkachenko, P. E., Тихонов, И. Н., Stepanov, A. A., Sinitsyna, A. A., Izotov, A., Butkova, T. V., Shulpekova, N. V., et al. (2022) · Molecules · doi:10.3390/molecules27061983 · Cited by 77