Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants
Abstract
Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinical study was performed on 69 preterm infants (<37 gestation wk). Weight gain was defined as the primary outcome measure. In antibiotic-treated infants, probiotic supplementation resulted in a higher body weight compared with placebo (p < 0.001). In the probiotic group, the fecal pH was significantly lower than in the placebo group. The fecal concentrations of acetate and lactate were 42 and 38% higher, respectively, in the probiotic group than in the placebo group. Fecal calprotectin was lower in the probiotic group (p = 0.041), while fecal IgA was higher in this group compared with the placebo group (p = 0.021).
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Bifidobacterium lactis Bb12 increased the fecal level of acetate and lactate in preterm infants.
“the Bifidobacterium lactis Bb12 increased the fecal level of acetate and lactate in preterm infants [243]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [243]
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- Authors
- Mohan, R., Koebnick, C., Schildt, J., Mueller, M., Radke, M., & Blaut, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- Kaiser Permanente (US)
- Klinikum Ernst von Bergmann (DE)
- Venue
- Pediatric Research
- Published
- 2008-10
- Volume
- 64
- Issue
- 4
- Pages
- 418-422
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W2087655186
- Cited by
- 165
- References
- 29
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 13 · 2012: 11
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium animalis subsp. lactis BB-12, probiotics, preterm infants, weight gain, fecal pH, calprotectin, secretory IgA, intestinal bacterial colonization
- MeSH terms
- Acetates, Bifidobacterium, Body Weight, Feces, Humans, Hydrogen-Ion Concentration, Immunoglobulin A, Infant, Newborn, Infant, Premature, Lactic Acid, Dietary Supplements, Probiotics, Leukocyte L1 Antigen Complex
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