Cited by 165Infant Nutrition and HealthProbiotics and Fermented FoodsGut microbiota and health

Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants

Mohan, Ruchika, Koebnick, Corinna, Schildt, Janko, Mueller, Manfred, Radke, Michael, Blaut, Michael·2008·Pediatric Research

Abstract

Preterm infants are prone to abnormal bacterial colonization of the intestine with ensuing adverse health effects. To examine whether the oral application of Bifidobacterium lactis Bb12 (probiotic) may improve selected indicators of health status in preterm infants, a double blind, placebo controlled randomized clinical study was performed on 69 preterm infants (<37 gestation wk). Weight gain was defined as the primary outcome measure. In antibiotic-treated infants, probiotic supplementation resulted in a higher body weight compared with placebo (p < 0.001). In the probiotic group, the fecal pH was significantly lower than in the placebo group. The fecal concentrations of acetate and lactate were 42 and 38% higher, respectively, in the probiotic group than in the placebo group. Fecal calprotectin was lower in the probiotic group (p = 0.041), while fecal IgA was higher in this group compared with the placebo group (p = 0.021).

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Crossref · 10.1203/pdr.0b013e318181b7fa

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Authors
Mohan, R., Koebnick, C., Schildt, J., Mueller, M., Radke, M., & Blaut, M.
Affiliations
  • German Institute of Human Nutrition (DE)
  • Kaiser Permanente (US)
  • Klinikum Ernst von Bergmann (DE)
Venue
Pediatric Research
Published
2008-10
Volume
64
Issue
4
Pages
418-422
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
OpenAlex
W2087655186
Cited by
165
References
29
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 9 · 2015: 7 · 2014: 12 · 2013: 13 · 2012: 11
FWCI
9.86
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Bifidobacterium animalis subsp. lactis BB-12, probiotics, preterm infants, weight gain, fecal pH, calprotectin, secretory IgA, intestinal bacterial colonization
MeSH terms
Acetates, Bifidobacterium, Body Weight, Feces, Humans, Hydrogen-Ion Concentration, Immunoglobulin A, Infant, Newborn, Infant, Premature, Lactic Acid, Dietary Supplements, Probiotics, Leukocyte L1 Antigen Complex

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