The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000

Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine

Marik, P. E., Pastores, S. M., Annane, D., Meduri, G. U., Sprung, C. L., Arlt, W., Keh, D., Briegel, J., Beishuizen, A., Dimopoulou, I., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817603ba · Cited by 912

Depressive disorders and immunity: 20 years of progress and discovery

Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676

Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

Kim, Y.-K., Na, K.-S., Myint, A.-M., & Leonard, B. E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.008 · Cited by 620

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

Iwata, M., Ota, K. T., & Duman, R. S. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.008 · Cited by 580

Glucocorticoids, cytokines and brain abnormalities in depression

Zunszain, P. A., Anacker, C., Cattaneo, A., Carvalho, L. A., & Pariante, C. M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.011 · Cited by 554

Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection

Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance

Webster, J. C., Oakley, R. H., Jewell, C. M., & Cidlowski, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121455098 · Cited by 482

Higher Than Normal Plasma Interleukin-6 Concentrations in Cancer Patients With Depression: Preliminary Findings

Musselman, D. L., Miller, A. H., Porter, M. R., Manatunga, A. K., Gao, F., Penna, S., Pearce, B. D., Landry, J. C., Glover, S. G., McDaniel, J. S., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1252 · Cited by 444

Cytokines and neuro–immune–endocrine interactions: a role for the hypothalamic–pituitary–adrenal revolving axis

Haddad, J. J., Saadé, N. E., & Safieh‐Garabedian, B. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00357-0 · Cited by 416

Adrenal Insufficiency in the Critically Ill

Marik, P. E., & Zaloga, G. P. (2002) · CHEST Journal · doi:10.1378/chest.122.5.1784 · Cited by 387

Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

Pariante, C. M. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.04.001 · Cited by 382

Adrenal insufficiency during septic shock*

Marik, P. E., & Zaloga, G. P. (2003) · Critical Care Medicine · doi:10.1097/00003246-200301000-00022 · Cited by 378

Immune suppression and immune activation in depression

Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338

Cytokines and Glucocorticoid Receptor Signaling

Pace, T. W. W., & Miller, A. H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04984.x · Cited by 339

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

Czarny, P., Wigner, P., Galecki, P., & Sliwinski, T. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.036 · Cited by 310

Inflammation and Depression

Zunszain, P. A., Hepgul, N., & Pariante, C. M. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_211 · Cited by 327

Interleukin 18 in the CNS

Alboni, S., Cervia, D., Sugama, S., & Conti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-9 · Cited by 306

Cytokines and depression: The need for a new paradigm

Capuron, L., & Dantzer, R. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00078-8 · Cited by 282

Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

Lagraauw, H. M., Kuiper, J., & Bot, I. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.007 · Cited by 289

Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?

Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247

Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement

Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.037 · Cited by 225

Lifetime stress exposure and health: A review of contemporary assessment methods and biological mechanisms

Shields, G. S., & Slavich, G. M. (2017) · Social and Personality Psychology Compass · doi:10.1111/spc3.12335 · Cited by 244

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age

van den Biggelaar, A. H. J., Gussekloo, J., de Craen, A. J. M., Frölich, M., Stek, M. L., van der Mast, R. C., & Westendorp, R. G. J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.01.011 · Cited by 209

Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients

Matthews, J. G., Ito, K., Barnes, P. J., & Adcock, I. M. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.018 · Cited by 204

Interleukin-6, Cortisol, and Depressive Symptoms in Ovarian Cancer Patients

Lutgendorf, S. K., Weinrib, A., Penedo, F. J., Russell, D. W., DeGeest, K., Costanzo, E. S., Henderson, P. J., Sephton, S. E., Rohleder, N., Lucci, J. A., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.1978 · Cited by 201

Do antidepressants regulate how cortisol affects the brain?

Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.009 · Cited by 194

The glucocorticoid receptor: part of the solution or part of the problem?

Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192

Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior

Raison, C. L., Borisov, A. S., Woolwine, B. J., Massung, B., Vogt, G., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.58 · Cited by 183

Stress, glucocorticoids and ageing of the immune system

Bauer, M. E. (2005) · Stress · doi:10.1080/10253890500100240 · Cited by 191

O eixo hipotálamo-pituitária-adrenal, a função dos receptores de glicocorticóides e sua importância na depressão

Juruena, M. F., Cleare, A. J., & Pariante, C. M. (2004) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462004000300009 · Cited by 185

Social stress increases the susceptibility to endotoxic shock

Quan, N., Avitsur, R., Stark, J. L., He, L., Shah, M., Caligiuri, M., Padgett, D. A., Marucha, P. T., & Sheridan, J. F. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00273-9 · Cited by 177

Major Depression: One Brain, One Disease, One Set of Intertwined Processes

Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 186

Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL-23 Cytokine Stimulation in Peripheral Mononuclear Cells

Vazquez‐Tello, A., Halwani, R., Hamid, Q. A., & Al‐Muhsen, S. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9828-3 · Cited by 161

Stress-induced sex differences: Adaptations mediated by the glucocorticoid receptor

Bourke, C. H., Harrell, C. S., & Neigh, G. N. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.024 · Cited by 166

Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters

Pariante, C. M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A. H., & Kerwin, R. W. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704368 · Cited by 159

Therapeutic Strategies for Treatment of Inflammation-related Depression

Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 162

Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids

Prigent, H., Maxime, V., & Annane, D. (2004) · Critical Care · doi:10.1186/cc2878 · Cited by 155

Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Pariante, C. M. (2004) · Stress · doi:10.1080/10253890500069650 · Cited by 147

Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder

Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.003 · Cited by 150

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Suda, K., & Matsuda, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031172 · Cited by 154

How does stress affect you? An overview of stress, immunity, depression and disease

Maddock, C., & Pariante, C. M. (2001) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00005285 · Cited by 145

Brain-immune interactions and disease susceptibility

Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 134

Interleukin 1α (IL-1α) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function

Wang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128

Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder

Carvalho, L. A., Bergink, V., Sumaski, L., Wijkhuijs, J. M., Hoogendijk, W. J. G., Birkenhäger, T. K., & Drexhage, H. A. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.118 · Cited by 130

Depression as a Risk Factor for Cancer: From Pathophysiological Advances to Treatment Implications

Currier, M. B., & Nemeroff, C. B. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-061212-171507 · Cited by 126

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Tatro, E. T., Everall, I. P., Kaul, M., & Achim, C. L. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.036 · Cited by 125

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124

Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway

Bailey, M. T., Engler, H., Powell, N. D., Padgett, D. A., & Sheridan, J. F. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00307.2007 · Cited by 124

Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome

Raddatz, D., hl, M. B., & Ramadori, G. P. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200505000-00012 · Cited by 124

Glucocorticoids in Sepsis: To Be or Not to Be

Vandewalle, J., & Libert, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01318 · Cited by 125

Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects

Rohleder, N., Wolf, J. M., & Kirschbaum, C. (2003) · Stress · doi:10.1080/1025389031000153658 · Cited by 118

Inflammation, Self-Regulation, and Health: An Immunologic Model of Self-Regulatory Failure

Shields, G. S., Moons, W. G., & Slavich, G. M. (2017) · Perspectives on Psychological Science · doi:10.1177/1745691616689091 · Cited by 121

Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases

Newton, R. C., Leigh, R., & Giembycz, M. A. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.003 · Cited by 117

Cortisol, cytokines, and hippocampal volume interactions in the elderly

Sudheimer, K. D., O'Hara, R. M., Spiegel, D., Powers, B. N., KRAEMER, H. C., Neri, E., Weiner, M. W., Hardan, A. Y., Hallmayer, J. F., & Dhabhar, F. S. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00153 · Cited by 115

Cortisol awakening response in patients with psychosis: systematic review and meta-analysis

Berger, M., Kraeuter, A. K., Romanik, D., Malouf, P., Amminger, G. P., & Sarnyai, Z. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.027 · Cited by 109

Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study

Timonen, M., Jokelainen, J. J., Hakko, H. H., Silvennoinen‐Kassinen, S., Meyer‐Rochow, V. B., Herva, A., & Räsänen, P. K. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001274 · Cited by 108

Inflaming sex differences in mood disorders

Rainville, J. R., & Hodes, G. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0124-7 · Cited by 112

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries

Martinez, G. J., Appleton, M., Kipp, Z. A., Loria, A. S., Min, B., & Hinds, T. D. (2023) · Physiological Reviews · doi:10.1152/physrev.00021.2023 · Cited by 115

CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor-α and Interferon-γ by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor β Isoform

Tliba, O., Cidlowski, J. A., & Amrani, Y. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.019679 · Cited by 103

Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen

Engler, H., Bailey, M. T., Engler, A., Stiner-Jones, L. M., Quan, N., & Sheridan, J. F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.007 · Cited by 97

Altered glucocorticoid immunoregulation in treatment resistant depression

Bauer, M. E., Papadopoulos, A. S., Poon, L., Perks, P., Lightman, S. L., Checkley, S. A., & Shanks, N. M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00009-4 · Cited by 91

Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters

Pariante, C. M., Kim, R. B., Makoff, A., & Kerwin, R. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705357 · Cited by 89

Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment

Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88

Cytokine alterations and cognitive impairment in major depressive disorder: From putative mechanisms to novel treatment targets

Misiak, B., Beszłej, J. A., Kotowicz, K., Szewczuk-Bogusławska, M., Samochowiec, J., Kucharska–Mazur, J., & Frydecka, D. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.021 · Cited by 87

Psychopharmacological Treatment of Depression, Anxiety, Irritability and Insomnia in Patients Receiving Interferon-α: a Prospective Case Series and a Discussion of Biological Mechanisms

Maddock, C., Baita, A., Orrù, M. G., Sitzia, R., Costa, A., Muntoni, E., Farci, M. G., Carpiniello, B., & Pariante, C. M. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040230 · Cited by 85

The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition

Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00136 · Cited by 86

Stress-Related Immune Markers in Depression: Implications for Treatment

Hughes, M. M., Connor, T. J., & Harkin, A. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw001 · Cited by 91

Examination of peripheral basal and reactive cortisol levels in major depressive disorder and the burnout syndrome: A systematic review

Rothe, N., Steffen, J., Penz, M. S., Kirschbaum, C., & Walther, A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.024 · Cited by 90

Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in depression: A meta-analysis

Su, M., Ouyang, X., & Song, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.038 · Cited by 80

Does Cortisol Mediate Endotoxin-Induced Inhibition of Pulsatile Luteinizing Hormone and Gonadotropin-Releasing Hormone Secretion?

Debus, N., Breen, K. M., Barrell, G. K., Billings, H. J., Brown, M. E., Young, E. A., & Karsch, F. J. (2002) · Endocrinology · doi:10.1210/en.2002-220291 · Cited by 80

Hypothalamic-Pituitary Cytokine Network

Kariagina, A., Romanenko, D., Ren, S.-G., & Chesnokova, V. (2003) · Endocrinology · doi:10.1210/en.2003-0669 · Cited by 79

Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol

Edwards, K. M., Bosch, J. A., Engeland, C. G., Cacioppo, J. T., & Marucha, P. T. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.03.011 · Cited by 76

Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression

Carvalho, L. A., Juruena, M. F., Papadopoulos, A. S., Poon, L., Kerwin, R., Cleare, A. J., & Pariante, C. M. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.44 · Cited by 75

Dominance of the strongest: Inflammatory cytokines versus glucocorticoids

Dejager, L., Vandevyver, S., Πέττα, Ι., & Libert, C. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.12.006 · Cited by 78

The Relationship of Cancer Symptom Clusters to Depressive Affect in the Initial Phase of Palliative Radiation

Francoeur, R. B. (2005) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2004.04.014 · Cited by 73

Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2×2 clinical trial

Savitz, J. B., Preskorn, S., Teague, T. K., Drevets, D. A., Yates, W. R., & Drevets, W. (2012) · BMJ Open · doi:10.1136/bmjopen-2011-000643 · Cited by 73

Deciphering sex differences in the immune system and depression

Rainville, J. R., Tsyglakova, M., & Hodes, G. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.12.004 · Cited by 73

Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy

Hapgood, J. P., Avenant, C., & Moliki, J. M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.06.002 · Cited by 72

Mechanisms and clinical consequences of critical illness associated adrenal insufficiency

Marik, P. E. (2007) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32818a6d74 · Cited by 71

The Antidepressant Clomipramine Regulates Cortisol Intracellular Concentrations and Glucocorticoid Receptor Expression in Fibroblasts and Rat Primary Neurones

Pariante, C. M., Hye, A., Williamson, R., Makoff, A., Lovestone, S., & Kerwin, R. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300195 · Cited by 70

Inescapable shock induces resistance to the effects of dexamethasone

O’Connor, K. A., Johnson, J. D., Hammack, S. E., Brooks, L. M., Spencer, R. L., Watkins, L. R., & Maier, S. F. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00035-5 · Cited by 69

In vitromodulation of the glucocorticoid receptor by antidepressants

Carvalho, L. A., & Pariante, C. M. (2008) · Stress · doi:10.1080/10253890701850759 · Cited by 69

Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression

FITZGERALD, P., O'BRIEN, S. M., SCULLY, P., RIJKERS, K., SCOTT, L. V., & DINAN, T. G. (2006) · Psychological Medicine · doi:10.1017/s003329170500632x · Cited by 66

Cause or consequence? Understanding the role of cortisol in the increased inflammation observed in depression

Amasi-Hartoonian, N., Sforzini, L., Cattaneo, A., & Pariante, C. M. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100356 · Cited by 77

Sepsis: State of the art

Marik, P. E., & Varón, J. (2001) · Disease-a-Month · doi:10.1067/mda.2001.119745 · Cited by 62

Low-dose hydrocortisone in pediatric septic shock: An exploratory study in a third world setting

Valoor, H. T., Singhi, S. C., & Jayashree, M. (2009) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181936ab3 · Cited by 61

Inflammatory Stimuli Inhibit Glucocorticoid-Dependent Transactivation in Human Pulmonary Epithelial Cells: Rescue by Long-Acting β2-Adrenoceptor Agonists

Rider, C. F., King, E. M., Holden, N. S., Giembycz, M. A., & Newton, R. C. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.181016 · Cited by 60

Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders

Juruena, M. F., Cleare, A. J., Bauer, M. E., & Pariante, C. M. (2003) · Acta Neuropsychiatrica · doi:10.1046/j.1601-5215.2003.00051.x · Cited by 59

Glucocorticoid Sensitivity Is Highly Variable in Critically Ill Patients With Septic Shock and Is Associated With Disease Severity*

Cohen, J., Pretorius, C. J., Ungerer, J. P. J., Cardinal, J., Blumenthal, A., Presneill, J., Gatica-Andrades, M., Jarrett, P., Lassig-Smith, M., Stuart, J., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001633 · Cited by 58

The Phosphodiesterase Type 4 Inhibitor, Rolipram, Enhances Glucocorticoid Receptor Function

Miller, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00381-0 · Cited by 57

Glucocorticoids and Inflammation: A Double-Headed Sword in Depression?

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