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Developmental Programming, a Pathway to Disease

Padmanabhan, Vasantha, Cardoso, Rodolfo C., Puttabyatappa, Muraly·2016·Endocrinology
DOI 10.1210/en.2016-1003
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Abstract

Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions.

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Metadata

Authors
Padmanabhan, V., Cardoso, R. C., & Puttabyatappa, M.
Affiliations
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109–5718
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2016-02-09
Volume
157
Issue
4
Pages
1328-1340
ISSN
  • 0013-7227
  • 1945-7170
DOI
10.1210/en.2016-1003
Cited by
208
References
26
Language
en

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