Cited by 63Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Homologous regulation of brain oxytocin receptors.

Insel, T R, Winslow, J T, Witt, D M·1992·Endocrinology

DOI 10.1210/endo.130.5.1315251

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Abstract

Specific receptors for oxytocin have been identified in rat forebrain. Previous studies have demonstrated that in select regions, these receptors are dependent on heterologous induction by gonadal steroids. To investigate whether brain oxytocin receptors are homologously regulated by oxytocin, we measured oxytocin receptor binding after hypothalamic paraventricular nucleus lesions, repeated central injections of oxytocin, and continuous central infusion of oxytocin via osmotic minipump. Neither lesions of the paraventricular nucleus nor repeated oxytocin injections altered the binding of the selective oxytocin receptor ligand [125I]OTA [125I] d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH2(9)] ornithine vasotocin, as measured by in vitro receptor autoradiography. After 10 days of continuous oxytocin infusion by osmotic minipump, oxytocin receptor binding decreased in every target field by at least 50%. This decrease appeared to represent a down-regulation of receptors and not displacement by exogenous peptide, as it persisted for at least 24 h after pump removal, and binding remained reduced in the presence of a saturating concentration of [125I] OTA. Reduction of oxytocin receptors in response to increased oxytocin release may represent an important physiological mechanism for the regulation of central oxytocin neurotransmission.

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Additional file 1 of Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms
Kato, Y., Kuwabara, H., Okada, T., Munesue, T., Benner, S., Kuroda, M., Kojima, M., Yassin, W., Eriguchi, Y., Kameno, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14100733
Additional file 2 of Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms
Kato, Y., Kuwabara, H., Okada, T., Munesue, T., Benner, S., Kuroda, M., Kojima, M., Yassin, W., Eriguchi, Y., Kameno, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14100736

Authors: Insel, T. R., Winslow, J. T., & Witt, D. M.
Affiliations: National Institute of Mental Health (US)
ORCID: Insel, T R
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1992-05
Volume: 130
Issue: 5
Pages: 2602-2608
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.130.5.1315251
OpenAlex: W2089520243
Cited by: 63
References: 18
Citations by year: 2025: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
FWCI: 6.87
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin receptor, receptor down-regulation, paraventricular nucleus, forebrain, receptor binding, arginine vasotocin, hypothalamus
MeSH terms: Animals, Autoradiography, Brain, Cerebral Ventricles, Injections, Intraventricular, Iodine Radioisotopes, Male, Organ Specificity, Oxytocin, Paraventricular Hypothalamic Nucleus, Rats, Inbred Strains, Receptors, Angiotensin, Stereotaxic Techniques, Receptors, Oxytocin, Rats

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Homologous regulation of brain oxytocin receptors.

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