The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Stimulatory Effect of Leptin on the Neuroendocrine Reproductive Axis of the Monkey1
Abstract
Leptin acts as a metabolic activator of the neuroendocrine reproductive axis in several rodent species, but whether leptin plays a similar role in primates is unknown. To explore this question, we examined the effects of leptin on gonadotropin and testosterone secretion in male rhesus monkeys that were fasted for 2 days. Mean plasma levels of LH and FSH, LH pulse frequency, and LH pulse amplitude were significantly higher in leptin-treated animals compared with saline-treated controls during the second day of the fast. To identify targets for leptin's action, we used in situ hybridization and computerized imaging to map leptin receptor (Ob-R) messenger RNA (mRNA) distribution. Ob-R mRNA was observed in the anterior pituitary and several areas of the brain, including the arcuate and ventromedial nuclei of the hypothalamus. Ob-R mRNA was coexpressed in both POMC and neuropeptide Y neurons in the arcuate nucleus, whereas little or no coexpression of Ob-R mRNA was evident in GnRH neurons. These results suggest that leptin is a metabolic signal to the reproductive axis in primates and imply that both POMC and neuropeptide Y neurons are involved in mediating leptin's effects in the brain.
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Cites
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Cited by
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Metadata
- Authors
- Finn, P. D., Cunningham, M. J., Pau, K.-Y. F., Spies, H. G., Clifton, D. K., & Steiner, R. A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1998-11
- Volume
- 139
- Issue
- 11
- Pages
- 4652-4662
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2127864011
- Cited by
- 294
- References
- 10
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- closed
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