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Cited by 234Thyroid Disorders and TreatmentsHormonal and reproductive studiesThyroid Cancer Diagnosis and Treatment

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Complex alteration of thyroid function in healthy centenarians.

Mariotti, S, Barbesino, G, Caturegli, P, Bartalena, L, Sansoni, P, Fagnoni, F, Monti, D, Fagiolo, U, Franceschi, C, Pinchera, A·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.77.5.8077303
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Abstract

Several changes in thyroid function have been described in the elderly and largely attributed to concomitant nonthyroidal illness. The extent to which aging per se contributes to these changes remains to be elucidated, and scanty data are available in extremely old subjects. The present study was designed to focus on thyroid function during physiological aging, taking advantage of two groups of selected aged individuals: group A of healthy centenarians (n = 41; age range, 100-110 yr) and group B including healthy elderly subjects selected by the criteria of the EURAGE SENIEUR protocol (n = 33; age range, 65-80 yr). Control groups included 98 healthy normal adult subjects (group C; age range, 20-64 yr) and 52 patients with miscellaneous nonthyroidal illness (group D; age range, 28-82 yr). Our previous report of a low prevalence of thyroid autoantibodies in centenarians was confirmed and extended by the finding of a similar low autoantibody prevalence in the highly selected healthy elderly population of group B. Subclinical primary hypothyroidism was found in 3 (7.3%) centenarians, and their data were excluded from further statistical evaluation. No significant difference was found in the median serum free T4 levels of groups A-C. Median (and range) serum free T3 (FT3) was lower in centenarians [3.67 pmol/L (2.3-5.5)] than in group B [5.22 pmol/L (3.4-6.1)] and group C [5.38 pmol/L (2.9-8.4); P < 0.0001 vs. both groups]. Similarly, the median serum TSH level of centenarians [0.97 mU/L (< 0.09 to 2.28)] was lower than those in groups B [1.17 mU/L (0.53-2.74)] and C [1.7 mU/L (0.4-4.8); P < 0.0001 vs. both groups]; moreover, serum TSH was also significantly (P < 0.01) lower in group B than in group C. Both serum FT3 and TSH concentrations showed a significant inverse correlation (r = -0.634; P < 0.0001 and r = -0.377; P < 0.0001, respectively) with age. Median serum FT3 in centenarians was lower than that in group D patients [4.61 pmol/L (2.15-6.6); P < 0.0001]. In contrast, median serum rT3 in centenarians [0.40 nmol/L (0.20-0.77)], although higher than those in groups B [0.24 nmol/L (0.15-0.37); P < 0.0001] and C [0.22 nmol/L (0.05-0.46); P < 0.0001], was significantly lower than that in group D [0.60 nmol/L (0.13-2.08); P < 0.0001]. In conclusion, thyroid function appears to be well preserved until the eighth decade of life if healthy subjects are studied, whereas a reduction of serum FT3 is observed in extreme aging.(ABSTRACT TRUNCATED AT 400 WORDS)

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Metadata

Authors
Mariotti, S., Barbesino, G., Caturegli, P., Bartalena, L., Sansoni, P., Fagnoni, F., Monti, D., Fagiolo, U., Franceschi, C., & Pinchera, A.
Affiliations
University of Pisa (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-11
Volume
77
Issue
5
Pages
1130-1134
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.77.5.8077303
OpenAlex
W1972724832
Cited by
234
References
20
Citations by year
2025: 3 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 2 · 2019: 7 · 2018: 14 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 14 · 2012: 13
FWCI
4.93
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroid function, centenarians, aging, free T3, free thyroxine, thyroid-stimulating hormone, thyroid autoantibodies, low T3 syndrome, older adults, thyroid hormones, TSH suppression, TSH stimulation test, TSH receptor antibodies
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Autoantibodies, Female, Humans, Iodide Peroxidase, Male, Middle Aged, Reference Values, Thyroglobulin, Thyroid Gland, Thyrotropin, Thyroxine

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