The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison’s Disease in a Randomized, Double Blind Trial
Abstract
Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids. Glucocorticoid and mineralocorticoid deficiencies in Addison's disease require life-long hormone replacement, but the associated failure of DHEA synthesis is not corrected. We conducted a randomized, double blind study in which 39 patients with Addison's disease received either 50 mg oral DHEA daily for 12 weeks, followed by a 4-week washout period, then 12 weeks of placebo, or vice versa. After DHEA treatment, levels of DHEAS and Delta(4)-androstenedione rose from subnormal to within the adult physiological range. Total testosterone increased from subnormal to low normal with a fall in serum sex hormone-binding globulin in females, but with no change in either parameter in males. In both sexes, psychological assessment showed significant enhancement of self-esteem with a tendency for improved overall well-being. Mood and fatigue also improved significantly, with benefit being evident in the evenings. No effects on cognitive or sexual function, body composition, lipids, or bone mineral density were observed. Our results indicate that DHEA replacement corrects this steroid deficiency effectively and improves some aspects of psychological function. Beneficial effects in males, independent of circulating testosterone levels, suggest that it may act directly on the central nervous system rather than by augmenting peripheral androgen biosynthesi…
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“In addition, some (but not all) studies have shown that DHEA replacement in adrenal insufficiency may improve HRQoL and mood, with reduced depression and anxiety scores (114 -116).”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [115]
In the citing paper
“Our previous placebo-controlled 3-month crossover trial of 39 patients (including 15 males) with primary adrenal insufficiency showed similar biochemical changes and enhanced psychological well-being, independent of gender (20).”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“score significantly worse than age-and sexmatched population controls on validated psychological tests that measure well-being (20,21).”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“No changes in body composition, BMD or cognition were demonstrated in any of these short-term studies of DHEA replacement.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“This 12-month study of DHEA replacement in patients with Addison's disease both supports the improved well-being documented in our previous short-term study and adds new information on longer-term effects of DHEA.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“The hormone profile of DHEA-treated subjects was similar to that observed in our previous study (20) with significant increases in androstenedione in both sexes and testosterone in women but not in men.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“Twenty-three subjects had taken part in our previous, short-term trial of DHEA (20) but were distributed comparably across DHEA (n ϭ 9) and placebo (n ϭ 14) groups.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“which is in keeping with observations in some short- (20,48,54) and longer-term trials (25) but differs from observations in women with primary or secondary adrenal failure (23,24).”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“Despite earlier reports suggesting changes in IGF-I with DHEA replacement, both our earlier short-term trial (20) and the present study showed no statistically significant change in circulating IGF-I levels, in agreement with another recent replacement study (50), arguing against a primary role of this hormone in mediating increases in lean muscle mass.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“Interestingly, similar abnormalities in the self-esteem subscale of GHQ-30 occurred in both of our studies [this one and an earlier shorter-term replacement study (20)]”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
In the citing paper
“suggesting there may be a disorderspecific profile of psychological deficit in Addison's disease.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [20]
Citations
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418
Double-blind treatment of major depression with dehydroepiandrosterone.
Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.646 · Cited by 411
Physiological importance of dehydroepiandrosterone.
Eberling, P., & Koivisto, V. A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92587-9 · Cited by 365
Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.10.4306 · Cited by 292
Dehydroepiandrosterone and its sulfate enhance memory retention in mice.
Flood, J. F., Smith, G. E., & Roberts, E. (1988) · Brain Research · doi:10.1016/0006-8993(88)91129-8 · Cited by 227
Arlt, W., Justl, H.-G., Callies, F., Reincke, M., Hübler, D., Oettel, M., Ernst, M., Schulte, H. M., & Allolio, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4850 · Cited by 199
Neuro-steroids: 3β-hydroxy-Δ5-derivatives in rat and monkey brain.
Robel, P., Bourreau, E., Corpéchot, C., Dang, D. C., Halberg, F., Clarke, C., Haug, M., Schlegel, M. L., Synguelakis, M., Vourch, C., et al. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90133-6 · Cited by 175
Research works printed but not linked: 27
- Butenandt, 1934, Isolierung neuen, physiologisch unwirksamen Sterindervates aus Mannerharn, Seine Verknupfung mit Dehdro-androsterone und Androsteron., Z Physiol Chem, 229, 192, 10.1515/bchm2.1934.229.4-6.192 · DOI
- Roberts, 1987, Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice., Brain Res, 406, 357, 10.1016/0006-8993(87)90807-9 · DOI
- Bologa, 1987, Dehydroepiandrosterone, its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures., J Neurosci Res, 17, 225, 10.1002/jnr.490170305 · DOI
- Newcomer, 1994, Glucocorticoid-induced impairment in declarative memory performance in adult humans., J Neurosci, 14, 2047, 10.1523/JNEUROSCI.14-04-02047.1994 · DOI · Paper page
- Landfield, 1978, Hippocampal aging and adrenocorticoids: quantitative correlations., Science, 202, 1098, 10.1126/science.715460 · DOI
- Starkman, 1981, Neuropsychiatric manifestations of patients with Cushing’s syndrome: relationship to cortisol and adrenocorticotrophic hormone levels., Arch Intern Med, 141, 215, 10.1001/archinte.1981.00340020077021 · DOI · Paper page
- Shafagoj, 1992, Dehydroepiandrosterone prevents dexamethasone-induced hypertension in rats, Am J Physiol., 263, E210
- Kimonides, 1999, Dehydroepiandrosterone (DHEA) antagonises the neurotoxic effects of corticosterone, translocation of SAPK 3 in hippocampal primary cultures., Neuroscience, 89, 429, 10.1016/S0306-4522(98)00347-9 · DOI
- Parker, 1978, The adrenarche: prolactin, gonadotropins, adrenal androgens and cortisol., J Clin Endocrinol Metab, 46, 396, 10.1210/jcem-46-3-396 · DOI
- Orentreich, 1984, Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood., J Clin Endocrinol Metab, 59, 551, 10.1210/jcem-59-3-551 · DOI · Paper page
- Barrett-Connor, 1986, A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease., N Engl J Med, 315, 1519, 10.1056/NEJM198612113152405 · DOI · Paper page
- Sambrook, 1992, Postmenopausal bone loss in rheumatoid arthritis: effect of estrogens and androgens., J Rheumatol, 19, 357
- Morales, 1994, Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age., J Clin Endocrinol Metab, 78, 1360
- Diamond, 1996, Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women, J Endocrinol., 150, S43
- Casson, 1998, Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-1 and decreases high-density lipoprotein: a six month trial., Fertil Steril, 70, 107, 10.1016/S0015-0282(98)00121-6 · DOI
- Reidel, 1993, Quality of life in patients with Addison’s disease: effects of different cortisol replacement modes., Exp Clin Endocrinol, 101, 106, 10.1055/s-0029-1211215 · DOI
- Cheetham, 1998, The effects of recombinant human IGF-1 administration on concentrations of acid labile subunit, IGF binding protein-3, IGF-1, IGF-II and proteolysis of IGF binding protein-3 in adolescents with insulin-dependent diabetes mellitus., J Endocrinol, 157, 81, 10.1677/joe.0.1570081 · DOI
- Goodyer, 1996, Adrenal secretion during major depression in 8- to 16- year olds. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation., Psychol Med, 26, 245, 10.1017/S0033291700034644 · DOI
- Guazzo, 1996, Cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate in the cerebrospinal fluid of man: relation to blood levels and the effects of age., J Clin Endocrinol Metab, 81, 3951
- Rust, 1986, The GRISS: a psychometric instrument for the assessment of sexual dysfunction., Arch Sex Behav, 15, 157, 10.1007/BF01542223 · DOI
- Young, 1997, Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in humans., J Clin Endocrinol Metab, 82, 2578
- Arlt, 1999, Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens., J Clin Endocrinol Metab, 84, 2170, 10.1210/jcem.84.6.5789 · DOI
- May, 1991, Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone., Life Sci, 46, 1627
- Wright, 1992, Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats., Int J Obesity, 16, 579
- Davis, 1996, Clinical review: androgens and the postmenopausal woman., J Clin Endocrinol Metab, 21, 227
- Kalmijn, 1998, A prospective study on cortisol, dehydroepiandrosterone sulfate and cognitive function in the elderly., J Clin Endocrinol Metab, 83, 3487, 10.1210/jcem.83.10.5164 · DOI
- Baulieu, 2000, Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue., Proc Natl Acad Sci USA, 97, 4279, 10.1073/pnas.97.8.4279 · DOI · Paper page
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Sorted by citations
Items 101–200 of 339
Androgenic hormones and aging — The link with female sexual function
Davison, S. L., & Davis, S. R. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.12.013 · Cited by 45
Juvenility in the context of life history theory
Hochberg, Z. (2008) · Archives of Disease in Childhood · doi:10.1136/adc.2008.137570 · Cited by 47
“25 It has been suggested that the primary effects of DHEA in humans are neurological and as a mood modulator.(26) 27 In that respect, adrenarche is timely at the age of maturation of the cerebral cortex of 6 years.”
BackgroundMorales, A., Black, A., Emerson, L., Barkin, J., Kuzmarov, I., & Day, A. (2009) · The Aging Male · doi:10.3109/13685530903294388 · Cited by 46
“Our findings also speak against the concept of DHEA as a neurosteroid with a central putative effect on libido [25] although the hormone has been found to have an effect on selfesteem and mood in younger individuals with Addison’s disease [26].”
ResultRice, S., Agarwal, N., Bolusani, H., Newcombe, R. G., Scanlon, M. F., Ludgate, M., & Rees, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2636 · Cited by 40
“In Addison’s disease, early studies demonstrated improvements in mood and self-esteem, with reduced fatigue and variable improvements in sexual function (10, 11), leading to suggestions that DHEA therapy might be considered as part of the standard replacement therapy for these patients.”
BackgroundTestosterone insufficiency in women: fact or fiction?
Guay, A., & Davis, S. (2002) · World journal of urology · doi:10.1007/s00345-002-0267-2 · Cited by 43
“Replacement with oral DHEA reversed these symptoms, as has been shown by others [29].”
BackgroundQuality of life in patients with adrenal disease: A systematic review
Ho, W., & Druce, M. R. (2018) · Clinical Endocrinology · doi:10.1111/cen.13719 · Cited by 43
Replacement therapy for Addison's disease: recent developments
Løvås, K., & Husebye, E. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.4.497 · Cited by 33
“Several clinical trials of oral DHEA replacement therapy in Addison’s disease or secondary adrenal insufficiency, or both, have been published [13,119-122,124-127] .”
BackgroundThe Use of Dehydroepiandrosterone Therapy in Clinical Practice
Cameron, D. R., & Braunstein, G. D. (2005) · Treatments in Endocrinology · doi:10.2165/00024677-200504020-00004 · Cited by 38
Cleare, A., O'Keane, V., & Miell, J. (2004) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00104-5 · Cited by 39
“In this condition, DHEA(-S) levels appear to be reduced in parallel to the reduction in cortisol, and replacement therapy with DHEA appears to give additional benefits over and above that seen with cortisol replacement (Arlt et al., 1999; Hunt et al., 2000).”
BackgroundAdolescent depression, cortisol and DHEA
Angold, A. C. (2003) · Psychological Medicine · doi:10.1017/s003329170300775x · Cited by 41
“On the other hand, outside the nervous system in the peripheral intracrine tissues, they are major metabolic precursors of androgens, particularly in women (Labrie et al. 1997; Hunt et al. 2000), so, once again, there is an enormous range of possible mechanisms by which these compounds could affect depression.”
InfluentialBurri, A. V., Ogata, S., Livshits, G., & Williams, F. M. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140289 · Cited by 34
Dehydroepiandrosterone for the treatment of systemic lupus erythematosus
van Vollenhoven, R. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.1.23 · Cited by 54
Fine tuning for quality of life: 21st century approach to treatment of Addison’s disease
Reisch, N., & Arlt, W. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.01.008 · Cited by 36
Granata, A., Tirabassi, G., Pugni, V., Arnaldi, G., Boscaro, M., Carani, C., & Balercia, G. (2013) · Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02673.x · Cited by 36
Vico, P. Á. R., Cauet, G., Rose, K. A., Lathe, R., & Degryse, E. (2002) · Yeast · doi:10.1002/yea.882 · Cited by 35
“Although DHEA was of benefit in primary adrenal failure (Hunt et al., 2001), confirming an in vivo role, DHEA replacement in old age gave mixed results (e.”
ResultRehabilitation in Endocrine Patients: A Novel Psychosomatic Approach
Sonino, N., & Fava, G. A. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000107558 · Cited by 33
Powrie, Y. S. L., & Smith, C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1324-0 · Cited by 36
Optimal glucocorticoid replacement in adrenal insufficiency
Øksnes, M., Ross, R. J. M., & Løvås, K. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.009 · Cited by 31
DHEA: why, when, and how much – DHEA replacement in adrenal insufficiency
Allolio, B., Arlt, W., & Hahner, S. (2007) · Annales d Endocrinologie · doi:10.1016/j.ando.2007.06.018 · Cited by 24
Ahboucha, S., Talani, G., Fanutza, T., Sanna, E., Biggio, G., Gamrani, H., & Butterworth, R. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.03.020 · Cited by 31
Androgen insufficiency in women
Braunstein, G. D. (2006) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2006.03.009 · Cited by 22
Christiansen, J., Gravholt, C., Fisker, S., Møller, N., Andersen, M., Svenstrup, B., Bennett, P., Ivarsen, P., Christiansen, J., & Jørgensen, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01810 · Cited by 31
“DHEA treatment (50 – 200 mg) for 3 months in same model was not followed by alterations in insulin sensitivity estimated by clamp (29) and treatment for 12 weeks in a gendermixed population did not affect insulin sensitivity estimated by homeostasis model assessment ( 7 ).”
MethodChristiansen, J., Andersen, N. H., Sørensen, K., Pedersen, E. M., Bennett, P., Andersen, M., Christiansen, J., Jørgensen, J. O., & Gravholt, C. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02750.x · Cited by 30
Alonso, N., Granada, M. L., Lucas, A., Salinas, I., Reverter, J., Oriol, A., & Sanmartí, A. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345290 · Cited by 30
In the Mood for Sex: The Value of Androgens
Apperloo, M. J. A., van der Stege, J. G., Hoek, A., & Schultz, W. C. M. W. (2003) · Journal of Sex & Marital Therapy · doi:10.1080/716100612-329 · Cited by 32
“In contrast, in a study by Hunt et al. (2000) that treated women with the same dose of DHEA, the subjects did not show any improvements in sexual functioning.”
ResultStrategies for the discovery of anti-aging compounds
Rizvi, S. I., & Jha, R. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.533653 · Cited by 28
“DHEA has been reported to improve mood state in the clinically depressed [101], improve physical and psychological well being in the elderly and middle-aged men and women [102] and correct hormone levels in patients with adrenal deficiencies [103].”
BackgroundAbnormalities in Metabolism and Hypothalamic–Pituitary–Adrenal Axis Function in Schizophrenia
Guest, P. C., Martins‐de‐Souza, D., Vanattou‐Saïfoudine, N., Harris, L. W., & Bahn, S. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00006-7 · Cited by 30
Chapter 17. Selective androgen receptor modulators (SARMs)
Zhi, L., & Martinborough, E. (2001) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(01)36057-8 · Cited by 35
The effects of dehydroepiandrosterone on sexual function: a systematic review
Peixoto, C., Carrilho, C. G., Barros, J. A., Ribeiro, T. T. S. B., Silva, L. M., Nardi, A. E., Cardoso, A., & Veras, A. B. (2017) · Climacteric · doi:10.1080/13697137.2017.1279141 · Cited by 30
Pharmacotherapy for women's sexual dysfunction
Basson, R. J. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903004184 · Cited by 23
“However, RCTs of DHEA supplementation have been conflicting [66-71].”
BackgroundLaureti, S., Falorni, A., & Santeusanio, F. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345252 · Cited by 27
Christiansen, J. J., Bruun, J. M., Christiansen, J. S., Jørgensen, J. O., & Gravholt, C. H. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0289 · Cited by 26
Evo-Devo of Child Growth III: Premature Juvenility as an Evolutionary Trade-Off
Hochberg, Z. (2010) · Hormone Research in Paediatrics · doi:10.1159/000282109 · Cited by 26
Brooke, A. M., Kalingag, L. A., Miraki‐Moud, F., Camacho‐Hübner, C., Maher, K. T., Walker, D. M., Hinson, J. P., & Monson, J. P. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02648.x · Cited by 24
Martina, V., Benso, A. S., Gigliardi, V. R., Masha, A., Origlia, C., Granata, R., & Ghigo, E. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02454.x · Cited by 20
Replacement therapy in Addison?s disease
Løvås, K., & Husebye, E. S. (2003) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.4.12.2145 · Cited by 26
“[9] found no impairment in cognitive function in 39 patients with Addison’s disease, strongly supporting this conclusion.”
BackgroundMethodResultInfluentialZhao, L., Zhao, A., Chen, T., Chen, W., Liu, J., Wei, R., Su, J., Tang, X., Liu, K., Zhang, R., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00409 · Cited by 23
Proteomic profiling in schizophrenia: enabling stratification for more effective treatment
Guest, P. C., Martins‐de‐Souza, D., Schwarz, E., Rahmoune, H., Alsaif, M., Tomasik, J., Turck, C. W., & Bahn, S. (2013) · Genome Medicine · doi:10.1186/gm429 · Cited by 26
“Notably, improve ments in some aspects of psychological function have also been demonstrated following DHEA treatment of patients with Addison’s disease [86].”
BackgroundDHEA supplementation: the claims in perspective.
Olech, E., & Merrill, J. (2005) · Cleveland Clinic journal of medicine · doi:10.3949/ccjm.72.11.965 · Cited by 25
Dehydroepiandrosterone Replacement Therapy
Arlt, W. (2001) · Seminars in Reproductive Medicine · doi:10.1055/s-2004-861554 · Cited by 25
“Improvement in mood and fatigue was also observed after DHEA replacement in Addison’s disease in the trial reported by Hunt et al.(66) In this double-blind, randomized crossover trial, 39 patients (24 women, 15 men) received 50 mg oral DHEA and placebo, each for 12 weeks.”
InfluentialAndrogen Replacement in Adolescents and Young Women with Hypopituitarism
Bilger, M., Speraw, S., Lafranchi, S., & Hanna, C. (2005) · Journal of Pediatric Endocrinology & Metabolism (JPEM) · doi:10.1515/jpem.2005.18.4.355 · Cited by 25
Long-Acting Hydrocortisone for Glucocorticoid Replacement Therapy
Johannsson, G., Nyström, H. F., Bergthorsdottir, R., Lennernäs, H., & Skrtic, S. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110621 · Cited by 23
Abrams, D., Shade, S., Couey, P., McCune, J., Lo, J. C., Bacchetti, P., Chang, B., Epling, L., Liegler, T., & Grant, R. (2007) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.0170 · Cited by 24
Improving outcomes in patients with adrenal insufficiency: a review of current and future treatments
Johannsson, G., Skrtic, S., Lennernäs, H., Quinkler, M., & Stewart, P. M. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.925865 · Cited by 21
Altered DHEA and DHEAS response to exercise in healthy older adults.
Aldred, S., Rohalu, M., Edwards, K., & Burns, V. E. (2009) · Journal of Aging and Physical Activity · doi:10.1123/japa.17.1.77 · Cited by 21
“, 1997), improving psychological well-being in the elderly (Morales, Haubrich, Hwang, Asakura, & Yen, 1998), and correcting hormone levels in patients with adrenal deficiencies (Hunt et al., 2000).”
BackgroundDehydroepiandrosterone and Erectile Function: A Review
El-Sakka, A. I. (2018) · The World Journal of Men's Health · doi:10.5534/wjmh.180005 · Cited by 20
“Additionally, other studies questioned the concept of DHEA as a neurosteroid with a central putative effect on libido [48], although this hormone had been found to influence self-esteem and mood in younger individuals [49].”
BackgroundGenome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus
Mo, Q., Lu, S., Garippa, C., Brownstein, M., & Simon, N. G. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.01.015 · Cited by 17
Ahboucha, S., Pomier-Layrargues, G., Vincent, C., Hassoun, Z., Tamaz, R., Baker, G., & Butterworth, R. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.002 · Cited by 20
Androgen replacement therapy in women
Lebbe, M., Hughes, D., Reisch, N., & Arlt, W. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.45 · Cited by 6
Metabolic and endocrinological causes of dementia
Flicker, L. A., & Ames, D. J. (2005) · International Psychogeriatrics · doi:10.1017/s1041610205001961 · Cited by 21
Sexual Dysfunction in Men and Women
Bhasin, S., & Basson, R. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00020-1 · Cited by 20
Dor, R. R. B., Marx, C. E., Shampine, L. J., Rubinow, D. R., & Schmidt, P. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3991-1 · Cited by 23
“…are also consistent with later reports of significantly elevated plasma ADT (or its glucuronide) and/or androstenedione after the administration of DHEA, either by oral or by transdermal routes (Bloch et al. 2013; Hunt et al. 2000; Kudielka et al. 1998; Labrie et al. 2009; Morales et al. 1998).”
Androgen Status in Healthy Premenopausal Women with Loss of Libido
Nyunt, A., Stephen, G., Gibbin, J., Durgan, L., Fielding, A., Wheeler, M., & Price, D. (2005) · Journal of Sex & Marital Therapy · doi:10.1080/00926230590475314 · Cited by 18
“In contrast, Hunt et al. (2000) reported improved well-being but not sexual function, and Lovas et al. (2003) reported that neither was improved by DHEA replacement.”
BackgroundAssies, J., Haverkort, E. B., Lieverse, R., & Vreken, P. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01868.x · Cited by 17
“Beneficial effects in males were independent of circulating testosterone levels, which did not rise significantly during DHEA treatment (Hunt et al., 2000).”
BackgroundResultDHEA(S)—a novel marker in Cushing’s disease
Burkhardt, T., Schmidt, N., Vettorazzi, E., Aberle, J., Mengel, M., & Flitsch, J. (2013) · Acta Neurochirurgica · doi:10.1007/s00701-012-1596-6 · Cited by 17
The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports
Choong, K., Lakshman, K. M., & Bhasin, S. (2008) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2008.00407.x · Cited by 21
Anterior pituitary hormone replacement therapy—a clinical review
Auernhammer, C. J., & Vlotides, G. (2007) · Pituitary · doi:10.1007/s11102-007-0001-6 · Cited by 17
“secondary adrenocortical insufficiency on general wellbeing [102, 104], mood [104] and alertness [106], as well”
BackgroundConsensus Document on substitution therapy with DHEA in the elderly
Valenti, G. (2006) · Aging Clinical and Experimental Research · doi:10.1007/bf03324662 · Cited by 14
Chronic fatigue syndrome: an endocrine disease off limits for endocrinologists?
Baschetti, R. (2003) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2003.01272.x · Cited by 17
Quality of life in Addison’s disease – the case for DHEA replacement *
Arlt, W. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01522.x · Cited by 17
“The need for replacement of DHEA deficiency in patients with primary and secondary adrenal failure is strongly supported by the results of two recent double-blind studies (Arlt et al., 1999; Hunt et al. 2000).”
BackgroundResultReduced Sulfotransferase SULT2A1 Activity in Patients With Alzheimer´s Disease
Vaňková, M., Hill, M., Velíková, M., Včelák, J., Vacínová, G., Lukášová, P., Vejražková, D., Dvořáková, K., Rusina, R., Holmerová, I., et al. (2015) · Physiological Research · doi:10.33549/physiolres.933160 · Cited by 16
Diagnosis and treatment of ACTH deficiency
Cooper, M. S., & Stewart, P. M. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-5224-0 · Cited by 16
“In addition to glucocorticoid and mineralocorticoid replacement, beneficial effects of 25–50 mg/day DHEA replacement on well-being have been reported in both primary and secondary adrenal failure [46,47].”
BackgroundWalsh, T., Baird, G., Atalay, M., Agarwal, S., Arcuri, D., Klinger, J., Mullin, C., Morreo, H., Normandin, B., Shiva, S., et al. (2021) · Pulmonary Circulation · doi:10.1177/2045894021989554 · Cited by 16
Fatigue in patients with systemic lupus erythematosus: the role of dehydroepiandrosterone sulphate
Overman, C., Hartkamp, A., Bossema, E., Bijl, M., Godaert, G., Bijlsma, J., Derksen, R., & Geenen, R. (2012) · Lupus · doi:10.1177/0961203312459105 · Cited by 16
Dehydroepiandrosterone to Enhance Physical Performance: Myth and Reality
Hahner, S., & Allolio, B. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.10.008 · Cited by 16
Psychological Challenges in Obstetrics and Gynecology
Cockburn, J., & Pawson, M. (2007) · doi:10.1007/978-1-84628-808-1 · Cited by 16
DHEA replacement in adrenal insufficiency
Arlt, W., & Allolio, B. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030534 · Cited by 15
Peixoto, C., Grande, A. J., Carrilho, C. G., Nardi, A. E., Cardoso, A., & Veras, A. B. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24721 · Cited by 15
“…a good methodological quality, which leads us to believe that the differences between these studies are related to the specificities of their medical diseases, specifically for these two studies (Finckh et al., 2005; Hunt et al., 2000), fibromyalgia and primary adrenal insufficiency, respectively.”
BackgroundMethodResultInfluentialKhanna, A., Khurana, R., Kyriacou, A., Davies, R., & Ray, D. (2015) · Endocrinology, Diabetes & Metabolism Case Reports · doi:10.1530/edm-15-0005 · Cited by 15
Effect of dehydroepiandrosterone on cell growth and mitochondrial function in TM-3 cells.
Shen, X.-H., Liu, L., Yin, F.-J., Ma, H.-T., & Zou, S. (2012) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2012.03.007 · Cited by 15
Mora, M., Sánchez, L., Serra-Prat, M., Palomera, E., Blanco, J., Aranda, G., Falcón, I., Cadenas, I., Boquet, X., Oriola, J., et al. (2011) · AGE · doi:10.1007/s11357-011-9255-z · Cited by 15
“Up to now, no consistent results have been obtained that justify long-term supplementation with this steroid in the general population of old women (Gurnell and Chatterjee 2001; Nair et al. 2006) and it is currently just recommended as substitution treatment for young women with primary adrenal insufficiency, where an…”
BackgroundIs DHEA replacement beneficial in chronic adrenal failure?
Lang, K., Burger‐Stritt, S., & Hahner, S. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.007 · Cited by 14
Effects of Dehydroepiandrosterone on Bone Mineral Density
Villareal, D. T. (2002) · Treatments in Endocrinology · doi:10.2165/00024677-200201060-00001 · Cited by 16
The management of glucocorticoid deficiency: Current and future perspectives
Dineen, R., Martin‐Grace, J., Thompson, C. J., & Sherlock, M. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.03.006 · Cited by 21
Therapies for adrenal insufficiency
Oki, K., & Yamane, K. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.9.1283 · Cited by 17
“conducted a randomised, placebo-controlled, crossover trial of oral DHEA 50 mg/day or placebo in patients with primary or secondary adrenal insufficiency [52,53].”
BackgroundMethodPoretsky, L., Brillon, D. J., Ferrando, S. J., Chiu, J. A., McElhiney, M. C., Ferenczi, A., Sison, M. C. I. P., Haller, I., & Rabkin, J. G. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.013 · Cited by 15
“One important difference in the design of the previously reported trials and our study involves study populations [18,49-61].”
BackgroundResultThe future endocrine patient. Reflections on the future of clinical endocrinology.
Lamberts, S. W., Romijn, J., & Wiersinga, W. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490169 · Cited by 14
Carmichael, J. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804169-7.00010-6 · Cited by 13
The pathophysiology of Post SSRI Sexual Dysfunction - Lessons from a case study.
Klaas, S., Siva, J., Bak, M., Govers, M., & Schreiber, R. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2022.114166 · Cited by 13
McHenry, C. M., Bell, P. M., Hunter, S., Thompson, C., Courtney, C., Ennis, C. N., Sheridan, B., McCance, D., Mullan, K., & Atkinson, A. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04356.x · Cited by 13
Androgens and Androgen Receptor
Chang, C. (2002) · Springer US · doi:10.1007/978-1-4615-1161-8 · Cited by 13
Christiansen, J. J., Gravholt, C. H., Fisker, S., Svenstrup, B., Bennett, P., Veldhuis, J., Andersen, M., Christiansen, J. S., & Jørgensen, J. O. L. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01998.x · Cited by 12
“This is in accordance with previous studies (Arlt et al., 1999; GebreMedhin et al., 2000; Hunt et al., 2000).”
BackgroundResultInfluentialVera, F. M., Manzaneque, J. M., Rodríguez, F. M., Vadillo, M., Navajas, F., Heiniger, A. I., Pérez, V., & Blanca, M. J. (2019) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12501 · Cited by 12
Uçar, A., Öner, N., Özek, G., Çetinçakmak, M., Abuhandan, M., Yildirim, A., Kaya, C., Ünverdi, S., Emeksiz, H., Yilmaz, Y., et al. (2016) · Endocrine · doi:10.1007/s12020-016-0872-2 · Cited by 12
Akute Nebenniereninsuffizienz („Addison-Krise“)
Woenckhaus, U., Vasold, A., & Bollheimer, L. C. (2005) · Intensivmedizin und Notfallmedizin · doi:10.1007/s00390-005-0546-4 · Cited by 13
Endocrine Replacement Therapy in Clinical Practice
Meikle, A. (2003) · Contemporary endocrinology · doi:10.1007/978-1-59259-375-0 · Cited by 12
“In the study examining men and estrogenized women, there, was an approx 35% rise in IGF-2 levels (112), a reduction in body fat, and an increase in LBM.”
Impaired attention in patients with adrenal insufficiency - Impact of unphysiological therapy.
Bacha, A. K., Kropp, P., Rahvar, A.-H., Flitsch, J., van de Loo, I., & Harbeck, B. (2021) · Steroids · doi:10.1016/j.steroids.2020.108788 · Cited by 11
Guidelines for diagnosis and treatment of adrenal insufficiency in adults
Novoa, P. D. M., Vela, E. T., García, N. P., Rodríguez, M. M., Guerras, I. S., Santamaría, M. D. L. Á. M. D. S., & Aulinas, A. (2014) · Endocrinología y Nutrición (English Edition) · doi:10.1016/s2173-5093(14)70069-8 · Cited by 14
Hormonal determinants of depression and cognitive function in independently-living elders.
Alfaro, S. R., Serra-Prat, M., Palomera, E., Falcón, I., Cadenas, I., Boquet, X., Burdoy, E., Mussoll, J., Serra, P., & Domingo, M. P. (2008) · Endocrinologia y Nutricion · doi:10.1016/s1575-0922(08)75076-9 · Cited by 11
Gueugnon, F., Gondcaille, C., Leclercq, S., Bellenger, J., Bellenger, S., Narce, M., Pineau, T., Bonnetain, F., & Savary, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.06.013 · Cited by 12
Severity and outcome of acute stroke in women: relation to adrenal sex steroid levels.
Pappa, T., Vemmos, K., Saltiki, K., Mantzou, E., Stamatelopoulos, K., & Alevizaki, M. (2012) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2011.06.003 · Cited by 11
“With respect to the metabolic and neurobiological role of this hormone, a large body of data has accumulated from clinical supplementation studies [50-53].”
BackgroundYin, F.-J., Kang, J., Han, N., & Ma, H.-T. (2015) · Genetics and Molecular Research · doi:10.4238/2015.september.22.24 · Cited by 10
Guest, F. L., Martins‐de‐Souza, D., Rahmoune, H., Bahn, S., & Guest, P. C. (2012) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832012005000002 · Cited by 14
Pharmacotherapy for sexual dysfunction in women
Basson, R. J. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.5.1045 · Cited by 12
“Randomised controlled trials of DHEA supplementation have been conflicting and research continues [41-45].”
BackgroundBlacha, A. K., Kropp, P., Rahvar, A.-H., Flitsch, J., van de Loo, I., & Harbeck, B. (2021) · Irish Journal of Medical Science · doi:10.1007/s11845-021-02731-y · Cited by 9
“Co-medication with dehydroepiandrosteron (DHEA) may have positive effects on mood and fatigue [16, 17], but as yet, there are no hard criteria for use.”
Heald, A., Walther, A., Davis, J. R. E., Moreno, G., Kane, J., Livingston, M., & Fowler, H. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00764 · Cited by 9
“Hunt et al. (2000) found an improvement in mood and fatigue after DHEA replacement in Addison’s disease in a randomized double blind trial.”
BackgroundAndrogen deficiency in hypopituitary women: its consequences and management
Esposito, D., Tivesten, Å., Olivius, C., Ragnarsson, O., & Johannsson, G. (2024) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-024-09873-1 · Cited by 8
Dual-release hydrocortisone and its benefits on cognitive function and quality of sleep
Krekeler, C., Kropp, P., Blacha, A. K., Rahvar, A.-H., & Harbeck, B. (2021) · Endocrine · doi:10.1007/s12020-020-02552-6 · Cited by 8
“[48]— has a decisive positive impact on the quality of life.”
BackgroundPharmacologic Treatment Options for Hypoactive Sexual Desire Disorder
Bolour, S. Y., & Braunstein, G. D. (2005) · Women s Health · doi:10.2217/17455057.1.2.263 · Cited by 9
Management of the androgen-deficient woman
Arlt, W. (2003) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(03)00060-1 · Cited by 7
Metadata
- Authors
- Hunt, P. J., Gurnell, E. M., Huppert, F. A., Richards, C., Prevost, A. T., Wass, J. A. H., Herbert, J., & Chatterjee, V. K. K.
- Affiliations
- University of Oxford (GB)
- University of Cambridge (GB)
- Community Medicine (A.T.P.), Cambridge, United Kingdom CB2 2QQ
- Departments of Medicine (E.M.G., C.R., V.K.K.C.), Cambridge, United Kingdom CB2 2QQ
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2000-12-01
- Volume
- 85
- Issue
- 12
- Pages
- 4650-4656
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2138758697
- Cited by
- 386
- References
- 45
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 58 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 10 · 2015: 13 · 2014: 15 · 2013: 5 · 2012: 12
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Hologic
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- dehydroepiandrosterone, Addison's disease, DHEA replacement therapy, DHEA sulfate, adrenal insufficiency, mood, fatigue, self-esteem, well-being, testosterone, sex hormone-binding globulin, androstenedione, neurosteroids, central nervous system effects, glucocorticoid deficiency, mineralocorticoid deficiency
- MeSH terms
- Addison Disease, Adult, Affect, Aged, Body Composition, Cognition, Dehydroepiandrosterone, Double-Blind Method, Fatigue, Female, Hormones, Humans, Male, Middle Aged, Sexual Behavior, Bone Density, Cross-Over Studies, Dehydroepiandrosterone Sulfate, Hormone Replacement Therapy
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