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Review of the in Vivo Functions of the p160 Steroid Receptor Coactivator Family

Xu, Jianming, Li, Qingtian·2003·Molecular Endocrinology
DOI 10.1210/me.2003-0116
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Abstract

The p160 steroid receptor coactivator (SRC) gene family contains three homologous members, which serve as transcriptional coactivators for nuclear receptors and certain other transcription factors. These coactivators interact with ligand-bound nuclear receptors to recruit histone acetyltransferases and methyltransferases to specific enhancer/promotor regions, which facilitates chromatin remodeling, assembly of general transcription factors, and transcription of target genes. This minireview summarizes our current knowledge about the molecular structures, molecular mechanisms, temporal and spatial expression patterns, and biological functions of the SRC family. In particular, this article highlights the roles of SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NCoA-2) and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1) in development, organ function, endocrine regulation, and nuclear receptor function, which are defined by characterization of the genetically manipulated animal models. Furthermore, this article also reviews our current understanding of the role of SRC-3 in breast cancer and discusses possible mechanisms for functional specificity and redundancy among SRC family members.

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Research works printed but not linked: 84

  1. Tsai, 1994, Molecular mechanisms of action of steroid/thyroid receptor superfamily members., Annu Rev Biochem, 63, 451, 10.1146/annurev.bi.63.070194.002315 · DOI · Paper page
  2. McKenna, 2002, Combinatorial control of gene expression by nuclear receptors and coregulators., Cell, 108, 465, 10.1016/S0092-8674(02)00641-4 · DOI · Paper page
  3. Meyer, 1989, Steroid hormone receptors compete for factors that mediate their enhancer function., Cell, 57, 433, 10.1016/0092-8674(89)90918-5 · DOI · Paper page
  4. Goo, 2003, Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins., Mol Cell Biol, 23, 140, 10.1128/MCB.23.1.140-149.2003 · DOI · Paper page
  5. Xu, 2002, Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function., Rev Endocr Metab Disord, 3, 185, 10.1023/A:1020016208071 · DOI
  6. Onate, 1995, Sequence and characterization of a coactivator for the steroid hormone receptor superfamily., Science, 270, 1354, 10.1126/science.270.5240.1354 · DOI · Paper page
  7. Takeshita, 1996, Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator., Endocrinology, 137, 3594, 10.1210/endo.137.8.8754792 · doi:10.1210/endo.137.8.8754792 · Paper page
  8. Kamei, 1996, A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors., Cell, 85, 403, 10.1016/S0092-8674(00)81118-6 · DOI · Paper page
  9. Hong, 1996, GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors., Proc Natl Acad Sci USA, 93, 4948, 10.1073/pnas.93.10.4948 · DOI · Paper page
  10. Voegel, 1996, TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors., EMBO J, 15, 3667, 10.1002/j.1460-2075.1996.tb00736.x · DOI · Paper page
  11. Torchia, 1997, The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function., Nature, 387, 677, 10.1038/42652 · DOI · Paper page
  12. Anzick, 1997, AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer., Science, 277, 965, 10.1126/science.277.5328.965 · DOI · Paper page
  13. Li, 1997, RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2., Proc Natl Acad Sci USA, 94, 8479, 10.1073/pnas.94.16.8479 · DOI · Paper page
  14. Chen, 1997, Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300., Cell, 90, 569, 10.1016/S0092-8674(00)80516-4 · DOI · Paper page
  15. Takeshita, 1997, TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1., J Biol Chem, 272, 27629, 10.1074/jbc.272.44.27629 · DOI · Paper page
  16. Suen, 1998, A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity., J Biol Chem, 273, 27645, 10.1074/jbc.273.42.27645 · DOI · Paper page
  17. Lee, 1998, Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits., J Biol Chem, 273, 16651, 10.1074/jbc.273.27.16651 · DOI · Paper page
  18. Kim, 1998, Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations., J Biol Chem, 273, 28564, 10.1074/jbc.273.44.28564 · DOI
  19. Na, 1998, Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor κB-mediated transactivations., J Biol Chem, 273, 10831, 10.1074/jbc.273.18.10831 · DOI · Paper page
  20. Charlier, 2002, Steroid receptor coactivator SRC-1 exhibits high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain., Neuroendocrinology, 76, 297, 10.1159/000066624 · DOI
  21. de la Calle-Mustienes, 2000, XTIF2, a Xenopus homologue of the human transcription intermediary factor, is required for a nuclear receptor pathway that also interacts with CBP to suppress Brachyury and XMyoD., Mech Dev, 91, 119, 10.1016/S0925-4773(99)00280-4 · DOI
  22. Bai, 2000, Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer., Cell, 103, 1047, 10.1016/S0092-8674(00)00208-7 · DOI · Paper page
  23. Kim, 1998, Molecular cloning of xSRC-3, a novel transcription coactivator from Xenopus, that is related to AIB1, p/CIP, and TIF2., Mol Endocrinol, 12, 1038, 10.1210/mend.12.7.0139 · DOI
  24. Huang, 1993, PAS is a dimerization domain common to Drosophila period and several transcription factors., Nature, 364, 259, 10.1038/364259a0 · DOI · Paper page
  25. Chen, 2000, The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation., Genes Dev, 14, 1209, 10.1101/gad.14.10.1209 · DOI
  26. Voegel, 1998, The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways., EMBO J, 17, 507, 10.1093/emboj/17.2.507 · DOI · Paper page
  27. Shiau, 1998, The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen., Cell, 95, 927, 10.1016/S0092-8674(00)81717-1 · DOI · Paper page
  28. Leo, 2000, The SRC family of nuclear receptor coactivators., Gene, 245, 1, 10.1016/S0378-1119(00)00024-X · DOI · Paper page
  29. Onate, 1998, The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors., J Biol Chem, 273, 12101, 10.1074/jbc.273.20.12101 · DOI · Paper page
  30. Li, 2000, p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin., Mol Cell Biol, 20, 2031, 10.1128/MCB.20.6.2031-2042.2000 · DOI
  31. Chen, 1999, Regulation of transcription by a protein methyltransferase., Science, 284, 2174, 10.1126/science.284.5423.2174 · DOI · Paper page
  32. Koh, 2001, Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities., J Biol Chem, 276, 1089, 10.1074/jbc.M004228200 · DOI · Paper page
  33. Spencer, 1997, Steroid receptor coactivator-1 is a histone acetyltransferase., Nature, 389, 194, 10.1038/38304 · DOI · Paper page
  34. Liu, 2001, Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor- dependent initiation and reinitiation of transcription from chromatin., Proc Natl Acad Sci USA, 98, 12426, 10.1073/pnas.231474798 · DOI
  35. Chakravarti, 1996, Role of CBP/P300 in nuclear receptor signalling., Nature, 383, 99, 10.1038/383099a0 · DOI · Paper page
  36. Sheppard, 2001, Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1., Mol Cell Biol, 21, 39, 10.1128/MCB.21.1.39-50.2001 · DOI
  37. Shang, 2000, Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription., Cell, 103, 843, 10.1016/S0092-8674(00)00188-4 · DOI · Paper page
  38. Demarest, 2002, Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators., Nature, 415, 549, 10.1038/415549a · DOI · Paper page
  39. Li, 2003, Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification., Mol Cell Biol, 23, 3763, 10.1128/MCB.23.11.3763-3773.2003 · DOI · Paper page
  40. Lee, 2002, Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities., Mol Cell Biol, 22, 3621, 10.1128/MCB.22.11.3621-3632.2002 · DOI · Paper page
  41. Dilworth, 2000, ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR in vitro., Mol Cell, 6, 1049, 10.1016/S1097-2765(00)00103-9 · DOI · Paper page
  42. Huang, 2003, A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription., EMBO J, 22, 2146, 10.1093/emboj/cdg219 · DOI · Paper page
  43. Fondell, 1996, Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex., Proc Natl Acad Sci USA, 93, 8329, 10.1073/pnas.93.16.8329 · DOI · Paper page
  44. Rachez, 1998, A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system., Genes Dev, 12, 1787, 10.1101/gad.12.12.1787 · DOI · Paper page
  45. Sharma, 2002, Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo., Proc Natl Acad Sci USA, 99, 7934, 10.1073/pnas.122004799 · DOI · Paper page
  46. Ito, 2001, The TRAP/SMCC/Mediator complex and thyroid hormone receptor function., Trends Endocrinol Metab, 12, 127, 10.1016/S1043-2760(00)00355-6 · DOI · Paper page
  47. Chen, 1999, Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase., Cell, 98, 675, 10.1016/S0092-8674(00)80054-9 · DOI · Paper page
  48. Rowan, 2000, Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway., J Biol Chem, 275, 4475, 10.1074/jbc.275.6.4475 · DOI · Paper page
  49. Carapeti, 1998, Assignment of the steroid receptor coactivator-1 (SRC-1) gene to human chromosome band 2p23., Genomics, 52, 242, 10.1006/geno.1998.5446 · doi:10.1006/geno.1998.5446
  50. Ning, 1999, Structure and chromosomal locations of mouse steroid receptor coactivator gene family., In Vitro Cell Dev Biol Anim, 35, 481, 10.1007/s11626-999-0055-z · doi:10.1007/s11626-999-0055-z
  51. Li, 1998, The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation., J Biol Chem, 273, 5948, 10.1074/jbc.273.10.5948 · DOI
  52. Misiti, 1998, Expression and hormonal regulation of coactivator and corepressor genes., Endocrinology, 139, 2493, 10.1210/endo.139.5.5971 · DOI · Paper page
  53. Xu, 1998, Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene., Science, 279, 1922, 10.1126/science.279.5358.1922 · DOI · Paper page
  54. Misiti, 1999, Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development., Endocrinology, 140, 1957, 10.1210/endo.140.4.6782 · DOI
  55. Nishihara, 2003, SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells., J Neurosci, 23, 213, 10.1523/JNEUROSCI.23-01-00213.2003 · DOI
  56. Apostolakis, 2002, Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice., Mol Endocrinol, 16, 1511, 10.1210/mend.16.7.0877 · DOI
  57. Weiss, 1999, Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone., EMBO J, 18, 1900, 10.1093/emboj/18.7.1900 · DOI · Paper page
  58. Takeuchi, 2002, Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T3-regulated transcription of genes in vivo., Endocrinology, 143, 1346, 10.1210/endo.143.4.8730 · DOI
  59. Sadow, 2003, Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action., Am J Physiol, 284, E36
  60. Sadow, 2003, Thyroid hormone receptor-specific interactions with steroid receptor coactivator (SRC) -1 in the pituitary., Mol Endocrinol, 17, 882, 10.1210/me.2002-0174 · DOI
  61. Qi, 1999, Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor α-regulated gene expression., Proc Natl Acad Sci USA, 96, 1585, 10.1073/pnas.96.4.1585 · DOI
  62. Puigserver, 1999, Activation of PPARγ coactivator-1 through transcription factor docking., Science, 286, 1368, 10.1126/science.286.5443.1368 · DOI · Paper page
  63. Picard, 2002, SRC-1 and TIF2 control energy balance between white and brown adipose tissues., Cell, 111, 931, 10.1016/S0092-8674(02)01169-8 · DOI · Paper page
  64. Kalkhoven, 1998, Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor., EMBO J, 17, 232, 10.1093/emboj/17.1.232 · DOI · Paper page
  65. Puustinen, 2001, Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies., Eur J Endocrinol, 145, 323, 10.1530/eje.0.1450323 · DOI
  66. Gehin, 2002, The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP., Mol Cell Biol, 22, 5923, 10.1128/MCB.22.16.5923-5937.2002 · DOI · Paper page
  67. Ghadessy, 1999, Oligospermic infertility associated with an androgen receptor mutation that disrupts interdomain and coactivator (TIF2) interactions., J Clin Invest, 103, 1517, 10.1172/JCI4289 · DOI
  68. Xu, 2000, The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development., Proc Natl Acad Sci USA, 97, 6379, 10.1073/pnas.120166297 · DOI · Paper page
  69. Yuan, 2002, Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen., Circulation, 105, 2653, 10.1161/01.CIR.0000018947.95555.65 · DOI
  70. Wang, 2000, Regulation of somatic growth by the p160 coactivator p/CIP., Proc Natl Acad Sci USA, 97, 13549, 10.1073/pnas.260463097 · DOI · Paper page
  71. Liao, 2002, Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1., J Steroid Biochem Mol Biol, 83, 3, 10.1016/S0960-0760(02)00254-6 · DOI
  72. Mendelsohn, 1999, The protective effects of estrogen on the cardiovascular system., N Engl J Med, 340, 1801, 10.1056/NEJM199906103402306 · DOI · Paper page
  73. Wu, 2002, Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by IκB kinase., Mol Cell Biol, 22, 3549, 10.1128/MCB.22.10.3549-3561.2002 · DOI · Paper page
  74. Werbajh, 2000, RAC-3 is a NF-κB coactivator., FEBS Lett, 485, 195, 10.1016/S0014-5793(00)02223-7 · DOI
  75. Weiss, 2002, Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency., Endocrinology, 143, 1554, 10.1210/endo.143.4.8828 · DOI
  76. Bautista, 1998, In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity., Clin Cancer Res, 4, 2925
  77. Bouras, 2001, Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu., Cancer Res, 61, 903
  78. List, 2001, Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue., Breast Cancer Res Treat, 68, 21, 10.1023/A:1017910924390 · DOI
  79. Osborne, 2003, Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer., J Natl Cancer Inst, 95, 353, 10.1093/jnci/95.5.353 · DOI · Paper page
  80. Font de Mora, 2000, AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor., Mol Cell Biol, 20, 5041, 10.1128/MCB.20.14.5041-5047.2000 · DOI · Paper page
  81. Smith, 1997, Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen., Mol Endocrinol, 11, 657, 10.1210/mend.11.6.0009 · doi:10.1210/mend.11.6.0009 · Paper page
  82. Planas-Silva, 2001, AIB1 enhances estrogen-dependent induction of cyclin D1 expression., Cancer Res, 61, 3858
  83. List, 2001, Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells., J Biol Chem, 276, 23763, 10.1074/jbc.M102397200 · DOI
  84. Cavarretta, 2002, Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERα transcriptional activity and MCF-7 proliferation., Mol Endocrinol, 16, 253

Cited by

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Metadata

Authors
Xu, J., & Li, Q.
Venue
Molecular Endocrinology
Publisher
The Endocrine Society
Published
2003-09-01
Volume
17
Issue
9
Pages
1681-1692
ISSN
  • 0888-8809 (ISSN-L)
  • 1944-9917
DOI
10.1210/me.2003-0116
OpenAlex
W1972158913
Cited by
493
References
4
FWCI
19.93
Type
journal article
Language
en
Open access
closed

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