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Cited by 347

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Education and Alzheimer disease without dementia: Support for the cognitive reserve hypothesis

Roe, Catherine M., Xiong, Chengjie, Miller, J. Phillip, Morris, John C.·2007·Neurology
DOI 10.1212/01.wnl.0000251303.50459.8a
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Abstract

BACKGROUND: Individuals with no cognitive impairment during life but with neuropathologic Alzheimer disease (AD) may represent cases of presymptomatic, or unrecognized early symptomatic, AD. The cognitive reserve hypothesis suggests that at a particular level of AD pathology, highly educated individuals are less likely to manifest clinical symptoms of dementia vs less-educated individuals. OBJECTIVE: To investigate whether education can help explain a clinical diagnosis of no dementia within 1 year of death among individuals with neuropathologic diagnoses of AD. METHODS: Samples of participants (age 65+ years at last clinical assessment) meeting each of three neuropathologic criteria for AD were constructed using data from the National Alzheimer's Coordinating Center Minimum and Neuropathology Data Sets. Generalized linear mixed models (using the logit link function) were used in each sample to examine whether years of education was associated with dementia within 1 year of death, adjusting for other relevant variables. RESULTS: Twelve percent of individuals meeting Khachaturian (122/1,009), 19% meeting low, intermediate, or high likelihood for National Institute on Aging/Reagan Institute (320/1,704), and 14% meeting possible, probable, or definite Consortium to Establish a Registry for Alzheimer's Disease (265/1,835) neuropathologic criteria for AD were nondemented at their final clinical assessment. Persons with more education were less likely to have a dementia diagnosis in each sample. CONCLUSIONS: Regardless of the neuropathologic criteria used, education is predictive of dementia status among individuals with neuropathologic Alzheimer disease. These results support the theory that individuals with greater cognitive reserve, as reflected in years of education, are better able to cope with AD brain pathology without observable deficits in cognition.

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Metadata

Authors
Roe, C. M., Xiong, C., Miller, J. P., & Morris, J. C.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-01-16
Volume
68
Issue
3
Pages
223-228
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000251303.50459.8a
OpenAlex
W2153859664
Cited by
347
References
12
FWCI
11.65
Type
journal article
Language
en
Open access
closed

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