Brain reserve and the prevention of dementia

The environment and disease: association or causation?

Hill, A. B. (2015) · Journal of the Royal Society of Medicine · doi:10.1177/0141076814562718 · Cited by 7,302 · see citing works

The Environment and Disease: Association or Causation?

Hill, A. B. (1965) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576505800503 · Cited by 6,974 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

What is cognitive reserve? Theory and research application of the reserve concept

STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

Aerobic Exercise Training Increases Brain Volume in Aging Humans

Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134 · see citing works

Effects of Cognitive Training Interventions With Older Adults: A Randomized Controlled Trial

Ball, K., Berch, D. B., Helmers, K. F., Jobe, J. B., Leveck, M. D., Marsiske, M., Morris, J. N., Rebok, G. W., Smith, D. M., Tennstedt, S. L., et al. (2002) · JAMA · doi:10.1001/jama.288.18.2271 · Cited by 2,049 · see citing works

Leisure Activities and the Risk of Dementia in the Elderly

Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., Ambrose, A. F., Sliwinski, M., & Buschke, H. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022252 · Cited by 1,961 · see citing works

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771 · see citing works

Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults

Willis, S. L., Tennstedt, S. L., Marsiske, M., Ball, K., Elias, J., Koepke, K. M., Morris, J. N., Rebok, G. W., Unverzagt, F. W., Stoddard, A. M., et al. (2006) · JAMA · doi:10.1001/jama.296.23.2805 · Cited by 1,496 · see citing works

Influence of social network on occurrence of dementia: a community-based longitudinal study

Fratiglioni, L., Wang, H.-X., Ericsson, K., Maytan, M., & Winblad, B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02113-9 · Cited by 1,361 · see citing works

Increased prefrontal and parietal activity after training of working memory

Olesen, P. J., Westerberg, H., & Klingberg, T. (2004) · Nature Neuroscience · doi:10.1038/nn1165 · Cited by 1,317 · see citing works

Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease

Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,312 · see citing works

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works

Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques

Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works

Late-Life Engagement in Social and Leisure Activities Is Associated with a Decreased Risk of Dementia: A Longitudinal Study from the Kungsholmen Project

Wang, H. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.12.1081 · Cited by 957 · see citing works

Brain reserve and dementia: a systematic review

VALENZUELA, M. J., & SACHDEV, P. (2006) · Psychological Medicine · doi:10.1017/s0033291705006264 · Cited by 932 · see citing works

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works

Brain reserve capacity on symptom onset after brain injury: A formulation and review of evidence for threshold theory.

Satz, P. (1993) · Neuropsychology · doi:10.1037/0894-4105.7.3.273 · Cited by 851 · see citing works

Influence of leisure activity on the incidence of Alzheimer's disease

Scarmeas, N., Levy, G., Tang, M.-X., Manly, J., & Stern, Y. (2001) · Neurology · doi:10.1212/wnl.57.12.2236 · Cited by 831 · see citing works

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

Adlard, P. A., Perreau, V. M., Pop, V., & Cotman, C. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0496-05.2005 · Cited by 806 · see citing works

Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study

Mahncke, H. W., Connor, B., Appelman, J., Ahsanuddin, O. N., Hardy, J. L., Wood, R. A., Joyce, N. M., Boniske, T., Atkins, S. M., & Merzenich, M. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605194103 · Cited by 679 · see citing works

Improving memory performance in the aged through mnemonic training: a meta-analytic study.

Verhaeghen, P., Marcoen, A., & Goossens, L. (1992) · Psychology and Aging · doi:10.1037/0882-7974.7.2.242 · Cited by 601 · see citing works

Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

Ickes, B. R., Pham, T. M., Sanders, L., Albeck, D. S., Mohammed, A. H. S., & Granholm, A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7415 · Cited by 541 · see citing works

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Jankowsky, J. L., Melnikova, T., Fadale, D. J., Xu, G. M., Slunt, H. H., Gonzales, V., Younkin, L. H., Younkin, S. G., Borchelt, D. R., & Savonenko, A. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5080-04.2005 · Cited by 517 · see citing works

Improving memory performance in the aged through mnemonic training: A meta-analytic study.

Verhaeghen, P., Marcoen, A., & Goossens, L. (1992) · Psychology and Aging · doi:10.1037//0882-7974.7.2.242 · Cited by 507 · see citing works

Cognitive training in Alzheimer's disease: a meta‐analysis of the literature

Sitzer, D., Twamley, E. W., & Jeste, D. V. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00789.x · Cited by 457 · see citing works

Social and Leisure Activities and Risk of Dementia: A Prospective Longitudinal Study

Fabrigoule, C., Letenneur, L., Dartigues, J. F., Zarrouk, M., Commenges, D., & Barberger‐Gateau, P. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb06093.x · Cited by 418 · see citing works

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works

Brain reserve and cognitive decline: a non-parametric systematic review

Valenzuela, M., & Sachdev, P. S. (2006) · Psychological Medicine · doi:10.1017/s0033291706007744 · Cited by 377 · see citing works

Education and Alzheimer disease without dementia

Roe, C. M., Xiong, C., Miller, J. P., & Morris, J. C. (2007) · Neurology · doi:10.1212/01.wnl.0000251303.50459.8a · Cited by 348 · see citing works

Structural Brain Alterations following 5 Days of Intervention: Dynamic Aspects of Neuroplasticity

May, A., Hajak, G., Gänßbauer, S., Steffens, T., Langguth, B., Kleinjung, T., & Eichhammer, P. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhj138 · Cited by 344 · see citing works

Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

Olazarán, J., Muñiz, R., Reisberg, ‌., Peña‐Casanova, J., del Ser, T., Cruz-Jentoft, A. J., Serrano, P., Navarro, E., de la Rocha, M. L. G., Frank, A., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000147478.03911.28 · Cited by 294 · see citing works

Environmental enrichment and the brain

Mohammed, A. H., Zhu, S., Darmopil, S., Hjerling‐Leffler, J., Ernfors, P., Winblad, B. G., Diamond, M. C., Eriksson, P. S., & Bogdanović, N. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38074-9 · Cited by 267 · see citing works

Long‐lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment

Artola, A., von Frijtag, J. C., Fermont, P. C. J., Gispen, W. H., Schrama, L. H., Kamal, A., & Spruijt, B. M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04552.x · Cited by 253 · see citing works

Differential effects of single versus combined cognitive and physical training with older adults: the SimA study in a 5-year perspective

Oswald, W. D., Gunzelmann, T., Rupprecht, R., & Hagen, B. (2006) · European Journal of Ageing · doi:10.1007/s10433-006-0035-z · Cited by 247 · see citing works

Training and Maintaining Memory Abilities in Healthy Older Adults: Traditional and Novel Approaches

Rebok, G. W., Carlson, M. C., & Langbaum, J. B. S. (2007) · The Journals of Gerontology Series B · doi:10.1093/geronb/62.special_issue_1.53 · Cited by 243 · see citing works

Assessment of complex mental activity across the lifespan: development of the Lifetime of Experiences Questionnaire (LEQ)

Valenzuela, M., & Sachdev, P. (2006) · Psychological Medicine · doi:10.1017/s003329170600938x · Cited by 232 · see citing works

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms

Costa, D. A., Cracchiolo, J. R., Bachstetter, A. D., Hughes, T. F., Bales, K. R., Paul, S. M., Mervis, R. F., Arendash, G. W., & Potter, H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.009 · Cited by 217 · see citing works

An association between head circumference and Alzheimer's disease in a population-based study of aging and dementia

Schofield, P. W., Logroscino, G., Andrews, H. F., Albert, S., & Stern, Y. (1997) · Neurology · doi:10.1212/wnl.49.1.30 · Cited by 203 · see citing works

Effects of differential environments on brain weights and enzyme activities in gerbils, rats, and mice

Rosenzweig, M. R., & Bennett, E. L. (1969) · Developmental Psychobiology · doi:10.1002/dev.420020208 · Cited by 184 · see citing works

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory

Levi, O., Jongen‐Rêlo, A. L., Feldon, J., Roses, A. D., & Michaelson, D. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00045-7 · Cited by 145 · see citing works

Memory training alters hippocampal neurochemistry in healthy elderly

Valenzuela, M., Jones, M., Rae, W. W. C., Rae, C., Graham, S., Shnier, R., & Sachdev, P. S. (2003) · Neuroreport · doi:10.1097/01.wnr.0000077548.91466.05 · Cited by 143 · see citing works

Brain reserve and the clinical expression of Alzheimer's disease.

Mortimer, J. A. (1997) · PubMed · Cited by 133 · see citing works

Complex mental activity and the aging brain: molecular, cellular and cortical network mechanisms.

Valenzuela, M., Breakspear, M., & Sachdev, P. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.07.007 · Cited by 123 · see citing works

Etiology of dementia of Alzheimer's type

Davison, A. N. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90107-x · Cited by 110 · see citing works

Long-Term Maintenance of Gains From Memory Training in Older Adults: Two 31/2Year Follow-up Studies

Neely, A. S., & Bakman, L. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.5.p233 · Cited by 110 · see citing works

Altered Synapse Formation in the Adult Somatosensory Cortex of Brain-Derived Neurotrophic Factor Heterozygote Mice

Genoud, C., Knott, G. W., Sakata, K., Lu, B., & Welker, E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4040-03.2004 · Cited by 106 · see citing works

Head circumference and incident Alzheimer’s disease

Graves, A. B., Mortimer, J. A., Bowen, J. D., McCormick, W. C., McCurry, S. M., Schellenberg, G. D., & Larson, E. B. (2001) · Neurology · doi:10.1212/wnl.57.8.1453 · Cited by 103 · see citing works

Regulation of dendritic spine stability

Smart, F. M., & Halpain, S. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:5 · Cited by 93 · see citing works

Leisure activities and the risk of dementia in the elderly

Sanders, A., & Verghese, J. (2007) · Cited by 85 · see citing works

A three-year follow-up of older adult participants in a memory-skills training program.

Scogin, F. R., & Bienias, J. L. (1988) · Psychology and Aging · doi:10.1037/0882-7974.3.4.334 · Cited by 76 · see citing works

Adult Neurogenesis

Kempermann, G. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511499722.006 · Cited by 74 · see citing works

Cognitive decline in high-functioning older adults: Reserve or ascertainment bias?

Tuokko, H. A., Garrett, D. D., McDowell, I., Silverberg, N. D., & Kristjansson, B. (2003) · Aging & Mental Health · doi:10.1080/1360786031000120750 · Cited by 70 · see citing works

Cognitive leisure activities, but not watching TV, for future brain benefits

Rundek, T., & Bennett, D. (2006) · Neurology · doi:10.1212/01.wnl.0000209497.38834.d7 · Cited by 68 · see citing works

Design your own memory strategies! Self-generated strategy training versus mnemonic training in old age: An 8-month follow-up

Derwinger, A., Neely, A. S., & Bäckman, L. (2005) · Neuropsychological Rehabilitation · doi:10.1080/09602010343000336 · Cited by 57 · see citing works

Behaviorally induced changes in length of cerebrum in rats

Altman, J., Wallace, R. B., Anderson, W. J., & Das, G. D. (1968) · Developmental Psychobiology · doi:10.1002/dev.420010209 · Cited by 43 · see citing works

Cognitive leisure activities, but not watching TV, for future brain benefits

Valenzuela, M., & Sachdev, P. S. (2006) · Neurology · doi:10.1212/01.wnl.0000239615.49557.63 · Cited by 20 · see citing works

Commentary: Activity each day keeps dementia away—does social interaction really preserve cognitive function?

Gallacher, J., Bayer, A. J., & Ben‐Shlomo, Y. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi107 · Cited by 15 · see citing works

The advantage of being broad-minded: Brain diameter and neuropsychological test performance in elderly war veterans

Jorm, A. F., Creasey, H. M., Broe, G. A., Sulway, M. R., Kos, S. C., & Dent, O. F. (1997) · Personality and Individual Differences · doi:10.1016/s0191-8869(97)80002-5 · Cited by 11 · see citing works

Dementia prevention, intervention, and care

Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S. G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31363-6 · Cited by 6,072 · see citing works

The projected effect of risk factor reduction on Alzheimer's disease prevalence

Barnes, D. E., & Yaffe, K. S. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70072-2 · Cited by 2,668 · see citing works

Defeating Alzheimer's disease and other dementias: a priority for European science and society

Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works

Religious Orders Study and Rush Memory and Aging Project

Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179939 · Cited by 1,260 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness*

Marra, A., Pandharipande, P. P., Girard, T. D., Patel, M. B., Hughes, C. G., Jackson, J. C., Thompson, J. L., Chandrasekhar, R., Ely, E. W., & Brummel, N. E. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003218 · Cited by 541 · see citing works

The benefits associated with volunteering among seniors: A critical review and recommendations for future research.

Anderson, N. D., The BRAVO Team, Damianakis, T., Kröger, E., Wagner, L. M., Dawson, D. R., Binns, M. A., Bernstein, S., Caspi, E., & Cook, S. L. (2014) · Psychological Bulletin · doi:10.1037/a0037610 · Cited by 391 · see citing works

The Study of Mental and Resistance Training (SMART) Study-Resistance Training and/or cognitive Training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial

Fiatarone Singh, M. A., Gates, N., Saigal, N., Wilson, G. C., Meiklejohn, J., Brodaty, H., Wen, W., Singh, N., Baune, B. T., Suo, C., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.09.010 · Cited by 424 · see citing works

Education, the brain and dementia: neuroprotection or compensation?

Brayne, C., Ince, P. G., Keage, H. A. D., McKeith, I. G., Matthews, F. E., Polvikoski, T. M., & Sulkava, R. O. (2010) · Brain · doi:10.1093/brain/awq185 · Cited by 392 · see citing works

The neurobiology of brain and cognitive reserve: Mental and physical activity as modulators of brain disorders

Nithianantharajah, J., & Hannan, A. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.001 · Cited by 324 · see citing works

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

Matthews, F. E., Brayne, C., Lowe, J., McKeith, I., Wharton, S. B., & Ince, P. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000180 · Cited by 279 · see citing works

Lifespan Mental Activity Predicts Diminished Rate of Hippocampal Atrophy

Valenzuela, M., Sachdev, P. S., Wen, W. X., Chen, X., & Brodaty, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002598 · Cited by 249 · see citing works

On whether the environmental enrichment may provide cognitive and brain reserves

Petrosini, L., Bartolo, P. D., Foti, F., Gelfo, F., Cutuli, D., Leggio, M. G., & Mandolesi, L. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.07.002 · Cited by 233 · see citing works

Cognitive leisure activities and their role in preventing dementia: a systematic review

Stern, C., & Munn, Z. (2010) · International Journal of Evidence-Based Healthcare · doi:10.1111/j.1744-1609.2010.00150.x · Cited by 228 · see citing works

Cognitive Exercise and Its Role in Cognitive Function in Older Adults

Gates, N., & Valenzuela, M. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-009-0085-y · Cited by 212 · see citing works

Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique?

Mowszowski, L., Batchelor, J., & Naismith, S. L. (2010) · International Psychogeriatrics · doi:10.1017/s1041610209991748 · Cited by 190 · see citing works

Brain Structural Change and Gait Decline: A Longitudinal Population‐Based Study

Callisaya, M. L., Beare, R. J., Phan, T. G., Blizzard, L., Thrift, A. G., Chen, J., & Srikanth, V. K. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12331 · Cited by 188 · see citing works

Brain and cognitive reserve: Mediator(s) and construct validity, a critique

Satz, P., Cole, M., Hardy, D. J., & Rassovsky, Y. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2010.493151 · Cited by 151 · see citing works

The cognitive burden in Huntington's disease: Pathology, phenotype, and mechanisms of compensation

Papoutsi, M., Labuschagne, I., Tabrizi, S. J., & Stout, J. C. (2014) · Movement Disorders · doi:10.1002/mds.25864 · Cited by 149 · see citing works

Cognitive and social lifestyle: links with neuropathology and cognition in late life

Bennett, D. A., Arnold, S. E., Valenzuela, M., Brayne, C., & Schneider, J. A. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1226-2 · Cited by 141 · see citing works

Complexity of Primary Lifetime Occupation and Cognitive Processing

Sörman, D. E., Hansson, P., Pritschke, I., & Ljungberg, J. K. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01861 · Cited by 121 · see citing works

Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia

Nyberg, J., Åberg, M., Schiöler, L., Nilsson, M., Wallin, A., Torén, K., & Kuhn, H. G. (2014) · Brain · doi:10.1093/brain/awu041 · Cited by 109 · see citing works

APOE-4 Genotype and Neurophysiological Vulnerability to Alzheimer's and Cognitive Aging

Bookheimer, S. Y., & Burggren, A. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153625 · Cited by 104 · see citing works

Cerebral small vessel disease, cognitive reserve and cognitive dysfunction

Pinter, D., Enzinger, C., & Fazekas, F. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7776-6 · Cited by 95 · see citing works

Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation

Arenaza‐Urquijo, E. M., Bejanin, A., Gonneaud, J., Wirth, M., Joie, R. L., Mutlu, J., Gaubert, M., Landeau, B., Sayette, V. D. L., Eustache, F., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.016 · Cited by 94 · see citing works

Effect of a Computerized Brain Exercise Program on Cognitive Performance in Older Adults

Miller, K. J., Dye, R. V., Kim, J., Jennings, J. L., O'Toole, E., Wong, J., & Siddarth, P. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.077 · Cited by 90 · see citing works

Potential Therapeutics for Vascular Cognitive Impairment and Dementia

Sun, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171016164734 · Cited by 87 · see citing works

Roles of vascular risk factors in the pathogenesis of dementia

Takeda, S., Rakugi, H., & Morishita, R. (2019) · Hypertension Research · doi:10.1038/s41440-019-0357-9 · Cited by 65 · see citing works

Predicting long-term outcome following traumatic brain injury (TBI)

Rassovsky, Y., Levi, Y., Agranov, E., Sela-Kaufman, M., Sverdlik, A., & Vakil, E. (2015) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2015.1015498 · Cited by 81 · see citing works

Sensory enrichment for people living with dementia: increasing the benefits of multisensory environments in dementia care through design

Jakob, A., & Collier, L. (2017) · Design for Health · doi:10.1080/24735132.2017.1296274 · Cited by 80 · see citing works

Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia

Kesler, S. R., Tanaka, H., & Koovakkattu, D. (2010) · Brain Imaging and Behavior · doi:10.1007/s11682-010-9104-1 · Cited by 77 · see citing works

Lifespan mental activity predicts diminished rate of hippocampal atrophy

Valenzuela, M., Brodaty, H., Wen, W., Chen, X., & Sachdev, P. S. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.05.284 · Cited by 66 · see citing works

SMR Neurofeedback Training Facilitates Working Memory Performance in Healthy Older Adults: A Behavioral and EEG Study

da Paz, V. K. C., Garcia, A., Neto, A. C. D. P., & Tomaz, C. A. B. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00321 · Cited by 66 · see citing works

Act-Belong-Commit

Donovan, R. J., & Anwar‐McHenry, J. (2014) · American Journal of Lifestyle Medicine · doi:10.1177/1559827614536846 · Cited by 63 · see citing works

Why is delirium more frequent in the elderly?

Bugiani, O. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05339-3 · Cited by 62 · see citing works

Brain and cognitive reserve.

Sachdev, P., & Valenzuela, M. (2009) · The American journal of geriatric psychiatry · doi:10.1097/jgp.0b013e318196a661 · Cited by 60 · see citing works

Can volunteering in later life reduce the risk of dementia? A 5-year longitudinal study among volunteering and non-volunteering retired seniors

Griep, Y., Hanson, L. L. M., Vantilborgh, T., Janssens, L., Jones, S. K., & Hyde, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173885 · Cited by 58 · see citing works

Plasticity of Health

Leischik, R., Dworrak, B., Strauß, M., Przybylek, B., Schöne, D., Horlitz, M., Mügge, A., & Dworrak, T. (2016) · doi:10.19209/gjom000001 · Cited by 57 · see citing works

Mechanisms mediating brain and cognitive reserve: Experience-dependent neuroprotection and functional compensation in animal models of neurodegenerative diseases

Nithianantharajah, J., & Hannan, A. J. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.026 · Cited by 57 · see citing works

Do general practitioners recognize mild cognitive impairment in their patients?

Kaduszkiewicz, H., Zimmermann, T. P., van den Bussche, H., Bachmann, C., Wiese, B., Bickel, H., Mösch, E., Romberg, H.-P., Jessen, F., Cvetanovska, G., et al. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0038-5 · Cited by 57 · see citing works

The role of cognitive reserve in cognitive aging: Results from the neurocognitive study on aging

Giogkaraki, E., Michaelides, M. P., & Constantinidou, F. (2013) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2013.847906 · Cited by 57 · see citing works

Impaired Adaptive Cellular Responses to Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Texel, S. J., & Mattson, M. P. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3569 · Cited by 56 · see citing works

Contribution of neural networks to Alzheimer disease's progression

Savioz, A., Leuba, G., Vallet, P. G., & Walzer, C. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.06.006 · Cited by 55 · see citing works

A critical review of research relating to the learning, use and effects of additional and multiple languages in later life

Pfenninger, S. E., & Singleton, D. (2019) · Language Teaching · doi:10.1017/s0261444819000235 · Cited by 53 · see citing works

Effects of Intentional Weight Loss on Physical and Cognitive Function in Middle-Aged and Older Obese Participants: A Pilot Study

Siervo, M., Nasti, G., Stephan, B. C. M., Papa, A., Muscariello, E., Wells, J. C. K., Prado, C. M. M., & Colantuoni, A. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720012 · Cited by 50 · see citing works

Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease

Roe, C. M., Fagan, A. M., Williams, M., Ghoshal, N., Aeschleman, M., Grant, E., Marcus, D. S., Mintun, M. A., Holtzman, D. M., & Morris, J. C. (2011) · Neurology · doi:10.1212/wnl.0b013e31820af900 · Cited by 49 · see citing works

Prevention of Dementia

Savica, R., & Petersen, R. C. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.11.006 · Cited by 49 · see citing works

Education, Atrophy, and Cognitive Change in an Epidemiological Sample in Early Old Age

Christensen, H., Batterham, P. J., Mackinnon, A. J., Anstey, K. J., Wen, W., & Sachdev, P. S. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181961a84 · Cited by 48 · see citing works

Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD

Curtin, P. C. P., Farrar, A. M., Oakeshott, S., Sutphen, J. C., Berger, J. D., Mazzella, M. J., Cox, K., He, D., Alosio, W., Park, L. C., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00361 · Cited by 48 · see citing works

Cerebrospinal Fluid Biomarkers, Education, Brain Volume, and Future Cognition

Roe, C. M., Fagan, A. M., Grant, E., Marcus, D. S., Benzinger, T. L. S., Mintun, M. A., Holtzman, D. M., & Morris, J. C. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.192 · Cited by 48 · see citing works

Cognitive performance protects against Alzheimer’s disease independently of educational attainment and intelligence

Hu, Y., Zhang, Y., Zhang, H., Gao, S., Wang, L., Wang, T., Han, Z., Sun, B., & Liu, G. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01695-4 · Cited by 47 · see citing works

Facilitating Aerobic Exercise Training in Older Adults with Alzheimer's Disease

Yu, F., & Kolanowski, A. M. (2009) · Geriatric Nursing · doi:10.1016/j.gerinurse.2008.11.001 · Cited by 45 · see citing works

Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study

Mirza, S. S., Portegies, M. L. P., Wolters, F. J., Albert Hofman, D., Koudstaal, P. J., Tiemeier, H. W., & Ikram, M. A. (2016) · Neuroepidemiology · doi:10.1159/000443649 · Cited by 40 · see citing works

A critical review of brain and cognitive reserve in Huntington’s disease

Soloveva, M. V., Jamadar, S. D., Poudel, G. R., & Georgiou‐Karistianis, N. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.003 · Cited by 38 · see citing works

A Population Perspective on Prevention of Dementia

Eggink, E., van Charante, E. P. M., van Gool, W. A., & Richard, E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060834 · Cited by 38 · see citing works

[Cognitive reserve: evidence, limitations and future research lines].

Díaz-Orueta, U., Buiza-Bueno, C., & Yanguas-Lezaun, J. (2010) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2009.12.007 · Cited by 33 · see citing works

Emerging drug therapies in Huntington's disease

Mason, S., & Barker, R. A. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902918299 · Cited by 34 · see citing works

Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration

Scheller, E., Abdulkadir, A., Peter, J., Tabrizi, S. J., Frackowiak, R. S. J., & Klöppel, S. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.058 · Cited by 32 · see citing works

Compensatory recruitment of neural resources in chronic alcoholism

Chanraud, S., & Sullivan, E. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00022-7 · Cited by 32 · see citing works

Neuropsychological tools to predict conversion from amnestic mild cognitive impairment to dementia. The TREDEM Registry

Gallucci, M., Battista, M. E. D., Battistella, G., Falcone, C., Bisiacchi, P. S., & Giorgi, E. D. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1349869 · Cited by 32 · see citing works

The social construction of dementia: Systematic review and metacognitive model of enculturation

Bosco, A., Schneider, J. M., Coleston-Shields, D. M., HIGGS, P. F. D., & Orrell, M. W. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.11.009 · Cited by 31 · see citing works

Tips on how to write a paper.

Johnson, T. (2008) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2008.07.007 · Cited by 31 · see citing works

Non-pharmacological strategies to delay cognitive decline

Lautenschlager, N. T., Anstey, K. J., & Kurz, A. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.07.012 · Cited by 30 · see citing works

Music Playing and Interhemispheric Communication: Older Professional Musicians Outperform Age-Matched Non-Musicians in Fingertip Cross-Localization Test

Piccirilli, M., Palermo, M. T., Germani, A., Bertoli, M. L., Ancarani, V., Buratta, L., Dioguardi, M. S., Scarponi, L., & D’Alessandro, P. (2020) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617720000946 · Cited by 29 · see citing works

Efficacy of Cognitive Training Experiences in the Elderly: Can Technology Help?

Buiza, C., González, M., Facal, D., Martinez, V., Díaz, U., Etxaniz, A., Urdaneta, E., & Yanguas, J. (2009) · Interacción · doi:10.1007/978-3-642-02707-9_37 · Cited by 26 · see citing works

Cognitive Training Enhances Pre-Attentive Neurophysiological Responses in Older Adults ‘At Risk’ of Dementia

Mowszowski, L., Hermens, D. F., Diamond, K., Norrie, L. M., Cockayne, N. L., Ward, P. B., Hickie, I. B., Lewis, S. J. G., Batchelor, J., & Naismith, S. L. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131985 · Cited by 29 · see citing works

Revisión del constructo deterioro cognitivo leve: aspectos generales

Rodríguez, J. L. S., & Morales, C. T. (2011) · Revista de Neurología · doi:10.33588/rn.5205.2010245 · Cited by 28 · see citing works

Sensory Design for Dementia Care – The Benefits of Textiles

Jakob, A., & Collier, L. (2017) · Journal of Textile Design Research and Practice · doi:10.1080/20511787.2018.1449078 · Cited by 26 · see citing works

Predictors of Response to Cholinesterase Inhibitors Treatment of Alzheimer’s Disease: Date Mining from the TREDEM Registry

Gallucci, M., Spagnolo, P., Aricò, M., & Grossi, E. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150747 · Cited by 25 · see citing works

Cognitive Reserve and Executive Functions in Adults with Type 2 Diabetes

Peña-González, P., Mondragón‐Maya, A., Silva‐Pereyra, J., & Roa‐Rojas, P. (2020) · Journal of Diabetes Research · doi:10.1155/2020/7941543 · Cited by 25 · see citing works

Lesion-induced and activity-dependent structural plasticity of Purkinje cell dendritic spines in cerebellar vermis and hemisphere

Gelfo, F., Florenzano, F., Foti, F., Burello, L., Petrosini, L., & Bartolo, P. D. (2015) · Brain Structure and Function · doi:10.1007/s00429-015-1109-5 · Cited by 25 · see citing works

Anemia and dementia among the elderly: the São Paulo Ageing & Health Study

Santos, I. S., Scazufca, M., Lotufo, P. A., Menezes, P. R., & Benseñor, I. M. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211001724 · Cited by 24 · see citing works

Understanding Alzheimer's Disease and Other Dementias

Draper, B. (2013) · Cited by 23 · see citing works

Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life

Ma, H., Zhou, T., Li, X., Maraganore, D. M., Heianza, Y., & Qi, L. (2022) · GeroScience · doi:10.1007/s11357-022-00545-z · Cited by 22 · see citing works

Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment

Rahman, M. M., Mim, S. A., Islam, M. R., Parvez, A., Islam, F., Uddin, M. B., Rahaman, M. S., Shuvo, P. A., Ahmed, M., Greig, N. H., et al. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220408102051 · Cited by 22 · see citing works

Cognitive leisure activities and their role in preventing dementia: a systematic review

Stern, C., & Munn, Z. (2009) · JBI library of systematic reviews · doi:10.11124/01938924-200907290-00001 · Cited by 4 · see citing works

Consideration of Cognitive Reserve

Cosentino, S., & Stern, Y. (2019) · Handbook on the Neuropsychology of Aging and Dementia · doi:10.1007/978-1-4614-3106-0_2 · Cited by 18 · see citing works

EFFECTS OF BILINGUALISM ON INHIBITORY CONTROL AND WORKING MEMORY: A STUDY WITH EARLY AND LATE BILINGUALS

Kramer, R., & Mota, M. B. (2015) · Gragoatá · doi:10.22409/gragoata.v20i38.33312 · Cited by 21 · see citing works

Is dementia preventable? Focus on Alzheimer’s disease

Barak, Y., & Aizenberg, D. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.159 · Cited by 21 · see citing works

Brain Games to Slow Cognitive Decline in Alzheimer's Disease

Anderson, K., & Grossberg, G. T. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.04.014 · Cited by 21 · see citing works

Effects of body mass index and education on verbal and nonverbal memory

Wit, L. D., Kirton, J. W., O’Shea, D. M., Szymkowicz, S. M., McLaren, M. E., & Dotson, V. M. (2016) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2016.1194366 · Cited by 19 · see citing works

Study of sociodemographic variables linked to lifestyle and their possible influence on cognitive reserve

Sánchez, J. L., Torrellas, C., Martín‐Vallejo, J., & Barrera, I. (2011) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2011.567976 · Cited by 18 · see citing works

Harnessing brain and cognitive reserve for the prevention of dementia.

Valenzuela, M., & Sachdev, P. S. (2009) · PubMed Central · Cited by 17 · see citing works

Association of cognitive impairment with sleep quality, depression and cardiometabolic risk factors in individuals with type 2 diabetes mellitus: A cross sectional study.

Gupta, A., Gupta, Y., Anjana, R., Ranjani, H., Kalaivani, M., Goyal, A., Jagannathan, N., Sharma, S., Mittal, B., Radhakrishnan, V., et al. (2021) · Journal of diabetes and its complications · doi:10.1016/j.jdiacomp.2021.107970 · Cited by 14 · see citing works

Postoperative cognitive dysfunction and its relationship to cognitive reserve in elderly total joint replacement patients

Scott, J., Mathias, J. L., Kneebone, A. C., & Krishnan, J. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2016.1233940 · Cited by 16 · see citing works

Clinical and Cognitive Correlates of Structural Hippocampal Change in “At-Risk” Older Adults

Elcombe, E. L., Lagopoulos, J., Mowszowski, L., Diamond, K., Paradise, M., Hickie, I. B., Lewis, S. J. G., & Naismith, S. L. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713509137 · Cited by 15 · see citing works

Prevention of late-life dementia: what works and what does not

Tipton, P. W., & Graff‐Radford, N. R. (2018) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.4263 · Cited by 15 · see citing works

From the Multifactorial Nature of Alzheimer`s Disease to Multitarget Therapy: The Contribution of the Translational Approach

Calzà, L., Baldassarro, V. A., Giuliani, A., Lorenzini, L., Fernández, M., Mangano, C., Sivilia, S., Alessandri, M., Gusciglio, M., Torricella, R., et al. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113139990140 · Cited by 14 · see citing works

Proper name retrieval in cognitive decline

Montemurro, S., Mondini, S., Nucci, M., & Semenza, C. (2018) · The Mental Lexicon · doi:10.1075/ml.18004.mon · Cited by 14 · see citing works

Interactional Effects Between Relational and Cognitive Reserves on Decline in Executive Functioning

Sauter, J., Widmer, E. D., Baeriswyl, M., Ballhausen, N., Vallet, F., Fagot, D., Kliegel, M., & Ihle, A. (2020) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa054 · Cited by 13 · see citing works

Midlife Long-Hour Working and Later-life Social Engagement Are Associated with Reduced Risks of Mild Cognitive Impairment among Community-Living Singapore Elderly

Deng, J.-H., Huang, K., Hu, X.-X., Huang, X., Tang, X., Wei, X., Feng, L., & Lu, G. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180605 · Cited by 13 · see citing works

Clinical Efficacy of a New Automated Hemoencefalographic Neurofeedback Protocol

Dias, Á. M., Deusen, A. M. V., Ferracioli-Oda, E., & Bonfim, M. R. (2012) · The Spanish Journal of Psychology · doi:10.5209/rev_sjop.2012.v15.n3.39385 · Cited by 12 · see citing works

Short-Term Response is not Predictive of Long-Term Response to Acetylcholinesterase Inhibitors in Old Age Subjects with Alzheimer’s Disease: A “Real World” Study

Boccardi, V., Baroni, M., Smirne, N., Clodomiro, A., Ercolani, S., Longo, A., Ruggiero, C., Bruni, A. C., & Mecocci, P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160904 · Cited by 12 · see citing works

Global Burden of Alzheimer's Disease and Other Dementias Attributed to High Fasting Plasma Glucose from 1990 to 2019

Wang, M., Huang, K., Jin, Y., & Zheng, Z.-J. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.47 · Cited by 11 · see citing works

Dementia and Alzheimer’s Disease

Barnes, D., Lopez, O., & Yaffe, K. (2012) · Springer eBooks · doi:10.1007/978-94-007-5061-6_31 · Cited by 60 · see citing works

Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats

Khalil, M. G., Ali, A. A., Hassanin, S. O., Al‐Najjar, A. H., Ghosh, S. B., & Mahmoud, M. O. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100146 · Cited by 11 · see citing works

Factors related to cognitive status among elders in southern Thailand

Taboonpong, S., Chailungka, P., & Aassanangkornchai, S. (2008) · Nursing and Health Sciences · doi:10.1111/j.1442-2018.2008.00396.x · Cited by 11 · see citing works

Role of cumulative biological risk in mediating socioeconomic disparities in cognitive function in the elderly: a mediation analysis

Akrivos, J., Zhu, C. W., & Haroutunian, V. H. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-035847 · Cited by 10 · see citing works

Leisure Activity Variety and Brain Volume Among Community-Dwelling Older Adults: Analysis of the Neuron to Environmental Impact Across Generations Study Data

Iizuka, A., Murayama, H., Machida, M., Amagasa, S., Inoue, S., Fujiwara, T., & Shobugawa, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.758562 · Cited by 10 · see citing works

Cognitive Reserve and Lifestyle in Spanish Individuals With Sporadic Alzheimer’s Disease

Rodríguez, J. L. S., Torrellas, C., Martín‐Vallejo, J., & Gómez, M. J. F. (2011) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317511428150 · Cited by 9 · see citing works

Harnessing brain and cognitive reserve for the prevention of dementia.

Valenzuela, M., & Sachdev, P. S. (2009) · PubMed Central · Cited by 17 · see citing works

Brain reserve and dementia: a systematic review

VALENZUELA, M. J., & SACHDEV, P. (2006) · Psychological Medicine · doi:10.1017/s0033291705006264 · Cited by 932 · see citing works

Brain Reserve and Cognitive Training in the Elderly

Sakka, P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-08939-3_16 · Cited by 3 · see citing works

P1–244: Brain reserve: The impact of complex mental activity on dementia incidence, cognitive decline and hippocampal structure and function

Valenzuela, M., & Sachdev, P. S. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.621

Do Lifestyle Activities Protect Against Cognitive Decline in Aging? A Review

Christie, G. J., Hamilton, T., Manor, B., Farb, N. A. S., Farzan, F., Sixsmith, A. J., Temprado, J.-J., & Moreno, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00381 · Cited by 76 · see citing works