Cited by 156Dementia and Cognitive Impairment ResearchMicroRNA in disease regulationAlzheimer's disease research and treatments

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Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

Sala Frigerio, Carlo, Lau, Pierre, Salta, Evgenia, Tournoy, Jos, Bossers, Koen, Vandenberghe, Rik, Wallin, Anders, Bjerke, Maria, Zetterberg, Henrik, Blennow, Kaj, De Strooper, Bart·2013·Neurology

DOI 10.1212/01.wnl.0000437306.37850.22

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Abstract

Objective We evaluated microRNAs (miRNAs) as potential biomarkers for Alzheimer disease (AD) by analyzing the expression level of miRNAs in CSF of patients with AD dementia and nonaffected control subjects. Methods Using quantitative PCR, we profiled the expression level of 728 miRNAs in CSF of nonaffected control subjects and patients with clinically ascertained AD dementia, and we further compared the expression level of candidate miRNAs in 37 control subjects and 35 patients with AD dementia. Results The level of hsa-miR-27a-3p in CSF is reduced in patients with dementia due to AD in 2 different cohorts of subjects (cohort 1: p = 0.008; cohort 2: p = 0.015; 2-tailed unpaired Welch t test). Moreover, low levels of hsa-miR-27a-3p were accompanied by high CSF tau levels and low CSF β-amyloid levels. Conclusions Our pilot study highlights hsa-miR-27a-3p as a candidate biomarker for AD and provides the groundwork for further confirmation studies in larger cohorts and in other hospitals.

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Authors: Sala Frigerio, C., Lau, P., Salta, E., Tournoy, J., Bossers, K., Vandenberghe, R., Wallin, A., Bjerke, M., Zetterberg, H., Blennow, K., & De Strooper, B.
Affiliations: From the VIB Center for the Biology of Disease (C.S.F., P.L., E.S., B.D.S.), Leuven; Center for Human Genetics and LIND (C.S.F., P.L., E.S., B.D.S.), and Alzheimer Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease (R.V.), University of Leuven; Geriatric Medicine (J.T.), and Neurology Department (R.V.), University Hospitals Leuven; Department of Clinical and Experimental Medicine and LIND (J.T.), Laboratory for Cognitive Neurology, Department of Neurosciences (R.V.), KU Leuven,...
Netherlands Institute for Neuroscience (NL)
ORCID: Lau, Pierre
Salta, Evgenia
Tournoy, Jos
Bossers, Koen
Vandenberghe, Rik
Wallin, Anders
Bjerke, Maria
Zetterberg, Henrik
Blennow, Kaj
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-12-10
Volume: 81
Issue: 24
Pages: 2103-2106
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000437306.37850.22
OpenAlex: W1975366875
Cited by: 156
References: 10
Citations by year: 2026: 3 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 17 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 17 · 2014: 9
FWCI: 10.16
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Lirias (KU Leuven) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, microRNA, cerebrospinal fluid, biomarkers, CSF tau
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pilot Projects, Cohort Studies, Biomarkers, MicroRNAs

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Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

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