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Correlation between rates of brain atrophy and cognitive decline in AD
Abstract
Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.
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Metadata
- Authors
- Fox, N. C., Scahill, R. I., Crum, W. R., & Rossor, M. N.
- Venue
- Neurology
- Published
- 1999-05
- Volume
- 52
- Issue
- 8
- Pages
- 1687-1687
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1966378897
- Cited by
- 338
- References
- 1
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- closed
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