Quantitative magnetic resonance techniques as surrogate markers of Alzheimer’s disease
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Recent advances in understanding the molecular biology of Alzheimer's disease (AD) offer the promise of useful therapeutic intervention in the foreseeable future. Hence, improved methods for early diagnosis and noninvasive surrogates of disease severity in AD have become more imperative. Various quantitative magnetic resonance (MR) techniques that measure the anatomic, biochemical, microstructural, functional, and blood-flow changes are being evaluated as possible surrogate measures of disease progression. Cross-sectional and longitudinal studies indicate that MR-based volume measurements are potential surrogates of disease progression in AD, starting from the preclinical stages. The validity of MR-based volumetry as a surrogate marker for therapeutic efficacy in AD remains to be tested in a positive disease-modifying drug trial. Recent development of amyloid imaging tracers for positron emission tomography has been a major breakthrough in the field of imaging markers for AD. Efforts to image plaques are also underway in MR imaging. As with indirect MR measures, these approaches of directly imaging the pathological substrate will need to undergo a validation process with longitudinal studies to prove their usefulness as surrogate markers in AD.
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The very mild/mild DAT group has significantly reduced whole brain and hippocampal volumes compared with non-demented controls.
“The very mild/mild DAT group also exhibited significantly reduced whole brain (nWBV) and hippocampal (HC) volumes, as has been reported previously.6, 27”
From Decreased cerebrospinal fluid Aβ <sub>42</sub> correlates with brain atrophy in cognitively normal elderly (2009) · cites this paper as [6]
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Fagan, A. M., Head, D., Shah, A. R., Marcus, D., Mintun, M., Morris, J. C., & Holtzman, D. M. (2009) · Annals of Neurology · doi:10.1002/ana.21559 · Cited by 327 · see citing works
“Whole-brain atrophy, the presumed consequence of years of axonal and neuronal degeneration, is a fundamental but not specific feature of AD and has been quantified antemortem by magnetic resonance imaging (MRI) in both cross-sectional and longitudinal studies.(6,7) The best studied fluid analytes in AD have been cereb…”
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Magnetic Resonance Imaging Traits in Siblings Discordant for Alzheimer Disease
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- Authors
- Kantarci, K., & Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Kantarci, Kejal
- Jack, Clifford R.
- Venue
- NeuroRX
- Published
- 2004-04
- Volume
- 1
- Issue
- 2
- Pages
- 196-205
- ISSN
- 1545-5343 (ISSN-L)
- PMC
- PMC534925
- OpenAlex
- W2072537889
- Cited by
- 80
- References
- 107
- Citations by year
- 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 9
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroRx (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AG11378, AG16574)
- National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, quantitative MRI, surrogate markers, disease progression, positron emission tomography, amyloid plaques, preclinical Alzheimer's disease, disease-modifying drugs
- MeSH terms
- Alzheimer Disease, Brain, Humans, Magnetic Resonance Imaging, Biomarkers
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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