Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction
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Tangential migration from the basal telencephalon to the cortex is a highly directional process, yet the mechanisms involved are poorly understood. Here we show that the basal telencephalon contains a repulsive activity for tangentially migrating cells, whereas the cerebral cortex contains an attractive activity. In vitro experiments demonstrate that the repulsive activity found in the basal telencephalon is maintained in mice deficient in both Slit1 and Slit2, suggesting that factors other than these are responsible for this activity. Correspondingly, in vivo analysis demonstrates that interneurons migrate to the cortex in the absence of Slit1 and Slit2, or even in mice simultaneously lacking Slit1, Slit2 and netrin 1. Nevertheless, loss of Slit2 and, even more so, Slit1 and Slit2 results in defects in the position of other specific neuronal populations within the basal telencephalon, such as the cholinergic neurons of the basal magnocellular complex. These results demonstrate that whereas Slit1 and Slit2 are not necessary for tangential migration of interneurons to the cortex, these proteins regulate neuronal migration within the basal telencephalon by controlling cell positioning close to the midline.
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Interneurons move toward the cortex along a gradient of increasing permissivity produced by chemoattractive cues in the developing LGE and pallium.
“Interneurons migrate toward the cortex following a gradient of increasing permissivity generated by chemoattractive cues produced in the developing LGE and pallium (Marín et al., 2003; Wichterle et al., 2003).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Marín et al., 2003
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- Authors
- Marín, O., Plump, A. S., Flames, N., Sánchez-Camacho, C., Tessier-Lavigne, M., & Rubenstein, J. L. R.
- Affiliations
- Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue,University of California San Francisco, CA 94143, USA
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of California, San Francisco (US)
- Department of Biological Sciences, Howard Hughes Medical Institute, 371 Serra Mall, Stanford University, Stanford, CA 94305, USA
- Corresponding author
- Rubenstein, John L. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-05-01
- Volume
- 130
- Issue
- 9
- Pages
- 1889-1901
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2172188544
- Cited by
- 156
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 8 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 12 · 2012: 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute
- National Alliance for Research on Schizophrenia and Depression
- University of California, Davis
- National Institute of Mental Health (R01 MH4942801, RO1MH51561-01A1, R01MH049428, K01 MH01046-01, RO1MH49428-01, K02 MH01046-01, R01MH51561-01A1, R01MH051561)
- National Institute on Drug Abuse (R01DA012462)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- interneuron migration, tangential migration, Slit1, Slit2, netrin-1, basal telencephalon, cerebral cortex, cholinergic neurons
- MeSH terms
- Netrin-1, Slit Homolog 2 Protein, Animals, Cell Movement, Cerebral Cortex, Interneurons, Nerve Growth Factors, Nerve Tissue Proteins, Tumor Suppressor Proteins, Intercellular Signaling Peptides and Proteins, Mice
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