Cited by 51Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationAxon Guidance and Neuronal Signaling

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex

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Peyre, Elise, Silva, Carla G., Nguyen, Laurent·2015·Frontiers in Cellular Neuroscience

Abstract

During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the cortical wall. As they reach this structure they undergo intracortical dispersion to settle in their final destination. At the cellular level, migrating interneurons are highly polarized cells that extend and retract processes using dynamic remodeling of microtubule and actin cytoskeleton. Different levels of molecular regulation contribute to interneuron migration. These include: (1) Extrinsic guidance cues distributed along migratory streams that are sensed and integrated by migrating interneurons; (2) Intrinsic genetic programs driven by specific transcription factors that grant specification and set the timing of migration for different subtypes of interneurons; (3) Adhesion molecules and cytoskeletal elements/regulators that transduce molecular signalings into coherent movement. These levels of molecular regulation must be properly integrated by interneurons to allow their migration in the cortex. The aim of this review is to summarize our current knowledge of the interplay between microenvironmental signals and cell autonomous programs that drive cortical interneuron porduction, tangential migration, and intergration in the developing cerebral cortex.

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Crossref · 10.3389/fncel.2015.00129

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  • These receptors activate intraneuronal signaling cascades that remodel microtubule and actin cytoskeletal components to extend and retract processes that move cells toward their destination.

    “These receptors activate intraneuronal signaling cascades that dynamically remodel microtubule and actin cytoskeletal components to extend and retract processes that move the cells toward their destination [133].”

    From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [133]

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Authors
Peyre, E., Silva, C. G., & Nguyen, L.
Affiliations
University of Liège (BE)
Corresponding author
Nguyen, Laurent
Venue
Frontiers in Cellular Neuroscience
Published
2015-04-14
Volume
9
Pages
129-129
ISSN
1662-5102 (ISSN-L)
OpenAlex
W1997205795
Cited by
51
References
248
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 1
FWCI
0.50
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fonds De La Recherche Scientifique - FNRS
  • Fonds Léon Fredericq
  • Walloon excellence in life sciences and biotechnology
  • Fondation Médicale Reine Elisabeth
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
cortical interneurons, interneuron migration, tangential migration, ganglionic eminence, transcription factors, adhesion molecules, cytoskeletal remodeling, microtubules, actin cytoskeleton, interneuron specification, cortical development, cell-autonomous signaling

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