Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex
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During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the cortical wall. As they reach this structure they undergo intracortical dispersion to settle in their final destination. At the cellular level, migrating interneurons are highly polarized cells that extend and retract processes using dynamic remodeling of microtubule and actin cytoskeleton. Different levels of molecular regulation contribute to interneuron migration. These include: (1) Extrinsic guidance cues distributed along migratory streams that are sensed and integrated by migrating interneurons; (2) Intrinsic genetic programs driven by specific transcription factors that grant specification and set the timing of migration for different subtypes of interneurons; (3) Adhesion molecules and cytoskeletal elements/regulators that transduce molecular signalings into coherent movement. These levels of molecular regulation must be properly integrated by interneurons to allow their migration in the cortex. The aim of this review is to summarize our current knowledge of the interplay between microenvironmental signals and cell autonomous programs that drive cortical interneuron porduction, tangential migration, and intergration in the developing cerebral cortex.
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These receptors activate intraneuronal signaling cascades that remodel microtubule and actin cytoskeletal components to extend and retract processes that move cells toward their destination.
“These receptors activate intraneuronal signaling cascades that dynamically remodel microtubule and actin cytoskeletal components to extend and retract processes that move the cells toward their destination [133].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [133]
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2 of the 248 references couldn’t be matched to a known paper.
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Parvalbumin interneuron vulnerability and brain disorders
Ruden, J. B., Dugan, L. L., & Konradi, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0778-9 · Cited by 194 · see citing works
Birey, F., Li, M.-Y., Gordon, A., Thete, M. V., Valencia, A. M., Revah, O., Pașca, A. M., Geschwind, D. H., & Pașca, S. P. (2022) · Cell stem cell · doi:10.1016/j.stem.2021.11.011 · Cited by 155 · see citing works
Buchsbaum, I. Y., & Cappello, S. (2019) · Development · doi:10.1242/dev.163766 · Cited by 128 · see citing works
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62 · see citing works
Oproescu, A.-M., Han, S., & Schuurmans, C. J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.642016 · Cited by 51 · see citing works
Symmank, J., Bayer, C., Schmidt, C., Hahn, A., Pensold, D., & Zimmer‐Bensch, G. (2018) · Epigenetics · doi:10.1080/15592294.2018.1475980 · Cited by 39 · see citing works
Non–cell-autonomous regulation of interneuron specification mediated by extracellular vesicles
Pipicelli, F., Baumann, N., Giaimo, R. D., Forero, A., Kyrousi, C., Bonrath, R., Maccarrone, G., Jabaudon, D., & Cappello, S. (2023) · Science Advances · doi:10.1126/sciadv.add8164 · Cited by 35 · see citing works
Woo, H. J., Yu, C., Kumar, K., & Jaques Reifman, A. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.61 · Cited by 34 · see citing works
Dopamine as a growth differentiation factor in the mammalian brain
Ohira, K. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266052 · Cited by 34 · see citing works
Imoh, P. O. (2023) · International Journal of Scientific Research and Modern Technology. · doi:10.38124/ijsrmt.v2i8.494 · Cited by 30 · see citing works
Interneuron odyssey: molecular mechanisms of tangential migration
Toudji, I., Toumi, A., Chamberland, É., & Rossignol, E. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1256455 · Cited by 28 · see citing works
Regulation of neuronal survival by DNA methyltransferases
Zimmer‐Bensch, G., & Symmank, J. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.219027 · Cited by 29 · see citing works
Topographical cues control the morphology and dynamics of migrating cortical interneurons
Leclech, C., Renner, M. L., Villard, C., & Métin, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2019.05.005 · Cited by 28 · see citing works
Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration
Bajaj, S., Bagley, J. A., Sommer, C., Vértesy, Á., Wong, S. N., Krenn, V., Lévi‐Strauss, J., & Knoblich, J. A. (2021) · The EMBO Journal · doi:10.15252/embj.2021108714 · Cited by 27 · see citing works
microRNA Biology on Brain Development and Neuroimaging Approach
Tsujimura, K., Shiohama, T., & Takahashi, E. (2022) · Brain Sciences · doi:10.3390/brainsci12101366 · Cited by 28 · see citing works
Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes
Miyoshi, G. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.09.012 · Cited by 28 · see citing works
Shaping the cerebral cortex by cellular crosstalk
Stoufflet, J., Tielens, S., & Nguyen, L. (2023) · Cell · doi:10.1016/j.cell.2023.05.040 · Cited by 25 · see citing works
Self-citationA Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons
Bartholomé, O., Bonardeaux, O. D. L. B., Neirinckx, V., & Rogister, B. (2020) · Cerebral Cortex Communications · doi:10.1093/texcom/tgaa026 · Cited by 21 · see citing works
Ansen-Wilson, L. J., & Lipinski, R. J. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.12.002 · Cited by 22 · see citing works
Fleitas, C., Marfull-Oromí, P., Chauhan, D., del Toro, D., Peguera, B., Zammou, B., Rocandio, D., Klein, R., Espinet, C., & Egea, J. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0380-20.2021 · Cited by 18 · see citing works
Pensold, D., & Zimmer‐Bensch, G. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518760783 · Cited by 18 · see citing works
Eid, L., Lokmane, L., Raju, P. K., Tadoum, S. B. T., Jiang, X., Toulouse, K., Lupien‐Meilleur, A., Charron-Ligez, F., Toumi, A., Backer, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02742-y · Cited by 17 · see citing works
Zamberletti, E., & Rubino, T. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.013 · Cited by 17 · see citing works
microRNA-dependent regulation of gene expression in GABAergic interneurons
Kołosowska, K., Schratt, G. M., & Winterer, J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1188574 · Cited by 15 · see citing works
Dopamine stimulates differentiation and migration of cortical interneurons
Ohira, K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.105 · Cited by 14 · see citing works
Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration
Munguba, H., Nikouei, K., Hochgerner, H., Oberst, P., Kouznetsova, A., Ryge, J., Muñoz‐Manchado, A. B., Close, J., Batista‐Brito, R., Linnarsson, S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.07.018 · Cited by 19 · see citing works
JNK Signaling Regulates Cellular Mechanics of Cortical Interneuron Migration
Smith, S. E., Coker, N. K., & Tucker, E. S. (2020) · eNeuro · doi:10.1523/eneuro.0132-20.2020 · Cited by 11 · see citing works
Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migrationPreprint
Munguba, H., Nikouei, K., Hochgerner, H., Oberst, P., Kouznetsova, A., Ryge, J., Batista‐Brito, R., Muñoz‐Manchado, A. B., Close, J., Linnarsson, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/593285 · Cited by 9 · see citing works
Viou, L., Atkins, M., Rousseau, V., Launay, P., Masson, J., Pace, C., Murakami, F., Barnier, J., & Métin, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02483-y · Cited by 8 · see citing works
DCX knockout ferret reveals a neurogenic mechanism in cortical development
Wang, W., Yin, C., Wen, S., Liu, Z., Wang, B., Zeng, B., Sun, L., Zhou, X., Zhong, S., Zhang, J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114508 · Cited by 7 · see citing works
Kounoupa, Z., Tivodar, S., Theodorakis, Κ., Kyriakis, D., Denaxa, M., & Karagogeos, D. (2023) · Journal of Cell Science · doi:10.1242/jcs.260373 · Cited by 7 · see citing works
Hara, Y., Katsuyama, T., Fukaya, M., Sugawara, T., Shiroshima, T., Sadakata, T., Osumi, N., & Sakagami, H. (2023) · eNeuro · doi:10.1523/eneuro.0125-23.2023 · Cited by 5 · see citing works
Nganou, G., Silva, C. G., Gladwyn-Ng, I. E., Engel, D., Coumans, B., Delgado‐Escueta, A. V., Tanaka, M., Nguyen, L., Grisar, T. M., de Nijs, L., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00234 · Cited by 4 · see citing works
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Telencephalic organoids as model systems to study cortical development and diseases
Yang, W. S., Kiral, F. R., & Park, I. (2024) · Organoid · doi:10.51335/organoid.2024.4.e1 · Cited by 1 · see citing works
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Genetics of cortical development
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DCX knockout ferret reveals a neurogenic mechanism in cortical developmentPreprint
Wang, W., Yin, C., Wen, S., Liu, Z., Wang, B., Zeng, B., Sun, L., Zhou, X., Zhong, S., Zhang, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.13.598795
The Development of the Central Nervous System and Human Neural Stem Cells
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Etude du rôle de la kinésine KIF21B au cours du développement cortical
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Decoding Brain Development and Function Through GABAergic Inhibitory Neurons
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Self-citationTangential migration in the telencephalon
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Self-citationReceptor Tyrosine Kinase Signaling in Mammalian Eye Development
Makrides, N., Wu, Y.-H., Almonte, Y., Zhang, X., & Tao, C. (2026) · Developmental Biology · doi:10.1016/j.ydbio.2026.09.005
- Authors
- Peyre, E., Silva, C. G., & Nguyen, L.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Nguyen, Laurent
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-04-14
- Volume
- 9
- Pages
- 129-129
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4396449
- OpenAlex
- W1997205795
- Cited by
- 51
- References
- 248
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 8 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Fonds Léon Fredericq
- Walloon excellence in life sciences and biotechnology
- Fondation Médicale Reine Elisabeth
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- cortical interneurons, interneuron migration, tangential migration, ganglionic eminence, transcription factors, adhesion molecules, cytoskeletal remodeling, microtubules, actin cytoskeleton, interneuron specification, cortical development, cell-autonomous signaling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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