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Cited by 304

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Essential role of non-canonical Wnt signalling in neural crest migration

Open access
De Calisto, Jaime, Araya, Claudio, Marchant, Lorena, Riaz, Chaudhary F., Mayor, Roberto·2005·Development
DOI 10.1242/dev.01857
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Abstract

Migration of neural crest cells is an elaborate process that requires the delamination of cells from an epithelium and cell movement into an extracellular matrix. In this work, it is shown for the first time that the non-canonical Wnt signalling [planar cell polarity (PCP) or Wnt-Ca2+] pathway controls migration of neural crest cells. By using specific Dsh mutants, we show that the canonical Wnt signalling pathway is needed for neural crest induction, while the non-canonical Wnt pathway is required for neural crest migration. Grafts of neural crest tissue expressing non-canonical Dsh mutants, as well as neural crest cultured in vitro, indicate that the PCP pathway works in a cell-autonomous manner to control neural crest migration. Expression analysis of non-canonical Wnt ligands and their putative receptors show that Wnt11 is expressed in tissue adjacent to neural crest cells expressing the Wnt receptor Frizzled7 (Fz7). Furthermore, loss- and gain-of-function experiments reveal that Wnt11 plays an essential role in neural crest migration. Inhibition of neural crest migration by blocking Wnt11 activity can be rescued by intracellular activation of the non-canonical Wnt pathway. When Wnt11 is expressed opposite its normal site of expression, neural crest migration is blocked. Finally, time-lapse analysis of cell movement and cell protrusion in neural crest cultured in vitro shows that the PCP or Wnt-Ca2+ pathway directs the formation of lamellipodia and filopodia in the neural crest cells that are required for their delamination and/or migration.

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Metadata

Authors
De Calisto, J., Araya, C., Marchant, L., Riaz, C. F., & Mayor, R.
Venue
Development
Publisher
The Company of Biologists
Published
2005-06-01
Volume
132
Issue
11
Pages
2587-2597
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.01857
OpenAlex
W2142339417
Cited by
304
References
102
FWCI
8.76
Type
journal article
Language
en
Open access
bronze

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