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DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling
Abstract
DNA methylation is a major epigenetic factor that has been postulated to regulate cell lineage differentiation. We report here that conditional gene deletion of the maintenance DNA methyltransferase I (Dnmt1) in neural progenitor cells (NPCs) results in DNA hypomethylation and precocious astroglial differentiation. The developmentally regulated demethylation of astrocyte marker genes as well as genes encoding the crucial components of the gliogenic JAK-STAT pathway is accelerated in Dnmt1–/– NPCs. Through a chromatin remodeling process, demethylation of genes in the JAK-STAT pathway leads to an enhanced activation of STATs, which in turn triggers astrocyte differentiation. Our study suggests that during the neurogenic period, DNA methylation inhibits not only astroglial marker genes but also genes that are essential for JAK-STAT signaling. Thus, demethylation of these two groups of genes and subsequent elevation of STAT activity are key mechanisms that control the timing and magnitude of astroglial differentiation.
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Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405
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ten Hoeve, J., de Jesus Ibarra-Sanchez, M., Fu, Y., Zhu, W., Tremblay, M., David, M., & Shuai, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5662-5668.2002 · Cited by 507
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Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906
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Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
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Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065
“Inactivation of DNMTs in the nervous system results in neurodevelopmental deficits and impaired neuronal functions (Fan et al., 2001; Fan et al., 2005; Feng et al., 2010a; LaPlant et al., 2010; Nguyen et al., 2007; Wu et al., 2010), suggesting that precise control of DNA methylation pattern is required for proper brai…”
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Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019
Self-citationAstrocyte Crosstalk in CNS Inflammation
Linnerbauer, M., Wheeler, M. A., & Quintana, F. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.012 · Cited by 989
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Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662
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Miller, F. D., & Gauthier, A. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.019 · Cited by 588
Boutz, P. L., Stoilov, P., Li, Q., Lin, C.-H., Chawla, G., Ostrow, K., Shiue, L., Ares, M., & Black, D. L. (2007) · Genes & Development · doi:10.1101/gad.1558107 · Cited by 577
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Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C. J., Gronostajski, R. M., & Anderson, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.019 · Cited by 514
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Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373
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Kang, P., Lee, H. K., Glasgow, S. M., Finley, M., Donti, T., Gaber, Z. B., Graham, B. H., Foster, A. E., Novitch, B. G., Gronostajski, R. M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.024 · Cited by 373
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Li, S., Overman, J. J., Katsman, D., Kozlov, S. V., Donnelly, C. J., Twiss, J. L., Giger, R. J., Coppola, G., Geschwind, D. H., & Carmichael, S. T. (2010) · Nature Neuroscience · doi:10.1038/nn.2674 · Cited by 329
Hutnick, L. K., Golshani, P., Namihira, M., Xue, Z., Matynia, A., Yang, X. W., Silva, A. J., Schweizer, F. E., & Fan, G. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp222 · Cited by 181
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Ratnu, V. S., Emami, M. R., & Bredy, T. W. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23886 · Cited by 144
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Pinto, L., Drechsel, D., Schmid, M.-T., Ninkovic, J., Irmler, M., Brill, M. S., Restani, L., Gianfranceschi, L., Cerri, C., Weber, S. N., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2399 · Cited by 100
Turner, J. D., Pelascini, L. P. L., Macedo, J. A., & Muller, C. P. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn897 · Cited by 104
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Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82
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Kaji, K., Factor, V. M., Andersen, J. B., Durkin, M. E., Tomokuni, A., Marquardt, J. U., Matter, M. S., Hoang, T., Conner, E. A., & Thorgeirsson, S. S. (2016) · Hepatology · doi:10.1002/hep.28563 · Cited by 61
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Stine, R. R., & Matunis, E. L. (2013) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-6621-1_14 · Cited by 56
DNA Epigenetics in Addiction Susceptibility
Kaplan, G., Xu, H., Abreu, K., & Feng, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.806685 · Cited by 34
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Duan, Z., & Lu, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.538683 · Cited by 32
Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
Noack, F., Pataskar, A., Schneider, M., Buchholz, F., Tiwari, V. K., & Calegari, F. (2019) · Life Science Alliance · doi:10.26508/lsa.201900331 · Cited by 29
Noguchi, H., Kimura, A., Murao, N., Namihira, M., & Nakashima, K. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1232679 · Cited by 18
Metadata
- Authors
- Fan, G., Martinowich, K., Chin, M. H., He, F., Fouse, S. D., Hutnick, L., Hattori, D., Ge, W., Shen, Y., Wu, H., ten Hoeve, J., Shuai, K., & Sun, Y. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-08-01
- Volume
- 132
- Issue
- 15
- Pages
- 3345-3356
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143008483
- Cited by
- 417
- References
- 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
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