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p53 suppresses the self-renewal of adult neural stem cells
Open accessAbstract
There is increasing evidence that tumors are heterogeneous and that a subset of cells act as cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of stem cell function, suggesting that similar mechanisms control normal and cancer stem cell properties. We show here that the prototypical tumor suppressor p53, which plays an important role in brain tumor initiation and growth, is expressed in the neural stem cell lineage in the adult brain. p53 negatively regulates proliferation and survival, and thereby self-renewal, of neural stem cells. Analysis of the neural stem cell transcriptome identified the dysregulation of several cell cycle regulators in the absence of p53, most notably a pronounced downregulation of p21 expression. These data implicate p53 as a suppressor of tissue and cancer stem cell self-renewal.
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“p53 is involved in restricting the self-renewal of several types of stem cells, including neural stem cells and hematopoietic stem cells (Cicalese et al., 2009; Liu et al., 2009; Meletis et al., 2006).”
From p53 at a glance (2010) · cites this paper as Meletis et al., 2006
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Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons
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Metadata
- Authors
- Meletis, K., Wirta, V., Hede, S.-M., Nistér, M., Lundeberg, J., & Frisén, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-01-15
- Volume
- 133
- Issue
- 2
- Pages
- 363-369
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1984885474
- Cited by
- 413
- References
- 6
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
